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    "92334-21690196":
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        "datetime_modified":"20220214T105737",
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        "time_start":"15:30:00",
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        "time_zone":"America\/Detroit",
        "event_title":"Machine Learning in Drug Development",
        "occurrence_title":"",
        "combined_title":"Machine Learning in Drug Development: BME 500 Seminar: Ellen Kuhl, Ph.D. Walter B Reinhold Professor in the School of Engineering, Robert Bosch Chair of Mechanical Engineering, Professor of Mechanical Engineering and, by courtesy, of Bioengineering,\u00a0Stanford University",
        "event_subtitle":"BME 500 Seminar: Ellen Kuhl, Ph.D. Walter B Reinhold Professor in the School of Engineering, Robert Bosch Chair of Mechanical Engineering, Professor of Mechanical Engineering and, by courtesy, of Bioengineering,\u00a0Stanford University",
        "event_type":"Workshop \/ Seminar",
        "event_type_id":"21",
        "description":"Abstract:\r\nAn undesirable side effect of drugs are cardiac arrhythmias, in particular a condition called torsades de pointes. Current paradigms for drug safety evaluation are costly, lengthy, and conservative, and impede efficient drug development. Here we combine multiscale experiment and simulation, high-performance computing, and machine learning to create an easy-to-use risk assessment diagram to quickly and reliable stratify the pro-arrhythmic potential of new and existing drugs. We capitalize on recent developments in machine learning and integrate information across ten orders of magnitude in space and time to provide a holistic picture of the effects of drugs, either individually or in combination with other drugs. We show, both experimentally and computationally, that drug-induced arrhythmias are dominated by the interplay of two currents with opposing effects: the rapid delayed rectifier potassium current and the L-type calcium current. Using Gaussian process classification, we create a classifier that stratifies safe and arrhythmic domains for any combinations of these two currents. We demonstrate that our classifier correctly identifies the risk categories of 23 common drugs, exclusively on the basis of their concentrations at 50% current block. Our study shapes the way towards establishing science-based criteria to accelerate drug development, design safer drugs, and reduce heart rhythm disorders.\r\nBio:\r\nEllen Kuhl is the Walter B. Reinhold Professor in the School of Engineering and Robert Bosch Chair of Mechanical Engineering at Stanford University. She received her PhD from the University of Stuttgart in 2000 and her Habilitation from the University of Kaiserslautern in 2004. Her area of expertise is Living Matter Physics, the design of theoretical and computational models to simulate and predict the behavior of living systems. Ellen has published more than 200 peer-reviewed journal articles, edited two books, and published a textbook on COVID-19. She is a founding member of the Living Heart Project, a translational research initiative to revolutionize cardiovascular science through realistic simulation with 400 participants from research, industry, and medicine from 24 countries. Ellen is the current Chair of the US National Committee on Biomechanics and a Member-Elect of the World Council of Biomechanics. She is a Fellow of the American Society of Mechanical Engineers and of the American Institute for Mechanical and Biological Engineering. She received the National Science Foundation Career Award in 2010, was selected as Midwest Mechanics Seminar Speaker in 2014, and received the Humboldt Research Award in 2016 and the ASME Ted Belytschko Applied Mechanics Award in 2021. Ellen is an All American triathlete, a multiple Boston, Chicago, and New York marathon runner, and a Kona Ironman World Championship finisher.\r\n\r\nZoom Link: https:\/\/umich.zoom.us\/j\/96508834308\r\n\r\nOrganized by:\r\nDr. Brendon Baker,\r\nAssistant Professor, Biomedical Engineering\r\n\r\nDr. David Nordsletten,\r\nAssociate Professor, Department of Biomedical Engineering and Cardiac Surgery",
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        "tags":["Michigan Engineering","biomedical","biomedical engineering","bme","Drug Discovery","Medicine","engineering"],
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        "event_title":"EEB Thursday Seminar: Light and dark side of the force: Marine bivalve-algal photosymbiosis in light gradients",
        "occurrence_title":"",
