{ "144927-21896159": { "datetime_modified":"20260211T154959", "datetime_start":"20260309T150000", "datetime_end":"20260309T160000", "has_end_time":1, "date_start":"2026-03-09", "date_end":"2026-03-09", "time_start":"15:00:00", "time_end":"16:00:00", "time_zone":"America\/Detroit", "event_title":"MCDB Seminar> Microenvironmental sensing by intestinal stem cells promotes adult Drosophila intestinal regeneration", "occurrence_title":"", "combined_title":"MCDB Seminar> Microenvironmental sensing by intestinal stem cells promotes adult Drosophila intestinal regeneration: Dr. Parthive Patel- University of Bristol UK", "event_subtitle":"Dr. Parthive Patel- University of Bristol UK", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"A failure to properly maintain or regenerate an epithelium results in the loss of its integrity, architecture and function, and thus also organismal homeostasis. In many adult epithelia, stem cells divide to replace damaged or lost tissue cell types. Stem cells are coaxed to proliferate by signalling cues produced by cells in the regenerative microenvironment that forms shortly after injury. Cells within this microenvironment can include other epithelial cells as well as other cell types and tissues associated with the organ. While much is known about how signalling cues from the regenerative microenvironment promotes stem cell proliferation in several adult epithelia, we know less about how stem cells sense damage or even damage-causing pathogens and how they translate this information to modify their behaviour for regeneration. Furthermore, even less is understood about how stem cells modulate their microenvironment after tissue damage to support regeneration. \n\nUsing the adult Drosophila intestine (or midgut), we have uncovered mechanisms that allow intestinal stem cells (ISCs) to recognise tissue damage as well as invading pathogens and translate this into their proliferation for regeneration. Moreover, we have found that after damage, these same ISC pathways can shape the regenerative microenvironment.\n\nHost: Laura Buttitta", "occurrence_notes":null, "guid":"144927-21896159@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/144927", "building_id":"1005169", "building_name":"Biological Sciences Building", "campus_maps_id":"631", "room":"1010", "location_name":"Biological Sciences Building", "has_livestream":0, "cost":"", "tags":["Biology","Bsbsigns","seminar"], "website":"https:\/\/lsa.umich.edu\/mcdb\/news-events\/upcoming-events.html#date=2026-02-02&view=month", "sponsors":[ { "group_name":"Department of Molecular, Cellular, and Developmental Biology", "group_id":"3755", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2026\/02\/event_144927_original-1.png", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2026\/02\/event_144927_original-1.png", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2026\/02\/event_144927_original-1.png", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2026\/02\/event_144927_original-1.png", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2026\/02\/event_144927_original-1.png", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2026\/02\/event_144927_original-1.png", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2026\/02\/event_144927_original-1.png", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2026\/02\/event_144927_original-1.png", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2026\/02\/event_144927_original-1.png", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2026\/02\/event_144927_original-1.png", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2026\/02\/event_144927_original-1.png", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2026\/02\/event_144927_original-1.png", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2026\/02\/event_144927_original-1.png", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2026\/02\/event_144927_original-1.png", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2026\/02\/event_144927_original-1.png", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2026\/02\/event_144927_original-1.png" }, "occurrence_count":1, "first_occurrence":21896159 } , "146319-21898875": { "datetime_modified":"20260308T184509", "datetime_start":"20260309T150000", "datetime_end":"20260309T160000", "has_end_time":1, "date_start":"2026-03-09", "date_end":"2026-03-09", "time_start":"15:00:00", "time_end":"16:00:00", "time_zone":"America\/Detroit", "event_title":"Perturbation of mixed characteristics test ideal", "occurrence_title":"", "combined_title":"Perturbation of mixed characteristics test ideal: Hanlin Cai, Columbia University", "event_subtitle":"Hanlin Cai, Columbia University", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Given a normal domain R of finite type over a mixed characteristic complete DVR or a perfect field of characteristic p, one can define the notion of a test ideal. In equal characteristic p, it is well known that test ideals are stable under small perturbations. The proof of this fact boils down to a fundamental result in Smith's thesis on tight closure, which states that there are no nonzero almost zero elements in the top local cohomology of R^+.In this talk, I will explain how to extend this result to the mixed characteristic setting, along with its applications to mixed characteristic test ideals. Time permitting, I will also outline the key ideas behind the proof. This is joint work in progress with Bhargav Bhatt and Linquan Ma.", "occurrence_notes":null, "guid":"146319-21898875@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/146319", "building_id":"1000166", "building_name":"East Hall", "campus_maps_id":"53", "room":"3088", "location_name":"East Hall", "has_livestream":0, "cost":"", "tags":["Mathematics","seminar"], "website":"", "sponsors":[ { "group_name":"Commutative Algebra Seminar - Department of Mathematics", "group_id":"4886", "website":"" }, { "group_name":"Department of Mathematics", "group_id":"3791", "website":"" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21898875 } }