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        "event_title":"Predictive analysis and deep learning of functional MRI in Alzheimer's disease",
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        "combined_title":"Predictive analysis and deep learning of functional MRI in Alzheimer's disease: BME Ph.D. Defense:\u00a0Michelle Karker",
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        "description":"Abstract:\r\nAlzheimer's disease (AD) and dementia pose a significant burden to individuals and public health. AD is expected to grow in prevalence in the coming decades due to the aging population. Brain atrophy is a major component of AD pathology and can occur before symptoms of cognitive impairment. However, pathological brain atrophy and symptoms of cognitive impairment may be a result of many years of disease impacts. Evidence supports the need for early detection of impacted neurocircuitry to foresee future progression to advanced stages of AD and develop treatments. This dissertation examines predictive modeling and deep learning methods to identify brain-behavior relationships and learn low-dimensional representations of brain activity from MR imaging data. The dissertation and methods are separated into four parts. \u00a0\r\n\r\nPart one of this work examines multivariate analysis approaches applied to functional connectivity from subjects with an early clinical phenotype of AD, mild cognitive impairment (MCI). A regression framework using partial least squares and feature selection demonstrated significant brain-behavior relationships with measures of cognition and memory. The results also confirm other findings that ecologically relevant task-based connectivity serves as a ``stress-test\" for memory-related deficits such as those observed in MCI. This approach elucidated brain regions that may be implicated in MCI and warrant future study (superior temporal gyrus, inferior parietal lobule, and superior frontal gyrus). Part two extends the multivariate analyses studied in part one to an additional brain imaging modality, arterial spin labeling (ASL). Cerebral blood flow (CBF) as measured by ASL demonstrated brain-behavior relationships with composite measures of memory and learning in a cohort along the spectrum of AD, demonstrating that CBF data warrant further investigation as a predictor in this application.\r\n\r\nParts three and four utilize a variational autoencoder (VAE) model, a deep learning approach to encode latent representations that aim to disentangle sources of fMRI signal. A surface-based VAE trained on only healthy controls is shown to be generalizable to patients with known AD pathology. The results maintained individual separation and high input\/decoder output spatial reconstruction correlation of r=0.8 across all three groups. Part four extended the surface-based model used in part three to a volumetric fMRI approach. Similarly to the surface-based model, high reconstruction accuracy (NRMSE=0.68) and temporal correlation (r=0.8) between input and decoder output are demonstrated. This approach is more readily applicable to 3D fMRI data as compared to the surface-based model.\u00a0\r\n\r\nIn summary, this work has proposed and developed multivariate and deep learning analysis techniques for brain imaging data in the context of AD with the ultimate goal of improving detection and intervention for early pathological changes in the brain.\r\n\r\nZoom Link: https:\/\/umich.zoom.us\/meeting\/register\/tJIpcOigrjIsHtJq_xJ1aboK1T0PdWpTkBP5\r\n*Registration Required\r\n\r\nCommittee Chair(s):\r\nDr. Scott J. Peltier and Dr. Douglas C. Noll",
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        "event_title":"BusinessObjects Upgrade Webinar",
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        "event_title":"Developmental Brown Bag: Children's and adults' understanding and learning about genetic inheritance",
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        "combined_title":"Developmental Brown Bag: Children's and adults' understanding and learning about genetic inheritance: David Menendez (He\/Him\/\u00c9l) Post-doctoral Researcher, Department of Psychology, University of Michigan",
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        "event_title":"Journey of Self-Discovery",
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        "combined_title":"Journey of Self-Discovery: Artwork of Richard Moizio",
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        "website":"http:\/\/www.richmoizio.com\/index.html",
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        "event_title":"What I Talk about when I Talk about Palestine",
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        "combined_title":"What I Talk about when I Talk about Palestine: Maurice Ebileeni",
