{ "97617-21794810": { "datetime_modified":"20220906T101625", "datetime_start":"20220926T160000", "datetime_end":"20220926T170000", "has_end_time":1, "date_start":"2022-09-26", "date_end":"2022-09-26", "time_start":"16:00:00", "time_end":"17:00:00", "time_zone":"America\/Detroit", "event_title":"RNA Innovation Seminar: David Shechner, University of Washington", "occurrence_title":"", "combined_title":"RNA Innovation Seminar: David Shechner, University of Washington: \"Meet the neighbors: A universal technology for probing RNA-interactions and RNA-scaffolded subcellular compartments in situ\"", "event_subtitle":"\"Meet the neighbors: A universal technology for probing RNA-interactions and RNA-scaffolded subcellular compartments in situ\"", "event_type":"Lecture \/ Discussion", "event_type_id":"13", "description":"David Shechner Ph.D.\r\nAssistant Professor of Pharmacology\r\nUniversity of Washington\r\n\r\nKeywords: RNA, proximity-biotinylation, subcellular architecture, nuclear architecture, spatial biology, biomolecular condensates, interactomics, nucleolus, Xist.\r\n\r\nAbstract: In the context of the living cell, very little RNA is naked. RNA molecules form complex, dynamic networks of molecular interactions that underlie a host of biochemical functions, and which are central to organizing subcellular compartmentalization. In humans, for example, RNAs are key determinants of chromatin folding, and they nucleate and scaffold a host of biomolecular condensates that collectively control cellular metabolic, epigenetic, and stress-signaling pathways. But, characterizing these structures\u2014identifying the biomolecules within an RNA's subcellular microenvironment\u2014remains technically cumbersome. \r\n\r\nTo address this challenge, I introduce oligonucleotide-mediated proximity-interactome mapping (O-MAP), a straightforward and flexible method for identifying the proteins, RNAs, and genomic loci near a target RNA, within its native cellular context. O-MAP uses programmable oligonucleotide probes to deliver proximity-biotinylating enzymes to a target RNA. These enzymes then pervasively label all nearby (~20 nm) molecules, enabling their enrichment by streptavidin pulldown. O-MAP induces exceptionally precise RNA-targeted biotinylation, and its modular design enables straightforward validation of probe pools and real-space optimization of the biotinylation radius, thus overcoming key technical challenges for the field. Moreover, O-MAP can be readily ported across different target RNAs and specimen types, including patient-derived organoids and tissue samples. And, O-MAP achieves this without complex cell-line engineering, using only off-the-shelf parts and standard manipulations. \r\n\r\nUsing a small cohort of model RNAs, we have developed a robust O-MAP toolkit for proteomic (O-MAP-MS), transcriptomic (O-MAP-Seq) and genome interaction (O-MAP-ChIP) discovery. O-MAP of the 47S-pre-rRNA\u2014the long noncoding RNA that scaffolds the nucleolus\u2014enabled a comprehensive \"multi-omic\" analysis of this subnuclear structure, and revealed hundreds of novel nucleolar protein-, RNA-, and chromatin interactions. O-MAP of XIST\u2014the master regulator of X-chromosome inactivation\u2014revealed novel RNAs that may play a role in this process, and unanticipated interactions between XIST and other chromatin-regulatory RNAs. Finally, targeting O-MAP to introns within a key cardiac developmental gene enabled unprecedented molecular dissection of a subnuclear compartment that would be impossible to purify biochemically.\r\n\r\nGiven these results, we believe that O-MAP will be a powerful tool for elucidating the mechanisms by which RNA molecules drive subcellular compartmentalization in time and space, with particular impact on our understanding of nuclear architecture. Moreover, with O-MAP's precision, flexibility, and ease, we anticipate its broad use in studying countless other RNA phenomena throughout biology, and as a clinical diagnostic- and discovery tool. \r\n\r\n\r\nHYBRID SEMINAR:\r\nIn-person: BSRB, ABC seminar rooms\r\nLivestream: https:\/\/myumi.ch\/NmGqG", "occurrence_notes":"hybrid option", "guid":"97617-21794810@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/97617", "building_id":"1005037", "building_name":"Taubman Biomedical Science Research Building", "campus_maps_id":"509", "room":"ABC Seminar room", "location_name":"Taubman Biomedical Science Research Building", "has_livestream":0, "cost":"", "tags":["Biosciences"], "website":"https:\/\/twitter.com\/ShechnerLab", "sponsors":[ { "group_name":"Center for RNA Biomedicine", "group_id":"4014", "website":"" }, { "group_name":"Biosciences Initiative", "group_id":"4165", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2022\/09\/event_97617_original-1.jpeg", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_thumb\/media\/attachments\/2022\/09\/event_97617_original-1.jpeg", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2022\/09\/event_97617_original-1.jpeg", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_large_2x\/media\/attachments\/2022\/09\/event_97617_original-1.jpeg", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2022\/09\/event_97617_original-1.jpeg", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb\/media\/attachments\/2022\/09\/event_97617_original-1.jpeg", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb_square\/media\/attachments\/2022\/09\/event_97617_original-1.jpeg", "group_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large\/media\/attachments\/2022\/09\/event_97617_original-1.jpeg", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large_lightbox\/media\/attachments\/2022\/09\/event_97617_original-1.jpeg", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_large_crop\/media\/attachments\/2022\/09\/event_97617_original-1.jpeg", "event_list":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_list\/media\/attachments\/2022\/09\/event_97617_original-1.jpeg", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2022\/09\/event_97617_original-1.jpeg", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2022\/09\/event_97617_original-1.jpeg", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_grid_2x\/media\/attachments\/2022\/09\/event_97617_original-1.jpeg", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_feature_large\/media\/attachments\/2022\/09\/event_97617_original-1.jpeg", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2022\/09\/event_97617_original-1.jpeg" }, "occurrence_count":1, "first_occurrence":21794810 } , "97248-21794227": { "datetime_modified":"20220823T105816", "datetime_start":"20220926T160000", "datetime_end":"20220926T173000", "has_end_time":1, "date_start":"2022-09-26", "date_end":"2022-09-26", "time_start":"16:00:00", "time_end":"17:30:00", "time_zone":"America\/Detroit", "event_title":"Taking from Charity? Political Contributions and the Market for Charitable Funds.", "occurrence_title":"", "combined_title":"Taking from Charity? Political Contributions and the Market for Charitable Funds.: Stephanie Karol, University of Michigan", "event_subtitle":"Stephanie Karol, University of Michigan", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"This paper estimates the effects of large donors\u2019 political contributions on charitable contributions and fundraising. Political contributions reduce the effectiveness of charitable fundraising, particularly in the Health and Other sectors. Charities therefore reduce fundraising, which contributes to an overall elasticity of private charitable contributions to political contributions of -0.07. This aggregate effect combines large political donors\u2019 charitable contribution behavior with spillover effects of their political giving on the charitable giving patterns of the remainder of the population. Subsequent analysis allows for heterogeneity in the ideologies of both political and charitable recipients.", "occurrence_notes":null, "guid":"97248-21794227@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/97248", "building_id":"1005188", "building_name":"Ross School of Business", "campus_maps_id":"547", "room":"R0320", "location_name":"Ross School of Business", "has_livestream":0, "cost":"", "tags":["seminar","Economics"], "website":"", "sponsors":[ { "group_name":"Department of Economics", "group_id":"3302", "website":"http:\/\/www.lsa.umich.edu\/econ" }, { "group_name":"Public Finance", "group_id":"3553", "website":"" }, { "group_name":"Department of Economics Seminars", "group_id":"3566", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2022\/08\/event_97248_original-1.jpeg", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_thumb\/media\/attachments\/2022\/08\/event_97248_original-1.jpeg", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2022\/08\/event_97248_original-1.jpeg", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2022\/08\/event_97248_original-1.jpeg", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2022\/08\/event_97248_original-1.jpeg", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb\/media\/attachments\/2022\/08\/event_97248_original-1.jpeg", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb_square\/media\/attachments\/2022\/08\/event_97248_original-1.jpeg", "group_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large\/media\/attachments\/2022\/08\/event_97248_original-1.jpeg", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large_lightbox\/media\/attachments\/2022\/08\/event_97248_original-1.jpeg", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_large_crop\/media\/attachments\/2022\/08\/event_97248_original-1.jpeg", "event_list":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_list\/media\/attachments\/2022\/08\/event_97248_original-1.jpeg", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2022\/08\/event_97248_original-1.jpeg", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2022\/08\/event_97248_original-1.jpeg", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_grid_2x\/media\/attachments\/2022\/08\/event_97248_original-1.jpeg", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_feature_large\/media\/attachments\/2022\/08\/event_97248_original-1.jpeg", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_feature_thumb\/media\/attachments\/2022\/08\/event_97248_original-1.jpeg" }, "occurrence_count":1, "first_occurrence":21794227 } , "97714-21794997": { "datetime_modified":"20220830T112221", "datetime_start":"20220926T163000", "datetime_end":"20220926T173000", "has_end_time":1, "date_start":"2022-09-26", "date_end":"2022-09-26", "time_start":"16:30:00", "time_end":"17:30:00", "time_zone":"America\/Detroit", "event_title":"Business+Tech Literacy Download: Digital Innovation in Fitness", "occurrence_title":"", "combined_title":"Business+Tech Literacy Download: Digital Innovation in Fitness", "event_subtitle":"", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Guest Speaker: Eswar Veluri | Equinox EVP, Chief Technology Officer\r\n\r\n\u2014\u2014\u2014\u2014\u2014\r\n\r\nBusiness+Tech is hosting the second annual +Tech Literacy Download for students across all schools and colleges. During this month-long series, participants will increase their technical literacy and competency through hands-on workshops ranging from coding languages to industry-lead information sessions