{ "42826-9661766": { "datetime_modified":"20170928T095102", "datetime_start":"20171006T153000", "datetime_end":"20171006T173000", "has_end_time":1, "date_start":"2017-10-06", "date_end":"2017-10-06", "time_start":"15:30:00", "time_end":"17:30:00", "time_zone":"America\/Detroit", "event_title":"Tappan Talks", "occurrence_title":"", "combined_title":"Tappan Talks: Allison Martino & Elizabeth Rauh", "event_subtitle":"Allison Martino & Elizabeth Rauh", "event_type":"Lecture \/ Discussion", "event_type_id":"13", "description":"Allison Martino and Elizabeth Rauh, U-M History of Art doctoral candidates, gives short talks followed by Q & A.\r\n\r\nAllison Martino, \"Cloth, Chairs, and Key Chains:\r\nThe Re-Invention of Gye Nyame as a National Symbol of Ghana\"\r\n\r\nAdinkra is best known as a mourning cloth among the Akan of Ghana. Yet the role of adinkra in practices of remembrance extends far beyond funerals. Since at least the early 19th century, the Akan have printed adinkra cloth with distinct graphic designs evoking multiple meanings related to proverbs, historical narratives, and moral beliefs. Joining visual and verbal arts, adinkra is a dynamic form of communication that oscillates between expressing personal, cultural, and national identities. Ghanaians have innovated the form and meaning of adinkra over time to mark changing relationships to the past and envisions of future aspirations.\r\n\r\nThis presentation examines how Ghanaians have re-invented adinkra from a precolonial Akan cultural practice to represent national culture. Specifically, it analyzes the shifting meanings and contexts of gye Nyame, one of the most popular adinkra symbols. Often translated as \u201cExcept God,\u201d gye Nyame is ubiquitous in Ghana today \u2013 ranging from plastic chairs and key chains to churches, currency notes, and tourist souvenirs. In tracing one motif across time and space, this talk reveals how Ghanaians have transformed gye Nyame and revitalized adinkra to resonate deeply in contemporary life.\r\n\r\nElizabeth Rauh, \"The Colored Horizons of Karbala: Rafa Nasiri and Contemporary Printmaking in Late 1960s Iraq\"\r\n\r\nThis presentation looks to Rafa Nasiri\u2019s (1940-2013) printmaking practice and its early experimentation with printed Arabic script as the locus from which he stimulated and historicized the contemporary graphic arts movement in Iraq. Although conversant in pan-Arab and international socialist realist strategies from his training in printmaking at the Institute of Fine Arts in Beijing (1958-1963), Nasiri\u2019s work in the 1960s offers experiments with global abstract expressionism and local religious prints. The need for educational programs and publications on the arts of Arab printing led Nasiri to travel around Iraq gathering popular printed textiles. Nasiri collected block printed (hafir al-tarsh) black and white calligraphic banners, which are carried in the streets during \u2018Ashura and the holy month of Muharram, when mass pilgrimage processions overtake Shi\u2018i Muslim shrines in the cities of Karbala and Najaf. He then cut these popular prints and their pious poetic verses into separate cartouches and adhered them directly onto his abstract works. \r\n\r\nDrawing upon communal rituals and public ceremonies moored Nasiri\u2019s contemporary graphic art practice within Iraq\u2019s historic printing technologies and social and religious practices. The collage-print series offered visual venerations of the Battle of Karbala (680 AD) as colorfully abstracted desert landscapes. Nestled within their references to that catastrophic landscape, the Shi\u2018i readymade prints associated Nasiri\u2019s works with the ancient battle and its religious performances of dissent against injustice and oppression. By imprinting his compositions with prefabricated calligraphic texts, Nasiri elicited collective memories of Karbala and created a representational strategy counter to the new Baathist regime\u2019s use of populist imagery. These works thus show how Rafa Nasiri marshaled Iraq\u2019s historic printing technologies and social traditions to depict popular expressions of the metaphoric horizons of Karbala.", "occurrence_notes":null, "guid":"42826-9661766@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/42826", "building_id":"1000216", "building_name":"Tappan Hall", "campus_maps_id":"148", "room":"180", "location_name":"Tappan Hall", "has_livestream":0, "cost":"", "tags":["History","Visual Arts"], "website":"http:\/\/www.lsa.umich.edu\/histart\/events", "sponsors":[ { "group_name":"History of Art", "group_id":"1034", "website":"http:\/\/www.lsa.umich.edu\/histart\/events" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":9661766 } , "43701-9832692": { "datetime_modified":"20170907T120930", "datetime_start":"20171006T160000", "datetime_end":"20171006T180000", "has_end_time":1, "date_start":"2017-10-06", "date_end":"2017-10-06", "time_start":"16:00:00", "time_end":"18:00:00", "time_zone":"America\/Detroit", "event_title":"Chicana