{ "122282-21848548": { "datetime_modified":"20240618T183120", "datetime_start":"20240603T160000", "datetime_end":"", "has_end_time":0, "date_start":"2024-06-03", "date_end":"", "time_start":"16:00:00", "time_end":"", "time_zone":"America\/Detroit", "event_title":"MBA WEEK 2024", "occurrence_title":"", "combined_title":"MBA WEEK 2024", "event_subtitle":"", "event_type":"Careers \/ Jobs", "event_type_id":"2", "description":"Join us for Leland's FREE MBA Week, 10 live online sessions covering the most important aspects of the MBA admissions process.This event will feature former admissions committee members and MBA application experts giving tactical insights and tips to get into top MBA programs. Example sessions include: \u201cWriting Standout Essays\u201d, \u201cHBS 2+2 Office Hours\u201d, \u201cLetter of Recommendation Deep Dive\u201d and more.All registrants will also receive free example essays, resources and guides!", "occurrence_notes":null, "guid":"122282-21848548@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/122282", "building_id":"", "building_name":"", "campus_maps_id":"", "room":"", "location_name":"", "has_livestream":0, "cost":"", "tags":[], "website":"", "sponsors":[ { "group_name":"University Career Center UCC", "group_id":"1140", "website":"http:\/\/careercenter.umich.edu" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21848548 } , "110276-21824711": { "datetime_modified":"20240528T093819", "datetime_start":"20240603T160000", "datetime_end":"20240603T170000", "has_end_time":1, "date_start":"2024-06-03", "date_end":"2024-06-03", "time_start":"16:00:00", "time_end":"17:00:00", "time_zone":"America\/Detroit", "event_title":"RNA Innovation Seminar: Alexandra Piotrowski-Daspit, University of Michigan", "occurrence_title":"", "combined_title":"RNA Innovation Seminar: Alexandra Piotrowski-Daspit, University of Michigan: RNA: the delivery perspective", "event_subtitle":"RNA: the delivery perspective", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"HYBRID SEMINAR:\r\nIn-person: BSRB, Kahn Auditorium \r\nZoom: https:\/\/umich.zoom.us\/webinar\/register\/WN_mr2BfdnHQ9OCJN7Eg7pk4Q\r\n\r\nAbstract: The primary barrier for clinical translation of RNA therapeutics remains delivery to target tissues in vivo. Upon entering the body, delivery vehicles encounter extracellular and intracellular barriers. It is also unclear how carrier design features impact physiological interactions with biological systems, highlighting the need for studies that elucidate these structure-function relationships. In this seminar, I will describe our work on developing polymeric nanoparticles (NPs) to deliver therapeutic RNAs to a variety of tissues following local and systemic IV administration. We find that gene therapy can be significantly enhanced using a new class of polymeric vehicles consisting of poly(amine-co-ester) (PACE) polymers that are designed for safe and effective nucleic acid delivery. We have also developed tools to study nanomaterial-biology interactions in animal models, including a high-throughput quantitative microscopy-based platform to measure circulation half-life and biodistribution in vivo. 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