{ "123842-21851944": { "datetime_modified":"20240925T123230", "datetime_start":"20240910T160000", "datetime_end":"20240910T170000", "has_end_time":1, "date_start":"2024-09-10", "date_end":"2024-09-10", "time_start":"16:00:00", "time_end":"17:00:00", "time_zone":"America\/Detroit", "event_title":"Mercer | Government Human Services Consulting Practice Overview", "occurrence_title":"", "combined_title":"Mercer | Government Human Services Consulting Practice Overview", "event_subtitle":"", "event_type":"Careers \/ Jobs", "event_type_id":"2", "description":"Are you ready to unlock the secrets to becoming a more effective purchaser of healthcare? Look no further than Mercer Government Human Services Consulting (GHSC), your trusted partner in navigating the complex world of public healthcare. Our team of experts is here to empower public entities with the knowledge and tools they need to make informed decisions. Join us virtually on September 10th for an exclusive event that willgive you an inside look into the incredible work we do. Get ready to heardirectly from our colleagues, gain valuable insights into career opportunities, and discover how Mercer GHSC is revolutionizing the healthcare landscape for public entities. Don't miss out on this exciting opportunity to shape the future of healthcare. We can't wait to see you there!", "occurrence_notes":null, "guid":"123842-21851944@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/123842", "building_id":"", "building_name":"", "campus_maps_id":"", "room":"", "location_name":"", "has_livestream":0, "cost":"", "tags":[], "website":"", "sponsors":[ { "group_name":"University Career Center UCC", "group_id":"1140", "website":"http:\/\/careercenter.umich.edu" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21851944 } , "125950-21856342": { "datetime_modified":"20240925T123327", "datetime_start":"20240910T160000", "datetime_end":"20240910T164500", "has_end_time":1, "date_start":"2024-09-10", "date_end":"2024-09-10", "time_start":"16:00:00", "time_end":"16:45:00", "time_zone":"America\/Detroit", "event_title":"Unlock Opportunities for Accounting Majors", "occurrence_title":"", "combined_title":"Unlock Opportunities for Accounting Majors", "event_subtitle":"", "event_type":"Careers \/ Jobs", "event_type_id":"2", "description":"To attend and receive the virtual link for this event, youMUST RSVP using the link below:https:\/\/tinyurl.com\/2ymbcwwmAccounting majors, this session is for you! Join us to hear from PwC audit, digital assurance & transparency and tax services professionals who will share aday in life of their respective roles and the driving factors that helpedthem select their career path. During this event you'll learn about the many ways you can put a degree in accounting to work.", "occurrence_notes":null, "guid":"125950-21856342@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/125950", "building_id":"", "building_name":"", "campus_maps_id":"", "room":"", "location_name":"", "has_livestream":0, "cost":"", "tags":[], "website":"", "sponsors":[ { "group_name":"University Career Center UCC", "group_id":"1140", "website":"http:\/\/careercenter.umich.edu" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21856342 } , "109309-21821374": { "datetime_modified":"20240827T110923", "datetime_start":"20240910T160000", "datetime_end":"20240910T171500", "has_end_time":1, "date_start":"2024-09-10", "date_end":"2024-09-10", "time_start":"16:00:00", "time_end":"17:15:00", "time_zone":"America\/Detroit", "event_title":"Utilizing Biocatalysis and Synthetic Chemistry to Access New Natural Products", "occurrence_title":"", "combined_title":"Utilizing Biocatalysis and Synthetic Chemistry to Access New Natural Products: Elizabeth Parkinson (Purdue)", "event_subtitle":"Elizabeth Parkinson (Purdue)", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Natural products (NPs) are a bountiful source of bioactive molecules. Bioinformatics data suggest hundreds-of-thousands of novel NPs remain to be discovered. Unfortunately, many NPs are not produced under standard laboratory conditions. We are developing methods to access NPs from cryptic biosynthetic gene clusters (BGCs) utilizing a combination of bioinformatics, synthetic chemistry, and biocatalysis. Specifically, we are focused in two areas: cyclic peptides and \u03b3-butyrolactone (GBL) hormones. For cyclic peptides, we recently developed SNaPP (Synthetic Natural Product Inspired Cyclic Peptides). SNaPP expedites bioactive molecule discovery by combining bioinformatics predictions of non-ribosomal peptide synthetases with chemical synthesis of the predicted natural products. SNaPP enabled us to discover several bioactive cyclic peptides. However, it also opened our eyes to the challenge of synthesizing small cyclic peptides. Using the results from SNaPP, we identified a PBP-like cyclase capable of performing challenging cyclizations, such as for tetrapeptides with a greatly expanded substrate scope that could have great utility as a biocatalyst. For GBLs, these molecules have previously been found to induce production of many bioactive NPs. Over half of Streptomyces strains are predicted to have GBL signaling pathways. Unfortunately, only a few GBLs and their cognate repressors are known because 1) GBLs are produced at very low quantities and 2) no rapid, efficient assays exist to identify them. We bioinformatically predicted previously uncharacterized GBL receptors that we predict bind to known GBLs or close derivatives. We have developed synthetic and biocatalytic methods to access GBLs and derivatives in fewer steps and improved stereoselectivies. Finally, we have developed GFP-based assays that allow rapid identification of active hormones. This information will allow us to further explore the addition of exogenous hormones as a method to induce production of cryptic biosynthetic gene clusters.", "occurrence_notes":null, "guid":"109309-21821374@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/109309", "building_id":"1000158", "building_name":"Chemistry Dow Lab", "campus_maps_id":"34", "room":"1640", "location_name":"Chemistry Dow Lab", "has_livestream":0, "cost":"", "tags":["Chemical Biology","Chemistry"], "website":"https:\/\/www.purdue.edu\/academics\/ogsps\/pulse\/groups\/profiles\/faculty\/parkinson.html", "sponsors":[ { "group_name":"Department of Chemistry", "group_id":"3761", "website":"https:\/\/lsa.umich.edu\/chem" }, { "group_name":"LSA Biophysics", "group_id":"3767", "website":"" }, { "group_name":"Chemical Biology", "group_id":"4385", "website":"" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21821374 } }