{ "114277-21832589": { "datetime_modified":"20231025T094006", "datetime_start":"20231120T160000", "datetime_end":"20231120T170000", "has_end_time":1, "date_start":"2023-11-20", "date_end":"2023-11-20", "time_start":"16:00:00", "time_end":"17:00:00", "time_zone":"America\/Detroit", "event_title":"ISRMT seminar: Geometry of half-space log-gamma polymers", "occurrence_title":"", "combined_title":"ISRMT seminar: Geometry of half-space log-gamma polymers: Sayan Das (University of Chicago)", "event_subtitle":"Sayan Das (University of Chicago)", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"The half-space directed polymer is a variant of directed polymer that studies how polymers behave in the presence of an attractive wall. Depending on the strength of the boundary, the polymers are expected to have two distinct phases: the bound phase and the unbound phase. In this talk, I will focus on the half-space polymer model with log-gamma weights which makes the model integrable. I will describe our results in the unbound phase where we obtain KPZ exponents and in the bound phase where we obtain stochastic boundedness of the endpoint. Our proof proceeds by constructing the half-space log-gamma line ensemble which has a novel feature of attraction\/repulsion at the boundaries. Based on two joint works: one with Guillaume Barraquand and Ivan Corwin, and one with Weitao Zhu.", "occurrence_notes":null, "guid":"114277-21832589@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/114277", "building_id":"1000166", "building_name":"East Hall", "campus_maps_id":"53", "room":"EH1866", "location_name":"East Hall", "has_livestream":0, "cost":"", "tags":["Mathematics","seminar"], "website":"https:\/\/sites.google.com\/umich.edu\/isrmt-seminar\/", "sponsors":[ { "group_name":"Integrable Systems and Random Matrix Theory Seminar - Department of Mathematics", "group_id":"4893", "website":"" }, { "group_name":"Department of Mathematics", "group_id":"3791", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2023\/10\/event_114277_original-1.jpeg", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2023\/10\/crop-event_114277_original-1.jpeg", "event_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_large\/media\/attachments\/2023\/10\/crop-event_114277_original-1.jpeg", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2023\/10\/crop-event_114277_original-1.jpeg", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_large_lightbox\/media\/attachments\/2023\/10\/crop-event_114277_original-1.jpeg", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb\/media\/attachments\/2023\/10\/crop-event_114277_original-1.jpeg", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2023\/10\/crop-event_114277_original-1.jpeg", "group_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large\/media\/attachments\/2023\/10\/crop-event_114277_original-1.jpeg", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large_lightbox\/media\/attachments\/2023\/10\/crop-event_114277_original-1.jpeg", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_large_crop\/media\/attachments\/2023\/10\/crop-event_114277_original-1.jpeg", "event_list":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_list\/media\/attachments\/2023\/10\/crop-event_114277_original-1.jpeg", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2023\/10\/crop-event_114277_original-1.jpeg", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2023\/10\/crop-event_114277_original-1.jpeg", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_grid_2x\/media\/attachments\/2023\/10\/crop-event_114277_original-1.jpeg", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_feature_large\/media\/attachments\/2023\/10\/crop-event_114277_original-1.jpeg", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_feature_thumb\/media\/attachments\/2023\/10\/crop-event_114277_original-1.jpeg" }, "occurrence_count":1, "first_occurrence":21832589 } , "109680-21822696": { "datetime_modified":"20231030T153200", "datetime_start":"20231120T160000", "datetime_end":"20231120T170000", "has_end_time":1, "date_start":"2023-11-20", "date_end":"2023-11-20", "time_start":"16:00:00", "time_end":"17:00:00", "time_zone":"America\/Detroit", "event_title":"RNA Innovation Seminar: George Lisi, Brown University", "occurrence_title":"", "combined_title":"RNA Innovation Seminar: George Lisi, Brown University: The Invisible Dance of CRISPR-Cas9 through Molecular Space and Time", "event_subtitle":"The Invisible Dance of CRISPR-Cas9 through Molecular Space and Time", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"HYBRID SEMINAR:\r\nIn-person: BSRB, ABC seminar rooms\r\nZoom: https:\/\/umich.zoom.us\/webinar\/register\/WN_5NWlftG_TZGoYjig93GN4w\r\n\r\nAbstract: This talk will focus on long-range signaling in CRISPR-Cas9, a cutting-edge genome editing tool. The transformative potential of Cas9 as a precision therapeutic cannot be realized without an understanding of its interdomain communication and the mitigation of deleterious off-target cleavage, which is being characterized at the atomic level in the group. A series of vignettes will highlight NMR studies of Cas9 through a \u201cdivide-and-conquer\u201d approach using engineered protein constructs and first demonstrate that multi-timescale motions in the catalytic nuclease of Cas9 propagates chemical information that regulates cleavage of double-stranded DNA. The talk will also highlight specificity-enhancing mutations in Cas9 that rewire its regulatory mechanism and RNA interactions at the molecular level to mitigate off-target DNA cleavage. Critical energetics of the mechanism will be discussed, including the importance of metal ions and the protonation state of the catalytic histidine, studied via catalytic pocket mutations that limit conformational sampling of the Cas9 active state. Lastly, insight from canonical Cas9s will be expanded to highly stable thermophiles that are more promising for genome engineering and offer tunable high-temperature DNA editing and RNA binding. The underlying chemistry and atomic level dynamics of Cas9 will be linked to its nucleic acid interactions and biological outcomes, hopefully opening new avenues for intuitive manipulation of its function and precision therapeutic properties.", "occurrence_notes":null, "guid":"109680-21822696@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/109680", "building_id":"1005037", "building_name":"Taubman Biomedical Science Research Building", "campus_maps_id":"509", "room":"ABC Seminar Room", "location_name":"Taubman Biomedical Science Research Building", "has_livestream":0, "cost":"", "tags":["Biosciences"], "website":"", "sponsors":[ { "group_name":"Center for RNA Biomedicine", "group_id":"4014", "website":"" }, { "group_name":"Biosciences Initiative", "group_id":"4165", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2023\/10\/event_109680_original-1.jpeg", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2023\/10\/event_109680_original-1.jpeg", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2023\/10\/event_109680_original-1.jpeg", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_large_2x\/media\/attachments\/2023\/10\/event_109680_original-1.jpeg", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2023\/10\/event_109680_original-1.jpeg", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb\/media\/attachments\/2023\/10\/event_109680_original-1.jpeg", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2023\/10\/event_109680_original-1.jpeg", "group_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large\/media\/attachments\/2023\/10\/event_109680_original-1.jpeg", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large_lightbox\/media\/attachments\/2023\/10\/event_109680_original-1.jpeg", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_large_crop\/media\/attachments\/2023\/10\/event_109680_original-1.jpeg", "event_list":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_list\/media\/attachments\/2023\/10\/event_109680_original-1.jpeg", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2023\/10\/event_109680_original-1.jpeg", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2023\/10\/event_109680_original-1.jpeg", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_grid_2x\/media\/attachments\/2023\/10\/event_109680_original-1.jpeg", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_feature_large\/media\/attachments\/2023\/10\/event_109680_original-1.jpeg", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_feature_thumb\/media\/attachments\/2023\/10\/event_109680_original-1.jpeg" }, "occurrence_count":1, "first_occurrence":21822696 } , "115414-21834645": { "datetime_modified":"20231205T123136", "datetime_start":"20231120T160000", "datetime_end":"20231120T170000", "has_end_time":1, "date_start":"2023-11-20", "date_end":"2023-11-20", "time_start":"16:00:00", "time_end":"17:00:00", "time_zone":"America\/Detroit", "event_title":"Scotiabank Information Session- Spotlight on Corporate Functions", "occurrence_title":"", "combined_title":"Scotiabank Information Session- Spotlight on Corporate Functions", "event_subtitle":"", "event_type":"Careers \/ Jobs", "event_type_id":"2", "description":"Scotiabank's Corporate Functions Internships for the Summer of2024 are officially live!\n\n\ud83d\udcbc Are you looking to gain experience in agrowing bank over the summer of 2024?\n\ud83d\udcca Do you have an analytical skillset and passion for solving problems?\n\ud83d\udd05 Are you a great team player and enjoy working in a collaborative work environment?\n\ud83d\udcda Are you interested in a way to pursue finance outside of banking roles? \n\nIf you answered \u201cyes\u201d to some or all of these questions, join our Information Session to learn about teams like Audit, Compliance, Treasury, RegulatoryRelations and more to prepare for our interview processes!", "occurrence_notes":null, "guid":"115414-21834645@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/115414", "building_id":"", "building_name":"", "campus_maps_id":"", "room":"", "location_name":"", "has_livestream":0, "cost":"", "tags":[], "website":"", "sponsors":[ { "group_name":"University Career Center UCC", "group_id":"1140", "website":"http:\/\/careercenter.umich.edu" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21834645 } }