{ "124296-21852857": { "datetime_modified":"20240815T095933", "datetime_start":"20241009T160000", "datetime_end":"20241009T170000", "has_end_time":1, "date_start":"2024-10-09", "date_end":"2024-10-09", "time_start":"16:00:00", "time_end":"17:00:00", "time_zone":"America\/Detroit", "event_title":"DCMB \/ CCMB Weekly Seminar", "occurrence_title":"", "combined_title":"DCMB \/ CCMB Weekly Seminar: Jingyi Jessica Li, PhD, \"Permutation Enhances the Rigor of Single-Cell Data Analysis\u201d", "event_subtitle":"Jingyi Jessica Li, PhD, \"Permutation Enhances the Rigor of Single-Cell Data Analysis\u201d", "event_type":"Lecture \/ Discussion", "event_type_id":"13", "description":"Abstract:\r\nEnsuring the reliability and accuracy of single-cell data analysis is critical, particularly in visualizing complex biological structures and addressing data sparsity. This talk introduces two novel statistical methods\u2014scDEED and mcRigor\u2014that leverage permutation-based techniques to enhance the rigor of these analyses.\r\n\r\nscDEED ([Xia et al., 2024, Nature Communications](https:\/\/www.nature.com\/articles\/s41467-024-45891-y)) addresses the challenge of evaluating the reliability of two-dimensional (2D) embeddings produced by visualization methods like t-SNE and UMAP, which are commonly used to visualize cell clusters. These methods, however, can sometimes misrepresent data structure, leading to erroneous interpretations. scDEED calculates a reliability score for each cell embedding, comparing the consistency between a cell's neighbors in the 2D embedding space and its pre-embedding neighbors. Cells with low reliability scores are flagged as dubious, while those with high scores are deemed trustworthy. Additionally, scDEED provides guidance for optimizing t-SNE and UMAP hyperparameters by minimizing the number of dubious embeddings, significantly improving visualization reliability across multiple datasets.\r\n\r\nmcRigor focuses on enhancing metacell partitioning in single-cell RNA-seq and ATAC-seq data analysis, a common strategy to address data sparsity by aggregating similar single cells into metacells. Existing algorithms often fail to verify metacell homogeneity, risking bias and spurious findings. mcRigor introduces a feature-correlation-based statistic to measure heterogeneity within a metacell, identifying dubious metacells composed of heterogeneous single cells. By optimizing metacell partitioning algorithm hyperparameters, mcRigor enhances the reliability of downstream analyses. Moreover, mcRigor allows for benchmarking and selecting the most suitable partitioning algorithm for a dataset, ensuring more robust discoveries.\r\n\r\nscDEED and mcRigor demonstrate the power of permutation-based approaches in refining single-cell data analysis, providing researchers with tools to achieve more accurate and reproducible insights into complex cellular processes.", "occurrence_notes":null, "guid":"124296-21852857@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/124296", "building_id":"1005047", "building_name":"Palmer Commons", "campus_maps_id":"188", "room":"Forum Hall", "location_name":"Palmer Commons", "has_livestream":0, "cost":"", "tags":["Basic Science","Talk","Structural Biology","seminar","Science","Research","Public Health","Precision Health","Physics","Medicine","Mathematics","Life Science","Lecture","Human Genetics","Applications","Biology","Biomedical Engineering","Biosciences","Cardiovascular","Chemistry","Discussion","Electrical Engineering and Computer Science","Engineering","Free","Learning Health Systems"], "website":"https:\/\/medschool.umich.edu\/events\/ccmb-seminar-series\/ccmb-seminar-jingyi-jessica-li-phd", "sponsors":[ { "group_name":"DCMB Seminar Series", "group_id":"3754", "website":"" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21852857 } , "127328-21858886": { "datetime_modified":"20241002T170035", "datetime_start":"20241009T160000", "datetime_end":"20241009T173000", "has_end_time":1, "date_start":"2024-10-09", "date_end":"2024-10-09", "time_start":"16:00:00", "time_end":"17:30:00", "time_zone":"America\/Detroit", "event_title":"Former Governors John Kasich and Steve Bullock on Democracy and Civic Discourse", "occurrence_title":"", "combined_title":"Former Governors John Kasich and Steve Bullock on Democracy and Civic Discourse: A Conversation Across Differences", "event_subtitle":"A Conversation Across