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However, how lipid metabolism regulates lysosomal homeostasis remains poorly understood.\n\nHere, we performed a genome-wide CRISPR screen in Mucolipidosis V (LYSET-deficient) cells and identified ether lipid synthesis as a key regulator of lysosomal homeostasis. Genetic or pharmacological inhibition of ether lipid synthesis reduced lysosome accumulation and partially restored lysosomal degradative capacity. Mechanistically, ether lipid reduction partially restored the maturation of a subset of lysosomal hydrolases and enhanced lysosomal exocytosis, thereby promoting lysosomal substrate clearance. These findings uncover a previously unrecognized mechanism by which lipid metabolism regulates lysosomal homeostasis and suggest new therapeutic opportunities for lysosomal storage disorders.", "occurrence_notes":null, "guid":"150858-21910314@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/150858", "building_id":"1005169", "building_name":"Biological Sciences Building", "campus_maps_id":"631", "room":"1010", "location_name":"Biological Sciences Building", "has_livestream":0, "cost":"", "tags":["Biology","Bsbsigns","Dissertation","Dissertation Defense","Graduate Students"], "website":"https:\/\/lsa.umich.edu\/mcdb\/news-events.html", "sponsors":[ { "group_name":"Department of Molecular, Cellular, and Developmental Biology", "group_id":"3755", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2026\/08\/event_150858_original-1.jpg", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2026\/08\/event_150858_original-1.jpg", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2026\/08\/event_150858_original-1.jpg", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2026\/08\/event_150858_original-1.jpg", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2026\/08\/event_150858_original-1.jpg", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb\/media\/attachments\/2026\/08\/event_150858_original-1.jpg", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb_square\/media\/attachments\/2026\/08\/event_150858_original-1.jpg", "group_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large\/media\/attachments\/2026\/08\/event_150858_original-1.jpg", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large_lightbox\/media\/attachments\/2026\/08\/event_150858_original-1.jpg", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_large_crop\/media\/attachments\/2026\/08\/event_150858_original-1.jpg", "event_list":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_list\/media\/attachments\/2026\/08\/event_150858_original-1.jpg", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2026\/08\/event_150858_original-1.jpg", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2026\/08\/event_150858_original-1.jpg", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_grid_2x\/media\/attachments\/2026\/08\/event_150858_original-1.jpg", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_feature_large\/media\/attachments\/2026\/08\/event_150858_original-1.jpg", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2026\/08\/event_150858_original-1.jpg" }, "occurrence_count":1, "first_occurrence":21910314 } , "150491-21909545": { "datetime_modified":"20260901T062116", "datetime_start":"20260902T090000", "datetime_end":"20260902T100000", "has_end_time":1, "date_start":"2026-09-02", "date_end":"2026-09-02", "time_start":"09:00:00", "time_end":"10:00:00", "time_zone":"America\/Detroit", "event_title":"Stockwell (2026-2027) (Housing)", "occurrence_title":"Opening Floor Meeting (5th)", "combined_title":"Stockwell (2026-2027) (Housing): Multiple conference events and sessions: Opening Floor Meeting (5th)", "event_subtitle":"Multiple conference events and sessions", "event_type":"Conference \/ Symposium", "event_type_id":"5", "description":"", "occurrence_notes":null, "guid":"150491-21909545@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/150491", "building_id":"", "building_name":"", "campus_maps_id":"", "room":"", "location_name":"Rosa Parks", "has_livestream":0, "cost":"", "tags":["Sessions"], "website":"https:\/\/sessions.studentlife.umich.edu\/p\/track\/17104", "sponsors":[ { "group_name":"Sessions @ Michigan", "group_id":"4791", "website":"https:\/\/sessions.studentlife.umich.edu\/" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":5, "first_occurrence":21909544 } }