{ "117693-21839844": { "datetime_modified":"20240124T133019", "datetime_start":"20240412T120000", "datetime_end":"20240412T130000", "has_end_time":1, "date_start":"2024-04-12", "date_end":"2024-04-12", "time_start":"12:00:00", "time_end":"13:00:00", "time_zone":"America\/Detroit", "event_title":"MCDB Seminar> Rewiring Cell Division", "occurrence_title":"", "combined_title":"MCDB Seminar> Rewiring Cell Division: Iain Cheeseman, Whitehead Institute, MIT", "event_subtitle":"Iain Cheeseman, Whitehead Institute, MIT", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Co-Hosts: Morgan DeSantis & Sue Hammoud (Human Genetics)", "occurrence_notes":null, "guid":"117693-21839844@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/117693", "building_id":"1005169", "building_name":"Biological Sciences Building", "campus_maps_id":"631", "room":"1060", "location_name":"Biological Sciences Building", "has_livestream":0, "cost":"", "tags":["Bsbsigns","Basic Science","Science","Research","Natural Sciences","Biosciences","Biology"], "website":"", "sponsors":[ { "group_name":"Department of Molecular, Cellular, and Developmental Biology", "group_id":"3755", "website":"" }, { "group_name":"Department of Human Genetics", "group_id":"1137", "website":"" }, { "group_name":"Program in Biology", "group_id":"3783", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2024\/01\/event_117693_original-1.png", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2024\/01\/event_117693_original-1.png", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2024\/01\/event_117693_original-1.png", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2024\/01\/event_117693_original-1.png", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2024\/01\/event_117693_original-1.png", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2024\/01\/event_117693_original-1.png", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2024\/01\/event_117693_original-1.png", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2024\/01\/event_117693_original-1.png", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2024\/01\/event_117693_original-1.png", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2024\/01\/event_117693_original-1.png", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2024\/01\/event_117693_original-1.png", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2024\/01\/event_117693_original-1.png", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2024\/01\/event_117693_original-1.png", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2024\/01\/event_117693_original-1.png", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2024\/01\/event_117693_original-1.png", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2024\/01\/event_117693_original-1.png" }, "occurrence_count":1, "first_occurrence":21839844 } , "121298-21846356": { "datetime_modified":"20240427T063141", "datetime_start":"20240412T120000", "datetime_end":"20240412T130000", "has_end_time":1, "date_start":"2024-04-12", "date_end":"2024-04-12", "time_start":"12:00:00", "time_end":"13:00:00", "time_zone":"America\/Detroit", "event_title":"Pro Football Hall of Fame \"Before the Snap\" ft. Eniko Somogyi", "occurrence_title":"", "combined_title":"Pro Football Hall of Fame \"Before the Snap\" ft. Eniko Somogyi", "event_subtitle":"", "event_type":"Careers \/ Jobs", "event_type_id":"2", "description":"The Pro Football Hall of Fame is proud to offer a series for learners in high school, college and beyond! \u201cBefore the Snap\u201d gives an insight to professional careers in and around the NFL, while giving thelive viewing audience the opportunity to interact with an industry expert.\n\nOur special guest is Eniko Somogyi, an IT Manger with the Los Angeles Rams.\n\nWe will be streaming the program LIVE on the Pro Football Hall of Fame\u2019s YouTube page and will take questions from students across the country throughout the program. To participate, all you will need to do is:\n - Visit https:\/\/www.youtube.com\/user\/ProFootballHOF at 12:00pm ET on Friday, March 22, 2024 to view the program.\n -To ask a question, comment on the post with the following information:\n* Name of School (if applicable)\n* Location\n* Question for Industry Expert\n\nIf you have any questions, do not hesitate to reach out! You can contact me at 330-588-3558 or by email at Jacob.Ray@ProFootballHOF.com\n", "occurrence_notes":null, "guid":"121298-21846356@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/121298", "building_id":"", "building_name":"", "campus_maps_id":"", "room":"", "location_name":"", "has_livestream":0, "cost":"", "tags":[], "website":"", "sponsors":[ { "group_name":"University Career Center UCC", "group_id":"1140", "website":"http:\/\/careercenter.umich.edu" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21846356 } , "109108-21821076": { "datetime_modified":"20240314T152302", "datetime_start":"20240412T120000", "datetime_end":"20240412T130000", "has_end_time":1, "date_start":"2024-04-12", "date_end":"2024-04-12", "time_start":"12:00:00", "time_end":"13:00:00", "time_zone":"America\/Detroit", "event_title":"Structural