{ "32165-4508946": { "datetime_modified":"20161021T143501", "datetime_start":"20161104T153000", "datetime_end":"20161104T163000", "has_end_time":1, "date_start":"2016-11-04", "date_end":"2016-11-04", "time_start":"15:30:00", "time_end":"16:30:00", "time_zone":"America\/Detroit", "event_title":"Smith Lecture: Changing World \u2013 Changing Exploration\ufeff", "occurrence_title":"", "combined_title":"Smith Lecture: Changing World \u2013 Changing Exploration\ufeff: John Thompson, Cornell", "event_subtitle":"John Thompson, Cornell", "event_type":"Lecture \/ Discussion", "event_type_id":"13", "description":"The world continues to change, most recently through global connectivity and digital technology that have been termed the \u201cFourth Industrial Revolution\u201d. This revolution is already impacting energy use, transportation, and employment. When combined with new materials and associated applications, there is potential for disruptive changes to metal markets and hence mining and exploration.\r\n\r\nThese developments build on existing trends that already affect mining such as population growth, basic human needs, emerging economies, and heightened expectations for quality of life and a clean environment. \r\nPredicting how these factors will play out in the short to long term is challenging. Potential decline in metal demand would clearly reduce exploration expenditure while rapid increases in metal use, or supply constraints, could cause metal-specific exploration booms, as happened with rare earth elements in 2010-11. Neither support consistent exploration efforts.\r\n\r\nMining and exploration have always adapted to fluctuating demand. The first primitive miners responded to early metal use, and new mines and more sophisticated tools developed over the subsequent 6000 years. The rate of change increased with the industrial revolution, new bulk mining methods, and dramatic changes in processing. Exploration responded with explorers going to new places, with new ideas and technology, and many excellent discoveries followed. While a spirit of adventure and field skills have remained consistent ingredients for success, many aspects of modern exploration would be unrecognizable to practitioners operating thirty-five years ago. Change will continue but predicting the end-result in thirty-five years is as difficult as it would have been to predict the present thirty-five years ago. \r\nGiven current trends in exploration, the following will be important areas for change.\r\n\r\nBusiness and partnerships: The effectiveness of funding strategies and partnerships among exploration-focused juniors and mid-tier or major producers has declined. New business models are needed. National companies and downstream technology companies both need to secure resources, a need that may offer exploration investment opportunities. Lastly, gaining community support will require models involving shared benefits and innovative partnerships.\r\n\r\nTechnology and tools: New mobile analytical equipment and sensors will generate increasing amounts of field data, which if used in conjunction with traditional techniques, will accelerate programs and decision making. Rapid drilling technology from fewer, smaller drill pads with real-time data will result in more targets being tested for less dollars and less impact.\r\nData: The data explosion also threatens to hinder effective exploration if not managed appropriately. Intelligent methods for QA-QC, integration and interrogation will help significantly if geared towards results.\r\n\r\nExploration strategy: In spite of new ore deposit models, we struggle to understand system footprints, the clusters of deposits they contain, and the potential for quality discoveries. Brownfields and Greenfields exploration require different applications, and Greenfields in particular needs renewed impetus that is only likely with new business and funding models.\r\nIn spite of global change and all its ramifications, quality discoveries are clearly required. These still create the most value with the least impact. It remains to be seen whether we can harness change to improve our odds of making these discoveries.", "occurrence_notes":null, "guid":"32165-4508946@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/32165", "building_id":"1000188", "building_name":"1100 North University Building", "campus_maps_id":"28", "room":"1528", "location_name":"1100 North University Building", "has_livestream":0, "cost":"", "tags":["Lecture"], "website":"", "sponsors":[ { "group_name":"Earth and Environmental Sciences", "group_id":"3170", "website":"http:\/\/www.lsa.umich.edu\/earth" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":4508946 } , "31058-4024876": { "datetime_modified":"20161014T154914", "datetime_start":"20161104T160000", "datetime_end":"20161104T190000", "has_end_time":1, "date_start":"2016-11-04", "date_end":"2016-11-04", "time_start":"16:00:00", "time_end":"19:00:00", "time_zone":"America\/Detroit", "event_title":"2016 Parents Weekend", "occurrence_title":"", "combined_title":"2016 Parents Weekend: LSA Honors Guest Speakers Luke Schaefer & Kathryn Edin", "event_subtitle":"LSA Honors Guest Speakers Luke Schaefer & Kathryn Edin", "event_type":"Reception \/ Open House", "event_type_id":"17", "description":"A NYT Bestseller and White House pick, $2.00 a Day, was the summer book for the Class of 2020, written