{
    "126150-21856601":
    {
        "datetime_modified":"20241023T123210",
        "datetime_start":"20241008T153000",
        "datetime_end":"20241008T163000",
        "has_end_time":1,
        "date_start":"2024-10-08",
        "date_end":"2024-10-08",
        "time_start":"15:30:00",
        "time_end":"16:30:00",
        "time_zone":"America\/Detroit",
        "event_title":"Kick It With Nike Inc., Information Session (Grad)",
        "occurrence_title":"",
        "combined_title":"Kick It With Nike Inc., Information Session (Grad)",
        "event_subtitle":"",
        "event_type":"Careers \/ Jobs",
        "event_type_id":"2",
        "description":"Learn more about Nike, Inc. and all our available internship opportunities! To be eligible, students must have a graduation date ofWinter 2025 or Spring 2026.",
        "occurrence_notes":null,
                "guid":"126150-21856601@events.umich.edu",
        "permalink":"http:\/\/events.umich.edu\/event\/126150",
        "building_id":"",
        "building_name":"",
        "campus_maps_id":"",
        "room":"",
        "location_name":"",
        "has_livestream":0,
        "cost":"",
        "tags":[],
        "website":"",
        "sponsors":[
             {
                "group_name":"University Career Center UCC",
                "group_id":"1140",
                "website":"http:\/\/careercenter.umich.edu"                }                    ],
        "image_url":"",
        "styled_images":{
                                        "event_thumb":"",
                                            "event_large":"",
                                            "event_large_2x":"",
                                            "event_large_lightbox":"",
                                            "group_thumb":"",
                                            "group_thumb_square":"",
                                            "group_large":"",
                                            "group_large_lightbox":"",
                                            "event_large_crop":"",
                                            "event_list":"",
                                            "event_list_2x":"",
                                            "event_grid":"",
                                            "event_grid_2x":"",
                                            "event_feature_large":"",
                                            "event_feature_thumb":""                    },
        "occurrence_count":1,
        "first_occurrence":21856601
    }    ,    "125060-21854307":
    {
        "datetime_modified":"20240912T140631",
        "datetime_start":"20241008T160000",
        "datetime_end":"",
        "has_end_time":0,
        "date_start":"2024-10-08",
        "date_end":"",
        "time_start":"16:00:00",
        "time_end":"",
        "time_zone":"America\/Detroit",
        "event_title":"Activation of L-histidine biosynthesis as a new antibiotic strategy against Mycobacterium tuberculosis",
        "occurrence_title":"",
        "combined_title":"Activation of L-histidine biosynthesis as a new antibiotic strategy against Mycobacterium tuberculosis: Luiz Sorio de Carvalho (Scripps Florida)",
        "event_subtitle":"Luiz Sorio de Carvalho (Scripps Florida)",
        "event_type":"Workshop \/ Seminar",
        "event_type_id":"21",
        "description":"The increasing prevalence of antimicrobial resistance is an important challenge that warrants new approaches to antibiotic development. Currently, all antibiotics inhibit biological processes. To explore whether activation of a biochemical pathway can elicit bactericidal effects we engineered variants of Mycobacterium tuberculosis ATP-phosphoribosyltransferase (ATP-PRT) that are resistant to allosteric inhibition by L-histidine, leading to supraphysiological activation of ATP-PRT and L-histidine overproduction. Upregulation of L-histidine biosynthesis significantly reduces the growth of M. tuberculosis in culture and causes a loss of fitness owing to nutrient and energy depletion. Moreover, the expression of allosteric variants in M. tuberculosis significantly reduced infections in human macrophages and in a mouse model of infection. Thus, metabolic activation is a new bactericidal mechanism that could be applied to antibiotic discovery more generally.",
        "occurrence_notes":null,
                "guid":"125060-21854307@events.umich.edu",
        "permalink":"http:\/\/events.umich.edu\/event\/125060",
        "building_id":"1000158",
        "building_name":"Chemistry Dow Lab",
        "campus_maps_id":"34",
        "room":"1640",
        "location_name":"Chemistry Dow Lab",
        "has_livestream":0,
        "cost":"",
        "tags":["Chemical Biology","Chemistry"],
        "website":"https:\/\/wertheim.scripps.ufl.edu\/profile\/carvalho-luiz-pedro\/",
        "sponsors":[
             {
                "group_name":"Department of Chemistry",
                "group_id":"3761",
                "website":"https:\/\/lsa.umich.edu\/chem"                },             {
                "group_name":"LSA Biophysics",
                "group_id":"3767",
                "website":""                },             {
                "group_name":"Chemical Biology",
                "group_id":"4385",
                "website":""                }                    ],
        "image_url":"",
        "styled_images":{
                                        "event_thumb":"",
                                            "event_large":"",
                                            "event_large_2x":"",
                                            "event_large_lightbox":"",
                                            "group_thumb":"",
                                            "group_thumb_square":"",
                                            "group_large":"",
                                            "group_large_lightbox":"",
                                            "event_large_crop":"",
                                            "event_list":"",
                                            "event_list_2x":"",
                                            "event_grid":"",
                                            "event_grid_2x":"",
                                            "event_feature_large":"",
                                            "event_feature_thumb":""                    },
        "occurrence_count":1,
        "first_occurrence":21854307
    }    }
