{ "109108-21821076": { "datetime_modified":"20240314T152302", "datetime_start":"20240412T120000", "datetime_end":"20240412T130000", "has_end_time":1, "date_start":"2024-04-12", "date_end":"2024-04-12", "time_start":"12:00:00", "time_end":"13:00:00", "time_zone":"America\/Detroit", "event_title":"Structural mechanisms of DNA priming by polymerase \u03b1\u2013primase", "occurrence_title":"", "combined_title":"Structural mechanisms of DNA priming by polymerase \u03b1\u2013primase: Brandt Eichman (Vanderbilt)", "event_subtitle":"Brandt Eichman (Vanderbilt)", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"The mechanism by which polymerase \u03b1\u2013primase (pol\u03b1\u2013primase) synthesizes chimeric RNA-DNA primers of defined length and composition, necessary for replication fidelity and genome stability, is unknown. Here, we report cryo-EM structures of pol\u03b1\u2013primase in complex with primed templates representing various stages of DNA synthesis. Our data show how interaction of the primase regulatory subunit with the primer 5\u2032-end facilitates handoff of the primer to pol\u03b1 and increases pol\u03b1 processivity, thereby regulating both RNA and DNA composition. The structures detail how flexibility within the heterotetramer enables synthesis across two active sites and provide evidence that termination of DNA synthesis is facilitated by reduction of pol\u03b1 and primase affinities for the varied conformations along the chimeric primer\/template duplex. Together, these findings elucidate a critical catalytic step in replication initiation and provide a comprehensive model for primer synthesis by pol\u03b1\u2013primase.", "occurrence_notes":null, "guid":"109108-21821076@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/109108", "building_id":"1000158", "building_name":"Chemistry Dow Lab", "campus_maps_id":"34", "room":"1640", "location_name":"Chemistry Dow Lab", "has_livestream":0, "cost":"", "tags":["Biophysics","seminar"], "website":"", "sponsors":[ { "group_name":"LSA Biophysics", "group_id":"3767", "website":"" }, { "group_name":"Department of Physics", "group_id":"1965", "website":"" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21821076 } , "115674-21835360": { "datetime_modified":"20231214T123048", "datetime_start":"20240412T120000", "datetime_end":"20240412T160000", "has_end_time":1, "date_start":"2024-04-12", "date_end":"2024-04-12", "time_start":"12:00:00", "time_end":"16:00:00", "time_zone":"America\/Detroit", "event_title":"The Art of Resistance in Early America", "occurrence_title":"", "combined_title":"The Art of Resistance in Early America", "event_subtitle":"", "event_type":"Exhibition", "event_type_id":"7", "description":"The exhibition addresses the theme of the LSA Fall 2023 semester at the University of Michigan: \"Arts & Resistance.\" This exhibit asks us to think about resistance in different settings, and in different forms. What \"arts\" did Americans in the eighteenth and nineteenth centuries use to resist various forms of power? The exhibit aims to show how the people of our nation's past tried to answer those questions\r\n\r\nExhibit Hours: Monday - Friday - Noon - 4 pm\r\n\r\nLink to online exhibit:https:\/\/clements.umich.edu\/exhibit\/the-art-of-resistance\/", "occurrence_notes":null, "guid":"115674-21835360@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/115674", "building_id":"1000159", "building_name":"William Clements Library", "campus_maps_id":"165", "room":"", "location_name":"William Clements Library", "has_livestream":0, "cost":"", "tags":["american culture","american history","Free","history","In Person","libraries","Library","Tour","Undergraduate","Undergraduate Students"], "website":"https:\/\/clements.umich.edu\/exhibit\/the-art-of-resistance\/", "sponsors":[ { "group_name":"William L. 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This is an opportunity to learn about the work our practice settings and opportunities as an integral member of our Retail, Inpatient, Infusion and Specialty patient care teams.\n\nOur Human Resources team will also be on hand, discussing and answering questions about our benefits, our health system, and the Cincinnati area. \n\nThis event is open to both new pharmacy residency graduates, as well as experienced pharmacists and those interested in relocating to the Cincinnati area. \n", "occurrence_notes":null, "guid":"120156-21844164@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/120156", "building_id":"", "building_name":"", "campus_maps_id":"", "room":"", "location_name":"", "has_livestream":0, "cost":"", "tags":[], "website":"", "sponsors":[ { "group_name":"University Career Center UCC", "group_id":"1140", "website":"http:\/\/careercenter.umich.edu" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21844164 } }