{ "141957-21889681": { "datetime_modified":"20251117T162550", "datetime_start":"20260115T120000", "datetime_end":"20260115T123000", "has_end_time":1, "date_start":"2026-01-15", "date_end":"2026-01-15", "time_start":"12:00:00", "time_end":"12:30:00", "time_zone":"America\/Detroit", "event_title":"CGIS: Summer 2026 International Internships with Omprakash Info Sessions (December 2025 & January 2026)", "occurrence_title":"", "combined_title":"CGIS: Summer 2026 International Internships with Omprakash Info Sessions (December 2025 & January 2026)", "event_subtitle":"", "event_type":"Presentation", "event_type_id":"16", "description":"The U-M Global Social Impact Internships Program with Omprakash helps students earn academic credit while pursuing independent social impact internships in Asia, Africa, and Latin America.\r\n\r\nInternship fields include health, engineering, education, human rights, sustainability, and gender-based advocacy.\r\n\r\nAlongside your internship, you will engage in critical dialogue and reflection about the complexities of striving for justice while crossing differences of culture and power, and you will create a series of digital storytelling posts that document your experiences through lenses informed by our course themes.\r\n\r\nInfo Session Dates and Times:\r\n\r\nWednesday, December 3, 2025 from 10:00-10:30 AM ET\r\nThursday, January 15, 2026 from 12:00-12:30 PM ET\r\nWednesday, January 28, 2026 from 11:00-11:30 AM ET\r\n\r\nPlease register via Calendly: https:\/\/calendly.com\/omprakash-org\/u-m-global-social-impact-internships-info-session\r\n\r\nInfo session Zoom link: https:\/\/us02web.zoom.us\/j\/82074105905\r\n\r\nFor more information and questions about Omprakash internships, please see: https:\/\/www.omprakash.org\/joinedge\/michigan-social-impact-internships\r\n\r\nYou can also contact the Omprakash staff for more information and to ask questions:\r\n\r\nEthan Goldbach: Director of EdGE Programs (ethan@omprakash.org)\r\nWilly Oppenheim: Executive Director (willy@omprakash.org)", "occurrence_notes":null, "guid":"141957-21889681@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/141957", "building_id":"null", "building_name":"Off Campus Location", "campus_maps_id":"1", "room":"", "location_name":"Virtual", "has_livestream":1, "livestream_type":"other", "livetream_require_login":0, "livestream_id":"", "livestream_link":"https:\/\/us02web.zoom.us\/j\/82074105905", "cost":"", "tags":["Africa","Travel","Southeast Asia","South America","Social Impact","Latin America","internships","Internship","International Education","international","India","Information Session","Abroad","All Majors Welcome","Asia","Career","Central America","Free","global engagement","global opportunities"], "website":"", "sponsors":[ { "group_name":"Center for Global and Intercultural Study", "group_id":"2726", "website":"http:\/\/www.lsa.umich.edu\/cgis" } ], 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expressions by trans-regulatory mutations\u201d", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Abstract\r\nGene expression evolution relies on regulatory mutations. Past studies suggested that optimizing gene expression by positive selection on cis-regulatory mutations is relatively easy because the corresponding adaptive landscapes are quite smooth. To what extent gene expression can be optimized via trans-regulatory mutations is, however, unknown. Analyzing the transcriptomes and proteomes of 16 yeast strains carrying all combinations of four auxotrophic mutations, we respectively construct 5,923 and 446 adaptive landscapes of mRNA and protein expressions where neighboring genotypes differ by a trans-regulatory mutation. We find that mRNA expression is less optimizable by trans-regulatory mutations than by cis-regulatory mutations due to a lower fraction of open adaptive paths via trans- than cis-changes, which may partially explain why trans-regulatory changes are rarer than cis-regulatory changes in gene expression evolution. Interestingly, the adaptive landscapes of protein expressions are substantially less rugged and thereby more navigable than those of mRNA expressions due to post-transcriptional buffering effects, suggesting that, for protein-coding genes, the evolvability of gene expression is even higher than the current estimate from adaptive landscapes of mRNA expressions. This high evolvability may have contributed to the prominence of gene expression changes as a mechanism of evolutionary adaptation.\r\n\r\n\r\nAbout the DCMB Tools & Technology Seminar Series\r\n\r\nThe DCMB Tools and Technology Seminar Series is held in Medical Science Building 1 (MS1), Room 4B700, each Thursday at 12pm EST. Each seminar highlights a computational tool, technology, or methodology that is under development or in current use and is of special interest to DCMB and University researchers. Presenters are U-M researchers and students.\r\n\r\nThese seminars are live-streamed and recorded and made available for future viewing via the DCMB YouTube Channel", "occurrence_notes":"Located in the newly remodeled MS1 B-Wing", "guid":"143179-21892395@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/143179", "building_id":"1000190", "building_name":"Medical Science Unit I", "campus_maps_id":"104", "room":"Room 4B700", "location_name":"Medical Science Unit I", "has_livestream":0, "cost":"", "tags":["Life Science","Biosciences","Biology","Bioinformatics","Basic Science"], "website":"https:\/\/www.youtube.com\/channel\/UCjvLXvfPupVHtGU_ckTDPwA\/videos", "sponsors":[ { "group_name":"Department of Computational Medicine and Bioinformatics DCMB", "group_id":"5384", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2026\/01\/event_143179_original-1.png", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_thumb\/media\/attachments\/2026\/01\/event_143179_original-1.png", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2026\/01\/event_143179_original-1.png", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_large_2x\/media\/attachments\/2026\/01\/event_143179_original-1.png", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2026\/01\/event_143179_original-1.png", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb\/media\/attachments\/2026\/01\/event_143179_original-1.png", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb_square\/media\/attachments\/2026\/01\/event_143179_original-1.png", "group_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large\/media\/attachments\/2026\/01\/event_143179_original-1.png", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large_lightbox\/media\/attachments\/2026\/01\/event_143179_original-1.png", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_large_crop\/media\/attachments\/2026\/01\/event_143179_original-1.png", "event_list":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_list\/media\/attachments\/2026\/01\/event_143179_original-1.png", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2026\/01\/event_143179_original-1.png", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2026\/01\/event_143179_original-1.png", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_grid_2x\/media\/attachments\/2026\/01\/event_143179_original-1.png", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_feature_large\/media\/attachments\/2026\/01\/event_143179_original-1.png", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2026\/01\/event_143179_original-1.png" }, "occurrence_count":1, "first_occurrence":21892395 } }