        "combined_title":"EEB Thursday Seminar: Light and dark side of the force: Marine bivalve-algal photosymbiosis in light gradients: Jingchun Li, Assistant Professor and Museum Curator of Invertebrates, University of Colorado",
        "event_subtitle":"Jingchun Li, Assistant Professor and Museum Curator of Invertebrates, University of Colorado",
        "event_type":"Workshop \/ Seminar",
        "event_type_id":"21",
        "description":"Abstract\r\nPhotosymbiotic associations between heterotrophic hosts and photosynthetic algae play crucial roles in maintaining the trophic and structural integrity of marine ecosystems. This relationship has independently evolved in diverse eukaryotic lineages including sponges, corals, and bivalves. However, the basic biology of photosymbioses and their evolutionary implications are not well-understood. In this talk, I will use a representative photosymbiotic bivalve group to investigate the partners\u2019 ecological and molecular adaptation to the photosymbiotic lifestyle. I will demonstrate that light availability play an important role in shaping the hosts\u2019 morphological adaptation, energy update, symbiont composition, and genomic evolution.",
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        "datetime_modified":"20220217T181529",
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        "event_title":"From Thermodynamics to Spin Trapping: Challenges across the Periodic Table",
        "occurrence_title":"",
        "combined_title":"From Thermodynamics to Spin Trapping: Challenges across the Periodic Table: Angela Wilson (Michigan State University)",
        "event_subtitle":"Angela Wilson (Michigan State University)",
        "event_type":"Other",
        "event_type_id":"22",
        "description":"Physical\nAngela Wilson (Michigan State University)",
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        "event_title":"Medical School Application Workshop",
        "occurrence_title":"",
        "combined_title":"Medical School Application Workshop: Stephanie Chervin",
        "event_subtitle":"Stephanie Chervin",
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        "description":"Are you planning on applying to medical school this summer and want help in this process? If so, we invite you to attend this Honors Program workshop led by Stephanie Chervin, LSA Honors Program Pre-Med Advisor, to help you:\r\n\r\n\u2022 Understand the timeline of the process from application to interview\r\n\r\n\u2022 Choose target medical programs\r\n\r\n\u2022 Get acquainted with the application service AMCAS\r\n\r\nBring your questions! This session is for current LSA Honors Program students only.",
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        "datetime_modified":"20220112T083607",
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        "event_title":"Positive Links Speaker Series",
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        "combined_title":"Positive Links Speaker Series: Management as a Calling with Andy Hoffman",
        "event_subtitle":"Management as a Calling with Andy Hoffman",
        "event_type":"Livestream \/ Virtual",
        "event_type_id":"24",
        "description":"Thursday, February 17, 2022 \r\n4:00-5:00 p.m. ET \r\nFree and open to the public, registration required: https:\/\/positiveorgs.bus.umich.edu\/events\/management-as-a-calling\/\r\n\r\nPositive Links: \r\n\r\nThe Positive Links Speaker Series, presented by Michigan Ross\u2019 Center for Positive Organizations, offers inspiring and practical science-based strategies to build and bolster thriving organizations. Attendees learn from leading positive organizational scholars and connect with our community of academics, students, staff, and leaders. \r\n\r\nAbout the talk: \r\n\r\nBusiness leaders have tremendous power to influence our society, how it operates, whether it is fair, and the extent to which it impacts the environment. And yet, we do not recognize or call out the responsibility that comes with that power. This session is meant to challenge future business leaders to think differently about their career, its purpose, and its value as a calling or vocation, one that is in service to society. Its message is for current and prospective business students, business leaders thinking anew about the role of business in society, and the business educators that train all these people.  \r\n\r\nWe face great challenges as a society today, from environmental problems like climate change and habitat destruction, to social problems like income inequality, unemployment, lack of a living wage, and poor access to affordable health care and education. Solutions to these challenges must come from the market (as comprised of corporations, the government, and nongovernmental organizations, as well as the many stakeholders in market transaction, such as the consumers, suppliers, buyers, insurance companies, and banks), the most powerful institution on earth, and from business, which is the most powerful entity within it.   \r\n\r\nThough government is an important and vital arbiter of the market, business is the force that transcends national boundaries, possessing resources that exceed those of many nations. Business is responsible for producing the buildings that we live and work in, the food we eat, the clothes we wear, the forms of mobility we employ, and the energy that propels us. This does not mean that only business can generate solutions or that there is no role for government, but with its unmatched powers of ideation, production, and distribution, business is positioned to bring the change we need at the scale we need it. Without business, the solutions will remain elusive. Indeed, if there are no solutions coming from the market, there will be no solutions. And without visionary and service-oriented leaders, business will never even try to find them.  \r\n\r\nAbout Hoffman: \r\n\r\nAndy Hoffman is the Holcim (US) Professor of Sustainable Enterprise at the University of Michigan; a position that holds joint appointments in the Stephen M. Ross School of Business and the School for Environment and Sustainability. Professor Hoffman's research uses organizational behavior models and theories to understand the cultural and institutional aspects of environmental issues for organizations.   \r\n\r\nHe has published over 100 articles\/book chapters, as well as 18 books, which have been translated into five languages. In this work, he focuses on the processes by which environmental issues both emerge and evolve as social, political, and managerial issues, including: the evolving nature of field level pressures related to environmental issues; the corporate responses that have emerged as a result of those pressures, particularly around the issue of climate change; the interconnected networks among non-governmental organizations and corporations and how those networks influence change processes within cultural and institutional systems; the social and psychological barriers to these change processes; and the underlying cultural values that are engaged when these barriers are overcome. He also writes about the role of academic scholars in public and political discourse.   \r\n\r\nAmong his list of honors, he has been awarded the Aspen Institute Faculty Pioneer Award (2016), American Chemical Society National Award (2016), Strategic Organization Best Essay Award (2016), Organization & Environment Best Paper Award (2014), Maggie Award (2013), JMI Breaking the Frame Award (2012), Connecticut Book Award (2011), Aldo Leopold Fellowship (2011), Aspen Environmental Fellowship (2011 and 2009), Manos Page Prize (2009), Aspen Institute Rising Star Award (2003), Rachel Carson Book Prize (2001), and Klegerman Award (1995).    \r\n\r\nHis work has been covered in numerous media outlets, including the New York Times, Scientific American, Time, the Wall Street Journal, National Geographic, Atlantic, and National Public Radio. He has served on numerous research committees for the National Academies of Science, the Johnson Foundation, the Climate Group, the China Council for International Cooperation on Environment and Development and the Environmental Defense Fund. Prior to academics, Andy worked for the US Environmental Protection Agency (Region 1), Metcalf & Eddy Environmental Consultants, T&T Construction & Design, and the Amoco Corporation. Andy serves on advisory boards for ecoAmerica, Next Era Renewable Energy Trust, SustainAbility, the Michigan League of Conservation Voters, the Center for Environmental Innovation, and the Stanford Social Innovation Review.  \r\n\r\nHost: \r\n\r\nSara Soderstrom, Associate Professor of Organizational Studies and Program in the Environment  \r\n\r\nSeries Sponsors: \r\n\r\nThe Center for Positive Organizations thanks Sanger Leadership Center, Tauber Institute for Global Operations, Samuel Zell & Robert H. Lurie Institute for Entrepreneurial Studies, and Diane (BA \u201873) and Paul (MBA \u201875) Jones for their support of the 2021-22 Positive Links Speaker Series.  \r\n\r\nSeries Promotional Partners: \r\n\r\nAdditionally, we thank Ann Arbor SPARK and the Managerial and Organizational Cognition (MOC) Division of the Academy of Management for their Positive Links Speaker Series promotional partnerships.",
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