{ "125332-21854752": { "datetime_modified":"20250117T160054", "datetime_start":"20250131T120000", "datetime_end":"20250131T130000", "has_end_time":1, "date_start":"2025-01-31", "date_end":"2025-01-31", "time_start":"12:00:00", "time_end":"13:00:00", "time_zone":"America\/Detroit", "event_title":"Uncovering the molecular interactions underlying MBD protein Liquid-liquid Phase Separation", "occurrence_title":"", "combined_title":"Uncovering the molecular interactions underlying MBD protein Liquid-liquid Phase Separation: Alaji Bah (SUNY Upstate Medical University)", "event_subtitle":"Alaji Bah (SUNY Upstate Medical University)", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Chromatin organization controls DNA\u2019s accessibility to regulatory factors to influence gene expression. Heterochromatin, or transcriptionally silent chromatin enriched in methylated DNA and methylated histone tails, self-assembles through multivalent interactions with its associated proteins into a condensed, but dynamic state. Liquid-liquid phase separation (LLPS) of key heterochromatin regulators, such as heterochromatin protein 1 (HP1), plays an essential role in heterochromatin assembly and function. Methyl-CpG-binding protein 2 (MeCP2), the most studied member of the methyl-CpG-binding domain (MBD) family of proteins, has been recently shown to undergo LLPS in the absence and presence of methylated DNA. These studies provide a new mechanistic framework for understanding the role of methylated DNA and its readers in heterochromatin formation. However, the details of the molecular interactions by which other MBD family members undergo LLPS to mediate genome organization and transcriptional regulation are not fully understood. Here, we focus on two MBD proteins, MBD2 and MBD3, that have distinct but interdependent roles in gene regulation. Using an integrated computational and experimental approach, we uncover the homotypic and heterotypic interactions governing MBD2 and MBD3 phase separation and DNA\u2019s influence on this process. We show that despite sharing the highest sequence identity and structural homology among all the MBD protein family members, MBD2 and MBD3 exhibit differing residue patterns resulting in distinct phase separation mechanisms. Understanding the molecular underpinnings of MBD protein condensation offers insights into the higher-order, LLPS-mediated organization of heterochromatin.", "occurrence_notes":null, "guid":"125332-21854752@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/125332", "building_id":"1000158", "building_name":"Chemistry Dow Lab", "campus_maps_id":"34", "room":"1640", "location_name":"Chemistry Dow Lab", "has_livestream":0, "cost":"", "tags":["Biophysics"], "website":"", "sponsors":[ { "group_name":"LSA Biophysics", "group_id":"3767", "website":"" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21854752 } , "125537-21864685": { "datetime_modified":"20250207T161055", "datetime_start":"20250131T123000", "datetime_end":"20250131T130000", "has_end_time":1, "date_start":"2025-01-31", "date_end":"2025-01-31", "time_start":"12:30:00", "time_end":"13:00:00", "time_zone":"America\/Detroit", "event_title":"Coral Reef Tank Visit", "occurrence_title":"", "combined_title":"Coral Reef Tank Visit", "event_subtitle":"", "event_type":"Tours", "event_type_id":"25", "description":"Join Professor Jim Bardwell for a peek behind the scenes at his large coral reef tank featuring many species of coral, anemone, and fish. Explore reef ecology and, if you're lucky, get a glimpse of a reclusive octopus! 30 minutes, limit 12 people. This program takes place in the research area of the Biological Sciences Building and is recommended for ages 6 and up.\r\nSpace is available first come, first served. Sign up and meet at the Welcome desk.", "occurrence_notes":null, "guid":"125537-21864685@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/125537", "building_id":"1005169", "building_name":"Museum of Natural History", "campus_maps_id":"646", "room":"Welcome Desk", "location_name":"Museum of Natural History", "has_livestream":0, "cost":"", "tags":["Museum","natural history museum"], "website":"", "sponsors":[ { "group_name":"Museum of Natural History", "group_id":"3445", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2024\/09\/event_125537_original-1.jpeg", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2024\/09\/event_125537_original-1.jpeg", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2024\/09\/event_125537_original-1.jpeg", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2024\/09\/event_125537_original-1.jpeg", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2024\/09\/event_125537_original-1.jpeg", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2024\/09\/event_125537_original-1.jpeg", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2024\/09\/event_125537_original-1.jpeg", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2024\/09\/event_125537_original-1.jpeg", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2024\/09\/event_125537_original-1.jpeg", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2024\/09\/event_125537_original-1.jpeg", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2024\/09\/event_125537_original-1.jpeg", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2024\/09\/event_125537_original-1.jpeg", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2024\/09\/event_125537_original-1.jpeg", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2024\/09\/event_125537_original-1.jpeg", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2024\/09\/event_125537_original-1.jpeg", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2024\/09\/event_125537_original-1.jpeg" }, "occurrence_count":40, "first_occurrence":21855342 } , "131167-21867873": { "datetime_modified":"20250114T152917", "datetime_start":"20250131T130000", "datetime_end":"20250131T160000", "has_end_time":1, "date_start":"2025-01-31", "date_end":"2025-01-31", "time_start":"13:00:00", "time_end":"16:00:00", "time_zone":"America\/Detroit", "event_title":"2025 Green Career Fair", "occurrence_title":"", "combined_title":"2025 Green Career Fair", "event_subtitle":"", "event_type":"Careers \/ Jobs", "event_type_id":"2", "description":"Looking for an internship, job, or networking opportunities? Save the date for the On-Campus Green Career Fair, hosted by the School for Environment & Sustainability. Find more information here (https:\/\/seas.umich.edu\/student-services\/career-services\/green-career-fair). \r\n\r\nParticipating employers are hiring specifically for environmental and sustainability focused positions. All University of Michigan students are welcome to attend, regardless of your degree. Registration is not required, but your U-M ID is required for entry. If the Green Career Fair overlaps with your classes, consider asking your professor if you can attend the fair and make up your work for that day.