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        "description":"Arabic is unconditionally the national language of Palestinians, but for many it is no longer their mother-tongue. More than a century after the early waves of immigration to the Americas, and more than seven decades after the Nakba of 48, generations of Palestinians have grown up in a variety of different contexts within Israel-Palestine and the world at large. This ongoing scattered state has led to the proliferation of Palestinian culture as it is simultaneously growing in multiple directions, depending on geographical, political, and lingual contextualization. The Palestinian story no longer exists exclusively in Arabic. A new generation of Palestinian and Palestinian-descended writers and artists from both Latin and North America, Scandinavia, and Europe at large, as well as Israel-Palestine are bringing stories of their heritage and the Palestinian nation into a variety of languages such Spanish, Italian, English, Danish, and Hebrew\u2014among so many other languages. \r\n\r\nIn this talk, Maurice Ebileeni explores how the Palestinian homeland is being imagined in multiple languages from a variety of positions both locally and globally and wishes to discuss unsettling questions about this current situation. He also invites us to look to the future to speculate about how a Palestinian nation might still house the notion of home for an increasingly diverse Palestinian population.\r\n\r\n***********************************************\r\n\r\nMaurice Ebileeni is a member of faculty in the English department at the University of Haifa. He is the author of Conrad, Faulkner, and the Problem of Nonsense and Being There, Being Here: Palestinian Writings in the World, and his work on Palestinian literature and culture has appeared in Comparative Literature, The Journal of Postcolonial Writing, Interventions, and Hebrew-language Ot, among others.",
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        "event_title":"We\u2019re Hiring! Improve Federal Programs with the U.S. Department of Health & Human Services, Office of Inspector General",
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        "description":"ATTN: This info session pertains to 4 upcoming FULL-TIME vacancies in OEI regional offices in Baltimore, Boston, Kansas City, and NewYork City. Open only to recent graduates (generally, within the past 2 years). U.S. CITIZENSHIP IS REQUIRED.  \n\nThe U.S. Department of Health and Human Services (HHS), Office of Inspector General, Office of Evaluation and Inspections (OEI) is seeking applicants to join our mission-driven,intellectually curious, and collaborative regional teams based in Baltimore, Boston, Kansas City, and New York City. OEI conducts national evaluations of the policies, procedures, and operations of HHS programs to provide HHS, Congress, and the public with timely, useful, and reliableinformation on significant issues. These evaluations focus on preventing fraud, waste, and abuse; promoting quality, safety, and value; and advancing excellence and innovation in HHS programs such as Medicare and Medicaid and in HHS agencies such as CDC, NIH, and FDA. OEI evaluations include recommendations to HHS to improve program operations. This info session will provide a brief introduction to HHS OIG\/OEI and more details about our upcoming vacancies. \n\nThe selected candidates will work in teams to research program issues, develop data collection instruments, conduct interviews, compile and analyze data, and write reports. Current inspections cover a broad range of public health topics such as the COVID-19 pandemic, the opioid epidemic, Medicare drug spending, quality of care in Medicare and Medicaid, and data quality issues. OEI is committed to promoting health equity through our evaluations and recommendations and to fostering diversity, equity, and inclusion among our staff. \n\nPlease visit our website (http:\/\/oig.hhs.gov) for more information about the organization and to read our reports (http:\/\/oig.hhs.gov\/oei\/subject_index.asp). Thevacancies will be posted to USAJobs.gov within the next several weeks.\n\nThis info session pertains to 4 upcoming full-time vacancies in OEI regional offices in Baltimore, Boston, Kansas City, and New York City. The vacancies will be posted on USAJobs.gov in September or October 2022. A bachelor\u2019s degree in a behavioral or social science field, or four years equivalent experience, is required; a master\u2019s degree or relevant experience conducting or presenting social science research or analyzing data is preferred. U.S. citizenship is required.",
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        "time_start":"14:30:00",
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        "event_title":"Cognitive Science Seminar Series",
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        "combined_title":"Cognitive Science Seminar Series: Alexander Johnson, Research Fellow, Department of Psychology",
        "event_subtitle":"Alexander Johnson, Research Fellow, Department of Psychology",
        "event_type":"Lecture \/ Discussion",
