{ "137280-21880020": { "datetime_modified":"20250911T122412", "datetime_start":"20251023T160000", "datetime_end":"20251023T170000", "has_end_time":1, "date_start":"2025-10-23", "date_end":"2025-10-23", "time_start":"16:00:00", "time_end":"17:00:00", "time_zone":"America\/Detroit", "event_title":"EEB Thursday Seminar Series - Understanding the fitness effects of mutations and implications for small populations", "occurrence_title":"", "combined_title":"EEB Thursday Seminar Series - Understanding the fitness effects of mutations and implications for small populations: Kirk Lohmueller, The University of California, Los Angeles", "event_subtitle":"Kirk Lohmueller, The University of California, Los Angeles", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Seminar Summary - Many mutations that occur in genomes are deleterious, resulting in a decrease in reproductive fitness. While such mutations are important for evolution and complex traits, much remains to be discovered. In this talk, I will discuss our work on estimating fitness effects of deleterious mutations using genetic variation data from natural populations. First, I will describe our computational approach, FitDadi, to estimate the distribution of fitness effects (DFE) for amino acid changing mutations in humans and other species. Analysis of how the DFE differs across species provides insights about how the DFE itself evolves. I also will describe our work inferring the DFE of mutations in noncoding regions of the human genome. Next, I provide a strategy to validate population genetic models of selection and dominance by testing whether they predict observed levels of inbreeding load and match observed genetic data. Lastly, I will discuss how insights gained from studying deleterious mutations may help identify small populations at risk of inbreeding depression.", "occurrence_notes":null, "guid":"137280-21880020@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/137280", "building_id":"1005169", "building_name":"Biological Sciences Building", "campus_maps_id":"631", "room":"1060", "location_name":"Biological Sciences Building", "has_livestream":0, "cost":"", "tags":["department of ecology and evolutionary biology","developmental biology","Ecology & Biology","Ecology And Evolutionary Biology","eeb","Biology"], "website":"https:\/\/lohmueller.eeb.ucla.edu", "sponsors":[ { "group_name":"Ecology and Evolutionary Biology", "group_id":"1190", "website":"" }, { "group_name":"EEB Thursday Seminars", "group_id":"3822", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2025\/09\/event_137280_original-1.png", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2025\/09\/event_137280_original-1.png", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2025\/09\/event_137280_original-1.png", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2025\/09\/event_137280_original-1.png", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2025\/09\/event_137280_original-1.png", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2025\/09\/event_137280_original-1.png", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2025\/09\/event_137280_original-1.png", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2025\/09\/event_137280_original-1.png", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2025\/09\/event_137280_original-1.png", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2025\/09\/event_137280_original-1.png", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2025\/09\/event_137280_original-1.png", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2025\/09\/event_137280_original-1.png", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2025\/09\/event_137280_original-1.png", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2025\/09\/event_137280_original-1.png", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2025\/09\/event_137280_original-1.png", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2025\/09\/event_137280_original-1.png" }, "occurrence_count":1, "first_occurrence":21880020 } , "137757-21880705": { "datetime_modified":"20251015T124301", "datetime_start":"20251023T160000", "datetime_end":"20251023T170000", "has_end_time":1, "date_start":"2025-10-23", "date_end":"2025-10-23", "time_start":"16:00:00", "time_end":"17:00:00", "time_zone":"America\/Detroit", "event_title":"Exploring Well-Being in Graduate Education: A Rackham Symposium", "occurrence_title":"Bridging Past, Present, and Future: A Reflective Discussion on Graduate Student Well-Being", "combined_title":"Exploring Well-Being in Graduate Education: A Rackham Symposium: Multiple conference events and sessions: Bridging Past, Present, and Future: A Reflective Discussion on Graduate Student Well-Being", "event_subtitle":"Multiple conference events and sessions", "event_type":"Conference \/ Symposium", "event_type_id":"5", "description":"Join faculty, staff, and students for a transformative event dedicated to advancing mental health and well-being in graduate education. Together, we'll explore research, share strategies, and build supportive academic communities.", "occurrence_notes":null, "guid":"137757-21880705@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/137757", "building_id":"", "building_name":"", "campus_maps_id":"", "room":"", "location_name":"Rackham Amphitheater", "has_livestream":0, "cost":"", "tags":["Sessions","Rgs-events","Rgs Events"], "website":"https:\/\/sessions.studentlife.umich.edu\/p\/track\/14589", "sponsors":[ { "group_name":"Sessions @ Michigan", "group_id":"4791", "website":"https:\/\/sessions.studentlife.umich.edu\/" }, { "group_name":"Rackham Graduate School", "group_id":"1187", "website":"https:\/\/www.facebook.com\/umichgradschool" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":22, "first_occurrence":21880684 } , "137313-21880124": { "datetime_modified":"20250808T001614", "datetime_start":"20251023T160000", "datetime_end":"20251023T170000", "has_end_time":1, "date_start":"2025-10-23", "date_end":"2025-10-23", "time_start":"16:00:00", "time_end":"17:00:00", "time_zone":"America\/Detroit", "event_title":"GEOMETRY SEMINAR: Non-negative curvature on vector bundles over homotopy spheres.", "occurrence_title":"", "combined_title":"GEOMETRY SEMINAR: Non-negative curvature on vector bundles over homotopy spheres.: K. Shankar (James Madison U)", "event_subtitle":"K. Shankar (James Madison U)", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"The seminal theorem of Cheeger and Gromoll characterizes open manifolds of non-negative sectional curvature by showing that any such manifold, $M^n$, is diffeomorphic to the normal bundle of a totally convex, closed submanifold $\\Sigma^k$, a \\textit{soul} of $M$. This brings up a far-reaching open problem: given a closed manifold $\\Sigma^k$ with non-negative sectional curvature, which vector bundles over $\\Sigma$ admit complete metrics with non-negative curvature? In this talk we will talk about the history of this problem and answer a longstanding question of Grove-Ziller. We show that every vector bundle over every homotopy 7-sphere admits non-negative curvature. This is joint work with David Duncan and Rebecca Field.", "occurrence_notes":null, "guid":"137313-21880124@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/137313", "building_id":"1000166", "building_name":"East Hall", "campus_maps_id":"53", "room":"3866", "location_name":"East Hall", "has_livestream":0, "cost":"", "tags":["Mathematics"], "website":"", "sponsors":[ { "group_name":"Geometry Seminar - Department of Mathematics", "group_id":"4891", "website":"" }, { "group_name":"Department of Mathematics", "group_id":"3791", "website":"" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21880124 } , "140524-21887272": { "datetime_modified":"20251021T090919", "datetime_start":"20251023T160000", "datetime_end":"20251023T190000", "has_end_time":1, "date_start":"2025-10-23", "date_end":"2025-10-23", "time_start":"16:00:00", "time_end":"19:00:00", "time_zone":"America\/Detroit", "event_title":"Gourd Times in the Grove", "occurrence_title":"", "combined_title":"Gourd Times in the Grove", "event_subtitle":"", "event_type":"Social \/ Informal Gathering", "event_type_id":"19", "description":"Join us on the North Campus Grove for free, family-friendly Fall fun! Enjoy an inflatable obstacle course, a petting zoo, a caramel apple bar, and more! Stop by with friends or family to enjoy the beautiful North Campus Grove and make cozy Autumn memories.", "occurrence_notes":null, "guid":"140524-21887272@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/140524", "building_id":"0", "building_name":"The Grove", "campus_maps_id":"564", "room":"", "location_name":"The Grove", "has_livestream":0, "cost":"", "tags":["Campus Involvement","CCI","cci programs","center for campus involvement","family friendly","food","free","free food","Free Stuff","freecandy","freefood","fun","get involved","getinvolved","go blue","goblue","north campus","outdoors","Student Caregivers"], "website":"", "sponsors":[ { "group_name":"Center for Campus Involvement CCI", "group_id":"1023", "website":"http:\/\/campusinvolvement.umich.edu" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2025\/10\/event_140524_original-1.png", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2025\/10\/event_140524_original-1.png", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2025\/10\/event_140524_original-1.png", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2025\/10\/event_140524_original-1.png", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2025\/10\/event_140524_original-1.png", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2025\/10\/event_140524_original-1.png", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2025\/10\/event_140524_original-1.png", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2025\/10\/event_140524_original-1.png", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2025\/10\/event_140524_original-1.png", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2025\/10\/event_140524_original-1.png", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2025\/10\/event_140524_original-1.png", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2025\/10\/event_140524_original-1.png", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2025\/10\/event_140524_original-1.png", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2025\/10\/event_140524_original-1.png", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2025\/10\/event_140524_original-1.png", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2025\/10\/event_140524_original-1.png" }, "occurrence_count":1, "first_occurrence":21887272 } , "138903-21884219": { "datetime_modified":"20251001T122323", "datetime_start":"20251023T160000", "datetime_end":"20251023T170000", "has_end_time":1, "date_start":"2025-10-23", "date_end":"2025-10-23", "time_start":"16:00:00", "time_end":"17:00:00", "time_zone":"America\/Detroit", "event_title":"IES