{ "119919-21843820": { "datetime_modified":"20240308T155946", "datetime_start":"20240401T150000", "datetime_end":"20240401T163000", "has_end_time":1, "date_start":"2024-04-01", "date_end":"2024-04-01", "time_start":"15:00:00", "time_end":"16:30:00", "time_zone":"America\/Detroit", "event_title":"Linguistic Anthropology Colloquium: \"Unsettling Signs: Indexical Disorder and the Diacritics of Raciolinguistic Life\"", "occurrence_title":"", "combined_title":"Linguistic Anthropology Colloquium: \"Unsettling Signs: Indexical Disorder and the Diacritics of Raciolinguistic Life\": Jonathan Rosa, Associate Professor of Education, Comparative Race and Ethnic Studies, and, by courtesy, Anthropology, Linguistics, and Comparative Literature, Stanford University", "event_subtitle":"Jonathan Rosa, Associate Professor of Education, Comparative Race and Ethnic Studies, and, by courtesy, Anthropology, Linguistics, and Comparative Literature, Stanford University", "event_type":"Lecture \/ Discussion", "event_type_id":"13", "description":"Unsettling Signs: Indexical Disorder and the Diacritics of Raciolinguistic Life\r\n\r\nThe framework of indexical order has been powerfully deployed in sociolinguistic and broader semiotic analyses throughout the world. This presentation critically engages with prevailing empiricist approaches to indexicality which focus on signs\u2019 heterogeneous meanings across contexts. It examines institutionalized attributions of deficiency and experiences of structural marginalization to offer the alternative framework of indexical disorder, which emphasizes the profound role of modern colonialism and racism in overdetermining signs\u2019 meaningfulness. The goal is to develop new insights into organizing power structures across contexts, as well as to rethink how indexicality can be a crucial analytic for understanding and unsettling these structures. \r\n\r\n\r\nJonathan Rosa is Associate Professor of Education, Comparative Race and Ethnic Studies, and, by courtesy, Anthropology, Linguistics, and Comparative Literature at Stanford University. He is author of Looking like a Language, Sounding like a Race: Raciolinguistic Ideologies and the Learning of Latinidad (2019, Oxford University Press) and co-editor of Language and Social Justice in Practice (2019, Routledge). His work has been published in scholarly journals such as Harvard Educational Review, American Anthropologist, American Ethnologist, and Journal of Linguistic Anthropology, as well as featured in media outlets including The New York Times, The Nation, NPR, and Univision.", "occurrence_notes":null, "guid":"119919-21843820@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/119919", "building_id":"1000167", "building_name":"West Hall", "campus_maps_id":"163", "room":"411", "location_name":"West Hall", "has_livestream":0, "cost":"", "tags":["AEM Featured","Anthropology"], "website":"", "sponsors":[ { "group_name":"Department of Anthropology", "group_id":"3469", "website":"https:\/\/lsa.umich.edu\/anthro" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21843820 } , "117832-21840084": { "datetime_modified":"20240331T210755", "datetime_start":"20240401T150000", "datetime_end":"20240401T160000", "has_end_time":1, "date_start":"2024-04-01", "date_end":"2024-04-01", "time_start":"15:00:00", "time_end":"16:00:00", "time_zone":"America\/Detroit", "event_title":"RTG NT: Mod p sheaves on mixed-characteristic affine Grassmannians", "occurrence_title":"", "combined_title":"RTG NT: Mod p sheaves on mixed-characteristic affine Grassmannians: Robert Cass", "event_subtitle":"Robert Cass", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Abstract: Affine Schubert varieties are certain subvarieties of the affine Grassmannian which show up in geometric contexts related to the Langlands program. Faltings and Pappas-Rapoport showed that in equal characteristic p, affine Schubert varieties are normal, Cohen-Macaulay, and Frobenius split. In previous work for split groups, I added global F-regularity to this list, with consequences for the theory of perverse mod p sheaves in characteristic p. In this talk, I will explain joint work with J. Louren\u00e7o where we explore similar questions for groups of mixed characteristic.", "occurrence_notes":null, "guid":"117832-21840084@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/117832", "building_id":"1000166", "building_name":"East Hall", "campus_maps_id":"53", "room":"3088", "location_name":"East Hall", "has_livestream":0, "cost":"", "tags":["Mathematics"], "website":"", "sponsors":[ { "group_name":"RTG Seminar on Number Theory - Department of Mathematics", "group_id":"4901", "website":"" }, { "group_name":"Department of Mathematics", "group_id":"3791", "website":"" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21840084 } , "118881-21841839": { "datetime_modified":"20240416T123137", "datetime_start":"20240401T150000", "datetime_end":"20240401T154500", "has_end_time":1, "date_start":"2024-04-01", "date_end":"2024-04-01", "time_start":"15:00:00", "time_end":"15:45:00", "time_zone":"America\/Detroit", "event_title":"SMBC