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        "description":"Title:\r\nGiving Structure to the Cognitive Map\r\n\r\nAbstract:\r\nThe cognitive map within the minds of animals is the mental process of perceiving and arranging relevant environmental features upon which behavioral decision making processes can be built (Tolman 1948). The previous 5-decades have seen investigation of the neural processes that underlie animals\u2019 ability to cognitively map spaces primarily through recording the electrical activity of neurons as animals navigate a physical space (O\u2019Keefe 1974). Among the most prominent features of the cognitive mapping system within the brain are the discovery of place cells which respond to an animals\u2019 specific location in space, and lay the foundation of seeing the hippocampus as being foundational to the cognitive map (O\u2019Keefe & Nadel 1978).\r\n\r\nRecently more attention has been placed on how the cognitive mapping system of the brain encodes for structural features (Behrens et al. 2018). However, little research has gone into how structural features directly interact with spatial representations of the hippocampal system. Data presented here demonstrates that while CA1 place-representations are relatively unimpacted by the structure of the space the animal is in, one synapse away in dorsal subiculum, a mapping of structure emerges within the activity patterns of individual and populations of neurons. These results show the importance of environmental structure when studying spatial navigation, and helps elucidate the relatively understudied brain region of the subiculum.",
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        "tags":["Cognitive Science","Graduate Students","Linguistics","Psychology"],
        "website":"https:\/\/lsa.umich.edu\/weinberginstitute\/seminar-series.html",
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        "datetime_modified":"20220919T121608",
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        "has_end_time":1,
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        "date_end":"2022-09-26",
        "time_start":"14:30:00",
        "time_end":"15:30:00",
        "time_zone":"America\/Detroit",
        "event_title":"How to talk about your immigration status to employers",
        "occurrence_title":"",
        "combined_title":"How to talk about your immigration status to employers",
        "event_subtitle":"",
        "event_type":"Careers \/ Jobs",
        "event_type_id":"2",
        "description":"As an international student, it is important for you to practice how to bring up your work authorization status during the recruitment process. We will be focusing on how to bring up your status or ways to address it with an employer. This workshop will give you the opportunity to interactively practice your script with your peers, and present yourself in the workplace. This workshop is NOT going to address how to apply for OPT and CPT or another alternative work visa- please visit the University ofMichigan\u2019s International Center: https:\/\/internationalcenter.umich.edu\r\n\r\n***This is a reoccurring event, please stay tuned to our internationalstudent newsletter for more program dates!***\r\n\r\nThis event's informationis shown in Handshake as well as on the Happening @ Michigan calendar so that it will be seen by a larger number of U-M Students. You can only register to attend this event within Handshake. If you'd like to indicate thatyou'll be attending this event and see more details, please go to umich.joinhandshake.com, locate the event in the events tab, and then click the 'Join Event' button.",
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        "datetime_modified":"20221128T084949",
        "datetime_start":"20220926T144500",
        "datetime_end":"20220926T151500",
        "has_end_time":1,
        "date_start":"2022-09-26",
        "date_end":"2022-09-26",
        "time_start":"14:45:00",
        "time_end":"15:15:00",
        "time_zone":"America\/Detroit",
        "event_title":"Wellness Everyday: Mindful Mondays",
        "occurrence_title":"",
        "combined_title":"Wellness Everyday: Mindful Mondays: WISE Hub: Weave My Net",
        "event_subtitle":"WISE Hub: Weave My Net",
        "event_type":"Well-being",
        "event_type_id":"12",
        "description":"Every Monday we offer a variety of guided sessions that will help you find calmness and community. In these sessions, we will introduce different forms of meditation, we will practice them, and then give you some materials that will help you carry on the practice throughout the week.\r\n\r\nAt WISE we know that the different dimensions of wellness are something that we should focus on every day not only in times of stress. We have created the Wellness Everyday Series to aid the WISE community\u2019s exposure to different aspects of their wellness and develop a practice of wellness every day. We look forward to having you join us in the WISE Office in room 3236 of the Undergraduate Science Building. When you are well it helps the community to become well.\r\n\r\n*These events are drop-in. No registration required.*",
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