{ "84794-21624994": { "datetime_modified":"20210728T123440", "datetime_start":"20210802T130000", "datetime_end":"20210802T140000", "has_end_time":1, "date_start":"2021-08-02", "date_end":"2021-08-02", "time_start":"13:00:00", "time_end":"14:00:00", "time_zone":"America\/Detroit", "event_title":"BME PhD Defense: Emine Sumeyra Turali-Emre", "occurrence_title":"", "combined_title":"BME PhD Defense: Emine Sumeyra Turali-Emre: Engineering Biomimetic Nanoparticles for Biomedical Applications", "event_subtitle":"Engineering Biomimetic Nanoparticles for Biomedical Applications", "event_type":"Presentation", "event_type_id":"16", "description":"Biomimetic nanoparticles (NPs) are bio-inspired inorganic nanoscale materials that replicate some biological nanostructures functionalities including self-assembly, catalysis, and enzyme inhibition. These functionalities are being investigated for and, in some cases, are being utilized in optics and electronics such as chemical sensors, superhydrophobic coatings, and antireflective surfaces. This thesis examines the utilization of biomimetic inorganic NPs for various problems in biomedical engineering.\r\n\r\nSpecifically, in the first part of this thesis, I address the problem on controversial explanations of the antibacterial and other biological activity of zinc oxide NPs that are frequently utilized in cosmetics, textiles, and biomedical fields. In the second part of the thesis, I explore the self-organization of NPs into biomimetic supraparticles (SPs) for nucleic acid delivery that can be exploited as drug delivery agents.\r\n\r\nNPs have been used in the antimicrobial field for a long time; however, their antibacterial mechanism of action against different types of bacteria remains unclear and, in many cases, misinterpreted. Most of the studies on antimicrobial NPs suggest reactive oxygen species (ROS) formation, ion release, and membrane damage as the primary source of antibacterial activity. In Chapter 2, we show that the mechanism of antibacterial activity for Staphylococcus aureus is remarkably more complex than generating ROS or the release of Zn2+ ions and is based on formation of biomimetic complexes of NPs with proteins. Gene expression analysis demonstrated that ZnO-NPs significantly affect carbohydrate metabolism and cell energetics, where the uridine monophosphate (UMP) biosynthesis pathway is highly upregulated. In Chapter 3, we explore the ZnO-NP mode of entry into S. aureus and the cell metabolism. Here, we showed that NPs enter the cells within 5 minutes of exposure and induce minimal membrane damage. We note that cells do not depolarize until 60 min post-NPs exposure. Thereby, we highlight that membrane damage is not the primary mechanism of action but rather a downstream effect of ZnO-NPs exposure to bacterial cells. Taken together, causing minimal ROS production and significant changes in carbohydrate metabolism and bioenergetics along with cell entry without immediate membrane damage imply the biomimetic function of these NPs. Further investigation into the antimicrobial mechanisms of biomimetic NPs is essential for future clinical translation. \r\n\r\nOver the past few decades, there has been considerable interest in developing nanoscale constructs as effective delivery tools for high molecular weight drugs. In chapter 4, I explore the self-assembly of NPs into compartmentalized SPs, which mimics the structure of a virus to deliver nucleic acid into cells. The time-dependent self-assembly mechanism reveals that these SPs are formed from nanocup intermediates. We found that this intermediate stage is essential for the utilization of SP compartments. Nucleic acid is added to the system at this stage before SP formation, and high encapsulation is achieved. Similar to virus infections, once cells uptake the SP, SP disassociates in endosomes and releases the cargo.\r\n\r\nOverall, the work presented in this thesis investigates and highlights the strong potential of biomimetic inorganic NPs use in next-generation biomedical applications. \r\n\r\nDate: Monday, August 2, 2021\r\nTIme: 1:00PM\r\nZoom: https:\/\/umich.zoom.us\/j\/95043183845\r\nChair: Prof. Nicholas Kotov", "occurrence_notes":null, "guid":"84794-21624994@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/84794", "building_id":"null", "building_name":"Off Campus Location", "campus_maps_id":"1", "room":"", "location_name":"Virtual", "has_livestream":1, "livestream_type":"zoom", "livetream_require_login":0, "livestream_id":"95043183845", "livestream_link":"https:\/\/umich.zoom.us\/j\/95043183845", "cost":"", "tags":["Science","Michigan Engineering","Medicine","engineering","bme","biomedical engineering","biomedical"], "website":"", "sponsors":[ { "group_name":"Biomedical