mechanisms of DNA priming by polymerase \u03b1\u2013primase", "occurrence_title":"", "combined_title":"Structural mechanisms of DNA priming by polymerase \u03b1\u2013primase: Brandt Eichman (Vanderbilt)", "event_subtitle":"Brandt Eichman (Vanderbilt)", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"The mechanism by which polymerase \u03b1\u2013primase (pol\u03b1\u2013primase) synthesizes chimeric RNA-DNA primers of defined length and composition, necessary for replication fidelity and genome stability, is unknown. Here, we report cryo-EM structures of pol\u03b1\u2013primase in complex with primed templates representing various stages of DNA synthesis. Our data show how interaction of the primase regulatory subunit with the primer 5\u2032-end facilitates handoff of the primer to pol\u03b1 and increases pol\u03b1 processivity, thereby regulating both RNA and DNA composition. The structures detail how flexibility within the heterotetramer enables synthesis across two active sites and provide evidence that termination of DNA synthesis is facilitated by reduction of pol\u03b1 and primase affinities for the varied conformations along the chimeric primer\/template duplex. Together, these findings elucidate a critical catalytic step in replication initiation and provide a comprehensive model for primer synthesis by pol\u03b1\u2013primase.", "occurrence_notes":null, "guid":"109108-21821076@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/109108", "building_id":"1000158", "building_name":"Chemistry Dow Lab", "campus_maps_id":"34", "room":"1640", "location_name":"Chemistry Dow Lab", "has_livestream":0, "cost":"", "tags":["seminar","Biophysics"], "website":"", "sponsors":[ { "group_name":"LSA Biophysics", "group_id":"3767", "website":"" }, { "group_name":"Department of Physics", "group_id":"1965", "website":"" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21821076 } , "115674-21835360": { "datetime_modified":"20231214T123048", "datetime_start":"20240412T120000", "datetime_end":"20240412T160000", "has_end_time":1, "date_start":"2024-04-12", "date_end":"2024-04-12", "time_start":"12:00:00", "time_end":"16:00:00", "time_zone":"America\/Detroit", "event_title":"The Art of Resistance in Early America", "occurrence_title":"", "combined_title":"The Art of Resistance in Early America", "event_subtitle":"", "event_type":"Exhibition", "event_type_id":"7", "description":"The exhibition addresses the theme of the LSA Fall 2023 semester at the University of Michigan: \"Arts & Resistance.\" This exhibit asks us to think about resistance in different settings, and in different forms. What \"arts\" did Americans in the eighteenth and nineteenth centuries use to resist various forms of power? The exhibit aims to show how the people of our nation's past tried to answer those questions\r\n\r\nExhibit Hours: Monday - Friday - Noon - 4 pm\r\n\r\nLink to online exhibit:https:\/\/clements.umich.edu\/exhibit\/the-art-of-resistance\/", "occurrence_notes":null, "guid":"115674-21835360@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/115674", "building_id":"1000159", "building_name":"William Clements Library", "campus_maps_id":"165", "room":"", "location_name":"William Clements Library", "has_livestream":0, "cost":"", "tags":["Undergraduate Students","Undergraduate","Tour","Library","libraries","In Person","history","Free","american history","american culture"], "website":"https:\/\/clements.umich.edu\/exhibit\/the-art-of-resistance\/", "sponsors":[ { "group_name":"William L. Clements Library", "group_id":"1727", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2023\/11\/event_115674_original-1.png", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2023\/11\/event_115674_original-1.png", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2023\/11\/event_115674_original-1.png", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2023\/11\/event_115674_original-1.png", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2023\/11\/event_115674_original-1.png", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2023\/11\/event_115674_original-1.png", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2023\/11\/event_115674_original-1.png", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2023\/11\/event_115674_original-1.png", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2023\/11\/event_115674_original-1.png", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2023\/11\/event_115674_original-1.png", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2023\/11\/event_115674_original-1.png", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2023\/11\/event_115674_original-1.png", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2023\/11\/event_115674_original-1.png", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2023\/11\/event_115674_original-1.png", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2023\/11\/event_115674_original-1.png", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2023\/11\/event_115674_original-1.png" }, "occurrence_count":91, "first_occurrence":21835227 } }