{ "143694-21893657": { "datetime_modified":"20260303T145140", "datetime_start":"20260318T160000", "datetime_end":"20260318T170000", "has_end_time":1, "date_start":"2026-03-18", "date_end":"2026-03-18", "time_start":"16:00:00", "time_end":"17:00:00", "time_zone":"America\/Detroit", "event_title":"CCMB\/DCMB Weekly Seminar Series featuring Li-San Wang, PhD (Associate Dean for Computing, Perelman School of Medicine)", "occurrence_title":"", "combined_title":"CCMB\/DCMB Weekly Seminar Series featuring Li-San Wang, PhD (Associate Dean for Computing, Perelman School of Medicine): \"From Association to Mechanism at Scale: Computational Frameworks for Alzheimer\u2019s Disease Genomics\"", "event_subtitle":"\"From Association to Mechanism at Scale: Computational Frameworks for Alzheimer\u2019s Disease Genomics\"", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Abstract\nLarge-scale human genetics has transformed Alzheimer\u2019s disease (AD) research. Through coordinated efforts such as the Alzheimer\u2019s Disease Genetics Consortium (ADGC) and the Alzheimer\u2019s Disease Sequencing Project (ADSP), dozens of reproducible risk loci have been identified across diverse populations. ADSP is now generating whole-genome sequence data at unprecedented scale, with an eventual goal of 150,000 genomes integrated with harmonized clinical and functional datasets. As data generation accelerates, interpretation of genetic discoveries has become the central bottleneck.\n\nIn this seminar, I will present computational frameworks developed within ADSP to bridge the gap between association and mechanism. These include multi-ancestry meta-analysis and fine-mapping approaches that leverage linkage disequilibrium differences to refine credible sets; integration of rare and structural variants within joint-calling pipelines; and colocalization strategies incorporating eQTL and other quantitative trait locus datasets to prioritize target genes. I will also discuss regulatory annotation tools such as INFERNO and BTS that integrate large collections of functional genomic tracks for context-specific variant interpretation, along with the informatics infrastructure developed within the NIA Genetics of Alzheimer\u2019s Disease Data Storage Site to support genome production, quality control, phenotype harmonization, and scalable coordination across more than 50,000 whole genomes. Together, these efforts illustrate how statistical genetics, functional genomics, and production-scale bioinformatics infrastructure can be integrated to advance mechanistic understanding of complex neurodegenerative disease. \n\nThe CCMB Seminar Series (Sponsored by DCMB) is held at Medical Science Unit I - 4B700, each Wednesday, at 4:00 pm EST, on bioinformatics-related topics. Each seminar is presented by an invited guest speaker. These seminars are live-streamed on Zoom.", "occurrence_notes":null, "guid":"143694-21893657@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/143694", "building_id":"1000190", "building_name":"Medical Science Unit I", "campus_maps_id":"104", "room":"4B700", "location_name":"Medical Science Unit I", "has_livestream":0, "cost":"", "tags":["Basic Science","Research","biomedical research","Biology","Bioinformatics"], "website":"https:\/\/medschool.umich.edu\/events\/ccmb-seminar-series\/ccmb-seminar-li-san-wang-phd\/2026-03-18", "sponsors":[ { "group_name":"DCMB Seminar Series", "group_id":"3754", "website":"" }, { "group_name":"Department of Computational Medicine and Bioinformatics DCMB", "group_id":"5384", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2026\/01\/event_143694_original-1.jpg", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2026\/01\/event_143694_original-1.jpg", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2026\/01\/event_143694_original-1.jpg", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2026\/01\/event_143694_original-1.jpg", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2026\/01\/event_143694_original-1.jpg", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2026\/01\/event_143694_original-1.jpg", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2026\/01\/event_143694_original-1.jpg", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2026\/01\/event_143694_original-1.jpg", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2026\/01\/event_143694_original-1.jpg", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2026\/01\/event_143694_original-1.jpg", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2026\/01\/event_143694_original-1.jpg", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2026\/01\/event_143694_original-1.jpg", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2026\/01\/event_143694_original-1.jpg", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2026\/01\/event_143694_original-1.jpg", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2026\/01\/event_143694_original-1.jpg", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2026\/01\/event_143694_original-1.jpg" }, "occurrence_count":1, "first_occurrence":21893657 } , "145150-21896735": { "datetime_modified":"20260402T123116", "datetime_start":"20260318T160000", "datetime_end":"20260318T170000", "has_end_time":1, "date_start":"2026-03-18", "date_end":"2026-03-18", "time_start":"16:00:00", "time_end":"17:00:00", "time_zone":"America\/Detroit", "event_title":"Michigan Democratic Party Coordinated Campaign Info Session on Campaign Opportunities", "occurrence_title":"", "combined_title":"Michigan Democratic Party Coordinated Campaign Info Session on Campaign Opportunities", "event_subtitle":"", "event_type":"Careers \/ Jobs", "event_type_id":"2", "description":"The Michigan Democratic Party's Coordinated Campaign is looking to fill 100+ positions for the upcoming 2026 midterm elections!If you are interested in opportunities to work on a campaign for the Michigan Democratic Party, please attend this information session where theirstaff will share more about upcoming job opportunities such as the field organizer role and campus fellows program.This event's information is shown in Handshake as well as on the Happening @ Michigan calendar so that it will be seen by a larger number of U-M Students. You can only register to attend this event within Handshake. If you'd like to indicate that you'll be attending this event and see more details, please go to thiswebpage:\u00a0 https:\/\/umich.joinhandshake.com\/events\/1908077\/share_preview\u00a0\u00a0We want to ensure full and equitable participation in our events. If an accessibility accommodation would promote your full participation in this event, please indicate your accommodation requirements via the link below, preferably at least 14 days prior to the program to ensure sufficient time for arranging your requestedaccommodation(s) or exploring suitable alternatives. If you have any questions regarding access to our programs, please don't hesitate to reach out to Cierra Sutherland at\u00a0cierrasu@umich.edu. Accessibility accommodation form:\u00a0https:\/\/forms.gle\/FmFn35ZLxJ8kvPfSA\u00a0\u00a0#UCC", "occurrence_notes":null, "guid":"145150-21896735@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/145150", "building_id":"", "building_name":"", "campus_maps_id":"", "room":"", "location_name":"Student Activities Building, Maize and Blue Auditorium, 515 E Jefferson St, Ann Arbor, MI, United States", "has_livestream":0, "cost":"", "tags":[], "website":"", "sponsors":[ { "group_name":"University Career Center UCC", "group_id":"1140", "website":"http:\/\/careercenter.umich.edu" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21896735 } }