Engineering", "group_id":"1143", "website":"https:\/\/www.facebook.com\/profile.php?id=100094127215673" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2021\/07\/event_84794_original-1.png", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_thumb\/media\/attachments\/2021\/07\/event_84794_original-1.png", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2021\/07\/event_84794_original-1.png", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2021\/07\/event_84794_original-1.png", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2021\/07\/event_84794_original-1.png", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb\/media\/attachments\/2021\/07\/event_84794_original-1.png", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb_square\/media\/attachments\/2021\/07\/event_84794_original-1.png", "group_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large\/media\/attachments\/2021\/07\/event_84794_original-1.png", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large_lightbox\/media\/attachments\/2021\/07\/event_84794_original-1.png", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_large_crop\/media\/attachments\/2021\/07\/event_84794_original-1.png", "event_list":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_list\/media\/attachments\/2021\/07\/event_84794_original-1.png", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2021\/07\/event_84794_original-1.png", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2021\/07\/event_84794_original-1.png", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_grid_2x\/media\/attachments\/2021\/07\/event_84794_original-1.png", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2021\/07\/event_84794_original-1.png", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_feature_thumb\/media\/attachments\/2021\/07\/event_84794_original-1.png" }, "occurrence_count":1, "first_occurrence":21624994 } , "83925-21619098": { "datetime_modified":"20210506T120651", "datetime_start":"20210802T133000", "datetime_end":"20210802T150000", "has_end_time":1, "date_start":"2021-08-02", "date_end":"2021-08-02", "time_start":"13:30:00", "time_end":"15:00:00", "time_zone":"America\/Detroit", "event_title":"CoderSpaces (Mondays)", "occurrence_title":"", "combined_title":"CoderSpaces (Mondays): Drop-in, Virtual Office Hours", "event_subtitle":"Drop-in, Virtual Office Hours", "event_type":"Meeting", "event_type_id":"14", "description":"Are you grappling with a piece of code, trying to compute on a cluster, or just getting started with a new method such as machine learning? Then we might have just the right space for you.\r\n\r\nAll members of the U-M community are invited to join our weekly virtual CoderSpaces, Mondays \u2013 Thursdays, during the Summer 2021 term to get research support and connect with others.\r\n\r\nThe virtual sessions are designed to assist faculty, staff, and students with research methodology, statistics, data science applications, and computational programming for research.\r\n\r\nOur hosts have a wide set of methodological and technological expertise. They come to you from a variety of departments and disciplines and are looking forward to serving the U-M community in their research endeavors.\r\n\r\nCoderSpaces provide a casual, productive, and inclusive environment. Everyone is welcome regardless of skill level.\r\n\r\nMondays 1:30-3 p.m.\r\n\r\nJoin via Zoom* (https:\/\/umich.zoom.us\/j\/97155787515)\r\n*Users will have to sign in with their UMICH (Level-1) credentials.\r\n\r\nwith Andrew Hlynka (CSCAR), Charles Antonelli (LSA Tech), Jonathan Golob (Michigan Medicine)\r\n\r\nExpertise: 3D graphical applications, C, C++, C#, CMake\/GNU Make, Fortran, Git, high performance computing, Java, JavaScript, Julia, Matlab, mobile app development, MPI, OpenMP, parallelization, performance analysis, PBS, Python, R, reproducible workflows (nextflow), shell, Slurm, SQL, statistical modeling", "occurrence_notes":null, "guid":"83925-21619098@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/83925", "building_id":"null", "building_name":"Off Campus Location", "campus_maps_id":"1", "room":"", "location_name":"Virtual", "has_livestream":1, "livetream_require_login":1, "cost":"", "tags":["Arc","Information And Technology","Office Hours","Data Science"], "website":"https:\/\/datascience.isr.umich.edu\/events\/coderspaces\/", "sponsors":[ { "group_name":"Information and Technology Services (ITS)", "group_id":"1179", "website":"https:\/\/x.com\/umichTECH" }, { "group_name":"CSCAR Workshops", "group_id":"2743", "website":"http:\/\/cscar.research.umich.edu\/" }, { "group_name":"Center for Political Studies - Institute for Social Research", "group_id":"3159", "website":"http:\/\/www.isr.umich.edu\/cps\/" }, { "group_name":"Institute for Healthcare Policy and Innovation", "group_id":"3336", "website":"http:\/\/www.ihpi.umich.edu" }, { "group_name":"Population Studies Center", "group_id":"3619", "website":"http:\/\/www.psc.isr.umich.edu\/" }, { "group_name":"LSA Technology