{ "129010-21862017": { "datetime_modified":"20241111T120336", "datetime_start":"20241120T110000", "datetime_end":"20241120T120000", "has_end_time":1, "date_start":"2024-11-20", "date_end":"2024-11-20", "time_start":"11:00:00", "time_end":"12:00:00", "time_zone":"America\/Detroit", "event_title":"DCMB \/ CCMB Weekly Seminar featuring Jennifer Phillips-Cremins, PhD (of University of Pennsylvania)", "occurrence_title":"", "combined_title":"DCMB \/ CCMB Weekly Seminar featuring Jennifer Phillips-Cremins, PhD (of University of Pennsylvania): Talk title: \"The Science of Connections: Bridging chromatin, synaptic plasticity, and neurophysiology\"", "event_subtitle":"Talk title: \"The Science of Connections: Bridging chromatin, synaptic plasticity, and neurophysiology\"", "event_type":"Livestream \/ Virtual", "event_type_id":"24", "description":"Abstract:\r\n\r\nThe Cremins Laboratory works at the spatial biology-technology interface to investigate the structure-function relationship of connections in the brain across the scales of chromatin, synapses, and circuits in normal neurophysiology and in neurological disorders. We have thus far focused in the nucleus on creating kilobase-resolution maps of higher-order folding of the chromatin fiber and understanding how classic epigenetic modifications work through long-range connections to govern genome function in neurodevelopment. We have developed and applied new molecular and computational technologies to elucidate chromatin folding patterns at kilobase-resolution genome-wide, thus discovering that long-range looping interactions in cis and inter-chromosomal interactions in trans change substantially during neural lineage commitment, somatic cell reprogramming, activation of post-mitotic neural circuits, and in neurological disorders. We have demonstrated that cohesin-mediated loops are necessary for the establishment of new gene expression programs in post-mitotic neurons, including the upregulation of genes encoding axon guidance, dendritic spine morphology, and synaptic plasticity during neuron maturation in vivo as well as activity-dependent transcription during neural stimulation in vitro. We have also identified cohesin-mediated loops anchored by divergently-oriented CTCF binding sites that are necessary and sufficient for the firing efficiency and localization of human replication origins during S phase re-entry after mitosis. Using fragile X syndrome as a natural perturbation, we have uncovered BREACHes (Beacons of Repeat Expansion Anchored by Contacting Heterochromatin) - rare inter-chromosomal interactions connecting heterochromatinized synaptic genes susceptible to repeat instability, thus providing early insight into the genome\u2019s structure-function relationship. Here, I will present new unpublished data describing 3D genome miswiring in a human neuron model with rare familial Alzheimer\u2019s mutations as well as the functional link among loops and activity-dependent gene expression during neural circuit activation in vitro and in vivo. The long-term goal of the Cremins lab is to elucidate how the genome\u2019s structure-function relationship influences synaptic plasticity and neurophysiology during memory encoding and consolidation and how this goes awry in intractable neurological disorders. \r\n\r\nBio:\r\n\r\nJennifer Phillips-Cremins, Ph.D. is an Associate Professor and Deans' Faculty Fellow in Engineering and Medicine at the University of Pennsylvania with primary appointments in the Departments of Genetics and Bioengineering. Dr. Cremins obtained her Ph.D. in Biomedical Engineering from the Georgia Institute of Technology in the laboratory of Andres Garcia. She conducted a multi-disciplinary postdoc in the laboratories of Job Dekker and Victor Corces. Dr. Cremins runs the Laboratory of Chromatin and Spatial Neurobiology at UPenn. Her primary research interests lie in understanding the long-range chromatin architecture mechanisms that govern neural specification and synaptic plasticity in healthy neurons and how chromatin-synapse communication is dysregulated in neurodevelopmental and neurodegenerative diseases. She has been selected as a 2014 New York Stem Cell Foundation Robertson Investigator, a 2015 Albert P. Sloan Foundation Fellow, a 2016 and 2018 Kavli Frontiers of Science Fellow, 2015 NIH Director's New Innovator Awardee, 2020 NSF CAREER Awardee, a 2020 CZI