{ "109814-21823014": { "datetime_modified":"20230804T133936", "datetime_start":"20231127T090000", "datetime_end":"20231127T200000", "has_end_time":1, "date_start":"2023-11-27", "date_end":"2023-11-27", "time_start":"09:00:00", "time_end":"20:00:00", "time_zone":"America\/Detroit", "event_title":"Illustrating the Renaissance Book: From Illumination to Woodcut", "occurrence_title":"", "combined_title":"Illustrating the Renaissance Book: From Illumination to Woodcut", "event_subtitle":"", "event_type":"Exhibition", "event_type_id":"7", "description":"Enjoy a selection of manuscripts and early printed books from the 15th to the 17th centuries that were illustrated with illuminations and woodcuts. Throughout the European Renaissance (1300-1700), many book illustrations were exclusively ornamental, while others focused on enhancing the meaning of the text. However, as the pages on display attest, all these illustrations share a common ground: they reveal the aesthetic and intellectual fashions first proposed by Italian artists of the 1400s, who were strongly committed to the recovery of the past of classical antiquity.\r\n\r\nThe word \u201cIllumination,\u201d from the Latin illuminare, \u201cto enlighten or to illuminate,\u201d refers to the embellishment of a manuscript or early printed book with luminous colors, notably gold and silver. This illumination was prominent in the frontispiece, or first page of text, which included the decoration of its borders and initial letter, and even miniatures, that is, scenes with an independent narrative. With the introduction of movable-type printing in 1454, these illuminations would be gradually replaced by woodcuts, which were printed from a woodblock that had been cut by knife along the grain of the wood.\r\n\r\nAvailable during Hatcher Gallery Exhibit Room hours (https:\/\/myumi.ch\/2m7d4).\r\n\r\nJoin us on September 13 for a talk by Pablo Alvarez, curator of the exhibit.", "occurrence_notes":null, "guid":"109814-21823014@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/109814", "building_id":"1000181", "building_name":"Hatcher Graduate Library", "campus_maps_id":"65", "room":"Hatcher Gallery Exhibit Room, 1st Floor", "location_name":"Hatcher Graduate Library", "has_livestream":0, "cost":"", "tags":["Library","Free","Exhibition","Books"], "website":"", "sponsors":[ { "group_name":"University Library", "group_id":"1186", "website":"https:\/\/www.facebook.com\/UMichLibrary\/" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2023\/08\/event_109814_original-1.jpeg", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2023\/08\/event_109814_original-1.jpeg", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2023\/08\/event_109814_original-1.jpeg", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2023\/08\/event_109814_original-1.jpeg", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2023\/08\/event_109814_original-1.jpeg", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2023\/08\/event_109814_original-1.jpeg", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2023\/08\/event_109814_original-1.jpeg", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2023\/08\/event_109814_original-1.jpeg", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2023\/08\/event_109814_original-1.jpeg", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2023\/08\/event_109814_original-1.jpeg", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2023\/08\/event_109814_original-1.jpeg", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2023\/08\/event_109814_original-1.jpeg", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2023\/08\/event_109814_original-1.jpeg", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2023\/08\/event_109814_original-1.jpeg", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2023\/08\/event_109814_original-1.jpeg", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2023\/08\/event_109814_original-1.jpeg" }, "occurrence_count":96, "first_occurrence":21822932 } , "109535-21822252": { "datetime_modified":"20230805T113442", "datetime_start":"20231127T090000", "datetime_end":"20231127T160000", "has_end_time":1, "date_start":"2023-11-27", "date_end":"2023-11-27", "time_start":"09:00:00", "time_end":"16:00:00", "time_zone":"America\/Detroit", "event_title":"Sarah Buckius: !!!techn010ffspring!!!", "occurrence_title":"", "combined_title":"Sarah Buckius: !!!techn010ffspring!!!: Lane Hall Exhibit, Fall 2023", "event_subtitle":"Lane Hall Exhibit, Fall 2023", "event_type":"Exhibition", "event_type_id":"7", "description":"Come explore the intricate and interlocking world of Sarah Buckius\u2019 \u201c!!!techn010ffspring!!!\u201d where feminist art meets science and the history of invention. On view at Lane Hall as part of U-M Arts Initiative\u2019s themed semester on Arts & Resistance, \u201c!!!techn010ffspring!!!\u201d critiques the patriarchal paradigms of the STEM field by highlighting the history of women inventors. This exhibition brings conceptual invention in fine art and performance to the disciplines of information technology, robotics, and engineering. Buckius creates \u201ctechnoffsprings\u201d: complex machines that weave together the history of inventions related to the gendered labor of women, especially regarding women\u2019s social roles as caregivers and subjects of care themselves. \r\nTrained as an engineer and an artist, Buckius\u2019 machines are intentionally complex, layered, and illogical or absurdly logical. In the nature of women\u2019s caregiving, they teeter between order and chaos. Her \u201cdigital tinkerings\u201d tell epic tales of motherhood, technology, female bodies, and commerce\u2014both personal and externalized through women\u2019s inventions and early forays that bridged caregiving and commerce. Buckius' work proposes improvisation as a form of absurdist resistance to, and alternative to, patriarchal, capitalist, production-based, and seemingly rational, useful, logical systems. \r\n\u201c!!!techn010ffspring!!!\u201d is open for viewing M-F, 9am-4pm or by appointment. University of Michigan instructors can email LaneHallExhibits@umich.edu to request a group tour or schedule a class visit.