{ "130570-21866304": { "datetime_modified":"20250107T153858", "datetime_start":"20250113T120000", "datetime_end":"20250113T150000", "has_end_time":1, "date_start":"2025-01-13", "date_end":"2025-01-13", "time_start":"12:00:00", "time_end":"15:00:00", "time_zone":"America\/Detroit", "event_title":"Dissertation Defense: Modeling of Cell Cycle Distortion and p16ink4a Significance in Human Papillomavirus-Infected Cells and Novel Use of Partial Differential Equations in Epidemiology Modeling", "occurrence_title":"", "combined_title":"Dissertation Defense: Modeling of Cell Cycle Distortion and p16ink4a Significance in Human Papillomavirus-Infected Cells and Novel Use of Partial Differential Equations in Epidemiology Modeling: Derrick Sund", "event_subtitle":"Derrick Sund", "event_type":"Presentation", "event_type_id":"16", "description":"Abstract:\r\n\r\nThe role of human papillomavirus (HPV) as a causative agent for epithelial cancers is well-known, but many open questions remain regarding the downstream gene regulatory effects of viral proteins E6 and E7 on the cell cycle. Here, we extend a cell cycle model originally presented by Gerard and Goldbeter [12] in order to capture the effects of E6 and E7 on key actors in the cell cycle. Results suggest that E6 is sufficient to reverse p53-induced quiescence, while E7 is sufficient to reverse p16INK4a-induced quiescence; both E6 and E7 are necessary when p53 and p16INK4a are both active. Moreover, E7 appears to play a role as a \u201cgrowth factor substitute\u201d, inducing cell division in the absence of growth factor. Low levels of E7 may permit regular cell division, but the results suggest that higher levels of E7 dysregulate the cell cycle in ways that may destabilize the cellular genome. We additionally explore factors related to susceptibility to apoptosis in HPV-positive cells, with results suggesting that while p16INK4a may be important in preventing apoptosis in such cells, this is unlikely to be due to stabilization of the cell cycle. The mechanisms explored here provide opportunities for developing new treatment targets that take advantage of the cell cycle regulatory system to prevent HPV-related cancer effects. In particular, suppression of p16INK4a activity may be a valuable target as an adjuvant to chemotherapy in HPV-positive cancers.\r\n\r\nAdditionally, we present a novel implementation of the standard SIR epidemiology model, refined to use partial differential equations instead of the usual ordinary differential equations. This enables the model to more easily consider factors like differing levels of vulnerability in a given population or different states of disease progression without needing to explicitly add more equations to the system. Case studies illustrating the use of this new framework are given, and some speculation on ways in which this model may be made further abstract are included at the end.", "occurrence_notes":null, "guid":"130570-21866304@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/130570", "building_id":"1000167", "building_name":"West Hall", "campus_maps_id":"163", "room":"242", "location_name":"West Hall", "has_livestream":0, "cost":"", "tags":["Graduate","Graduate Students","Mathematics","Dissertation"], "website":"", "sponsors":[ { "group_name":"Department of Mathematics", "group_id":"3791", "website":"" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21866304 } , "130692-21866528": { "datetime_modified":"20250108T000406", "datetime_start":"20250113T120000", "datetime_end":"20250113T180000", "has_end_time":1, "date_start":"2025-01-13", "date_end":"2025-01-13", "time_start":"12:00:00", "time_end":"18:00:00", "time_zone":"America\/Detroit", "event_title":"Igniting Growth", "occurrence_title":"", "combined_title":"Igniting Growth: Richard Moizio (Painter), Armani PlantSeeds (Musician & Producer)", "event_subtitle":"Richard Moizio (Painter), Armani PlantSeeds (Musician & Producer)", "event_type":"Exhibition", "event_type_id":"7", "description":"January 8-20, 2025\r\nReception: Thursday, January 9, 4:30-6:00 pm\r\nDuderstadt Center Gallery\r\n\r\nGrowth can come from outside inspiration, life experiences, pain, illness, etc. This interactive exhibit is not just a display of art and music but an experiment focusing on the creative process and how inspiration may affect and alter that process. As artists, we find the constant need to evolve and grow. We can become complacent in our ideas. This is when inspiration from a different book, or music or other source can ignite a new direction\/phase