by Kathryn J. Edin (Professor of Sociology & Public Health, Johns Hopkins University) and H. Luke Schaefer (Associate Professor of Social Work and the Gerald R. Ford School of Public Policy, University of Michigan). Through their research, the authors discovered, surprisingly, that one and a half million households in America live on $2.00 a day, per person. Edin and Schaefer spoke with family members about their stories: where they live, how they came to be in their situation, what they do to survive. \r\n\r\nHonors is pleased to welcome the authors as guest lecturers at the 2016 Family Weekend, Friday, November 4, in Angell Aud B for an open talk and book signing. The event begins at 4:00p, followed by a meet and greet in the Perlman Honors Commons with light refreshments.", "occurrence_notes":null, "guid":"31058-4024876@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/31058", "building_id":"1", "building_name":"Angell Hall", "campus_maps_id":"12", "room":"Auditorium B", "location_name":"Angell Hall", "has_livestream":0, "cost":"", "tags":["Honors"], "website":"http:\/\/www.twodollarsaday.com", "sponsors":[ { "group_name":"LSA Honors Program", "group_id":"3353", "website":"http:\/\/honors.umich.edu" }, { "group_name":"Michigan Learning Communities", "group_id":"3795", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2016\/06\/event_31058_original.jpeg", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_thumb\/media\/attachments\/2016\/06\/event_31058_original.jpeg", 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Hall", "has_livestream":0, "cost":"", "tags":["Alumni"], "website":"", "sponsors":[ { "group_name":"Department of American Culture", "group_id":"3309", "website":"http:\/\/lsa.umich.edu\/ac" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2016\/10\/event_35388_original.jpeg", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_thumb\/media\/attachments\/2016\/10\/event_35388_original.jpeg", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2016\/10\/event_35388_original.jpeg", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2016\/10\/event_35388_original.jpeg", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2016\/10\/event_35388_original.jpeg", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb\/media\/attachments\/2016\/10\/event_35388_original.jpeg", 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"event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_grid_2x\/media\/attachments\/2016\/10\/event_35388_original.jpeg", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_feature_large\/media\/attachments\/2016\/10\/event_35388_original.jpeg", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_feature_thumb\/media\/attachments\/2016\/10\/event_35388_original.jpeg" }, "occurrence_count":1, "first_occurrence":5210405 } , "33247-4710139": { "datetime_modified":"20161031T171539", "datetime_start":"20161104T160000", "datetime_end":"20161104T170000", "has_end_time":1, "date_start":"2016-11-04", "date_end":"2016-11-04", "time_start":"16:00:00", "time_end":"17:00:00", "time_zone":"America\/Detroit", "event_title":"Biophysics Seminar: Josh Karslake and Tehetina Woldemichael, Post-Doctoral Students", "occurrence_title":"", "combined_title":"Biophysics Seminar: Josh Karslake and Tehetina Woldemichael, Post-Doctoral Students: Tehetina Woldemichael and Jason Karslake", "event_subtitle":"Tehetina Woldemichael and Jason Karslake", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Tehetina Woldemichael\r\n\r\n\"Exploring Drug Bioaccumulation and Stabilization with respect to Endolysosomal Ion Homeostasis Using a Systems-based Mathematical Modeling Approach\"\r\nEven though most of the FDA approved drugs currently out in the market as well as in the process of development are weakly basic drugs, the bioaccumulation and stabilization of these drugs remains to be a topic that has not been well understood. For this purpose, we use a model drug, Clofazimine (CFZ), which is an FDA approved, weakly basic and poorly soluble drug that has been used worldwide to treat patients with leprosy and tuberculosis diseases, curing over 14 million people in the last twenty years, to investigate its bioaccumulation and stabilization properties. During prolonged oral administration, CFZ accumulates in macrophages of humans and mice as Crystal Like Drug Inclusions (CLDIs), which have been chemically characterized to be composed of hydrochloride salts of CFZ (CFZ-HCl) crystals. However, the mechanism by which the formation and stabilization of these insoluble complexes in cells is not known. Thus, due to sufficient proton and chloride levels in endolysosomes, we hypothesize that the drug accumulation and stabilization processes are occurring inside intracellular compartments of likely endolysosomal origin, in macrophages of humans as well as mice. To test our hypothesis, we adapt a systems-based mathematical lysosomal ion regulation model which consists of lysosomal membrane proteins, such as, the Vacuolar ATPase (V-ATPase), Cl-\/H+ antiporter known as CLC7, and membrane proton leak in order to investigate the key lysosomal parameters that play essential role in the physiological, dose-dependent CFZ-HCl crystal bioaccumulation. Furthermore, we examine the stabilization of the free base (CFZ) versus salt form (CFZ-HCl) of the drug by mathematically fitting an in vitro pH-dependent solubility