{ "30989-3962780": { "datetime_modified":"20160615T134715", "datetime_start":"20160701T130000", "datetime_end":"20160701T140000", "has_end_time":1, "date_start":"2016-07-01", "date_end":"2016-07-01", "time_start":"13:00:00", "time_end":"14:00:00", "time_zone":"America\/Detroit", "event_title":"Dissertation Defense: Mechanisms that underlie experience-dependent assembly of neural circuits", "occurrence_title":"", "combined_title":"Dissertation Defense: Mechanisms that underlie experience-dependent assembly of neural circuits: Ann Marie Macara", "event_subtitle":"Ann Marie Macara", "event_type":"Other", "event_type_id":"22", "description":"Candidate for PhD in Molecular, Cellular, and Developmental Biology\r\n\r\nAbstract:\r\nI aim to understand the interaction between the environment and the developing brain through investigating how sensory experience shapes behavior. Sensory experience modifies neural connections through activity-dependent plasticity, enabling animals to cope with environmental variability. Classic work, particularly those in vertebrate visual systems, has provided important insights into the mechanisms that underlie experience-dependent plasticity of the developing circuit. However, there are significant gaps explaining the mechanism by which sensory experience shapes circuit function during development. Particularly, how experience-dependent changes in synaptic transmission during development affect behavior in the mature animal are poorly understood. This dissertation examines how noxious sensory experience during development changes synaptic transmission in the nociceptive circuit to shape behavior in Drosophila melanogaster. Drosophila provides a relatively simple and genetically amenable model for analyzing both neural development and mechanisms underlying behaviors, and is thus a powerful model for discovering basic principles underlying experience-dependent plasticity during development. One well-characterized set of Drosophila sensory neurons is the nociceptors. The nociceptors respond to noxious environmental cues such as intense radiation, chemical or mechanical stimuli. The cell bodies and dendrites of these neurons lie just underneath the larval cuticle, and their dendrites receive sensory inputs from the environment. Their axons, in turn, project to the central nervous system to provide inputs to the nociceptive circuits, which eventually leads to appropriate motor responses. In larvae, activation of the nociceptors elicits a robust behavioral response. To address how noxious stimuli alters the nociceptive circuit, I have established a calcium live-imaging technique to physiologically measure neural dynamics within larval brains and have developed a behavioral assay to probe motor output. Through the use of these experimental techniques, I have determined that excessive noxious experience during a sensitive period in development modifies nociceptive behavior through an intrinsic program of circuit development. These findings suggest that the development of the larval nociceptive circuit is shaped by sensory inputs and neural activity. Moreover, my collaborative work demonstrates that the developmental plasticity is es\u00actablished through serotonergic inhibition which specifically modifies synapses in the nociceptive, but not mechanosensory, pathway. We further show that excessive stimulation of nociceptors activates serotonergic neurons to sensitize the presynaptic terminals of nociceptors to serotoninergic inhibition after development is completed, leading to abated nociceptive behavior. This is the first demonstration, to our knowledge, that noxious sensory experience shapes the development of Drosophila, and reveals a neural mechanism involved in offsetting harmful environmental stimuli.", "occurrence_notes":null, "guid":"30989-3962780@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/30989", "building_id":"1000172", "building_name":"Rackham Graduate School (Horace H.)", "campus_maps_id":"71", "room":"East Conference Room, 4th Floor", "location_name":"Rackham Graduate School (Horace H.)", "has_livestream":0, "cost":"", "tags":["Research","Dissertation Defense","Biology"], "website":"", "sponsors":[ { "group_name":"Department of Molecular, Cellular, and Developmental Biology", "group_id":"3755", "website":"" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":3962780 } , "30742-3738397": { "datetime_modified":"20160518T153725", "datetime_start":"20160701T130000", "datetime_end":"20160701T133000", "has_end_time":1, "date_start":"2016-07-01", "date_end":"2016-07-01", "time_start":"13:00:00", "time_end":"13:30:00", "time_zone":"America\/Detroit", "event_title":"Study Abroad First Step Session", "occurrence_title":"", "combined_title":"Study Abroad First Step Session", "event_subtitle":"", "event_type":"Presentation", "event_type_id":"16", "description":"Where will study abroad take you? Find out at a CGIS First Step session.