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        "event_title":"We\u2019re Biased. So Now What?: Personalizing and Mitigating Unconscious Bias",
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        "combined_title":"We\u2019re Biased. So Now What?: Personalizing and Mitigating Unconscious Bias",
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        "description":"Many of us are committed to DEI and accept the extensive evidence from scholarly studies in psychology and neuroscience demonstrating that we all have unconscious biases that affect our interactions with others. The question then becomes, how do we not only become aware of our biases, but also work to overcome them.\nLearning Objectives:\n\nGain knowledge of societal biases and self-awareness of one\u2019s unconscious biases\nDevelop strategies to advocate for inclusion in light of unconscious bias\n\nThis workshop is designed for University of Michigan master\u2019s students, doctoral students, and postdoctoral fellows. For faculty and staff, please contact RackhamEvents@umich.edu to see if we can accommodate your attendance.\nRegistration is required at https:\/\/myumi.ch\/qAA31.\nWe want to ensure full and equitable participation in our events. If an accommodation would promote your full participation in this event, please follow the registration link to indicate your accommodation requirements. Please let us know as soon as possible in order to have adequate time, preferably one week, to arrange for your requested accommodations or an effective alternative.",
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        "tags":["Diversity","Graduate Students"],
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        "event_title":"VIRTUAL | CEW+Inspire Midweek Mindfulness-Guided Sit",
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        "event_title":"Arts Production in an Era of Crowdfunding: Introduction to Data from the Kickstarter Platform",
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        "event_title":"DS 101: Understanding Accessibility for Projects",
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        "description":"Digital Scholarship 101: Workshop Series\r\n\r\nThis series of workshops helps scholars avoid outdated projects, unpreserved knowledge, uncredited labor, and privacy or consent issues by emphasizing process in the project life cycle. Workshop participants learn how to conceptualize the life cycle of a project using human-centered design and backwards modelling when planning their projects to better understand how to version, archive, and preserve their research projects. Throughout the series, thematic questions around sustainability, preservation, accessibility, privacy, consent, grant requirements, and teaching with research will be examined. We encourage you to come with a project in mind and bring materials if available, but is not required to attend.\r\n\r\nDigital Scholarship 101: You\u2019ve heard about \u201caccessibility,\u201d but do you know what it means for your project? This workshop will teach you how to make your project \u2014 both its products and processes \u2014 accessible to all. You will learn principles, standards, and techniques for developing digital projects that are equitably accessible to people with a range of abilities\/disabilities, technologies, and backgrounds. For grants that require projects to meet accessibility guidelines, you will learn to develop an accessibility plan for applications. As a result of this workshop, participants will understand how and why accessibility matters in digital projects, and will have resources to use and refer back to as projects progress.",
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        "tags":["Accessibility","Digital Humanities","Digital Project","Digital Projects","Digital Scholarship","Digital Studies","Ds 101","Humanities","Library","Lsa","Online Collections","Online Exhibits","Qualitative Social Sciences","Workshop"],
        "website":"https:\/\/ttc.iss.lsa.umich.edu\/ttc\/sessions\/ds-101-understanding-accessibility-for-projects\/register\/",
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        "event_title":"The Home Depot Spring Career Day",
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        "description":"Cancer survivorship has increased in recent decades due to advancements in anticancer treatments, yet cancer survivors continue to suffer from irreversible premature ovarian insufficiency and loss of fertility caused by radiation and chemotherapy. Restoration of reproductive function is uniquely challenging because women are born with a non-renewable reserve of ovarian follicles, the functional units of the ovary each carrying an oocyte (egg) and hormone producing somatic cells. Removal of ovarian tissue prior to gonadotoxic treatments and culture of isolated ovarian follicles is a safe fertility preservation option for pediatric and adult patients and does not require delays in treatment or hormonal stimulation. However, a high-yield, translational, and reproducible in vitro culture system that produces fertilizable eggs does not exist. Survival, growth, and maturation of early-stage primordial follicles, which constitute the majority of the follicular reserve, depend on bidirectional paracrine signaling through soluble cytokines and interactions with the extracellular matrix (ECM). To meet the needs of growing ovarian follicles we designed a biomimetic hydrogel for in vitro follicle culture that restores critical cell-cell and cell-matrix interactions for improved follicle outcomes. We hypothesized that a degradable poly(ethylene glycol) (PEG)-based matrix with tunable biophysical properties would (1) enable co-encapsulation of follicles and cells for paracrine signaling and (2) mimic the ECM functions of ovarian tissue.\r\n\r\nFirst, we established that our degradable hydrogel could support co-culture of multiple cell types by co-encapsulating isolated murine primary follicles with adipose-derived stem cells (ADSCs) that secrete survival- and growth-promoting cytokines, compensating for the loss of native stromal cells. Bidirectional crosstalk between follicles and ADSCs promoted folliculogenesis and follicles doubled in size compared to follicles cultured without the ADSCs. Second, we incorporated ECM-sequestering peptides that retain cell-secreted ECM molecules, such as laminin, fibronectin, collagen type 1, and perlecan, thereby restoring cell-matrix interactions and improving growth factor binding. Secondary follicles cultured in PEG functionalized with peptides that bind basement membrane proteins exhibited greater than 93% survival, reached 340 \u00b5m in diameter, and achieved oocyte maturation rates of 84%. Lastly, we combined these approaches for restoring paracrine signaling and ECM function for culture of primordial follicles, the most immature and difficult to grow, but most abundant type of follicle in the ovary. We embedded hydrogels with ECM-sequestering dextran fibers to act as a scaffold for ECM deposition, better mimicking the fibrous structure of native ECM. ECM deposition and subsequent cell binding to fibers facilitated follicle and cell aggregation within the hydrogel matrix. Oocyte survival and growth was significantly improved in conditions which formed follicle-like aggregates surrounded by stroma, likely due to restoration of key cell-cell and cell-matrix interactions that promote follicle development.\r\n\r\nIn conclusion, we have engineered a fully synthetic hydrogel culture system that recapitulates the cellular and extracellular components of native ovarian tissue for improved follicle outcomes. This translational biomaterial is significant for guiding the development of a standardized in vitro culture system for maturation of human follicles and a safe fertility preservation option for cancer survivors unable to produce mature eggs. This biomimetic hydrogel also has broader impacts in the field of tissue engineering as it facilitates cell-driven reconstruction of their native microenvironments, providing a more comprehensive model for deciphering key mechanisms that drive regeneration in vitro.\r\n\r\nDate: Wednesday, February 16, 2022\r\nTime: 3:00 PM EST\r\nZoom: https:\/\/umich.zoom.us\/j\/99438979027   Passcode: GoFollicle\r\nChair: Dr. Ariella Shikanov",
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        "tags":["biomedical","biomedical engineering","Biosciences","engineering","Life Science","Michigan Engineering","Research","Science"],
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