data of CFZ-HCl crystals obtained at pH ranging between extracellular, cellular and subcellular pH values, and determining the solubility properties dictated by the apparent pKa, intrinsic free base and salt solubility, pHmax, and Ksp values. Collectively, our computational results as well as the CFZ-HCl solubility parameters in relation to the ion contents and pH of the microenvironment suggest that the physiological and preferential accumulation and stabilization mechanisms of CFZ-HCl crystals in macrophages, more specifically in macrophage lysosomes, are primarily determined by the lysosomal V-ATPase. \r\n\r\nJason Karslake\r\n\"Population Density Modulates Drug Inhibition and Treatment Outcomes for Bacterial Infections\"\r\n\r\nThe inoculum effect (IE) is an increase in the minimum inhibitory concentration (MIC) of an antibiotic as a function of the initial size of a microbial population. The IE has been observed in a wide range of bacteria, implying that antibiotic efficacy may depend on population density. Such density dependence could have dramatic effects on bacterial population dynamics and potential treatment strategies, but explicit measures of per capita growth as a function of density are generally not available. Instead, the IE measures MIC as a function of initial population size, and population density changes by many orders of magnitude on the timescale of the experiment. Therefore, the functional relationship between population density and antibiotic inhibition is generally not known, leaving many questions about the impact of the IE on different treatment strategies unanswered. To address these questions, here we directly measured real-time per capita growth of Enterococcus faecalis populations exposed to antibiotic at fixed population densities using multiplexed computer-automated culture devices. We show that density-dependent growth inhibition is pervasive for commonly used antibiotics, with some drugs showing increased inhibition and others decreased inhibition at high densities. For several drugs, the density dependence is mediated by changes in extracellular pH, a community-level phenomenon not previously linked with the IE. Using a simple mathematical model, we demonstrate how this density dependence can modulate population dynamics in constant drug environments. Then, we illustrate how time-dependent dosing strategies can mitigate the negative effects of density-dependence. Finally, we show that these density effects lead to bistable treatment outcomes for a wide range of antibiotic concentrations in a pharmacological model of antibiotic treatment. As a result, infections exceeding a critical density often survive otherwise effective treatments.", "occurrence_notes":null, "guid":"33247-4710139@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/33247", "building_id":"1000158", "building_name":"Chemistry Dow Lab", "campus_maps_id":"34", "room":"1300", "location_name":"Chemistry Dow Lab", "has_livestream":0, "cost":"", "tags":["Biophysics","Chemistry"], "website":"", "sponsors":[ { "group_name":"LSA Biophysics", "group_id":"3767", "website":"" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":4710139 } , "34071-5299966": { "datetime_modified":"20161102T041140", "datetime_start":"20161104T160000", "datetime_end":"20161104T180000", "has_end_time":1, "date_start":"2016-11-04", "date_end":"2016-11-04", "time_start":"16:00:00", "time_end":"18:00:00", "time_zone":"America\/Detroit", "event_title":"Diversity and Disability in Bollywood Films", "occurrence_title":"", "combined_title":"Diversity and Disability in Bollywood Films: Prof. Joyojeet Pal", "event_subtitle":"Prof. Joyojeet Pal", "event_type":"Film Screening", "event_type_id":"11", "description":"In this talk, we discuss the portrayals of disability in Indian cinema since the early talkie days, and track the changes in the ways these portrayals have changed over time. We consider three core concepts - dependence, disequilibrium, and punishment. Using video clips from Tamil, Hindi, and Malayalam films from across various decades, we look at how these themes are tied to mythology and religion, and more recently to the idea of a developmental state. \r\nSpeaker Bio\r\nJoyojeet Pal is an assistant professor at the School of Information, his research is on technology and accessibility in the Global South. He researched and produced the documentary \"For the Love of a Man\" on cinema fan culture in India which was nominated for best documentary in the Venice Classics series at the 2015 Venice Film Festival.\r\n--", "occurrence_notes":null, "guid":"34071-5299966@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/34071", "building_id":"1005177", "building_name":"North Quad", "campus_maps_id":"553", "room":"1255", "location_name":"North Quad", "has_livestream":0, "cost":"", "tags":["Bollywood Films","Disability","Diversity"], "website":"", "sponsors":[ { "group_name":"Council for Disability Concerns", "group_id":"3315", "website":"https:\/\/cfdc.umich.edu\/" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":5299966 } , "31297-4178859": { "datetime_modified":"20160711T103106", "datetime_start":"20161104T160000", "datetime_end":"20161104T173000", "has_end_time":1, "date_start":"2016-11-04", "date_end":"2016-11-04", "time_start":"16:00:00", "time_end":"17:30:00", "time_zone":"America\/Detroit", "event_title":"Family Weekend