Fotos Exhibit Reception", "occurrence_title":"", "combined_title":"Chicana Fotos Exhibit Reception: Featuring the artist, Nancy De Los Santos", "event_subtitle":"Featuring the artist, Nancy De Los Santos", "event_type":"Reception \/ Open House", "event_type_id":"17", "description":"Featuring photographs by accomplished filmmaker and writer Nancy De Los Santos, \"Chicano Fotos\" offers a striking depiction of struggles for social justice among Mexican Americans in the 1970s. The exhibit, which makes its way to Lane Hall from Wayne State University's Walter P. Reuther Library, includes rare images of scenes from Chicana\/o history, such as the United Farm Workers of America organizing activities in Chicago, protests against police brutality and for farm worker rights in Texas, and the first global conference on women, the International Women\u2019s Year Conference, in Mexico City. \r\n\r\nThis reception will celebrate \"Chicana Fotos\" with the artist herself, Nancy De Los Santos, who has dedicated her life and career to rewriting and redefining images of Latina\/os in mainstream media. All members of the community interested in viewing and discussing the exhibit are welcome to attend.\r\n\r\nThis exhibit and reception are presented with support of the Department of Women's Studies and the Latina\/o Studies Program.", "occurrence_notes":null, "guid":"43701-9832692@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/43701", "building_id":"1000183", "building_name":"Lane Hall", "campus_maps_id":"84", "room":"Gathering Space", "location_name":"Lane Hall", "has_livestream":0, "cost":"", "tags":["Women's Studies","Art","Latina\/o Studies"], "website":"https:\/\/lsa.umich.edu\/women\/about-us\/exhibit-space.html", "sponsors":[ { "group_name":"Women's and Gender Studies Department", "group_id":"2809", "website":"http:\/\/www.lsa.umich.edu\/wgs" }, { "group_name":"Department of American Culture", "group_id":"3309", "website":"http:\/\/lsa.umich.edu\/ac" }, { "group_name":"Latina\/o Studies", "group_id":"3632", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2017\/09\/event_43701_original.jpeg", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2017\/09\/event_43701_original.jpeg", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2017\/09\/event_43701_original.jpeg", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2017\/09\/event_43701_original.jpeg", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2017\/09\/event_43701_original.jpeg", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb\/media\/attachments\/2017\/09\/event_43701_original.jpeg", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb_square\/media\/attachments\/2017\/09\/event_43701_original.jpeg", "group_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large\/media\/attachments\/2017\/09\/event_43701_original.jpeg", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2017\/09\/event_43701_original.jpeg", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_large_crop\/media\/attachments\/2017\/09\/event_43701_original.jpeg", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2017\/09\/event_43701_original.jpeg", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2017\/09\/event_43701_original.jpeg", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2017\/09\/event_43701_original.jpeg", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_grid_2x\/media\/attachments\/2017\/09\/event_43701_original.jpeg", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_feature_large\/media\/attachments\/2017\/09\/event_43701_original.jpeg", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_feature_thumb\/media\/attachments\/2017\/09\/event_43701_original.jpeg" }, "occurrence_count":1, "first_occurrence":9832692 } , "41927-9495448": { "datetime_modified":"20170803T081117", "datetime_start":"20171006T160000", "datetime_end":"20171006T180000", "has_end_time":1, "date_start":"2017-10-06", "date_end":"2017-10-06", "time_start":"16:00:00", "time_end":"18:00:00", "time_zone":"America\/Detroit", "event_title":"CSAS Lecture Series | Summer in South Asia Fellowship Symposium", "occurrence_title":"", "combined_title":"CSAS Lecture Series | Summer in South Asia Fellowship Symposium", "event_subtitle":"", "event_type":"Conference \/ Symposium", "event_type_id":"5", "description":"Ten undergraduate students were selected to be 2017 Summer in South Asia Fellows. Fellows designed, implemented, and enacted their proposals for their summers in India. At the symposium, students will share their experiences in India, drawing from their internships, research, and interactions with the culture. \r\n \r\nMeet the fellows here: http:\/\/ii.umich.edu\/csas\/undergraduate-students\/summer-in-south-asia-fellowships\/2017-fellows.html", "occurrence_notes":null, "guid":"41927-9495448@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/41927", "building_id":"1000165", "building_name":"Weiser