\r\nPresentations are every Tuesday, Wednesday, Thursday, and Friday from 1\u20131:30pm from June 8\u2013August 4 (except July 5-6).\r\nTake your first step toward a study abroad experience at UM and learn more about study programs around the world, scholarships and other financial aid, and much more.\r\nAttending a CGIS First Step session is a required part of applying to a CGIS study abroad program. Fulfill this requirement before the school year even begins!", "occurrence_notes":null, "guid":"30742-3738397@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/30742", "building_id":"1000054", "building_name":"East Quadrangle", "campus_maps_id":"54", "room":"1338", "location_name":"East Quadrangle", "has_livestream":0, "cost":"", "tags":["Diversity","Inclusion","International","Language","Social Impact","Social Justice","Study Abroad","Undergraduate"], "website":"", "sponsors":[ { "group_name":"Center for Global and Intercultural Study", "group_id":"2726", "website":"http:\/\/www.lsa.umich.edu\/cgis" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2016\/05\/event_30742_original.jpeg", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2016\/05\/event_30742_original.jpeg", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2016\/05\/event_30742_original.jpeg", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2016\/05\/event_30742_original.jpeg", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2016\/05\/event_30742_original.jpeg", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb\/media\/attachments\/2016\/05\/event_30742_original.jpeg", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb_square\/media\/attachments\/2016\/05\/event_30742_original.jpeg", "group_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large\/media\/attachments\/2016\/05\/event_30742_original.jpeg", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large_lightbox\/media\/attachments\/2016\/05\/event_30742_original.jpeg", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_large_crop\/media\/attachments\/2016\/05\/event_30742_original.jpeg", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2016\/05\/event_30742_original.jpeg", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2016\/05\/event_30742_original.jpeg", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2016\/05\/event_30742_original.jpeg", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_grid_2x\/media\/attachments\/2016\/05\/event_30742_original.jpeg", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_feature_large\/media\/attachments\/2016\/05\/event_30742_original.jpeg", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_feature_thumb\/media\/attachments\/2016\/05\/event_30742_original.jpeg" }, "occurrence_count":32, "first_occurrence":3738374 } , "31092-4068757": { "datetime_modified":"20160628T181509", "datetime_start":"20160701T150000", "datetime_end":"", "has_end_time":0, "date_start":"2016-07-01", "date_end":"", "time_start":"15:00:00", "time_end":"", "time_zone":"America\/Detroit", "event_title":"Senior Recital: James Russell, flute", "occurrence_title":"", "combined_title":"Senior Recital: James Russell, flute", "event_subtitle":"", "event_type":"Performance", "event_type_id":"15", "description":"PROGRAM: Swallow - Falling Grace; Russell - The Man Who Cried Jazz, Breath, Freedom; Henderson - Serenity; Pearson - Jeanine; Blakey - Look at the Birdie", "occurrence_notes":null, "guid":"31092-4068757@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/31092", "building_id":"1000445", "building_name":"Stearns Building", "campus_maps_id":"144", "room":"Cady Room", "location_name":"Stearns Building", "has_livestream":0, "cost":"Free - no tickets required", "tags":["Free","Music","North campus"], "website":"http:\/\/music.umich.edu", "sponsors":[ { "group_name":"School of Music, Theatre & Dance (SMTD)", "group_id":"155", "website":"http:\/\/smtd.umich.edu\/events" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":4068757 } , "30789-3756542": { "datetime_modified":"20160520T181506", "datetime_start":"20160701T190000", "datetime_end":"", "has_end_time":0, "date_start":"2016-07-01", "date_end":"", "time_start":"19:00:00", "time_end":"", "time_zone":"America\/Detroit", "event_title":"Center Stage Strings Master Class: Yizhak Schotten, viola", "occurrence_title":"", "combined_title":"Center Stage Strings Master Class: Yizhak Schotten, viola", "event_subtitle":"", "event_type":"Lecture \/ Discussion", "event_type_id":"13", "description":"A glimpse behind the scenes in the making of a young artist and the relationship between a teacher and a student. Three Center Stage Strings students perform for this master teacher in a fun and engaging experience for all involved!", "occurrence_notes":null, "guid":"30789-3756542@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/30789", "building_id":"1000440", "building_name":"Earl V. Moore Building", "campus_maps_id":"52", "room":"Britton Recital Hall", "location_name":"Earl V. 