\r\nThis project was made possible by a grant from the Arts Initiative at the University of Michigan and co-sponsored by U-M\u2019s Department of Women\u2019s and Gender Studies and the Institute for Research on Women and Gender with support from the Santa Cruz County Arts Council.", "occurrence_notes":null, "guid":"109535-21822252@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/109535", "building_id":"1000183", "building_name":"Lane Hall", "campus_maps_id":"84", "room":"", "location_name":"Lane Hall", "has_livestream":0, "cost":"", "tags":["feminism","Art","focus on women","institute for research on women and gender","Arts Initiative","Diversity Equity and Inclusion","Engineering","Exhibition"], "website":"", "sponsors":[ { "group_name":"Institute for Research on Women and Gender", "group_id":"1031", "website":"http:\/\/irwg.umich.edu\/" }, { "group_name":"Women's and Gender Studies Department", "group_id":"2809", "website":"http:\/\/www.lsa.umich.edu\/wgs" }, { "group_name":"Arts Initiative", "group_id":"4583", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2023\/08\/event_109535_original-1.png", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2023\/08\/event_109535_original-1.png", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2023\/08\/event_109535_original-1.png", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2023\/08\/event_109535_original-1.png", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2023\/08\/event_109535_original-1.png", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2023\/08\/event_109535_original-1.png", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2023\/08\/event_109535_original-1.png", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2023\/08\/event_109535_original-1.png", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2023\/08\/event_109535_original-1.png", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2023\/08\/event_109535_original-1.png", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2023\/08\/event_109535_original-1.png", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2023\/08\/event_109535_original-1.png", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2023\/08\/event_109535_original-1.png", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2023\/08\/event_109535_original-1.png", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2023\/08\/event_109535_original-1.png", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2023\/08\/event_109535_original-1.png" }, "occurrence_count":82, "first_occurrence":21822148 } , "114983-21833899": { "datetime_modified":"20231108T093650", "datetime_start":"20231127T100000", "datetime_end":"", "has_end_time":0, "date_start":"2023-11-27", "date_end":"", "time_start":"10:00:00", "time_end":"", "time_zone":"America\/Detroit", "event_title":"Liz Tidwell Dissertation Defense", "occurrence_title":"", "combined_title":"Liz Tidwell Dissertation Defense: Liz Tidwell (PI: Markos Koutmos)", "event_subtitle":"Liz Tidwell (PI: Markos Koutmos)", "event_type":"Presentation", "event_type_id":"16", "description":"TITLE: Development of multidisciplinary methods for identifying small molecules with FMN riboswitch binding capacity\r\n\r\nABSTRACT: Antibiotic resistance remains a pressing global concern, costing lives and taxing healthcare systems worldwide. One of the major factors of increasing rates of antibiotic resistance is that most antibiotics target the bacterial ribosome or a limited range of proteins. Due to the narrow range of targets and the relatively small number of antibiotics, resistance to commonly used treatments arises quickly and can spread across bacterial populations. While there have been efforts to identify new targets for antimicrobial compounds and develop antibiotics with different chemical structures and mechanisms of action, there continues to be a dearth of innovation in developing truly innovative antibiotic compounds. \r\n\r\nIn this thesis, I discuss efforts to develop a series of tools to aid in the identification of new molecular scaffolds, small molecules that can be altered to optimize antibacterial effects, for an underexplored antibiotic target. Specifically, these methods target bacterial riboswitches, structured RNA elements that regulate vital biosynthetic pathways by binding a specific small molecule. Riboswitches are present in many bacteria, including bacteria that pose the greatest risks to human health. Each riboswitch is defined by the specific molecule it binds to; this dissertation focuses on the flavin mononucleotide riboswitch (FRS) The FRS binds to flavin mononucleotide, an important cofactor for protein function and a key part of multiple metabolic cycles. Bacteria often use FRS to regulate riboflavin biosynthesis, which is crucial for cellular growth and energy production. Since the FRS is a regulator for a vital pathway, identifying molecules with distinct molecular structures that bind to the riboswitch could be optimized into novel antibiotics. \r\n\r\nWhile FRS has a wealth of previous characterization and some previously identified binding partners; however, none of these candidates have advanced beyond preliminary mouse studies, far from actual implementation as a drug. We developed Fluorescent Ligand Equilibrium Displacement (FLED), a robust, rapid, and repeatable method, to identify molecules capable of interacting with the FRS. This method was applied to large libraries of compounds and their preliminary hits, investigated using classical biochemical techniques. We also pioneered methods for analyzing RNA using the analytical technology Ion Mobility Mass Spectrometry (IM-MS). We utilized it to study both transfer RNAs and FRS. While the previously mentioned methods are versatile tools for screening compound libraries, they do not account for the high cost of molecule libraries, nor the limitations inherent to screening vast molecular libraries. We employed two computational screening methods to reduce the number of compounds screened before identifying a new binding partner. These methods, coupled with FLED, were used to investigate the predictions and determine if the current setup does increase the rate of compound discovery.\r\n\r\nThe results described here support using FLED, IM-MS, and computational screening to identify small molecule candidates for development as FMN riboswitch-targeted antibiotics. It also provides preliminary work toward new a method to measure transcription termination of riboswitches. Finally, discusses the significance of such tools in the path toward antibiotic development.", "occurrence_notes":null, "guid":"114983-21833899@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/114983", "building_id":"1000172", "building_name":"Rackham Graduate School (Horace H.)", "campus_maps_id":"71", "room":"East Conference Room - 4th Floor", "location_name":"Rackham Graduate School (Horace H.)", "has_livestream":1, "livestream_type":"zoom", "livetream_require_login":0, "livestream_id":"98578394734", "livestream_password":"FMN", "livestream_link":"https:\/\/umich.zoom.us\/j\/98578394734", "cost":"", "tags":[], "website":"", "sponsors":[ { "group_name":"LSA Biophysics", "group_id":"3767", "website":"" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21833899 } }