{ "125336-21854756": { "datetime_modified":"20250306T114528", "datetime_start":"20250404T120000", "datetime_end":"20250404T130000", "has_end_time":1, "date_start":"2025-04-04", "date_end":"2025-04-04", "time_start":"12:00:00", "time_end":"13:00:00", "time_zone":"America\/Detroit", "event_title":"Population dynamics and universal statistics of tumor-inhabiting bacteria", "occurrence_title":"", "combined_title":"Population dynamics and universal statistics of tumor-inhabiting bacteria: Andrew Mugler (Pitt)", "event_subtitle":"Andrew Mugler (Pitt)", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Environments such as the ocean, the soil, and the human body support tremendous microbial diversity. Uncovering the mechanisms by which a large number of microbial species can coexist on limited resources remains an important open problem. Here I will discuss this problem in unique context: bacteria that inhabit tumors. Bacterial colonization of solid tumors is widespread, but how the tumor environment affects bacterial growth (and vice versa) is poorly understood. Our experimental collaborators infect mouse tumors with DNA-barcoded bacteria, creating competition among thousands of clonal bacterial \"species\". We find that after an initial expansion period, clone sizes exhibit universal power-law statistics. These statistics are robust across experiments and collection times, and unique to bacteria grown in the tumor environment rather than in liquid culture. Combining population ecology with nonequilibrium statistical physics, we develop a mechanistic theory of intra-tumor bacterial growth that includes an infection bottleneck, local growth constraints, global resource competition, and environmental noise. Our simple physical theory captures the dynamics and the statistics of the experiments, explains the uniqueness of the observations to the tumor environment, and represents an important step in quantitatively characterizing the tumor microbiome.", "occurrence_notes":null, "guid":"125336-21854756@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/125336", "building_id":"1000158", "building_name":"Chemistry Dow Lab", "campus_maps_id":"34", "room":"1640", "location_name":"Chemistry Dow Lab", "has_livestream":0, "cost":"", "tags":["Biophysics"], "website":"", "sponsors":[ { "group_name":"LSA Biophysics", "group_id":"3767", "website":"" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21854756 } , "121866-21875796": { "datetime_modified":"20250806T162329", "datetime_start":"20250404T120000", "datetime_end":"20250404T124500", "has_end_time":1, "date_start":"2025-04-04", "date_end":"2025-04-04", "time_start":"12:00:00", "time_end":"12:45:00", "time_zone":"America\/Detroit", "event_title":"Sea Monsters", "occurrence_title":"", "combined_title":"Sea Monsters", "event_subtitle":"", "event_type":"Film Screening", "event_type_id":"11", "description":"The film follows a curious and adventurous Dolichorhynchops \u2013 familiarly known as a \u2018dolly\u2019 \u2013 as she travels through the most dangerous oceans in history. Along the way, she encounters long-necked plesiosaurs, giant turtles, enormous fish, fierce sharks, and the most dangerous sea monster of all\u2013 the mosasaur.", "occurrence_notes":null, "guid":"121866-21875796@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/121866", "building_id":"1005169", "building_name":"Museum of Natural History", "campus_maps_id":"646", "room":"", "location_name":"Museum of Natural History", "has_livestream":0, "cost":"Tickets are $8 and are available in the museum store on the day of the show.", "tags":["Museum","museums","natural history museum"], "website":"", "sponsors":[ { "group_name":"Planetarium & Dome Theater at the Museum of Natural History", "group_id":"3825", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2024\/05\/event_121866_original-1.jpg", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2024\/05\/event_121866_original-1.jpg", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2024\/05\/event_121866_original-1.jpg", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2024\/05\/event_121866_original-1.jpg", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2024\/05\/event_121866_original-1.jpg", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2024\/05\/event_121866_original-1.jpg", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2024\/05\/event_121866_original-1.jpg", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2024\/05\/event_121866_original-1.jpg", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2024\/05\/event_121866_original-1.jpg", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2024\/05\/event_121866_original-1.jpg", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2024\/05\/event_121866_original-1.jpg", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2024\/05\/event_121866_original-1.jpg", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2024\/05\/event_121866_original-1.jpg", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2024\/05\/event_121866_original-1.jpg", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2024\/05\/event_121866_original-1.jpg", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2024\/05\/event_121866_original-1.jpg" }, "occurrence_count":180, "first_occurrence":21847469 } , "132400-21870884": { "datetime_modified":"20250205T181816", "datetime_start":"20250404T120000", "datetime_end":"20250404T123000", "has_end_time":1, "date_start":"2025-04-04", "date_end":"2025-04-04", "time_start":"12:00:00", "time_end":"12:30:00", "time_zone":"America\/Detroit", "event_title":"Vinson Lam, carillon", "occurrence_title":"", "combined_title":"Vinson Lam, carillon", "event_subtitle":"", "event_type":"Performance", "event_type_id":"15", "description":"Vinson Lam performs on the Charles Baird Carillon, an instrument of 53 bronze bells located inside the Burton Memorial Tower. The largest bell, which strikes the hour, weighs 12 tons, while the smallest bell, 4\u00bd octaves above, weighs just 15 pounds.\n\nThirty-minute recitals are performed on the Charles Baird\u00a0Carillon\u00a0at noon every weekday that classes are in session, followed by visitor Q&A with the carillonist.\u00a0The bell chamber may be accessed via a combination of elevator and stairs. Take the elevator to the highest floor possible (floor 8), and then climb two flights of stairs (39 steps) to the bell chamber (floor 10). Hearing protection earmuffs are provided for visitors. Be prepared to walk on ice and snow in the bell chamber during winter.\u00a0Built in 1936, the Charles Baird\u00a0Carillon\u00a0is not ADA accessible. Visitors with mobility concerns are invited to\u00a0visit the Lurie\u00a0Carillon.", "occurrence_notes":null, "guid":"132400-21870884@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/132400", "building_id":"1000155", "building_name":"Burton Memorial Tower", "campus_maps_id":"25", "room":"", "location_name":"Burton Memorial Tower", "has_livestream":0, "cost":"Free - no tickets required", "tags":["Free","Music","Talk"], "website":"", "sponsors":[ { "group_name":"School of Music, Theatre & Dance (SMTD)", "group_id":"155", "website":"http:\/\/smtd.umich.edu\/events" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2025\/02\/event_132400_original-1.jpg", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2025\/02\/event_132400_original-1.jpg", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2025\/02\/event_132400_original-1.jpg", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2025\/02\/event_132400_original-1.jpg", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2025\/02\/event_132400_original-1.jpg", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2025\/02\/event_132400_original-1.jpg", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2025\/02\/event_132400_original-1.jpg", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2025\/02\/event_132400_original-1.jpg", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2025\/02\/event_132400_original-1.jpg", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2025\/02\/event_132400_original-1.jpg", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2025\/02\/event_132400_original-1.jpg", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2025\/02\/event_132400_original-1.jpg", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2025\/02\/event_132400_original-1.jpg", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2025\/02\/event_132400_original-1.jpg", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2025\/02\/event_132400_original-1.jpg", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2025\/02\/event_132400_original-1.jpg" }, "occurrence_count":1, "first_occurrence":21870884 } }