{ "107247-21815675": { "datetime_modified":"20230428T123119", "datetime_start":"20230413T150000", "datetime_end":"20230413T160000", "has_end_time":1, "date_start":"2023-04-13", "date_end":"2023-04-13", "time_start":"15:00:00", "time_end":"16:00:00", "time_zone":"America\/Detroit", "event_title":"Sherwin-Williams Engineering Summer\/Fall Co-op Open Interviews", "occurrence_title":"", "combined_title":"Sherwin-Williams Engineering Summer\/Fall Co-op Open Interviews", "event_subtitle":"", "event_type":"Careers \/ Jobs", "event_type_id":"2", "description":"We currently have last minute openings for 6-month co-ops in Chemistry and Engineering (Chemical or Polymers preferred) starting in Juneand running to December. \n\nPositions are located in the Greater Cleveland, OH area. \n\nExperience will be one of the following: Commercialization Engineering, Continuous Improvement or Bench Work in the Lab.", "occurrence_notes":null, "guid":"107247-21815675@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/107247", "building_id":"", "building_name":"", "campus_maps_id":"", "room":"", "location_name":"", "has_livestream":0, "cost":"", "tags":[], "website":"", "sponsors":[ { "group_name":"University Career Center UCC", "group_id":"1140", "website":"http:\/\/careercenter.umich.edu" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21815675 } , "104808-21810292": { "datetime_modified":"20230408T003620", "datetime_start":"20230413T150000", "datetime_end":"20230413T160000", "has_end_time":1, "date_start":"2023-04-13", "date_end":"2023-04-13", "time_start":"15:00:00", "time_end":"16:00:00", "time_zone":"America\/Detroit", "event_title":"Topology Seminar: On the high-dimensional rational cohomology of arithmetic Chevalley groups", "occurrence_title":"", "combined_title":"Topology Seminar: On the high-dimensional rational cohomology of arithmetic Chevalley groups: Robin Sroka (McMaster University)", "event_subtitle":"Robin Sroka (McMaster University)", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"While the rational cohomology of arithmetic groups such as SL_n(Z) and Sp_{2n}(Z) can often be completely computed if the cohomological degree is small compared to n, little is known about it for high cohomological degrees. In this talk, I will discuss vanishing results that have recently been obtained for the high-dimensional rational cohomology of SL_n(Z), Sp_{2n}(Z) and other arithmetic Chevalley groups. This is related to a conjecture of Church--Farb--Putman and based on joint works with Br\u00fcck--Miller--Patzt--Wilson, Br\u00fcck--Patzt and Br\u00fcck--Santos Rego.", "occurrence_notes":null, "guid":"104808-21810292@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/104808", "building_id":"1000166", "building_name":"East Hall", "campus_maps_id":"53", "room":"3866", "location_name":"East Hall", "has_livestream":0, "cost":"", "tags":["Mathematics"], "website":"", "sponsors":[ { "group_name":"Topology Seminar - Department of Mathematics", "group_id":"4910", "website":"" }, { "group_name":"Department of Mathematics", "group_id":"3791", "website":"" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", 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"time_zone":"America\/Detroit", "event_title":"IPE Winter Study Abroad 101 Info Sessions", "occurrence_title":"", "combined_title":"IPE Winter Study Abroad 101 Info Sessions", "event_subtitle":"", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Interested in going abroad for a full winter semester? Start here!\u00a0This info session will cover everything you need to know to get started and what steps to take next in the application process. Q&A included!", "occurrence_notes":null, "guid":"105532-21812197@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/105532", "building_id":"", "building_name":"", "campus_maps_id":"", "room":"", "location_name":"", "has_livestream":0, "cost":"", "tags":["Sessions"], "website":"https:\/\/sessions.studentlife.umich.edu\/p\/track\/8990", "sponsors":[ { "group_name":"Sessions @ Michigan", "group_id":"4791", "website":"https:\/\/sessions.studentlife.umich.edu\/" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21812197 } , "107413-21815977": { "datetime_modified":"20230409T130536", "datetime_start":"20230413T153000", "datetime_end":"20230413T163000", "has_end_time":1, "date_start":"2023-04-13", "date_end":"2023-04-13", "time_start":"15:30:00", "time_end":"16:30:00", "time_zone":"America\/Detroit", "event_title":"Tracing molecules through space and time to understand and treat disease", "occurrence_title":"", "combined_title":"Tracing molecules through space and time to understand and treat disease: Biomedical Engineering (BME 500) Seminar Series - Christian Metallo, PhD", "event_subtitle":"Biomedical Engineering (BME 500) Seminar Series - Christian Metallo, PhD", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Abstract:\r\nMetabolism is central to virtually all cellular