\r\n\r\nIf you have any questions, please email seas-careers@umich.edu.", "occurrence_notes":null, "guid":"131167-21867873@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/131167", "building_id":"1000191", "building_name":"Michigan League", "campus_maps_id":"108", "room":"Ballroom (2nd Floor)", "location_name":"Michigan League", "has_livestream":0, "cost":"", "tags":["Career"], "website":"https:\/\/seas.umich.edu\/student-services\/career-services\/green-career-fair", "sponsors":[ { "group_name":"School for Environment and Sustainability", "group_id":"3454", "website":"https:\/\/www.facebook.com\/UMichSEAS\/" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2025\/01\/event_131167_original-1.png", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_thumb\/media\/attachments\/2025\/01\/crop-event_131167_original-1.png", "event_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_large\/media\/attachments\/2025\/01\/crop-event_131167_original-1.png", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_large_2x\/media\/attachments\/2025\/01\/crop-event_131167_original-1.png", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2025\/01\/crop-event_131167_original-1.png", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb\/media\/attachments\/2025\/01\/crop-event_131167_original-1.png", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb_square\/media\/attachments\/2025\/01\/crop-event_131167_original-1.png", "group_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large\/media\/attachments\/2025\/01\/crop-event_131167_original-1.png", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large_lightbox\/media\/attachments\/2025\/01\/crop-event_131167_original-1.png", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_large_crop\/media\/attachments\/2025\/01\/crop-event_131167_original-1.png", "event_list":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_list\/media\/attachments\/2025\/01\/crop-event_131167_original-1.png", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2025\/01\/crop-event_131167_original-1.png", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2025\/01\/crop-event_131167_original-1.png", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_grid_2x\/media\/attachments\/2025\/01\/crop-event_131167_original-1.png", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_feature_large\/media\/attachments\/2025\/01\/crop-event_131167_original-1.png", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_feature_thumb\/media\/attachments\/2025\/01\/crop-event_131167_original-1.png" }, "occurrence_count":1, "first_occurrence":21867873 } , "131814-21869281": { "datetime_modified":"20250215T123154", "datetime_start":"20250131T130000", "datetime_end":"20250131T134500", "has_end_time":1, "date_start":"2025-01-31", "date_end":"2025-01-31", "time_start":"13:00:00", "time_end":"13:45:00", "time_zone":"America\/Detroit", "event_title":"Explore Deloitte: Recruiting Workshop (Option 1)", "occurrence_title":"", "combined_title":"Explore Deloitte: Recruiting Workshop (Option 1)", "event_subtitle":"", "event_type":"Careers \/ Jobs", "event_type_id":"2", "description":"Recruiting Workshop: About Deloitte + Recruiting TipsJoin Deloitte recruiters for a Deloitte overview, plus tips and tricks to prepare for recruiting with us!During this session we\u2019ll go in-depth on who we are, what we offer, and what sets Deloitte apart. We'll also dive into mastering recruiting etiquette. Learn how to network effectively, prepare for virtual interviews, and communicate professionally. This session will equip you with essential skills to enhance your job search and make a lasting impression with Deloitte. Don't missthis opportunity to elevate your professional presence! Regardless of your major or preferred business, this session will provide a general overview of the campus recruiting process at Deloitte.This event will be in held via Zoom webinar Friday, January 31st from 1:00pm - 1:45pm ET\u00a0 and will not require video participation by attendees. Final Zoom details will be sent to registrants as the date approaches.", "occurrence_notes":null, "guid":"131814-21869281@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/131814", "building_id":"", "building_name":"", "campus_maps_id":"", "room":"", "location_name":"", "has_livestream":0, "cost":"", "tags":[], "website":"", "sponsors":[ { "group_name":"University Career Center UCC", "group_id":"1140", "website":"http:\/\/careercenter.umich.edu" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21869281 } , "131998-21869622": { "datetime_modified":"20250131T122050", "datetime_start":"20250131T130000", "datetime_end":"20250131T143000", "has_end_time":1, "date_start":"2025-01-31", "date_end":"2025-01-31", "time_start":"13:00:00", "time_end":"14:30:00", "time_zone":"America\/Detroit", "event_title":"IGR\/Marsal Ed Studies Grad Students 1\/31\/25 (CommonGround)", "occurrence_title":"", "combined_title":"IGR\/Marsal Ed Studies Grad Students 1\/31\/25 (CommonGround)", "event_subtitle":"", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"", "occurrence_notes":null, "guid":"131998-21869622@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/131998", "building_id":"", "building_name":"", "campus_maps_id":"", "room":"", "location_name":"", "has_livestream":0, "cost":"", "tags":["Sessions"], "website":"https:\/\/sessions.studentlife.umich.edu\/p\/track\/13595", "sponsors":[ { "group_name":"Sessions @ Michigan", "group_id":"4791", "website":"https:\/\/sessions.studentlife.umich.edu\/" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21869622 } }