Differences", "event_type":"Lecture \/ Discussion", "event_type_id":"13", "description":"Two former governors, one Republican and one Democrat, considered moderates in their respective parties, discuss ways in which to have civil and civic discourse in an era of political divisiveness. \r\n\r\nSpeaker bios:\r\n\r\nJohn Kasich served as the 69th Governor of Ohio (2011-2019). He touts his accomplishments as \"leading the Ohio Comeback, restoring Ohio\u2019s fiscal stability, diversifying the state\u2019s economy with more than 500,000 new private-sector jobs, expanding health care coverage for low-income Ohioans, protecting vulnerable residents, and championing a number of reforms to protect the environment.\" Kasich ran for President during the 2016 GOP primary. He was the last candidate to leave the race and finished third in the total delegate count. His message focused on unifying Americans rather than dividing them, championing the great potential of our citizens to make positive impacts in their own communities, a strong national defense and the importance of our international alliances. He previously served in Congress (1982-2000), where he was Chairman of the House Budget Committee and also served for 18 years on the Armed Services Committee. \r\n\r\nSteve Bullock was elected Montana\u2019s 24th Governor, serving from 2013-2020. He worked with a Republican-majority legislature to improve access to health care, kick dark money out of state elections, make record investments in education, protect access to public lands, invest in infrastructure, and strengthen Montana\u2019s economy. Bullock brought diverse interests together to address challenging issues, from sage grouse and forest management to the Main Street Montana Project. By executive action, he led the nation in preserving net neutrality and combating dark money. Nationally, Bullock was elected Chair of the National Governors Association, Western Governors Association and Democratic Governors Association. Bullock served as Montana\u2019s attorney general from 2009-2013. As attorney general, Bullock defended Montana\u2019s hundred-year ban on corporate campaign spending, gaining national prominence for leading the challenge to the Supreme Court\u2019s Citizens United decision.", "occurrence_notes":null, "guid":"127328-21858886@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/127328", "building_id":"1005101", "building_name":"Weill Hall (Ford School)", "campus_maps_id":"527", "room":"Annenberg Auditorium", "location_name":"Weill Hall (Ford School)", "has_livestream":0, "cost":"", "tags":["Discussion","Politics","Talk"], "website":"https:\/\/fordschool.umich.edu\/event\/2024\/former-governors-john-kasich-and-steve-bullock-democracy-and-civic-discourse", "sponsors":[ { "group_name":"Gerald R. Ford School of Public Policy", "group_id":"3102", "website":"http:\/\/www.fordschool.umich.edu\/" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2024\/10\/event_127328_original-1.jpeg", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2024\/10\/event_127328_original-1.jpeg", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2024\/10\/event_127328_original-1.jpeg", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2024\/10\/event_127328_original-1.jpeg", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2024\/10\/event_127328_original-1.jpeg", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2024\/10\/event_127328_original-1.jpeg", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2024\/10\/event_127328_original-1.jpeg", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2024\/10\/event_127328_original-1.jpeg", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2024\/10\/event_127328_original-1.jpeg", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2024\/10\/event_127328_original-1.jpeg", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2024\/10\/event_127328_original-1.jpeg", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2024\/10\/event_127328_original-1.jpeg", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2024\/10\/event_127328_original-1.jpeg", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2024\/10\/event_127328_original-1.jpeg", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2024\/10\/event_127328_original-1.jpeg", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2024\/10\/event_127328_original-1.jpeg" }, "occurrence_count":1, "first_occurrence":21858886 } }