Services", "group_id":"4207", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2021\/05\/event_83925_original-2.png", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2021\/05\/event_83925_original-2.png", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2021\/05\/event_83925_original-2.png", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2021\/05\/event_83925_original-2.png", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2021\/05\/event_83925_original-2.png", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2021\/05\/event_83925_original-2.png", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2021\/05\/event_83925_original-2.png", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2021\/05\/event_83925_original-2.png", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2021\/05\/event_83925_original-2.png", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2021\/05\/event_83925_original-2.png", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2021\/05\/event_83925_original-2.png", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2021\/05\/event_83925_original-2.png", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2021\/05\/event_83925_original-2.png", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2021\/05\/event_83925_original-2.png", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2021\/05\/event_83925_original-2.png", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2021\/05\/event_83925_original-2.png" }, "occurrence_count":16, "first_occurrence":21619085 } , "77718-20270716": { "datetime_modified":"20211209T160155", "datetime_start":"20210802T140000", "datetime_end":"20210802T150000", "has_end_time":1, "date_start":"2021-08-02", "date_end":"2021-08-02", "time_start":"14:00:00", "time_end":"15:00:00", "time_zone":"America\/Detroit", "event_title":"LSA Technology Services Research Support Office Hours", "occurrence_title":"", "combined_title":"LSA Technology Services Research Support Office Hours", "event_subtitle":"", "event_type":"Other", "event_type_id":"22", "description":"The Research Team within LSA Technology Services is excited to announce virtual office hours for research computing support. These are regularly scheduled times when we will have subject matter experts in geographic information systems, high performance computing, digital scholarship, and computer programming available for drop-in support. Faculty, staff, and students with research-related questions pertaining to any of these areas can stop by to ask questions, get help working through a problem, or inquire about a new project\u2014no appointment necessary!\r\n\r\nNot sure what we can do to help? Read on for more details about the services provided by each of these teams.\r\n\r\n*Digital Scholarship*\r\nOur digital scholarship team specializes in humanities, social sciences, and interdisciplinary digital project methods and can provide assistance with:\r\n* Conceptualizing, planning, and finding resources for a digital project\r\n* How to version, archive, and preserve a project\r\n* Sustainability, preservation, accessibility, privacy, consent, or grant requirements\r\nNew to digital projects? We can also talk about how to demonstrate the scholarly rigor of your digital project, accurately credit the labor required of the project at every stage, and how to provide evidence and metrics for promotion and job dossiers.\r\n\r\n*Geographic Information Systems (GIS)*\r\n\r\nOur GIS specialists can help with your geographic data needs, including the following:\r\n* Making maps for use in a class, grant proposal, or publication\r\n* Geospatial analysis: identifying spatial patterns and trends in your data\r\n* Georeferencing: assigning geographic coordinates to a historic paper map or a hand-drawn sketch for digital use as a basemap or combined display with other data\r\n* Geocoding: convert a spreadsheet with addresses into latitude-longitude so you can plot your data on a map\r\n* StoryMaps: harness the power of maps to tell your story\r\n* Integrating smartphones or tablets and GIS in your field courses or researchSetting up workshops for a class or group interested in learning to use GIS in the context of your discipline\r\n* Assistance with ESRI's ArcGIS platform, including ArcGIS Pro and ArcGIS Online, or other geospatial software\r\n* Developing your own custom GIS web application or mobile application\r\n\r\n*High Performance Computing (HPC)*\r\n\r\nOur HPC team can help with:\r\n* Accessing U-M\u2019s new Great Lakes HPC (High Performance Computing) cluster\r\n* Moving your computational work from your laptop or workstation to the cluster, freeing up your machines for other tasks\r\n* Compiling, installing, or configuring a wide range of computational software\r\n* Setting up automated workflows to save time\r\n* Debugging your programs to see why they are crashing\r\n* Evaluating the benefits of parallel computing, more memory or system resources for your code\r\nWe regularly support Python, R, MATLAB, C\/C++, Java, Julia, Go, and many other applications.\r\n\r\n*Research Support Programming*\r\n\r\nOur computer programming team can help with any of 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