in our life. \r\n\r\nThis is an interactive exhibit, bring your earbuds and smartphone to enjoy the full experience. For more information, please contact Rich Moizio at rmoizio@comcast.net or Armani PlantSeeds at plantseeds313@gmail.com", "occurrence_notes":null, "guid":"130692-21866528@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/130692", "building_id":"1000396", "building_name":"Duderstadt Center", "campus_maps_id":"181", "room":"Gallery 1019", "location_name":"Duderstadt Center", "has_livestream":0, "cost":"", "tags":["Art","Exhibition","Music"], "website":"https:\/\/www.dc.umich.edu\/2025\/01\/04\/igniting-growth\/", "sponsors":[ { "group_name":"Duderstadt Center", "group_id":"4245", "website":"http:\/\/dc.umich.edu" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2025\/01\/event_130692_original-1.png", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2025\/01\/event_130692_original-1.png", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2025\/01\/event_130692_original-1.png", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_large_2x\/media\/attachments\/2025\/01\/event_130692_original-1.png", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2025\/01\/event_130692_original-1.png", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb\/media\/attachments\/2025\/01\/event_130692_original-1.png", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb_square\/media\/attachments\/2025\/01\/event_130692_original-1.png", "group_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large\/media\/attachments\/2025\/01\/event_130692_original-1.png", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large_lightbox\/media\/attachments\/2025\/01\/event_130692_original-1.png", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_large_crop\/media\/attachments\/2025\/01\/event_130692_original-1.png", "event_list":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_list\/media\/attachments\/2025\/01\/event_130692_original-1.png", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2025\/01\/event_130692_original-1.png", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2025\/01\/event_130692_original-1.png", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_grid_2x\/media\/attachments\/2025\/01\/event_130692_original-1.png", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_feature_large\/media\/attachments\/2025\/01\/event_130692_original-1.png", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2025\/01\/event_130692_original-1.png" }, "occurrence_count":13, "first_occurrence":21866523 } , "130748-21866713": { "datetime_modified":"20250110T130940", "datetime_start":"20250113T120000", "datetime_end":"20250113T160000", "has_end_time":1, "date_start":"2025-01-13", "date_end":"2025-01-13", "time_start":"12:00:00", "time_end":"16:00:00", "time_zone":"America\/Detroit", "event_title":"More than Gray: Reimagining Early America in Full Color", "occurrence_title":"", "combined_title":"More than Gray: Reimagining Early America in Full Color", "event_subtitle":"", "event_type":"Exhibition", "event_type_id":"7", "description":"The American past was lived in full color, but this vibrant history can be easily missed in surviving evidence. You can\u2019t deny that there\u2019s something about a black-and-white photograph that feels\u2026 stuffy. With portraits showing people with their shirts buttoned right to the neck and everything in shades of gray and brown, our imaginations can incline to thinking of the past as a bit staid, if not downright dull. But look a little closer, and you\u2019ll see signs that the fashion choices available to those who came before us were more colorful than you might first think. From the fabrics they wore, to the games they played, or the books they read, their world was alive with bright hues. This exhibit invites you to reimagine history with a fuller color palette and picture the vibrancy and joy that just might be hidden behind the unsmiling photographs.\r\n\r\nExhibition opening weekdays from 12-4.", "occurrence_notes":null, "guid":"130748-21866713@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/130748", "building_id":"1000159", "building_name":"William Clements Library", "campus_maps_id":"165", "room":"", "location_name":"William Clements Library", "has_livestream":0, "cost":"", "tags":["Library","libraries","history","Free","Exhibition","Exhibit","american history","american culture"], "website":"https:\/\/myumi.ch\/zXQ3w", "sponsors":[ { "group_name":"William L. 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