{ "138857-21884142": { "datetime_modified":"20250905T105802", "datetime_start":"20250910T160000", "datetime_end":"20250910T170000", "has_end_time":1, "date_start":"2025-09-10", "date_end":"2025-09-10", "time_start":"16:00:00", "time_end":"17:00:00", "time_zone":"America\/Detroit", "event_title":"CCMB\/DCMB Weekly Seminar Series featuring Winston Timp, PhD (Prof. at Johns Hopkins)", "occurrence_title":"", "combined_title":"CCMB\/DCMB Weekly Seminar Series featuring Winston Timp, PhD (Prof. at Johns Hopkins): \u201cDecoding the Central Dogma with Single Molecule Sequencing\u201d", "event_subtitle":"\u201cDecoding the Central Dogma with Single Molecule Sequencing\u201d", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Abstract\r\n\r\nSingle molecule sequencing has evolved from a niche technology into a robust, accessible platform for decoding the complexities of genome regulation and cellular identity. In this talk, we'll explore how recent improvements in accuracy, throughput, and targeted enrichment now allow us to phase variants, resolve repetitive loci, and detect epigenetic modifications\u2014often in the same molecule. These methods enable analysis of allele-specific methylation, chromatin accessibility, and protein-DNA interactions, even in challenging regions like centromeres or BRCA1. We'll also cover how these techniques apply to spatial and single-cell transcriptomics, empowering nuanced studies in neuroscience and cancer. Altogether, this work moves us closer to a future where multiomic profiling at single-molecule resolution becomes routine\u2014at the bench, not just the core.\r\n\r\nShort Bio\r\n\r\nWinston Timp, an associate professor of biomedical engineering, focuses on the development and application of sequencing technologies to gain a deeper understanding of biology and a more accurate set of clinical tools for human disease. He holds joint appointments in the Department of Molecular Biology and Genetics and the Division of Infectious Diseases at the Johns Hopkins University School of Medicine.\r\n\r\nTimp\u2019s research integrates the principles of biophysics, molecular biology and computational biology to create new tools for exploring the epigenomes and genomes of different lifeforms ranging in size from the flu virus to hummingbirds to California redwoods. Based on the knowledge gained from these studies, Timp and his team apply their toolsets to clinical samples for the diagnosis, surveillance, and treatment of human disease.", "occurrence_notes":null, "guid":"138857-21884142@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/138857", "building_id":"1005047", "building_name":"Palmer Commons", "campus_maps_id":"188", "room":"Great Lakes North", "location_name":"Palmer Commons", "has_livestream":0, "cost":"", "tags":["Virtual","Research","Life Science","Free","Biosciences","Bioinformatics","Basic Science"], "website":"https:\/\/medschool.umich.edu\/events\/ccmb-seminar-series\/ccmb-seminar-winston-timp-phd\/2025-09-10", "sponsors":[ { "group_name":"Department of Computational Medicine and Bioinformatics DCMB", "group_id":"5384", "website":"" }, { "group_name":"DCMB Seminar Series", "group_id":"3754", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2025\/09\/event_138857_original-1.png", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2025\/09\/event_138857_original-1.png", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2025\/09\/event_138857_original-1.png", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2025\/09\/event_138857_original-1.png", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2025\/09\/event_138857_original-1.png", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2025\/09\/event_138857_original-1.png", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2025\/09\/event_138857_original-1.png", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2025\/09\/event_138857_original-1.png", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2025\/09\/event_138857_original-1.png", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2025\/09\/event_138857_original-1.png", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2025\/09\/event_138857_original-1.png", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2025\/09\/event_138857_original-1.png", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2025\/09\/event_138857_original-1.png", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2025\/09\/event_138857_original-1.png", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2025\/09\/event_138857_original-1.png", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2025\/09\/event_138857_original-1.png" }, "occurrence_count":1, "first_occurrence":21884142 } , "138021-21881209": { "datetime_modified":"20250822T154951", "datetime_start":"20250910T160000", "datetime_end":"20250910T170000", "has_end_time":1, "date_start":"2025-09-10", "date_end":"2025-09-10", "time_start":"16:00:00", "time_end":"17:00:00", "time_zone":"America\/Detroit", "event_title":"Computing the adapted Wasserstein distance between the laws of stochastic processes", "occurrence_title":"", "combined_title":"Computing the adapted Wasserstein distance between the laws of stochastic processes: Fang Rui Lim", "event_subtitle":"Fang Rui Lim", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Recently, the adapted Wasserstein (AW) distance has emerged as an attractive alternative to the usual distances between laws of stochastic processes due to its application to dynamic optimisation problems, such as optimal stopping, for example. However, similar to classical Wasserstein distance, the exact value of the AW distance is difficult to determine in general. In this talk, we discuss two methods \u2014 a transfer principle, and a discretisation approach \u2014 to compute, either explicitly or numerically, the AW distance between the laws of certain stochastic processes, such as mean-square continuous Gaussian processes and stochastic differential equations.", "occurrence_notes":null, "guid":"138021-21881209@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/138021", "building_id":"1000166", "building_name":"East Hall", "campus_maps_id":"53", "room":"4448", "location_name":"East Hall", "has_livestream":0, "cost":"", "tags":["Mathematics"], "website":"", "sponsors":[ { "group_name":"Financial\/Actuarial Mathematics Seminar - Department of Mathematics", "group_id":"4890", "website":"" }, { "group_name":"Department of Mathematics", "group_id":"3791", "website":"" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21881209 } }