{ "145732-21897741": { "datetime_modified":"20260224T135948", "datetime_start":"20260226T120000", "datetime_end":"20260226T130000", "has_end_time":1, "date_start":"2026-02-26", "date_end":"2026-02-26", "time_start":"12:00:00", "time_end":"13:00:00", "time_zone":"America\/Detroit", "event_title":"Regenerative biology and engineered tissue models", "occurrence_title":"", "combined_title":"Regenerative biology and engineered tissue models: Brendan Harley, Sc.D.", "event_subtitle":"Brendan Harley, Sc.D.", "event_type":"Lecture \/ Discussion", "event_type_id":"13", "description":"Advances in the fields of tissue engineering and regenerative medicine require biomaterials that\ninstruct, rather than simply permit, a desired cellular response. A major challenge to progress in\nour field is the complex organization of the tissues in our bodies, which are hierarchical, vary in\nspace and time, and can differ person-to person. Prof. Harley\u2019s research program is developing\nbiomaterials\u00a0that replicate the complex cellular and extracellular microenvironment found in the\ntissues and organs of our body. These include porous, hydrogel\/granular, and composite\nbiomaterials for musculoskeletal tissue regeneration, hematopoietic stem cell biomanufacturing,\nand as model systems to investigate endometrial pathologies and invasive brain cancer. I will\ndescribe efforts using bioinspired design motifs to create composite biomaterials to regenerate\ncraniomaxillofacial bones and musculoskeletal insertions. I will also describe (granular) hydrogel\nmodels to study niche regulation of hematopoietic stem cells and patient-derived glioblastoma\nspecimens. These tools enable study of dynamic processes such as remodeling and multicellular\nsignaling that inform stem cell quiescence as well as brain cancer invasion and drug resistance.\nHowever, contemporary tissue engineering efforts must also consider patient heterogeneity,\ngender\/sex, and social factors. Hence, I will also describe efforts to account for sex differences in\ntissue engineering models as well as to create hierarchical models of the endometrial tissue\nmicroenvironment to investigate endometriosis. These new paradigms are essential for\naccelerating translation of scientific discoveries into innovations that improve our collective quality\nof life.\n\nBiography\nBrendan Harley is the Robert W. Schaefer Professor in the Dept. of Chemical and Biomolecular\nEngineering at the University of Illinois at Urbana-Champaign as well as Program Leader in the\nCancer Center at Illinois. He received a B.S. in Engineering Sciences from Harvard University, a\nSc.D. in Mechanical Engineering from MIT, and performed postdoctoral studies at the Joint\nProgram for Transfusion Medicine at Children\u2019s Hospital Boston.\nHis research group develops tissue engineering technologies for musculoskeletal regeneration,\nhematopoietic stem cell biomanufacturing, as well as to investigate endometrial pathologies and\ninvasive brain cancer. He is a decorated instructor and helps lead multiple interdisciplinary\nresearch programs at Illinois. Dr. Harley co-founded a regenerative medicine company,\nOrthomimetics Ltd., to commercialize an osteochondral regeneration technology.\nDr. Harley has received a number of awards and honors including an NSF CAREER award (2013),\nthe Young Investigator Award (2014) and the Clemson Award for Basic Research (2021) from the\nSociety for Biomaterials, as well as university research, teaching, and promotion awards (U.\nIllinois). He is an elected Fellow of the American Association for the Advancement of Science, the\nAmerican Institute for Medical and Biological Engineering, and the Biomedical Engineering Society.", "occurrence_notes":null, "guid":"145732-21897741@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/145732", "building_id":"1000205", "building_name":"1027 E. Huron Building", "campus_maps_id":"537", "room":"G550", "location_name":"1027 E. Huron Building", "has_livestream":0, "cost":"", "tags":["chemical engineering"], "website":"http:\/\/che.engin.umich.edu\/", "sponsors":[ { "group_name":"Chemical Engineering", "group_id":"3218", "website":"http:\/\/che.engin.umich.edu\/" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2026\/02\/event_145732_original-1.png", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2026\/02\/event_145732_original-1.png", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2026\/02\/event_145732_original-1.png", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2026\/02\/event_145732_original-1.png", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2026\/02\/event_145732_original-1.png", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2026\/02\/event_145732_original-1.png", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2026\/02\/event_145732_original-1.png", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2026\/02\/event_145732_original-1.png", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2026\/02\/event_145732_original-1.png", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2026\/02\/event_145732_original-1.png", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2026\/02\/event_145732_original-1.png", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2026\/02\/event_145732_original-1.png", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2026\/02\/event_145732_original-1.png", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2026\/02\/event_145732_original-1.png", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2026\/02\/event_145732_original-1.png", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2026\/02\/event_145732_original-1.png" }, "occurrence_count":1, "first_occurrence":21897741 } , "143999-21894433": { "datetime_modified":"20260224T101438", "datetime_start":"20260226T120000", "datetime_end":"20260226T160000", "has_end_time":1, "date_start":"2026-02-26", "date_end":"2026-02-26", "time_start":"12:00:00", "time_end":"16:00:00", "time_zone":"America\/Detroit", "event_title":"Revolutionary Paine: Andy Murphy Student-Curated Class Exhibit Common Sense", "occurrence_title":"", "combined_title":"Revolutionary Paine: Andy Murphy Student-Curated Class Exhibit Common Sense", "event_subtitle":"", "event_type":"Exhibition", "event_type_id":"7", "description":"Thomas Paine\u2019s \u201cCommon Sense\u201d was one of the most influential works of the American Revolution. The first edition was published on January 10, 1776, with an initial print run of just 1,000 copies; but within weeks demand soared. The students of Andy Murphy\u2019s POLISCI 495 course co-curated the exhibition \u201cRevolutionary Paine\u201d to document the whirlwind caused by its publication. On view at the Clements January 16-May 8, weekdays from 12-4 pm.", "occurrence_notes":null, "guid":"143999-21894433@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/143999", "building_id":"1000159", "building_name":"William Clements Library", "campus_maps_id":"165", "room":"Avenir Foundation Reading Room", "location_name":"William Clements Library", "has_livestream":0, "cost":"", "tags":["Americana","Exhibit","Exhibition","history"], "website":"https:\/\/clements.umich.edu\/exhibit\/revolutionary-paine\/", "sponsors":[ { "group_name":"William L. Clements Library", "group_id":"1727", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2026\/01\/event_143999_original-1.png", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2026\/01\/event_143999_original-1.png", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2026\/01\/event_143999_original-1.png", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2026\/01\/event_143999_original-1.png", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2026\/01\/event_143999_original-1.png", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2026\/01\/event_143999_original-1.png", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2026\/01\/event_143999_original-1.png", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2026\/01\/event_143999_original-1.png", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2026\/01\/event_143999_original-1.png", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2026\/01\/event_143999_original-1.png", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2026\/01\/event_143999_original-1.png", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2026\/01\/event_143999_original-1.png", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2026\/01\/event_143999_original-1.png", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2026\/01\/event_143999_original-1.png", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2026\/01\/event_143999_original-1.png", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2026\/01\/event_143999_original-1.png" }, "occurrence_count":81, "first_occurrence":21894392 } }