functions and contributes to a range of diseases. A quantitative understanding of how biochemical pathways are dysregulated in the context of diseases such as cancer, metabolic syndrome, and neuropathy is necessary to identify new therapeutic targets. To this end we apply stable isotope tracers, mass spectrometry, and metabolic flux analysis (MFA) to study metabolism in mammalian cells, animal models, and human patients. We are particularly interested in understanding how amino acid and lipid metabolism are coordinated in the context of specific disease states. Serine, glycine and one carbon metabolism is critically important for cell function and health, but the amino acids associated with this pathway are commonly reduced in patients with metabolic syndrome. Here I will detail how we apply MFA and related methods to decipher why serine and glycine are reduced in mouse models of diabetes. At the same time, modulating dietary serine, glycine, and fat impacts lipid metabolism and neuropathy phenotypes in C57BL\/6 mice. In turn, supplementation of serine improves sensory function in diabetic animals, suggesting potential therapeutic strategies for treating patients with serine-associated neuropathy. These data provide mechanistic insights into potential drivers diabetes co-morbidities and the role of amino acids in chronic disease.\u00a0\r\n\r\nBio:\r\nChristian Metallo is a professor in the Molecular and Cell Biology Laboratory and holds the Daniel and Martina Lewis Chair at the Salk Institute for Biological Studies. He received his BS in chemical engineering from the University of Pennsylvania and his PhD in chemical engineering from the University of Wisconsin-Madison. He completed a postdoctoral fellowship at MIT in chemical engineering studying cancer metabolism before starting his lab in the Bioengineering department at UC San Diego in 2011. He aims to understand how nutrition and metabolism contribute to diseases such as cancer, macular disease and peripheral neuropathy, applying metabolic flux analysis and biochemical engineering approaches to address these questions.\r\n\r\nZoom:\r\nhttps:\/\/umich.zoom.us\/j\/91712262512", "occurrence_notes":null, "guid":"107413-21815977@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/107413", "building_id":"1000403", "building_name":"Cooley Building", "campus_maps_id":"42", "room":"Room G906", "location_name":"Cooley Building", "has_livestream":1, "livestream_type":"zoom", "livetream_require_login":0, "livestream_id":"91712262512", "livestream_link":"https:\/\/umich.zoom.us\/j\/91712262512", "cost":"", "tags":["Biointerfaces","Biology","biomedical","biomedical engineering","Biosciences","engineering"], "website":"", "sponsors":[ { "group_name":"Biomedical Engineering", "group_id":"1143", "website":"https:\/\/www.facebook.com\/profile.php?id=100094127215673" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2023\/04\/event_107413_original-1.jpeg", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2023\/04\/event_107413_original-1.jpeg", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2023\/04\/event_107413_original-1.jpeg", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2023\/04\/event_107413_original-1.jpeg", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2023\/04\/event_107413_original-1.jpeg", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb\/media\/attachments\/2023\/04\/event_107413_original-1.jpeg", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb_square\/media\/attachments\/2023\/04\/event_107413_original-1.jpeg", "group_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large\/media\/attachments\/2023\/04\/event_107413_original-1.jpeg", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large_lightbox\/media\/attachments\/2023\/04\/event_107413_original-1.jpeg", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_large_crop\/media\/attachments\/2023\/04\/event_107413_original-1.jpeg", "event_list":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_list\/media\/attachments\/2023\/04\/event_107413_original-1.jpeg", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2023\/04\/event_107413_original-1.jpeg", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2023\/04\/event_107413_original-1.jpeg", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_grid_2x\/media\/attachments\/2023\/04\/event_107413_original-1.jpeg", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2023\/04\/event_107413_original-1.jpeg", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_feature_thumb\/media\/attachments\/2023\/04\/event_107413_original-1.jpeg" }, "occurrence_count":1, "first_occurrence":21815977 } , "105324-21811557": { "datetime_modified":"20230428T123058", "datetime_start":"20230413T160000", "datetime_end":"20230413T170000", "has_end_time":1, "date_start":"2023-04-13", "date_end":"2023-04-13", "time_start":"16:00:00", "time_end":"17:00:00", "time_zone":"America\/Detroit", "event_title":"Bring