{ "122175-21848404": { "datetime_modified":"20240520T094410", "datetime_start":"20240524T150000", "datetime_end":"20240524T160000", "has_end_time":1, "date_start":"2024-05-24", "date_end":"2024-05-24", "time_start":"15:00:00", "time_end":"16:00:00", "time_zone":"America\/Detroit", "event_title":"MCAIM Seminar: Inference of Dynamic Networks in Biological Systems", "occurrence_title":"", "combined_title":"MCAIM Seminar: Inference of Dynamic Networks in Biological Systems: Jae Kyoung Kim, Korea Advanced Institute of Science & Technology (KAIST)", "event_subtitle":"Jae Kyoung Kim, Korea Advanced Institute of Science & Technology (KAIST)", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Abstract: Biological systems are complex dynamic networks. In this talk, I will introduce GOBI (General Model-based Inference), a simple and scalable method for inferring regulatory networks from time-series data. GOBI can infer gene regulatory networks and ecological networks that cannot be obtained with previous causation detection methods (e.g., Granger, CCM, PCM). I will then introduce Density-PINN (Physics-Informed NeuralNetwork), a method for inferring the shape of the time-delay distribution of interactions in a network. The inferred shape of time-delay distribution can be used to identify the number of pathways that induce a signaling response against antibiotics, which solves the long-standing mystery, the major source of cell-to-cell heterogeneity in response to stress. Finally, I will talk how to infer the dynamic information from just network structure information, which can be used to identify the targets (nodes) perturbing the homeostasis of the systems. \r\n\r\n[1] Jo H, Hong H, Hwang HJ, Chang W, Kim JK, Density Physics-Informed Neural Network identifies sources of cell heterogeneity in signal transduction under antibiotic stress, Cell Patterns (2024) \r\n\r\n[2] Park SH, Ha S, Kim JK, A general model-based causal inference overcomes the curse of synchrony and indirect effect, Nature Communications (2023) \r\n\r\n[3] Hirono Y, Moon SH, Hong H, Kim JK, Robust Perfect Adaptation of Reaction Fluxes Ensured by Network Topology, Arxiv (2023)\r\n\r\nEvent will be in-person and on Zoom: https:\/\/umich.zoom.us\/j\/98734707290", "occurrence_notes":null, "guid":"122175-21848404@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/122175", "building_id":"1000166", "building_name":"East Hall", "campus_maps_id":"53", "room":"1084", "location_name":"East Hall", "has_livestream":0, "cost":"", "tags":["Mathematics"], "website":"", "sponsors":[ { "group_name":"MCAIM - Department of Mathematics", "group_id":"4897", "website":"" }, { "group_name":"Department of Mathematics", "group_id":"3791", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2024\/05\/event_122175_original-1.jpeg", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2024\/05\/event_122175_original-1.jpeg", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2024\/05\/event_122175_original-1.jpeg", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2024\/05\/event_122175_original-1.jpeg", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2024\/05\/event_122175_original-1.jpeg", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2024\/05\/event_122175_original-1.jpeg", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2024\/05\/event_122175_original-1.jpeg", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2024\/05\/event_122175_original-1.jpeg", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2024\/05\/event_122175_original-1.jpeg", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2024\/05\/event_122175_original-1.jpeg", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2024\/05\/event_122175_original-1.jpeg", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2024\/05\/event_122175_original-1.jpeg", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2024\/05\/event_122175_original-1.jpeg", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2024\/05\/event_122175_original-1.jpeg", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2024\/05\/event_122175_original-1.jpeg", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2024\/05\/event_122175_original-1.jpeg" }, "occurrence_count":1, "first_occurrence":21848404 } , "122229-21848484": { "datetime_modified":"20240520T100555", "datetime_start":"20240524T180000", "datetime_end":"20240524T210000", "has_end_time":1, "date_start":"2024-05-24", "date_end":"2024-05-24", "time_start":"18:00:00", "time_end":"21:00:00", "time_zone":"America\/Detroit", "event_title":"ASC Event. Farewell Reception for the UMAPS Winter 2024 Cohort", "occurrence_title":"", "combined_title":"ASC Event. Farewell Reception for the UMAPS Winter 2024 Cohort", "event_subtitle":"", "event_type":"Reception \/ Open House", "event_type_id":"17", "description":"**Farewell Reception honoring the UMAPS Winter 2024 Cohort**\r\nFriday, May 24 | 6:00\u20139:00 PM\r\nPendleton Room (2nd Floor) Michigan Union\r\nOpen to the public. \r\nRSVP is requested: https:\/\/forms.gle\/zWUXgn2RaqLb9Dyi9\r\n\r\nJoin us in honoring and celebrating the accomplishments of the winter 2024 University of Michigan African Presidential Scholars (UMAPS) cohort as they complete their program. The UMAPS program brings together distinguished African scholars to pursue research, collaborate with faculty, and contribute to the intellectual life of the university.", "occurrence_notes":null, "guid":"122229-21848484@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/122229", "building_id":"1000120", "building_name":"Michigan Union", "campus_maps_id":"191", "room":"Pendleton Room (2nd Floor)", "location_name":"Michigan Union", "has_livestream":0, "cost":"", "tags":["African Studies","African Studies Center","Reception"], "website":"https:\/\/forms.gle\/zWUXgn2RaqLb9Dyi9", "sponsors":[ { "group_name":"African Studies Center", "group_id":"3187", "website":"http:\/\/www.ii.umich.edu\/asc\/" }, { "group_name":"International Institute", "group_id":"1968", "website":"http:\/\/www.ii.umich.edu" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2024\/05\/event_122229_original-1.png", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2024\/05\/event_122229_original-1.png", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2024\/05\/event_122229_original-1.png", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2024\/05\/event_122229_original-1.png", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2024\/05\/event_122229_original-1.png", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2024\/05\/event_122229_original-1.png", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2024\/05\/event_122229_original-1.png", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2024\/05\/event_122229_original-1.png", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2024\/05\/event_122229_original-1.png", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2024\/05\/event_122229_original-1.png", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2024\/05\/event_122229_original-1.png", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2024\/05\/event_122229_original-1.png", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2024\/05\/event_122229_original-1.png", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2024\/05\/event_122229_original-1.png", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2024\/05\/event_122229_original-1.png", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2024\/05\/event_122229_original-1.png" }, "occurrence_count":1, "first_occurrence":21848484 } }