Energy Seminar Series - Industrial Ecology Perspectives on the Electric Vehicle Transition \u2013 October 23, 2025 \u2014 Co-organized with the Center for Sustainable Systems", "occurrence_title":"", "combined_title":"IES Energy Seminar Series - Industrial Ecology Perspectives on the Electric Vehicle Transition \u2013 October 23, 2025 \u2014 Co-organized with the Center for Sustainable Systems: Alissa Kendall, University of California Davis", "event_subtitle":"Alissa Kendall, University of California Davis", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Hosted by Greg Keoliean\r\n\r\nAbstract:\r\nThe field of industrial ecology has long sought to understand the flows of resources and waste through our human-made systems and technologies, often with some intention of anticipating and avoiding unintended consequences. This perspective is particularly relevant to decarbonization strategies, where we have great urgency to change the technologies and operations of our energy and transport systems to meet climate targets, but which require a life cycle perspective to understand their true capacity to reduce emissions and to understand their other environmental, social or governance issues. In this talk I will discuss the use of life cycle assessment and material flow analysis for improving the transition to a decarbonized future with particular focus on electric vehicles and their batteries as a key, but not complete, solution for decarbonization of the transport sector.\r\n\r\nBiography:\r\nProf. Alissa Kendall holds a degree in Environmental Engineering from Duke University (B.S.E. 2000), and a PhD jointly conferred in Environmental Engineering and Natural Resource Policy from University of Michigan Ann Arbor (2007) for work conducted at the Center for Sustainable Systems. Prior to pursuing her graduate education, she worked as an automotive product development engineer focusing on hybrid and electric vehicles. She joined UC Davis as an assistant professor in 2007 and is now the Ray B. Krone Endowed Professor of Environmental Engineering in the UC Davis Department of Civil and Environmental Engineering and is the Director of the UC Davis Institute of Transportation Studies. During her time at UC Davis, she co-founded and chaired the Energy Graduate Group, an interdisciplinary Energy Systems degree program, and created the graduate certificate in Industrial Ecology.\r\nAs an industrial ecology scholar, her research focuses on understanding and reducing the environmental effects of many the key systems our modern world relies on including transport, civil infrastructure, and agriculture. She has authored and co-authored nearly 100 peer-reviewed journal articles, and her research has been honored with several awards including the Laudis Medal from the International Society of Industrial Ecology, UC Davis Chancellor\u2019s Fellow award, and the UC Davis College of Engineering\u2019s Mid-Career Research Award (2023).", "occurrence_notes":null, "guid":"138903-21884219@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/138903", "building_id":"1000189", "building_name":"Dana Natural Resources Building", "campus_maps_id":"45", "room":"2315", "location_name":"Dana Natural Resources Building", "has_livestream":0, "cost":"", "tags":["Materials Science","CAEN","Civil and Environmental Engineering","Electrical Engineering and Computer Science","Energy","Engineering","Environment","Free","Industrial and Operations Engineering","Interdisciplinary","Law","Social Sciences","Mechanical Engineering","Michigan Engineering","Naval Architecture and Marine Engineering","North Campus","Nuclear Engineering and Radiological Sciences","Research","Science","seminar","Sustainability"], "website":"https:\/\/ies.engin.umich.edu\/energy-seminar-series\/", "sponsors":[ { "group_name":"Institute for Energy Solutions", "group_id":"5361", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2025\/10\/event_138903_original-1.jpg", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2025\/10\/event_138903_original-1.jpg", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2025\/10\/event_138903_original-1.jpg", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2025\/10\/event_138903_original-1.jpg", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2025\/10\/event_138903_original-1.jpg", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2025\/10\/event_138903_original-1.jpg", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2025\/10\/event_138903_original-1.jpg", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2025\/10\/event_138903_original-1.jpg", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2025\/10\/event_138903_original-1.jpg", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2025\/10\/event_138903_original-1.jpg", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2025\/10\/event_138903_original-1.jpg", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2025\/10\/event_138903_original-1.jpg", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2025\/10\/event_138903_original-1.jpg", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2025\/10\/event_138903_original-1.jpg", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2025\/10\/event_138903_original-1.jpg", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2025\/10\/event_138903_original-1.jpg" }, "occurrence_count":1, "first_occurrence":21884219 } }