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Main, Ann Arbor, MI", "location_name":"Off Campus Location", "has_livestream":0, "cost":"General Admission: $25, Reserved: $32. 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As a self-taught artist, Kohli is not bound to school taught rules but rather follows instinct and spontaneity. This also allows her to freely create her own processes. Moments of introspection and feelings of acceptance are what Kohli wishes to offer viewers of her work, and these goals are inspired by her deep love of spirituality and Bikram yoga.", "occurrence_notes":null, "guid":"30719-3703666@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/30719", "building_id":"1000316", "building_name":"University Hospitals", "campus_maps_id":"158", "room":"Gifts of Art Gallery \u2014 University Hospital Main Lobby, Floor 1", "location_name":"University Hospitals", "has_livestream":0, "cost":"", "tags":["Health & Wellness","Art"], "website":"http:\/\/www.med.umich.edu\/goa\/performances.htm", "sponsors":[ { "group_name":"Gifts of Art", "group_id":"3108", "website":"http:\/\/www.med.umich.edu\/goa\/" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2016\/05\/event_30719_original.jpeg", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_thumb\/media\/attachments\/2016\/05\/event_30719_original.jpeg", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2016\/05\/event_30719_original.jpeg", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_large_2x\/media\/attachments\/2016\/05\/event_30719_original.jpeg", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2016\/05\/event_30719_original.jpeg", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb\/media\/attachments\/2016\/05\/event_30719_original.jpeg", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb_square\/media\/attachments\/2016\/05\/event_30719_original.jpeg", "group_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large\/media\/attachments\/2016\/05\/event_30719_original.jpeg", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large_lightbox\/media\/attachments\/2016\/05\/event_30719_original.jpeg", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_large_crop\/media\/attachments\/2016\/05\/event_30719_original.jpeg", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2016\/05\/event_30719_original.jpeg", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2016\/05\/event_30719_original.jpeg", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2016\/05\/event_30719_original.jpeg", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_grid_2x\/media\/attachments\/2016\/05\/event_30719_original.jpeg", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_feature_large\/media\/attachments\/2016\/05\/event_30719_original.jpeg", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2016\/05\/event_30719_original.jpeg" }, "occurrence_count":84, "first_occurrence":3703654 } , "30720-3703750": { "datetime_modified":"20160513T151140", "datetime_start":"20160702T080000", "datetime_end":"20160702T200000", "has_end_time":1, "date_start":"2016-07-02", "date_end":"2016-07-02", "time_start":"08:00:00", "time_end":"20:00:00", "time_zone":"America\/Detroit", "event_title":"Gifts of Art presents Concrete Ephemera: Street Art Captured", "occurrence_title":"", "combined_title":"Gifts of Art presents Concrete Ephemera: Street Art Captured: David Zinn", "event_subtitle":"David Zinn", "event_type":"Exhibition", "event_type_id":"7", "description":"David Zinn has been drawing on sidewalks for well over a decade, using chalk and charcoal to create anamorphic 3D creatures which, when viewed at a precise angle, appear to exist in the real world. They often incorporate parts of the landscape and found objects, such as cracks in concrete or leaves on the ground. He is inspired by a desire to place cheerful art underfoot in unexpected places and to embrace the temporary nature of all things. For this exhibit, photographs of his street art installations will be on display. Zinn is a lifelong Michigander with a degree in creative writing from the U-M Residential College, and he worked for many years as a children\u2019s radio host on WCBN and Michigan Radio. Zinn will also give an artist demonstration alongside a musical performance by Magdalen Fossum in the University Hospital Courtyard on Thurs, July 21, 2016 from 12:00-1:00 