{ "131118-21867762": { "datetime_modified":"20250114T090454", "datetime_start":"20250408T120000", "datetime_end":"20250408T130000", "has_end_time":1, "date_start":"2025-04-08", "date_end":"2025-04-08", "time_start":"12:00:00", "time_end":"13:00:00", "time_zone":"America\/Detroit", "event_title":"Department of Biological Chemistry Seminar Series: Interrogating the Druggable Proteome with Proximity Pharmacology", "occurrence_title":"", "combined_title":"Department of Biological Chemistry Seminar Series: Interrogating the Druggable Proteome with Proximity Pharmacology: Dr. Fleur Ferguson, University of California, San Diego", "event_subtitle":"Dr. Fleur Ferguson, University of California, San Diego", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Please join us for a seminar at 12 noon in 3330 MS I.", "occurrence_notes":null, "guid":"131118-21867762@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/131118", "building_id":"1000190", "building_name":"Medical Science Unit I", "campus_maps_id":"104", "room":"3330", "location_name":"Medical Science Unit I", "has_livestream":0, "cost":"", "tags":["biolgical chemistry","biological","biological chemistry","biological science","biology","Biosciences","Life Science","Basic Science"], "website":"", "sponsors":[ { "group_name":"Biological Chemistry", "group_id":"3136", "website":"" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21867762 } , "134642-21874652": { "datetime_modified":"20250403T113332", "datetime_start":"20250408T120000", "datetime_end":"20250408T130000", "has_end_time":1, "date_start":"2025-04-08", "date_end":"2025-04-08", "time_start":"12:00:00", "time_end":"13:00:00", "time_zone":"America\/Detroit", "event_title":"EEB Tuesday Seminar Series - Seasonal migration as a driver of life history trade-offs and genetic diversity in Nearctic-Neotropical passerines", "occurrence_title":"", "combined_title":"EEB Tuesday Seminar Series - Seasonal migration as a driver of life history trade-offs and genetic diversity in Nearctic-Neotropical passerines: Max Witynski, Ph.D. Student EEB, Winger Lab", "event_subtitle":"Max Witynski, Ph.D. Student EEB, Winger Lab", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Evolutionary trade-offs between fecundity and survival are ubiquitous in evolution. In high-latitude seasonal environments, most birds breed during resource-rich summers, and migrate to lower-latitude environments during the winter to survive. However, the trade-off between fecundity and survival appears to scale with migration distance: By migrating farther, birds may gain higher survival benefits, but in doing so, they sacrifice time that they might have spent raising offspring. Longer migrations are thus associated with \"slower\" life histories (higher survival, fewer offspring), but this apparently straightforward trade-off belies an intriguing underlying paradox: Slower life histories are typically associated with lower genetic diversity, but in migratory birds, there is evidence that longer migrations are positively correlated with genetic diversity, possibly because they promote demographic stability. Nevertheless, populations of long-distance migrants readily switch strategies, implying that populations will move quickly toward new optima if migration\u2019s survival benefits no longer outweigh its reproductive costs, with unknown population genetic consequences. My dissertation will combine movement ecology and population genetics to assess the ways in which seasonal migration has mediated life history trade-offs and impacted genetic diversity within species, with the goal of understanding how the risks of migration have translated to rewards over evolutionary timescales.", "occurrence_notes":null, "guid":"134642-21874652@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/134642", "building_id":"1005169", "building_name":"Biological Sciences Building", "campus_maps_id":"631", "room":"1010", "location_name":"Biological Sciences Building", "has_livestream":0, "cost":"", "tags":["evolutionary biology","evolution","environmental","Environment","eeb","Ecosystems","ecosystem","Ecology And Evolutionary Biology","Ecology & Biology","Ecology","Biology"], "website":"", "sponsors":[ { "group_name":"EEB Tuesday Lunch Seminars", "group_id":"3823", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2025\/04\/event_134642_original-1.png", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2025\/04\/event_134642_original-1.png", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2025\/04\/event_134642_original-1.png", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2025\/04\/event_134642_original-1.png", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2025\/04\/event_134642_original-1.png", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb\/media\/attachments\/2025\/04\/event_134642_original-1.png", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb_square\/media\/attachments\/2025\/04\/event_134642_original-1.png", "group_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large\/media\/attachments\/2025\/04\/event_134642_original-1.png", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large_lightbox\/media\/attachments\/2025\/04\/event_134642_original-1.png", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_large_crop\/media\/attachments\/2025\/04\/event_134642_original-1.png", "event_list":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_list\/media\/attachments\/2025\/04\/event_134642_original-1.png", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2025\/04\/event_134642_original-1.png", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2025\/04\/event_134642_original-1.png", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_grid_2x\/media\/attachments\/2025\/04\/event_134642_original-1.png", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_feature_large\/media\/attachments\/2025\/04\/event_134642_original-1.png", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_feature_thumb\/media\/attachments\/2025\/04\/event_134642_original-1.png" }, "occurrence_count":1, "first_occurrence":21874652 } , "133612-21873303": { "datetime_modified":"20250310T090903", "datetime_start":"20250408T120000", "datetime_end":"20250408T130000", "has_end_time":1, "date_start":"2025-04-08", "date_end":"2025-04-08", "time_start":"12:00:00", "time_end":"13:00:00", "time_zone":"America\/Detroit", "event_title":"Elliot S. Valenstein Distinguished Lecture | Synapse Specific Structural Plasticity: A Cellular Mechanism of Spaced Learning", "occurrence_title":"", "combined_title":"Elliot S. Valenstein Distinguished Lecture | Synapse Specific Structural Plasticity: A Cellular Mechanism of Spaced Learning: Kristen Harris, Professor of Neuroscience at the University of Texas at Austin", "event_subtitle":"Kristen Harris, Professor of Neuroscience at the University of Texas at Austin", "event_type":"Lecture \/ Discussion", "event_type_id":"13", "description":"Synapses form trillions of connections in the brain. Long-term potentiation (LTP) is a cellular mechanism vital for learning that modifies the strength and structure of synapses. Three-dimensional electron microscopy reveals distinct pre- to post-synaptic arrangements: strong active zones (AZs) with tightly docked vesicles, weak AZs with loose or non-docked vesicles, and nascent zones (NZs) with a postsynaptic density but no presynaptic vesicles. LTP can be temporarily saturated preventing further increases in synaptic strength. I will discuss how NZ plasticity provides a time dependent and synapse-specific AZ expansion during LTP that ultimately encourages highly effective dendritic spine clusters regulated by the spine apparatus. I will also tell you why we have developed a new synaptopodin knockout rat system to investigate mechanisms of this process. We propose that the saturation of LTP protects recently formed memories and that the regrowth of nascent zones may account for the advantage of spaced over massed learning.\r\n\r\nAbout the speaker: Kristen Harris\u2019s professional career started at Harvard Medical school where she rose to the rank of associate professor. She was the recruited as a full Professor to Boston Univ. where she helped establish their graduate program in experimental and computational neuroscience. She was recruited as a Georgia Research Alliance Eminent scholar to the Medical College of Georgia, and in 2006 joined the Center for Learning and Memory at the University of Texas at Austin. She is renowned for her work on synapse structure and function pioneering three-dimensional reconstruction from serial section electron microscopy. Her lab had developed novel tools sharing them and data (synapseweb.clm.utexas.edu) that are widely used resources. She is the recipient of Sloan Research Fellowship, Javits Merit Award, Brain Research Foundation Fellowship, and continuous funding for her lab, including her current lead as PI on the NSF NeuroNex grant to investigate synaptic weight with 26 international and national coPIs. She is known for innovative teaching and presentations at conferences worldwide. She was recently elected to the National Academy of Sciences.\r\n\r\nThe talk will be followed by a reception with light refreshments.", "occurrence_notes":null, "guid":"133612-21873303@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/133612", "building_id":"1000166", "building_name":"East Hall", "campus_maps_id":"53", "room":"4448", "location_name":"East Hall", "has_livestream":0, "cost":"", "tags":["Psychology","Neuroscience"], "website":"", "sponsors":[ { "group_name":"Department of Psychology", "group_id":"3615", "website":"http:\/\/www.lsa.umich.edu\/psych\/" }, { "group_name":"Brain & Behavior", "group_id":"3662", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2025\/03\/event_133612_original-1.png", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2025\/03\/event_133612_original-1.png", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2025\/03\/event_133612_original-1.png", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2025\/03\/event_133612_original-1.png", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2025\/03\/event_133612_original-1.png", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb\/media\/attachments\/2025\/03\/event_133612_original-1.png", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb_square\/media\/attachments\/2025\/03\/event_133612_original-1.png", "group_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large\/media\/attachments\/2025\/03\/event_133612_original-1.png", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large_lightbox\/media\/attachments\/2025\/03\/event_133612_original-1.png", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_large_crop\/media\/attachments\/2025\/03\/event_133612_original-1.png", "event_list":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_list\/media\/attachments\/2025\/03\/event_133612_original-1.png", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2025\/03\/event_133612_original-1.png", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2025\/03\/event_133612_original-1.png", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_grid_2x\/media\/attachments\/2025\/03\/event_133612_original-1.png", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_feature_large\/media\/attachments\/2025\/03\/event_133612_original-1.png", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2025\/03\/event_133612_original-1.png" }, "occurrence_count":1, "first_occurrence":21873303 } }