Meet & Greets - (Global Markets Sales)", "occurrence_title":"", "combined_title":"SMBC Meet & Greets - (Global Markets Sales)", "event_subtitle":"", "event_type":"Careers \/ Jobs", "event_type_id":"2", "description":"SMBC Meet & Greets - (Global Markets Sales: Credit Sales \/ Rates Sales \/ Risk Solutions (Marketing)\n\nOur SMBC Meet and Greet Series isfor all students seeking a 2025 internship or analyst opportunity with our firm. Each session will consist of overviews of the various groups that hire into our programs led by the business members themselves followed by an open-forum Q&A session. Since each session will be different, studentsare encouraged to attend as many as they like.\n\nMacro Rates Sales \nTheMacro Rates Sales team offers an expansive suite of derivative and cash rates and FX products for SMBC\u2019s institutional clients, including hedge funds, asset managers, insurers, and real estate investors. \n\nCredit Sales \nThe Credit Sales team offers a broad range of investment services and facilitates client transactions across investment-grade, high-yield,asset-backed, collateralized loan, and emerging market products. Each group manages servicing clients across the world.\n\nRisk Solutions Sales\nThe Risk Solutions Sales team provides a wide array of interest rate and FX hedging products and services to SMBC\u2019s corporate, sponsor, and project finance clients in close partnership with Macro Rates Trading and the Investment Banking and Coverage teams.\n\nLogistics: \nLocation: Teams\nMeeting ID: 258 165 075 136 \nPasscode: xVLtUa \n\n", "occurrence_notes":null, "guid":"118881-21841839@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/118881", "building_id":"", "building_name":"", "campus_maps_id":"", "room":"", "location_name":"", "has_livestream":0, "cost":"", "tags":[], "website":"", "sponsors":[ { "group_name":"University Career Center UCC", "group_id":"1140", "website":"http:\/\/careercenter.umich.edu" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21841839 } , "109301-21821365": { "datetime_modified":"20240319T113413", "datetime_start":"20240401T160000", "datetime_end":"20240401T171500", "has_end_time":1, "date_start":"2024-04-01", "date_end":"2024-04-01", "time_start":"16:00:00", "time_end":"17:15:00", "time_zone":"America\/Detroit", "event_title":"Gomberg Lecture - How a Love of RNA Biophysics Lead to the Discovery of a Novel Antiviral", "occurrence_title":"", "combined_title":"Gomberg Lecture - How a Love of RNA Biophysics Lead to the Discovery of a Novel Antiviral: Blanton Tolbert (Howard Hughes Medical Institute)", "event_subtitle":"Blanton Tolbert (Howard Hughes Medical Institute)", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Positive Strand RNA viruses persist to pose serious threats to human health and global economies. Disease progression mediated by viral pathogenesis requires numerous intersections between host proteins and viral RNA (vRNA) structures. Host-vRNA complexes drive essential processes in the replication cycles of viruses; as such, they represent untapped targets for therapeutic intervention. In my seminar, I will describe the mechanisms by which the mutually antagonistic human hnRNP A1 and AUF1 proteins compete for the same vRNA structure to differentially regulate Enterovirus (EV) translation efficiency. By screening a library of small molecule RNA binders, we discovered that the compound DMA-135 binds SLII IRES domain to dose-dependently inhibit viral replication by attenuating viral translation. Serial passaging of EV-A71 in the presence of low doses of DMA-135 selects for revertant viruses with drug-resistant mutations that map to the SLII bulge environment. Comparative structure-function studies reveal that the cellular mechanism of action of DMA-135 is to tip the SLII-hnRNP regulatory axis towards significantly lower levels of IRES-dependent translation, and the virus can compensate by evolving mutations that restore homeostasis. Our work defines the antiviral mechanism of action of DMA-135; it demonstrates that functional specificity can be modulated through natural and drug-dependent viral evolution; and it shows how small molecules can reveal new insights about host-virus interfaces that regulate early stages of EV replication.", "occurrence_notes":null, "guid":"109301-21821365@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/109301", "building_id":"1000158", "building_name":"Chemistry Dow Lab", "campus_maps_id":"34", "room":"1640", "location_name":"Chemistry Dow Lab", "has_livestream":0, "cost":"", "tags":["Chemical Biology","Chemistry","Science"], "website":"https:\/\/www.hhmi.org\/about\/senior-leadership\/blanton-s-tolbert", "sponsors":[ { "group_name":"Department of Chemistry", "group_id":"3761", "website":"https:\/\/lsa.umich.edu\/chem" }, { "group_name":"Chemical Biology", "group_id":"4385", "website":"" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21821365 } }