{ "143191-21892406": { "datetime_modified":"20260105T124948", "datetime_start":"20260129T120000", "datetime_end":"20260129T130000", "has_end_time":1, "date_start":"2026-01-29", "date_end":"2026-01-29", "time_start":"12:00:00", "time_end":"13:00:00", "time_zone":"America\/Detroit", "event_title":"DCMB Tools and Technology Seminar by Haoran Li", "occurrence_title":"", "combined_title":"DCMB Tools and Technology Seminar by Haoran Li: \u201cImproving gene isoform quantification with miniQuant\u201d", "event_subtitle":"\u201cImproving gene isoform quantification with miniQuant\u201d", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Abstract\r\nRNA sequencing has been widely applied for gene isoform quantification, but limitations exist in quantifying isoforms of complex genes accurately, especially for short reads. Here we identify genes that are difficult to quantify accurately with short reads and illustrate the information benefit of using long reads to quantify these regions. We present miniQuant, which ranks genes with quantification errors caused by the ambiguity of read alignments and integrates the complementary strengths of long reads and short reads with optimal combination in a gene- and data-specific manner to achieve more accurate quantification. These results are supported by rigorous mathematical proofs, validated with a wide range of simulation data, experimental validations and more than 17,000 public datasets from GTEx, TCGA and ENCODE consortia. We demonstrate miniQuant can uncover isoform switches during the differentiation of human embryonic stem cells to pharyngeal endoderm and primordial germ cell-like cells.\r\n\r\nAbout the DCMB Tools & Technology Seminar Series\r\n\r\nThe DCMB Tools and Technology Seminar Series is held in Medical Science Building 1 (MS1), Room 4B700, each Thursday at 12pm EST. Each seminar highlights a computational tool, technology, or methodology that is under development or in current use and is of special interest to DCMB and University researchers. Presenters are U-M researchers and students.\r\n\r\nThese seminars are live-streamed and recorded and made available for future viewing via the DCMB YouTube Channel", "occurrence_notes":null, "guid":"143191-21892406@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/143191", "building_id":"1000190", "building_name":"Medical Science Unit I", "campus_maps_id":"104", "room":"Room 4B700", "location_name":"Medical Science Unit I", "has_livestream":0, "cost":"", "tags":["Basic Science","Research","Life Science","Biosciences","Biology","Bioinformatics"], "website":"https:\/\/medschool.umich.edu\/events\/tools-technology-seminar-series\/tools-and-technology-seminar-haoran-li\/2026-01-29", "sponsors":[ { "group_name":"Department of Computational Medicine and Bioinformatics DCMB", "group_id":"5384", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2026\/01\/event_143191_original-1.png", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2026\/01\/event_143191_original-1.png", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2026\/01\/event_143191_original-1.png", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2026\/01\/event_143191_original-1.png", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2026\/01\/event_143191_original-1.png", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2026\/01\/event_143191_original-1.png", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2026\/01\/event_143191_original-1.png", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2026\/01\/event_143191_original-1.png", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2026\/01\/event_143191_original-1.png", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2026\/01\/event_143191_original-1.png", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2026\/01\/event_143191_original-1.png", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2026\/01\/event_143191_original-1.png", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2026\/01\/event_143191_original-1.png", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2026\/01\/event_143191_original-1.png", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2026\/01\/event_143191_original-1.png", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2026\/01\/event_143191_original-1.png" }, "occurrence_count":1, "first_occurrence":21892406 } , "143999-21894405": { "datetime_modified":"20260224T101438", "datetime_start":"20260129T120000", "datetime_end":"20260129T160000", "has_end_time":1, "date_start":"2026-01-29", "date_end":"2026-01-29", "time_start":"12:00:00", "time_end":"16:00:00", "time_zone":"America\/Detroit", "event_title":"Revolutionary Paine: Andy Murphy Student-Curated Class Exhibit Common Sense", "occurrence_title":"", "combined_title":"Revolutionary Paine: Andy Murphy Student-Curated Class Exhibit Common Sense", "event_subtitle":"", "event_type":"Exhibition", "event_type_id":"7", "description":"Thomas Paine\u2019s \u201cCommon Sense\u201d was one of the most influential works of the American Revolution. The first edition was published on January 10, 1776, with an initial print run of just 1,000 copies; but within weeks demand soared. The students of Andy Murphy\u2019s POLISCI 495 course co-curated the exhibition \u201cRevolutionary Paine\u201d to document the whirlwind caused by its publication. On view at the Clements January 16-May 8, weekdays from 12-4 pm.", "occurrence_notes":null, "guid":"143999-21894405@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/143999", "building_id":"1000159", "building_name":"William Clements Library", "campus_maps_id":"165", "room":"Avenir Foundation Reading Room", "location_name":"William Clements Library", "has_livestream":0, "cost":"", "tags":["Americana","Exhibit","Exhibition","history"], "website":"https:\/\/clements.umich.edu\/exhibit\/revolutionary-paine\/", "sponsors":[ { "group_name":"William L. 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