Reception", "occurrence_title":"", "combined_title":"Family Weekend Reception", "event_subtitle":"", "event_type":"Reception \/ Open House", "event_type_id":"17", "description":"in conjunction with the University of Michigan Parents and Family weekend", "occurrence_notes":null, "guid":"31297-4178859@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/31297", "building_id":"1000054", "building_name":"East Quadrangle", "campus_maps_id":"54", "room":"Lower Atrium", "location_name":"East Quadrangle", "has_livestream":0, "cost":"", "tags":["Food","Free"], "website":"", "sponsors":[ { "group_name":"Residential College", "group_id":"1029", "website":"" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":4178859 } , "33022-4650817": { "datetime_modified":"20161104T181639", "datetime_start":"20161104T161000", "datetime_end":"20161104T173000", "has_end_time":1, "date_start":"2016-11-04", "date_end":"2016-11-04", "time_start":"16:10:00", "time_end":"17:30:00", "time_zone":"America\/Detroit", "event_title":"Group, Lie and Number Theory", "occurrence_title":"", "combined_title":"Group, Lie and Number Theory: p-adic analytic twists, modularity, and strong subconvexity", "event_subtitle":"p-adic analytic twists, modularity, and strong subconvexity", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"One of the principal analytic questions about automorphic L-functions are the so-called subconvex estimates on the size of their critical values, deeply arithmetic both in proofs and in the often spectacular consequences. In this talk, we will present our recent subconvexity bound for the central value of the L-function associated to a fixed cuspidal newform f twisted by a Dirichlet character chi of a high prime power conductor. From an adelic viewpoint, the analogy between this so-called \"depth aspect\" and the familiar t-aspect is particularly natural, as one is focusing on ramification at one (finite or infinite) place at a time. We prove our results by exhibiting strong cancellation between the Hecke eigenvalues of f and the values of chi, which act as twists by exponentials with a p-adically analytic phase. Among the tools, we develop p-adic counterparts to Farey dissection and van der Corput estimates for exponential sums. This is joint work with Valentin Blomer. Speaker(s): Djordje Milicevic (Bryn Mawr College)", "occurrence_notes":null, "guid":"33022-4650817@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/33022", "building_id":"1000166", "building_name":"East Hall", "campus_maps_id":"53", "room":"3088", "location_name":"East Hall", "has_livestream":0, "cost":"", "tags":["Mathematics"], "website":"", "sponsors":[ { "group_name":"Department of Mathematics", "group_id":"3791", "website":"" }, { "group_name":"Group, Lie and Number Theory Seminar - Department of Mathematics", "group_id":"4892", "website":"" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":4650817 } , "34148-4861494": { "datetime_modified":"20161104T181640", "datetime_start":"20161104T161000", "datetime_end":"20161104T173000", "has_end_time":1, "date_start":"2016-11-04", "date_end":"2016-11-04", "time_start":"16:10:00", "time_end":"17:30:00", "time_zone":"America\/Detroit", "event_title":"Preprint Algebraic Geometry Seminar", "occurrence_title":"", "combined_title":"Preprint Algebraic Geometry Seminar: The dualizing sheaf on first-order deformations of toric surface singularities (following Altmann and Koll\\'ar)", "event_subtitle":"The dualizing sheaf on first-order deformations of toric surface singularities (following Altmann and Koll\\'ar)", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"https:\/\/arxiv.org\/abs\/1601.07805 Speaker(s): Harold Blum (UM)", "occurrence_notes":null, "guid":"34148-4861494@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/34148", "building_id":"1000166", "building_name":"East Hall", "campus_maps_id":"53", "room":"1866", "location_name":"East Hall", "has_livestream":0, "cost":"", "tags":["Mathematics"], "website":"", "sponsors":[ { "group_name":"Department of Mathematics", "group_id":"3791", "website":"" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":4861494 } , "35694-5305475": { "datetime_modified":"20161104T181640", "datetime_start":"20161104T161000", "datetime_end":"20161104T170000", "has_end_time":1, "date_start":"2016-11-04", "date_end":"2016-11-04", "time_start":"16:10:00", "time_end":"17:00:00", "time_zone":"America\/Detroit", "event_title":"Student AIM Seminar", "occurrence_title":"", "combined_title":"Student AIM Seminar: Optimizing Scalable Adaptive Choice Experiments with Multi-Armed Bandit Algorithms", "event_subtitle":"Optimizing Scalable Adaptive Choice Experiments with Multi-Armed Bandit Algorithms", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Multi-armed Bandit methods have been successful for A\\B testing. It is the main algorithm behind google analytics. I will apply these methods to the scenario where we have large list of 100+ items and we want to find out which are the best ones (most desirable by consumers). My focus will be on large MaxDiff studies whose main purpose is identifying the top few items for the sample. I will present a new adaptive approach called Bandit MaxDiff that may increase efficiency fourfold over standard non-adaptive MaxDiff. I show simulated results based on data from a large consumer packaged goods manufacturer. 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