Hall", "campus_maps_id":"47", "room":"Room 110", "location_name":"Weiser Hall", "has_livestream":0, "cost":"", "tags":["India","Volunteer","Social Justice","Social Impact","Multicultural","Leadership","International","Environment","Community Service"], "website":"http:\/\/ii.umich.edu\/csas\/undergraduate-students\/summer-in-south-asia-fellowships\/2017-fellows.html", "sponsors":[ { "group_name":"Center for South Asian Studies", "group_id":"3273", "website":"http:\/\/www.ii.umich.edu\/csas" }, { "group_name":"International Institute", "group_id":"1968", "website":"http:\/\/www.ii.umich.edu" }, { "group_name":"Asian Languages and Cultures", "group_id":"3364", "website":"http:\/\/www.lsa.umich.edu\/asian" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2017\/08\/event_41927_original.jpeg", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_thumb\/media\/attachments\/2017\/08\/event_41927_original.jpeg", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2017\/08\/event_41927_original.jpeg", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2017\/08\/event_41927_original.jpeg", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2017\/08\/event_41927_original.jpeg", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb\/media\/attachments\/2017\/08\/event_41927_original.jpeg", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb_square\/media\/attachments\/2017\/08\/event_41927_original.jpeg", "group_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large\/media\/attachments\/2017\/08\/event_41927_original.jpeg", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2017\/08\/event_41927_original.jpeg", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_large_crop\/media\/attachments\/2017\/08\/event_41927_original.jpeg", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2017\/08\/event_41927_original.jpeg", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2017\/08\/event_41927_original.jpeg", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2017\/08\/event_41927_original.jpeg", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_grid_2x\/media\/attachments\/2017\/08\/event_41927_original.jpeg", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_feature_large\/media\/attachments\/2017\/08\/event_41927_original.jpeg", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_feature_thumb\/media\/attachments\/2017\/08\/event_41927_original.jpeg" }, "occurrence_count":1, "first_occurrence":9495448 } , "44924-10012261": { "datetime_modified":"20170922T093252", "datetime_start":"20171006T160000", "datetime_end":"20171006T173000", "has_end_time":1, "date_start":"2017-10-06", "date_end":"2017-10-06", "time_start":"16:00:00", "time_end":"17:30:00", "time_zone":"America\/Detroit", "event_title":"Minor in Writing Info Session", "occurrence_title":"", "combined_title":"Minor in Writing Info Session", "event_subtitle":"", "event_type":"Social \/ Informal Gathering", "event_type_id":"19", "description":"The Sweetland Minor in Writing is designed for undergraduate students who are interested in developing their disciplinary and professional writing abilities while pursuing their majors. It gives you the freedom to write about what matters to you while helping you develop as a writer and thinker. \r\n\r\nStudents currently in the Minor program come from all over the university bringing a wealth of diverse interests to the classroom. You might find a screenwriter sitting between a scientist and a musician or Kinesiology, Business, and Communications majors giving each other feedback on their writing. \r\n\r\nWith a Sweetland Minor in Writing you will earn a credential that certifies your writing expertise to prospective employers and graduate programs. You will also pick up new media skills designing and creating content for your electronic writing portfolios. \r\n\r\nIf you are interested in learning more about the Sweetland Minor in Writing from current students and faculty you can attend our informal Minor in Writing Information Session on Friday, October 6th from 4-5:30pm at Sweetland's Peer Writing Center in Angell Hall G219. Food and refreshments provided.\r\n\r\nThe deadline to apply is Monday, October 23rd at noon.\r\n\r\nMore info at http:\/\/lsa.umich.edu\/sweetland\/undergraduates\/minor-in-writing\/application-process.html", "occurrence_notes":null, "guid":"44924-10012261@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/44924", "building_id":"1", "building_name":"Angell Hall", "campus_maps_id":"12", "room":"G219", "location_name":"Angell Hall", "has_livestream":0, "cost":"", "tags":["Interdisciplinary","Writing","Undergraduate","Majors"], "website":"", "sponsors":[ { "group_name":"Sweetland Center for Writing", "group_id":"1122", "website":"http:\/\/www.lsa.umich.edu\/sweetland" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":10012261 } , "45475-10195170": { "datetime_modified":"20171006T103301", "datetime_start":"20171006T160000", "datetime_end":"20171006T170000", "has_end_time":1, "date_start":"2017-10-06", "date_end":"2017-10-06", "time_start":"16:00:00", "time_end":"17:00:00", "time_zone":"America\/Detroit", "event_title":"NERS Colloquium: Jinsong Huang, Ph.D., University of North Carolina", "occurrence_title":"", "combined_title":"NERS Colloquium: Jinsong Huang, Ph.D., University of North Carolina", "event_subtitle":"", "event_type":"Lecture \/ Discussion", "event_type_id":"13", "description":"Jinsong Huang, Ph.D.