pm.", "occurrence_notes":null, "guid":"30720-3703750@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/30720", "building_id":"1000316", "building_name":"University Hospitals", "campus_maps_id":"158", "room":"Gifts of Art Gallery \u2014 University Hospital Main Corridor, Floor 2", "location_name":"University Hospitals", "has_livestream":0, "cost":"", "tags":["Health & Wellness","Art"], "website":"http:\/\/www.med.umich.edu\/goa\/exhibits.htm", "sponsors":[ { "group_name":"Gifts of Art", "group_id":"3108", "website":"http:\/\/www.med.umich.edu\/goa\/" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2016\/05\/event_30720_original.jpeg", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_thumb\/media\/attachments\/2016\/05\/event_30720_original.jpeg", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2016\/05\/event_30720_original.jpeg", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_large_2x\/media\/attachments\/2016\/05\/event_30720_original.jpeg", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2016\/05\/event_30720_original.jpeg", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb\/media\/attachments\/2016\/05\/event_30720_original.jpeg", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb_square\/media\/attachments\/2016\/05\/event_30720_original.jpeg", "group_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large\/media\/attachments\/2016\/05\/event_30720_original.jpeg", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large_lightbox\/media\/attachments\/2016\/05\/event_30720_original.jpeg", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_large_crop\/media\/attachments\/2016\/05\/event_30720_original.jpeg", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2016\/05\/event_30720_original.jpeg", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2016\/05\/event_30720_original.jpeg", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2016\/05\/event_30720_original.jpeg", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_grid_2x\/media\/attachments\/2016\/05\/event_30720_original.jpeg", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_feature_large\/media\/attachments\/2016\/05\/event_30720_original.jpeg", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_feature_thumb\/media\/attachments\/2016\/05\/event_30720_original.jpeg" }, "occurrence_count":84, "first_occurrence":3703738 } , "30717-3703498": { "datetime_modified":"20160513T143042", "datetime_start":"20160702T080000", "datetime_end":"20160702T200000", "has_end_time":1, "date_start":"2016-07-02", "date_end":"2016-07-02", "time_start":"08:00:00", "time_end":"20:00:00", "time_zone":"America\/Detroit", "event_title":"Gifts of Art presents Detroit Area Artists Photo Portrait Project", "occurrence_title":"", "combined_title":"Gifts of Art presents Detroit Area Artists Photo Portrait Project: Donita Simpson", "event_subtitle":"Donita Simpson", "event_type":"Exhibition", "event_type_id":"7", "description":"Donita Simpson is a Detroit based photographer who creates images of Detroit area artists in their personal creative environments. She has an M.F.A. in photography from Wayne State University, and her work is currently on exhibit in The Outwin 2016: American Portraiture Today at the Smithsonian National Portrait Gallery. The Detroit Area Artists Portrait Project contains images of artists that have been making art in and around the city for over 20 years. 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Many different styles of alternative bindings and printing methods will be shown that often push the boundaries of traditional books and, in the process, become art objects. The show will also include mixed media sculptural pieces by Ray Wetzel and Phillip Dewey. 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The root of her work is an emotional reaction to the environment, implying landscapes not necessarily seen but felt. Veedell lives and works in San Francisco, and she is inspired by her global travels to places as far away as India and as near as Napa Valley, California. 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The group\u2019s purpose is to share knowledge, techniques and work collaboratively on projects and exhibits as decided by the group. The definition of a portal is a door, means of entrance, gateway, approach or architectural composition surrounding an opening. 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Working together they have developed a wonderful exchange and interplay of ideas, concepts and techniques, involving meticulous fabrication with many different materials and processes. Their influences are varied and vast: modern art, scientific phenomena, 20th century artifacts, nature and film play upon their ideas and how they manifest them into jewelry objects. 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