Your Differences", "occurrence_title":"", "combined_title":"Bring Your Differences", "event_subtitle":"", "event_type":"Careers \/ Jobs", "event_type_id":"2", "description":"This event will highlight the importance of \"Bringing your Differences\" to an organization. The attendees will learn about our diversity and inclusion efforts, Employee Resource Groups (ERGs), and some of our employee benefits that support our employees' differences.", "occurrence_notes":null, "guid":"105324-21811557@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/105324", "building_id":"", "building_name":"", "campus_maps_id":"", "room":"", "location_name":"", "has_livestream":0, "cost":"", "tags":[], "website":"", "sponsors":[ { "group_name":"University Career Center UCC", "group_id":"1140", "website":"http:\/\/careercenter.umich.edu" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21811557 } , "105996-21813536": { "datetime_modified":"20230413T181512", "datetime_start":"20230413T160000", "datetime_end":"20230413T173000", "has_end_time":1, "date_start":"2023-04-13", "date_end":"2023-04-13", "time_start":"16:00:00", "time_end":"17:30:00", "time_zone":"America\/Detroit", "event_title":"Capillary electrophoresis-mass spectrometry for top-down proteomics: past, current, and future", "occurrence_title":"", "combined_title":"Capillary electrophoresis-mass spectrometry for top-down proteomics: past, current, and future: Liangliang Sun (Michigan State University)", "event_subtitle":"Liangliang Sun (Michigan State University)", "event_type":"Other", "event_type_id":"22", "description":"Top-down proteomics (TDP) aims to characterize the proteome samples in a proteoform-specific manner and accomplish the human proteoform project (PMID: 34767442), which requires highly efficient separation and sensitive detection of proteoforms due to the extremely high sample complexity. Capillary electrophoresis-mass spectrometry (CE-MS) for top-down MS analysis of intact proteins\/proteoforms is pioneered by the McLafferty, Lee, and Smith groups in 1990s. CE-MS is a powerful analytical technique for proteoform measurements due to its extremely high efficiency and sensitivity for proteoform separation and detection. However, due to the limitations of MS instrumentation and robustness of CE-MS interface, CE-MS had not been widely adopted until the recent 10 years. During the last decade, CE-MS interface has tremendous improvement in terms of sensitivity and robustness and several interfaces have been commercialized. MS instrumentation has impressive improvement in terms of mass resolution, gas-phase fragmentation performance, speed, and sensitivity. Using the modern instrumentation, it is straightforward to achieve the identification of thousands of proteoforms from whole cell lysates using CE-MS\/MS with high reproducibility. For example, our group recently demonstrated the identification of over 23,000 proteoforms from colorectal cancer cells and documented drastically different proteoform profiles between metastatic and non-metastatic colorectal cancer cells using CE-MS\/MS (PMID: 36542699). It is also approachable to delineate large proteoforms (e.g., monoclonal antibodies) and membrane proteoforms using CE-MS and MS\/MS. We expect that CE-MS will be a powerful analytical tool for high-throughput TDP of various complex biological samples in the next several years. \r\n \r\n \nLiangliang Sun (Michigan State University)", "occurrence_notes":null, "guid":"105996-21813536@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/105996", "building_id":"1000158", "building_name":"Chemistry Dow Lab", "campus_maps_id":"34", "room":"1640 ", "location_name":"Chemistry Dow Lab", "has_livestream":0, "cost":"", "tags":["Biosciences","Chemistry","Science"], "website":"", "sponsors":[ { "group_name":"Department of Chemistry", "group_id":"3761", "website":"https:\/\/lsa.umich.edu\/chem" }, { "group_name":"Analytical Chemistry", "group_id":"4384", "website":"" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21813536 } , "102178-21803636": { "datetime_modified":"20221213T150207", "datetime_start":"20230413T160000", "datetime_end":"20230413T163000", "has_end_time":1, "date_start":"2023-04-13", "date_end":"2023-04-13", "time_start":"16:00:00", "time_end":"16:30:00", "time_zone":"America\/Detroit", "event_title":"CGIS Virtual First Step Sessions", "occurrence_title":"", "combined_title":"CGIS Virtual First Step Sessions", "event_subtitle":"", "event_type":"Livestream \/ Virtual", "event_type_id":"24", "description":"CGIS offers First Steps sessions virtually (via Zoom) every Monday and Thursday from 4:00pm to 4:30pm during the academic year while classes are in session, with the exception of holidays.\r\n\r\nFirst Step sessions are a great opportunity to learn more about the application process prior to meeting with an advisor. 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