{ "125052-21854297": { "datetime_modified":"20240827T112246", "datetime_start":"20240829T160000", "datetime_end":"", "has_end_time":0, "date_start":"2024-08-29", "date_end":"", "time_start":"16:00:00", "time_end":"", "time_zone":"America\/Detroit", "event_title":"Spectroscopic studies of nucleic acid structure, dynamics and photophysics", "occurrence_title":"", "combined_title":"Spectroscopic studies of nucleic acid structure, dynamics and photophysics: Julia Widom (University of Oregon)", "event_subtitle":"Julia Widom (University of Oregon)", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"RNA performs a diverse set of biological functions, many of which require it to fold into specific structures. Many techniques have been developed to study RNA folding, a number of which are based on fluorescence detection. I will present work in which we used fluorescent analogues of the natural RNA bases to selectively probe the structures of different conformational subpopulations of RNA. We investigated the photophysical properties of base analogues in different structural contexts using a combination of time-resolved fluorescence measurements and fluorescence-detected circular dichroism spectroscopy, which circumvents the ensemble averaging that typically limits the power of bulk spectroscopic methods such as CD. Ensemble averaging can also be avoided by performing measurements on single molecules. I will present work in which we utilized single-molecule microscopy to investigate the ensemble of structures adopted by RNA \"switches\". These studies reveal how the 3D structure of RNA is impacted by intrinsic factors such as base sequence and extrinsic factors such as the binding of small molecules.", "occurrence_notes":null, "guid":"125052-21854297@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/125052", "building_id":"1000158", "building_name":"Chemistry Dow Lab", "campus_maps_id":"34", "room":"1640", "location_name":"Chemistry Dow Lab", "has_livestream":0, "cost":"", "tags":["Chemistry","Physical Chemistry"], "website":"https:\/\/news.uoregon.edu\/expert\/julia-widom-department-chemistry-and-biochemistry", "sponsors":[ { "group_name":"Department of Chemistry", "group_id":"3761", "website":"https:\/\/lsa.umich.edu\/chem" }, { "group_name":"Physical Chemistry", "group_id":"4390", "website":"" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21854297 } , "124602-21853305": { "datetime_modified":"20240820T125248", "datetime_start":"20240829T163000", "datetime_end":"20240829T173000", "has_end_time":1, "date_start":"2024-08-29", "date_end":"2024-08-29", "time_start":"16:30:00", "time_end":"17:30:00", "time_zone":"America\/Detroit", "event_title":"Computing in LSA: An Ice Cream Info-Social", "occurrence_title":"", "combined_title":"Computing in LSA: An Ice Cream Info-Social", "event_subtitle":"", "event_type":"Social \/ Informal Gathering", "event_type_id":"19", "description":"Thursday, August 29th; 4:30pm to 5:30pm; 1140 &1160 USB\r\n\r\nPlease join us for a welcome back event, with sundaes, information and swag!\r\n\r\n- Learn about computing options across LSA\r\n- Meet computing education faculty\r\n- Mingle with peers, make new friends\r\n- Build a sundae\r\n- Get swag\r\n\r\nQuestions? Please contact pcas.events@umich.edu", "occurrence_notes":"We'll be using 1140 USB and 1160 USB for this event.", "guid":"124602-21853305@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/124602", "building_id":"1005046", "building_name":"Undergraduate Science Building", "campus_maps_id":"508", "room":"1140", "location_name":"Undergraduate Science Building", "has_livestream":0, "cost":"", "tags":["Information and Technology","Social","Undergraduate","Welcome to Michigan"], "website":"https:\/\/docs.google.com\/forms\/d\/e\/1FAIpQLSdHp0USQeNKyX-1jS_Ww-VCelHHyvuZ0K3jQ6cblDDxVgcCkw\/viewform?usp=sf_link", "sponsors":[ { "group_name":"Program in Computing for Arts and Science", "group_id":"4798", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2024\/08\/event_124602_original-1.png", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2024\/08\/event_124602_original-1.png", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2024\/08\/event_124602_original-1.png", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2024\/08\/event_124602_original-1.png", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2024\/08\/event_124602_original-1.png", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2024\/08\/event_124602_original-1.png", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2024\/08\/event_124602_original-1.png", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2024\/08\/event_124602_original-1.png", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2024\/08\/event_124602_original-1.png", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2024\/08\/event_124602_original-1.png", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2024\/08\/event_124602_original-1.png", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2024\/08\/event_124602_original-1.png", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2024\/08\/event_124602_original-1.png", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2024\/08\/event_124602_original-1.png", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2024\/08\/event_124602_original-1.png", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2024\/08\/event_124602_original-1.png" }, "occurrence_count":1, "first_occurrence":21853305 } }