\r\nDepartment of Applied Physical Sciences University of North Carolina, Chapel Hill\r\n\r\nTitle: Halide Perovskites \u2013Promising Materials for Radiation Detection beyond Solar Cells\r\n\r\nThe research of halide perovskite solar cells continues to boom with device energy conversion efficiency approaching that of single crystal silicon solar cells within less than six years. One critical step in understanding why hybrid perovskite solar cells work so well is to determine the influence of defects on photon to current conversion process. I will present the advance in understanding the optoelectronic properties, unusual defect physics, and influence of defects on critical properties such as carrier diffusion length, charge recombination lifetime, carrier mobility and ion migration of solution processed perovskite materials. The discovery of the extraordinary properties enables new application of halide perovskite in radiation detection beyond solar cells. The recent\r\n development of X-ray sensors, imagers, and gamma-ray spectrum detectors will be presented.\r\nJinsong Huang received his PhD degree in Material\r\nScience and Engineering from the University of California-\r\nLos Angeles in 2007. After working in Agiltron Inc. as a\r\nresearch scientist for two years, he joined the University of\r\nNebraska-Lincoln in 2009 as an assistant professor in the\r\nDepartment of Mechanical and Materials Engineering, and\r\nwas promoted to associate professor with tenure in 2014,\r\nand professor in 2016. He joined the faculty in the\r\ndepartment of Applied Physical Sciences of University of North Carolina at Chapel Hill in 2017. His current research interests include solution processed electronic materials for applications in sensing, energy and consumer electronics. He has authored over 150 publications, and over 20 patents, 6 book chapters and 2 book. He served as the Chair of Material Engineering PhD Program at UNL, and was awarded as William E. Brooks Engineering Leadership Fellow in 2014, and Susan J. Rosowski University Professorship in 2015. He has received several awards including Edgerton Innovation Award (2012), NSF CAREER Award (2013), and DOD Young Investigator Award (2010).", "occurrence_notes":null, "guid":"45475-10195170@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/45475", "building_id":"1000403", "building_name":"Cooley Building", "campus_maps_id":"42", "room":"White Auditorium", "location_name":"Cooley Building", "has_livestream":0, "cost":"", "tags":["Discussion","Lecture","Nuclear Engineering and Radiological Sciences"], "website":"", "sponsors":[ { "group_name":"Nuclear Engineering & Radiological Sciences", "group_id":"4000", "website":"" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":10195170 } , "44345-9908977": { "datetime_modified":"20170913T115110", "datetime_start":"20171006T160000", "datetime_end":"20171006T170000", "has_end_time":1, "date_start":"2017-10-06", "date_end":"2017-10-06", "time_start":"16:00:00", "time_end":"17:00:00", "time_zone":"America\/Detroit", "event_title":"NERS Colloquium: Glenn Knoll Lecture (tentative)", "occurrence_title":"", "combined_title":"NERS Colloquium: Glenn Knoll Lecture (tentative)", "event_subtitle":"", "event_type":"Lecture \/ Discussion", "event_type_id":"13", "description":"Title: Glenn Knoll Lecture (tentative)", "occurrence_notes":null, "guid":"44345-9908977@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/44345", "building_id":"1000403", "building_name":"Cooley Building", "campus_maps_id":"42", "room":"2906 Baer Room", "location_name":"Cooley Building", "has_livestream":0, "cost":"", "tags":["Lecture","Nuclear Engineering and Radiological Sciences"], "website":"", "sponsors":[ { "group_name":"Nuclear Engineering & Radiological Sciences", "group_id":"4000", "website":"" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":9908977 } , "42543-10152993": { "datetime_modified":"20171003T105436", "datetime_start":"20171006T160000", "datetime_end":"20171006T170000", "has_end_time":1, "date_start":"2017-10-06", "date_end":"2017-10-06", "time_start":"16:00:00", "time_end":"17:00:00", "time_zone":"America\/Detroit", "event_title":"Pre-Doctoral Student - Katherine Gentry and Brian Linhares", "occurrence_title":"", "combined_title":"Pre-Doctoral Student - Katherine Gentry and Brian Linhares: Katherine Gentry \"Dynamic Interplay of Cytochrome P450 & Redox Partners\" and Brian Linhares \"Fragment-Based Identification and Optimization of Inhibitors Targeting BCL6-Co-Repressor Interactions.