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        "event_title":"Weekly DCMB Seminar with Refreshments",
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        "combined_title":"Weekly DCMB Seminar with Refreshments: Michael A. Beer (Professor at Johns Hopkins), \"Sequence-based Machine Learning for Modeling Cell State Transitions\"",
        "event_subtitle":"Michael A. Beer (Professor at Johns Hopkins), \"Sequence-based Machine Learning for Modeling Cell State Transitions\"",
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        "description":"Abstract:\r\n\r\nMost disease associated genomic variants have relatively modest effects on target gene expression in reporter or CRISPR perturbation assays. In addition, enhancer disruption in vivo often has surprisingly weak phenotypic consequences. I will present machine learning (ML) methods (gkm-SVM and DNN) which we use to learn the complex transcription factor combinations that control enhancer activity and cell fate. I will then use these methods to develop a quantitative model for enhancer activity which shows that while promoter knockdown has robust effects on target gene expression, individual enhancer knockdown is often weaker and affects temporal transition dynamics, but not the final steady state.  This model provides an explanation of the paradox of how enhancer variation can be strongly associated with disease risk while having individually weak effects, by showing in detail how gene regulatory networks control developmentally important and disease relevant cell state transitions and cancer.\r\n\r\nhttps:\/\/umich-health.zoom.us\/j\/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09",
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        "event_title":"2023 Equity Research & Institutional Equity Stock Pitch Workshop",
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        "event_title":"Explore Deloitte Michigan | Deloitte Presentation for Freshmen, Sophomores & Juniors",
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        "location_name":"Michigan Union",
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        "event_title":"CANCELED - CAS Lecture | Armeno-Turkish: The Space of Language in the Late Medieval and Early Modern Worlds",
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        "combined_title":"CANCELED - CAS Lecture | Armeno-Turkish: The Space of Language in the Late Medieval and Early Modern Worlds: Dr. Rachel Goshgarian, Associate Professor of History at Lafayette College; Vice President of the Society for Armenian Studies",
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        "description":"We apologize that we have had to cancel this event. We will repost the event when we are able to reschedule it.\r\n\r\nArmenians consistently composed works in Turkish (with Armenian letters), from the thirteenth through the twentieth centuries. Most historians have had a tendency to shy away from using Armeno-Turkish as a means of getting at myriad aspects of both pre-Ottoman Anatolian and Ottoman pasts. In fact, aside from a few unique examples, Armeno-Turkish texts have almost uniquely been used by historians when considering aspects of Armenian history, literature, or identity, rather than as a tool for looking at realities present inside an overarching Turkish language space, or the Ottoman Empire. In reflecting upon the volume of texts composed in Armeno-Turkish from the late medieval through the modern periods, one can\u2019t help but understand that many Armenians\u2014whether monolingual, bilingual or multilingual\u2014were engaged with oral and written Turkish linguistic and literary cultures. And that they participated in the shared space of the Turkish lyric throughout\u2014and before and beyond\u2014the Ottoman Empire.\r\n\r\nRachel Goshgarian is Associate Professor of History at Lafayette College. She is a social historian who is interested in the circulation of ideas, patterns of social organization and the communication of cultural ideals. She works with primary sources composed in Armenian, Arabic, Persian, Turkish and Armeno-Turkish, and her academic work is also deeply informed by interrogations and interpretations of material culture. Her first monograph, The City in Late Medieval Anatolia: Inter-faith Interactions and Urbanism in the Middle East, is forthcoming with I.B. Tauris in 2022. Goshgarian has also co-edited Architecture and Landscape in Medieval Anatolia, 1100-1500 with Patricia Blessing (Edinburgh: Edinburgh University Press, 2017) and co-authored Kendi Kendine Ermenice (or, Teach Yourself Armenian) with \u015e\u00fckru Il\u0131\u00e7ak (Istanbul: Armenian Patriarchate, 2006). Rachel Goshgarian is a member of the Middle East Studies Association, the Ottoman and Turkish Studies Association, and is the vice president of the Society for Armenian Studies. She serves as Reviews and Reconsiderations Editor of the Journal of the Society for Armenian Studies.\r\n\r\nIf there is anything we can do to make this event accessible to you, please contact us at armenianstudies@umich.edu. Please be aware that advance notice is necessary as some accommodations may require more time for the university to arrange.",
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        "event_title":"A Conversation with Nikki Giovanni",
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        "event_title":"ELI Workshop: Writing in Academic Style",
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