Neurodegenerative Disease Pairs Awardee, the 2022 ISSCR Susan B. Lim Outstanding New Investigator Award, and as a recipient of the 2021 NIH Pioneer Award.", "occurrence_notes":null, "guid":"129010-21862017@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/129010", "building_id":"1005047", "building_name":"Palmer Commons", "campus_maps_id":"188", "room":"Forum Hall", "location_name":"Palmer Commons", "has_livestream":0, "cost":"", "tags":["Precision Health","Learning Health Systems","Lecture","Life Science","Mathematics","Medicine","Michigan Engineering","Pediatrics","Physics","Information and Technology","Public Health","Research","Science","seminar","Structural Biology","Talk","Undergraduate","Virtual","In Person","Applications","Basic Science","Biointerfaces","Biology","Biomedical Engineering","Biosciences","Cardiovascular","Chemistry","Discussion","Education","Electrical Engineering and Computer Science","Engineering","Free","Graduate Students","Human Genetics"], "website":"https:\/\/medschool.umich.edu\/events\/ccmb-seminar-series\/ccmb-seminar-jennifer-e-phillips-cremins-phd\/2024-11-20", "sponsors":[ { "group_name":"DCMB Seminar Series", "group_id":"3754", "website":"" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21862017 } , "124179-21852618": { "datetime_modified":"20241115T181508", "datetime_start":"20241120T110000", "datetime_end":"20241120T170000", "has_end_time":1, "date_start":"2024-11-20", "date_end":"2024-11-20", "time_start":"11:00:00", "time_end":"17:00:00", "time_zone":"America\/Detroit", "event_title":"Kelly Church & Cherish Parrish: In Our Words, An Intergenerational Dialogue", "occurrence_title":"", "combined_title":"Kelly Church & Cherish Parrish: In Our Words, An Intergenerational Dialogue", "event_subtitle":"", "event_type":"Exhibition", "event_type_id":"7", "description":"Exhibition Dates: September 13 \u2013 December 7, 2024Opening Reception: September 19, 2024\n\nKelly Church & Cherish Parrish: In Our Words, An Intergenerational Dialogue is a major exhibition that centers the subjectivities of two contemporary Indigenous artists whose practices have sustained and bolstered the relevance of the age-old Anishinaabe practice of black ash basket-making in the 21st century. The exhibition highlights the significance of community-based conversations between mother and daughter, and their ongoing conversations with elders (ancestors), young folx, and future generations as vital aspects of their methodology. These conversations often take place during basket gatherings - where community members come together and share stories and teachings that can encompass Anishinaabe creation stories, as well as those of survivance and resilience, to inform the materiality and liveness of their work. The curatorial and interpretive framework of this exhibition contends that the deeply situated and temporal works by Church (Stamps, BFA 1998) and Parrish (LSA, BA 2020) are repositories for Anishinaabe ways of knowing, thinking, and making that contribute to the complexity of American art and its histories. The expansive and bold practices of Church and Parrish affirm the sovereignty of Anishinaabe lifeways and the importance of including Indigenous narratives that have systematically been left out. Thus, the thematic survey of their work will explore the under-examined themes that inform their work such as Native women\u2019s labor as carriers of culture and knowledge-keepers, the legacy of boarding schools and ancestors who walked on, the treaties in Michigan and the long-overlooked legacy of Anishinaabe intellectual life and their relevance today. Just like the practice of weaving and interlacing distinct strips of black ash to create one whole, Church and Parrish will address the diverse and interconnected themes with approximately 30-35 works, including 15-17 new works. Together, the exhibition offers an incisive critique of the colonial, racist paradigm of systemic erasure and assimilation that continues to this day, with the ongoing crises of missing and murdered Indigenous women, culture wars, and climate change that threaten Indigenous ways of living, sustenance, and making. \nCurated by Srimoyee Mitra with Curatorial Assistant Zoi Crampton.\nStamps Gallery is grateful to Michigan Humanities and U-M Arts Initiative for generously supporting the exhibition and programs. 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