\u201d", "event_subtitle":"Katherine Gentry \"Dynamic Interplay of Cytochrome P450 & Redox Partners\" and Brian Linhares \"Fragment-Based Identification and Optimization of Inhibitors Targeting BCL6-Co-Repressor Interactions.\u201d", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Katherine Gentry: \"Dynamic Interplay of Cytochrome P450 & Redox Partners\"\r\nAbstract: Cytochrome P450s (cytP450s) are a ubiquitous superfamily of enzymes that play a vital role in the metabolism of many substrates including over 70% of the drugs on the market. For each turn of its catalytic cycle, cytP450 requires two electrons from its redox partners: Cytochrome P450 Reductase (CPR) and cytochrome b5 (cytb5). We are interested in how these proteins interact with each other specifically in the presence of lipid membrane mimetics and in the presence of various substrates. Here we use NMR spectroscopy and other biophysical tools to characterize the effect membrane has on the interaction between cytb5 and cytochrome c, a model for cytP450. Our findings reveal the importance of studying these membrane proteins in a biologically relevant membrane mimetic both structurally and kinetically. We have also begun work on understanding how CPR and cytb5 compete for binding to cytP450 and unravelling the structural and dynamic basis for this competition. Our data reveals how substrates can help to modulate the interaction between the two redox partners and cytP450, starting to define a complete picture of this trio of proteins. \r\n\r\nand \r\n\r\nBrian Linhares: \u201cFragment-based identification and optimization of inhibitors targeting BCL6-co-repressor interactions.\u201d\r\nAbstract: Constitutively overexpressed B-Cell Lymphoma protein 6 (BCL6) is an oncogenic driver in various subtypes of Diffuse Large B-Cell Lymphoma. In normal B-Cell physiology, BCL6 governs cell development and regulates affinity antibody maturation, through mediating the formation of transcription repression complexes. The N-terminal BTB domain of BCL6 (BCL6BTB) is responsible for dimerization and for recruitment of co-repressors, notably HDAC3-binding partner Silencing Mediator of Retinoic acid and Thyroid hormone (SMRT), via the Lateral Groove (LG), a unique structural motif of the BCL6-SMRT protein-protein binding interface. This site has therefore been promoted for pharmacological intervention, yet the development of potent, selective inhibitors with favorable drug-like properties has largely eluded campaigns to target BCL6. I will report the identification and optimization of a novel inhibitor scaffold of BCL6 BTB. Fragment-based screening identified a hit that binds at the LG, and structure determination of the fragment hit in complex with BCL6 BTB to high-resolution revealed the binding mode. Guided by the previously determined structure of BCL6BTB-SMRT BCL6 Binding Domain (SMRTBBD), structure-based drug design, in tandem with biophysical approaches, led an extensive investment in synthetic medicinal chemistry to target an adjacent pocket at the LG that is also occupied in BCL6BTB-SMRTBBD. Exploring substitutions to more fully occupy this pocket yielded small-molecule inhibitors with mid-micromolar affinity for BCL6BTB, which represents a 100-fold improvement in potency from the hit. As an inhibitor scaffold, our compounds may hold potential as chemical probes, and in scaffold hopping to aid in further inhibitor development", "occurrence_notes":null, "guid":"42543-10152993@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/42543", "building_id":"null", "building_name":"Off Campus Location", "campus_maps_id":"1", "room":"", "location_name":"Off Campus Location", "has_livestream":0, "cost":"", "tags":["Chemistry","Biophysics"], "website":"", "sponsors":[ { "group_name":"LSA Biophysics", "group_id":"3767", "website":"" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":10152993 } , "38406-9969026": { "datetime_modified":"20170131T114502", "datetime_start":"20171006T160000", "datetime_end":"20171006T180000", "has_end_time":1, "date_start":"2017-10-06", "date_end":"2017-10-06", "time_start":"16:00:00", "time_end":"18:00:00", "time_zone":"America\/Detroit", "event_title":"SLE at Friends of the Campus Farm Workday", "occurrence_title":"", "combined_title":"SLE at Friends of the Campus Farm Workday", "event_subtitle":"", "event_type":"Community Service", "event_type_id":"4", "description":"Join other Oxford and SLE residents for farmwork in the Greenhouse with Friends of the Campus Farm at Matthaei Botanical Gardens. Meet new people, get your hands dirty, and feel the warmth in the greenhouse during these winter days! 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