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        "description":"The increasing prevalence of antimicrobial resistance is an important challenge that warrants new approaches to antibiotic development. Currently, all antibiotics inhibit biological processes. To explore whether activation of a biochemical pathway can elicit bactericidal effects we engineered variants of Mycobacterium tuberculosis ATP-phosphoribosyltransferase (ATP-PRT) that are resistant to allosteric inhibition by L-histidine, leading to supraphysiological activation of ATP-PRT and L-histidine overproduction. Upregulation of L-histidine biosynthesis significantly reduces the growth of M. tuberculosis in culture and causes a loss of fitness owing to nutrient and energy depletion. Moreover, the expression of allosteric variants in M. tuberculosis significantly reduced infections in human macrophages and in a mouse model of infection. Thus, metabolic activation is a new bactericidal mechanism that could be applied to antibiotic discovery more generally.",
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        "tags":["Chemical Biology","Chemistry"],
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        "description":"Eager for Adventure? Join us for an info session about AmeriCorps NCCC to discover how this national service opportunity offers travel across the country, building job skills like leadership, earning money for school, and the chance to make a difference.\u00a0The webinar will be interactive, share about our program options,walk through all the benefits, and cover the requirements to serve. We\u2019ll help you decide if NCCC is the right fit for you!\u00a0Note: There are two age requirements to serve in AmeriCorps NCCC. Corps members are 18-26 and team leaders are 18 and older (no upper age limit).",
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