on emerging technologies. Accelerate your technical literacy today by saving the date for the +Tech Literacy Download!", "occurrence_notes":null, "guid":"97714-21794997@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/97714", "building_id":"null", "building_name":"Off Campus Location", "campus_maps_id":"1", "room":"", "location_name":"Virtual", "has_livestream":0, "cost":"", "tags":["Business","technology","Undergraduate Students","Michigan Engineering","Graduate Students","Entrepreneurship","Virtual","Welcome to Michigan"], "website":"https:\/\/sessions.studentlife.umich.edu\/track\/event\/session\/57808", "sponsors":[ { "group_name":"Business+Tech at Michigan Ross", "group_id":"4653", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2022\/08\/event_97714_original-1.png", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_thumb\/media\/attachments\/2022\/08\/event_97714_original-1.png", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2022\/08\/event_97714_original-1.png", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_large_2x\/media\/attachments\/2022\/08\/event_97714_original-1.png", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2022\/08\/event_97714_original-1.png", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb\/media\/attachments\/2022\/08\/event_97714_original-1.png", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb_square\/media\/attachments\/2022\/08\/event_97714_original-1.png", "group_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large\/media\/attachments\/2022\/08\/event_97714_original-1.png", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large_lightbox\/media\/attachments\/2022\/08\/event_97714_original-1.png", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_large_crop\/media\/attachments\/2022\/08\/event_97714_original-1.png", "event_list":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_list\/media\/attachments\/2022\/08\/event_97714_original-1.png", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2022\/08\/event_97714_original-1.png", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2022\/08\/event_97714_original-1.png", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2022\/08\/event_97714_original-1.png", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_feature_large\/media\/attachments\/2022\/08\/event_97714_original-1.png", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2022\/08\/event_97714_original-1.png" }, "occurrence_count":1, "first_occurrence":21794997 } , "98313-21796478": { "datetime_modified":"20220908T112741", "datetime_start":"20220926T163000", "datetime_end":"20220926T173000", "has_end_time":1, "date_start":"2022-09-26", "date_end":"2022-09-26", "time_start":"16:30:00", "time_end":"17:30:00", "time_zone":"America\/Detroit", "event_title":"IOE 813 Seminar Series", "occurrence_title":"", "combined_title":"IOE 813 Seminar Series: Improving Outcomes of Public Health and Healthcare Policy", "event_subtitle":"Improving Outcomes of Public Health and Healthcare Policy", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Speaker: Kevin Smith, PhD Candidate, U-M IOE\r\n\r\nDescription: Social Inequality can be defined by unequal outcomes that occur as a result of uneven distribution of resources. 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His research is focused on applying industrial engineering and operations research tools to improve outcomes resulting from problems of social inequality. The mission of his research is to inform policymakers and the public of the critical factors that impact decisions with particular applications in organ allocation, pandemic risk planning, and clinical kidney stone care thus far. Additionally, he is motivated to allocate resources equitably and improve decision-making outcomes in these settings. His work aims to highlight systemic shortcomings of current healthcare and public health policies and create models that derive equitable outcomes using interpretable and accessible results.\r\n\r\nThe seminar series \u201cProviding Better Healthcare through Systems Engineering\u201d is presented by the U\u2010M Center for Healthcare Engineering and Patient Safety (CHEPS): Our mission is to improve the safety and quality of healthcare delivery through a multi\u2010disciplinary, systems\u2010engineering approach.\r\n\r\nFor the Zoom link and password, and to be added to the weekly e\u2010mail for the series, please RSVP or contact genehkim@umich.edu", "occurrence_notes":null, "guid":"98313-21796478@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/98313", "building_id":"1000429", "building_name":"Industrial and Operations Engineering Building", "campus_maps_id":"73", "room":"Room 1680", "location_name":"Industrial and Operations Engineering Building", "has_livestream":0, 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For example, some believe a perfect pairing would be Cabernet with duck confit with turnips or Pinot Noir with bison rib eye steaks with roasted garlic \u2014 wines with sauces, spicy food, hors d\u2019oeurvres, etc. But other things can be perfectly paired such as fruit and cheese, a couple, or a clothing selection.\r\n\r\nSometimes pairs are made more perfect when they are catalysts for the imagination. That is what curators Margaret Carney, Ph.D., and Juli McLoone are serving in \"A Perfect Pairing of Cookbooks and Dinnerware.\" The right ingredients along with an inspired recipe creates a delicious and beautiful meal that is enhanced when the cuisine is presented on a thoughtfully curated table setting, or, we hope, in a thoughtfully curated exhibit. 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