{ "125093-21854406": { "datetime_modified":"20250326T093027", "datetime_start":"20250408T160000", "datetime_end":"", "has_end_time":0, "date_start":"2025-04-08", "date_end":"", "time_start":"16:00:00", "time_end":"", "time_zone":"America\/Detroit", "event_title":"The Radical Lives of Anaerobes and How to Fight Them", "occurrence_title":"", "combined_title":"The Radical Lives of Anaerobes and How to Fight Them: Brandon Greene (UCSB)", "event_subtitle":"Brandon Greene (UCSB)", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Pathogenic bacteria that infect the gastrointestinal and respiratory tract form biofilms that are largely anaerobic, modulating their metabolic lifestyle and virulence. Many of these microbes utilize acetate fermentation via the enzyme pyruvate formate lyase (PFL), which catalyzes the production of acetyl-CoA and formate from pyruvate via a radical mechanism, enabling additional ATP production and the de novo synthesis of proteins and nucleic acids. We have investigated the mechanism of PFL via mechanism-based inhibitors to reveal the essential role of two cysteine thiyl radicals in catalysis and estimate their reactivity for the first time. Additionally, we have demonstrated the role of nitric oxide (NO) as an irreversible inhibitor of they glycyl radical enzyme PFL as well as glycyl radical enzymes as a class and their radical S-adenosylmethionine-dependent activases via the production of dinitrosyl iron complexes. These results set the stage for the development of mechanism-based inhibitors of PFL and other glycyl radical enzymes and provide a biochemically informed approach to narrow-spectrum site-specific antibiotic development for the treatment of gastrointestinal and pulmonary disease.", "occurrence_notes":null, "guid":"125093-21854406@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/125093", "building_id":"1000158", "building_name":"Chemistry Dow Lab", "campus_maps_id":"34", "room":"1640", "location_name":"Chemistry Dow Lab", "has_livestream":0, "cost":"", "tags":["Chemical Biology","Chemistry"], "website":"https:\/\/www.chem.ucsb.edu\/people\/brandon-greene", "sponsors":[ { "group_name":"Department of Chemistry", "group_id":"3761", "website":"https:\/\/lsa.umich.edu\/chem" }, { "group_name":"LSA Biophysics", "group_id":"3767", "website":"" }, { "group_name":"Chemical Biology", "group_id":"4385", "website":"" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21854406 } , "134551-21874506": { "datetime_modified":"20250401T114502", "datetime_start":"20250408T160000", "datetime_end":"20250408T173000", "has_end_time":1, "date_start":"2025-04-08", "date_end":"2025-04-08", "time_start":"16:00:00", "time_end":"17:30:00", "time_zone":"America\/Detroit", "event_title":"Why Gender History Needs Women\u2019s History (and vice-versa)", "occurrence_title":"", "combined_title":"Why Gender History Needs Women\u2019s History (and vice-versa): Margaret Chowning", "event_subtitle":"Margaret Chowning", "event_type":"Lecture \/ Discussion", "event_type_id":"13", "description":"Margaret Chowning is the Muriel McKevitt Sonne Chair Professor of Latin American History (emerita) at the University of California, Berkeley. She is the author of Wealth and Power in Provincial Mexico from the Late Colony to the Revolution (Stanford, 1999), Rebellious Nuns: The Troubled History of a Mexican Convent (Oxford, 2006), and Catholic Women and Mexican Politics, 1750-1940 (Princeton, 2023).\u00a0She is working on a book of urban history in Mexico, with special attention to the impact that liberal policies and liberal \u201cvalues\u201d exerted on gender relations and urban life in the nineteenth century.\r\n\r\nHer presentation, \u201cWhy Gender History Needs Women\u2019s History (and vice-versa),\u201d is drawn from her experience conceptualizing, researching, and organizing her recent book, Catholic Women and Mexican Politics.", "occurrence_notes":null, "guid":"134551-21874506@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/134551", "building_id":"1000152", "building_name":"Tisch Hall", "campus_maps_id":"541", "room":"1014", "location_name":"Tisch Hall", "has_livestream":0, "cost":"", "tags":["History","Humanities","Latin America","Women's Studies"], "website":"", "sponsors":[ { "group_name":"Department of History", "group_id":"3470", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2025\/04\/event_134551_original-1.jpg", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2025\/04\/event_134551_original-1.jpg", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2025\/04\/event_134551_original-1.jpg", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2025\/04\/event_134551_original-1.jpg", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2025\/04\/event_134551_original-1.jpg", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb\/media\/attachments\/2025\/04\/event_134551_original-1.jpg", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb_square\/media\/attachments\/2025\/04\/event_134551_original-1.jpg", "group_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large\/media\/attachments\/2025\/04\/event_134551_original-1.jpg", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large_lightbox\/media\/attachments\/2025\/04\/event_134551_original-1.jpg", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_large_crop\/media\/attachments\/2025\/04\/event_134551_original-1.jpg", "event_list":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_list\/media\/attachments\/2025\/04\/event_134551_original-1.jpg", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2025\/04\/event_134551_original-1.jpg", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2025\/04\/event_134551_original-1.jpg", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_grid_2x\/media\/attachments\/2025\/04\/event_134551_original-1.jpg", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_feature_large\/media\/attachments\/2025\/04\/event_134551_original-1.jpg", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_feature_thumb\/media\/attachments\/2025\/04\/event_134551_original-1.jpg" }, "occurrence_count":1, "first_occurrence":21874506 } , "133548-21873231": { "datetime_modified":"20250408T142035", "datetime_start":"20250408T160000", "datetime_end":"20250408T190000", "has_end_time":1, "date_start":"2025-04-08", "date_end":"2025-04-08", "time_start":"16:00:00", "time_end":"19:00:00", "time_zone":"America\/Detroit", "event_title":"Winter 2025 - Diversity and Inclusion Department Design Showcases", "occurrence_title":"Michigan Housing Diversity and Inclusion Design Showcase", "combined_title":"Winter 2025 - Diversity and Inclusion Department Design Showcases: Michigan Housing Diversity and Inclusion Design Showcase", "event_subtitle":"", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"The Michigan Housing Diversity and Inclusion Department is looking forward to starting the design process for three new multicultural spaces which will be part of the Central Campus Residential Development, scheduled to open in Fall of 2026:Building One - Grace Lee Boggs Multicultural Lounge\nBuilding Three - Mino-Bimaadiziwin Multicultural Lounge\nBuilding Five - Origins Multicultural Engagement Space\nThe focus of the design showcases will be to gather feedback related to the functional components of the lounge, such as the furniture and color schemes for each lounge. The design showcase opportunities are drop-in style, so please join us at any point of time you are able.", "occurrence_notes":null, "guid":"133548-21873231@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/133548", "building_id":"", "building_name":"", "campus_maps_id":"", "room":"", "location_name":"Ambatana - The Afro American Multicultural Lounge, South Quad, 600 East Madison Street, Ann Arbor, MI", "has_livestream":0, "cost":"", "tags":["Sessions"], "website":"https:\/\/sessions.studentlife.umich.edu\/p\/track\/13963", "sponsors":[ { "group_name":"Sessions @ Michigan", "group_id":"4791", "website":"https:\/\/sessions.studentlife.umich.edu\/" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21873231 } }