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        "event_title":"Human Genetics Research Seminar Series",
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        "combined_title":"Human Genetics Research Seminar Series: presenting Danesh Moazed, PhD, Professor and HHMI Investigator in the Department of Cell Biology at Harvard Medical School",
        "event_subtitle":"presenting Danesh Moazed, PhD, Professor and HHMI Investigator in the Department of Cell Biology at Harvard Medical School",
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        "description":"Monday, March 9, 2026\r\n11:00am - 12:00pm\r\n1020 Kahn Auditorium, BSRB\r\n\r\nDanesh Moazed, PhD\r\nProfessor and HHMI Investigator in the Department of Cell Biology at Harvard Medical School\r\n\u201cSeminar Title TBD\u201d\r\n\r\nHosted By: Sue Hammoud, PhD, Department of Human Genetics\r\n\r\n__\r\n\r\nDanesh Moazed, Ph.D., is a Professor and HHMI Investigator in the Department of Cell Biology at Harvard Medical School.  He is a member of the Harvard Biophysics Program and the Harvard Initiative for RNA Medicine (HIRM). He received his undergraduate and Ph.D. degrees from the University of California in Santa Cruz and performed postdoctoral studies at the University of California in San Francisco.\r\n\r\nThe Moazed lab studies how genes are silenced and how silencing is epigenetically inherited across generations.  The lab\u2019s interests revolve around diverse pathways of heterochromatin-mediated gene silencing in yeast and mammalian cells.  Work in budding yeast focuses on the structure and function of a diverged and relatively simple form of heterochromatin, which requires only three Silent information regulator (\u201cSir\u201d) proteins that form a histone deacetylase and chromatin-binding complex.  Work in fission yeast focuses on a conserved example of heterochromatin that requires the nuclear RNA interference (RNAi) machinery, other RNA processing pathways, Heterochromatin protein 1 (HP1) homologs, and histone-modifying enzymes.  In mammalian cells, the work is focused on HP1-mediated and other heterochromatin formation pathways.  The lab uses approaches ranging from genetics and genomics, biochemical purification and reconstitution, and structural biology for their studies.  Ultimately, the lab seeks to understand the conserved fundamental principles that govern the assembly, function, and epigenetic propagation of heterochromatin.",
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        "combined_title":"Human Genetics Research Seminar Series: presenting Hiten Madhani, MD, PhD, Professor, Biochemistry and Biophysics Stuart Lindsay Endowed Professor in Experimental Pathology VII University of California, San Francisco",
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        "event_title":"SCSAP Special Research Seminar and Town Hall Event",
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        "combined_title":"SCSAP Special Research Seminar and Town Hall Event: Aviv Regev, PhD, Genentech",
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        "datetime_start":"20260330T110000",
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        "combined_title":"Human Genetics Research Seminar Series: presenting Jean Gautier, PhD, Dr.Sc., Chair, Department of Epigenetics and Molecular Carcinogenesis The University of Texas MD Anderson Cancer Center at Houston",
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        "datetime_modified":"20260107T120142",
        "datetime_start":"20260406T110000",
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        "combined_title":"Human Genetics Research Seminar Series: presenting Stephan Z\u00fcchner, MD, PhD, Professor of Human Genetics and Neurology The Dr. John T. Macdonald Foundation Department of Human Genetics University of Miami Miller School of Medicine",
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        "datetime_modified":"20260107T120418",
        "datetime_start":"20260413T110000",
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        "combined_title":"Human Genetics Research Seminar Series: presenting Yang Shi, PhD Professor of Epigenetics Ludwig Institute for Cancer Research, Oxford University, Oxford, England",
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        "description":"Monday, September 14, 2026\r\n11:00am - 12:00pm\r\nLocation TBD\r\n\r\nYang Shi, PhD\r\nProfessor of Epigenetics\r\nLudwig Institute for Cancer Research\r\nOxford University, Oxford, England\r\n\u201cSeminar Title TBD\u201d\r\n\r\nHosted By: Shigeki Iwase, PhD, Department of Human Genetics\r\n___\r\nBefore joining Ludwig Oxford in 2020, I was Professor of Cell Biology and C. H. Waddington Professor of Pediatrics at Harvard Medical School. I received my PhD from New York University and postdoctoral training at Princeton University. I joined Harvard Medical School as an Assistant Professor in 1991 and was appointed a Professor of Pathology in 2004. In 2009 I joined the Newborn Medicine Division of Boston Children\u2019s Hospital.\r\n\r\nI am interested in identifying key epigenetic regulators in cancer, elucidating their mechanism of action and providing the conceptual basis for translating our basic findings to the clinic via the development of new therapeutic strategies. With the discovery of the first histone methyl eraser, LSD1, in 2004, our group demonstrated that histone methylation is dynamically regulated, which overturned the long-held dogma that such modifications were static and irreversible. We have also discovered many additional histone demethylases with different specificities, and novel readers, including those that specifically recognize unmodified lysine and arginine and suggest that the unmodified states are not simply a ground neutral state of epigenetic information but rather likely code for epigenetic information as modified states. Importantly, many of these chromatin enzymes and readers have since been implicated in various types of human cancers, indicating an important role of chromatin regulation in tumorigenesis.\r\n\r\nMore recently, we have also been studying RNA modifications and how they impact gene expression regulation. In many ways this exciting field parallels the early days of chromatin biochemistry and biology, i.e., the nature and the biological and pathological functions of RNA modifications, as well as the enzymes responsible for writing, erasing and reading them, are just beginning to be understood.\r\n\r\nAt Ludwig Oxford, my lab is focusing on two questions. First, how to convert \u201ccold tumors to \u201chot\u201d and how to sustain durable responses to cancer immune checkpoint blockade therapy. Second, how to induce therapeutic differentiation of cancers, using acute myeloid leukemia and diffuse intrinsic pontine glioma as models where chromatin\/epigenetics have been shown to play a crucial role in the maintenance of a poorly differentiated state.",
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        "combined_title":"Human Genetics Research Seminar Series: presenting Ira Hall, PhD, Professor of Genetics Director of the Yale Center for Genomic Health Yale School of Medicine",
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        "combined_title":"Human Genetics Research Seminar Series: presenting Malia Fullerton, DPhil, University of Washington",
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