{ "125333-21854753": { "datetime_modified":"20250124T095054", "datetime_start":"20250207T120000", "datetime_end":"20250207T130000", "has_end_time":1, "date_start":"2025-02-07", "date_end":"2025-02-07", "time_start":"12:00:00", "time_end":"13:00:00", "time_zone":"America\/Detroit", "event_title":"Physical and molecular mechanisms of engineered T cell activation", "occurrence_title":"", "combined_title":"Physical and molecular mechanisms of engineered T cell activation: Shalini Low-Nam (Purdue)", "event_subtitle":"Shalini Low-Nam (Purdue)", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Cytotoxic T cells expressing engineered chimeric antigen receptors (CARs) consolidate key components of native T cell triggering machinery into a single transmembrane receptor capable of scanning for specific pathogenic markers. These programmable therapeutics are capable of identifying and destroying target cells but have had limited clinical success and often exhibit off-target toxicities. The mechanistic determinants for threshold setting in CAR T cells are still poorly understood and are expected to inform future improvements of the therapies. Signaling onset, at the cell surface, may be tuned by spatiotemporal, topographic, mechanical, and chemical parameters. Using an in vitro cell:cell killing assay using low CAR T cell:target cell ratios, we show that small numbers of binding interactions by CAR T cells are sufficient to induce target cell death. This single cell sensitivity is enhanced by mechanical features of the microenvironment. To explore the potency of individual cells, we mapped CAR T cell inputs to cellular activation and cytotoxic responses using a single molecule in vitro reconstitution assay. We monitored the collection of binding interactions that culminate in polarization of lytic granules that are trafficked to the intercellular junction and may undergo exocytosis to release cytolytic factors. We found that, surprisingly, some CAR T cells mobilize cytotoxic responses to a small number of antigenic binding events, suggesting a different molecular activation threshold than previously appreciated. These characteristics bear an uncanny resemblance to the native T cell receptor (TCR), leading us to explore how the native receptor may be contributing to CAR T cell function. I will discuss how mechanochemical features of the CAR T cell:target cell junction tune the activation setpoint and our efforts to map the molecular mechanisms underlying the mobilization of the cytotoxic response.", "occurrence_notes":null, "guid":"125333-21854753@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/125333", "building_id":"1000158", "building_name":"Chemistry Dow Lab", "campus_maps_id":"34", "room":"1640", "location_name":"Chemistry Dow Lab", "has_livestream":0, "cost":"", "tags":["Biophysics"], "website":"", "sponsors":[ { "group_name":"LSA Biophysics", "group_id":"3767", "website":"" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21854753 } , "130603-21866434": { "datetime_modified":"20250222T063235", "datetime_start":"20250207T120000", "datetime_end":"20250207T130000", "has_end_time":1, "date_start":"2025-02-07", "date_end":"2025-02-07", "time_start":"12:00:00", "time_end":"13:00:00", "time_zone":"America\/Detroit", "event_title":"Registered Nurse Lunch & Learn with Sentara", "occurrence_title":"", "combined_title":"Registered Nurse Lunch & Learn with Sentara", "event_subtitle":"", "event_type":"Careers \/ Jobs", "event_type_id":"2", "description":"Let's have lunch together!I'm Christina Berry, Sentara's RN Student Liaison and if you're curious about Sentara and would like to network with me, this is our time to do just that!\u00a0Join me at noon on Monday, February 3: https:\/\/bit.ly\/48tOGUL\u00a0Let\u2019s talk about how to apply, Sentara\u2019s Nurse Residency Program, Summer internships, benefits of working with Sentara, and anything else you might have questions about!Can\u2019t attend this event?Lunch & Learn sessions are currently scheduled weekly from January to March 2025. \u00a0Don't forget to look for Sentara sponsored events that can be pivotal in your job search!\u00a0 Make that all-important face-to-face connection with Sentara hiring managers & recruiters.\u00a0 Check for upcoming events at your preferred location at www.sentaracareers.com\/events.I look forward to connecting with you soon!Benefits: Sentara offers an attractive array of full-time benefits to include Medical, Dental, Vision, Paid Time Off, Sick, Tuition Reimbursement, a 401k\/403B with matching funds, 401a, Performance Plus Bonus, Career Advancement Opportunities, Work Perks, and more.\u00a0Our success is supported by a family-friendly culture that encourages community involvement and creates unlimited opportunities for development and growth.\u00a0Be a part of an excellent healthcare organization that cares about our People, Quality, Patient Safety, Service, and Integrity. Join a team that has a mission to improve health every day and a vision to be the healthcare choice of the communities that we serve!", "occurrence_notes":null, "guid":"130603-21866434@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/130603", "building_id":"", "building_name":"", "campus_maps_id":"", "room":"", "location_name":"", "has_livestream":0, "cost":"", "tags":[], "website":"", "sponsors":[ { "group_name":"University Career Center UCC", "group_id":"1140", "website":"http:\/\/careercenter.umich.edu" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21866434 } , "132247-21870659": { "datetime_modified":"20250203T142143", "datetime_start":"20250207T120000", "datetime_end":"20250207T130000", "has_end_time":1, "date_start":"2025-02-07", "date_end":"2025-02-07", "time_start":"12:00:00", "time_end":"13:00:00", "time_zone":"America\/Detroit", "event_title":"Sacred Glaciers: Exploring 4000 Year Old Shrines of Camelid Herders in the High Altitudes of the Peruvian Andes", "occurrence_title":"", "combined_title":"Sacred Glaciers: Exploring 4000 Year Old Shrines of Camelid Herders in the High Altitudes of the Peruvian Andes: Jhon Cruz Qui\u00f1ones, Ph.D. Candidate, University of Michigan Department of Anthropology", "event_subtitle":"Jhon Cruz Qui\u00f1ones, Ph.D. Candidate, University of Michigan Department of Anthropology", "event_type":"Lecture \/ Discussion", "event_type_id":"13", "description":"Ceremonies and rituals in herding societies are practices believed to protect herders and their flocks. These rituals also help maintain social reproduction and cope with the uncertainties surrounding flock fertility. This phenomenon has been documented in modern camelid herders in the Andes. Rich ethnohistorical and ethnographic data reveal the significance of worshiping deities, mythical heroes, and ancestral spirits in llama herder communities. However, our understanding of these ceremonies and rites during camelid domestication\u2014when hunter-gatherers transitioned to herding\u2014remains limited. This talk will present findings from a 4,000-year-old ceremonial center that served as a gathering place for small groups of herders in the upper Santa Valley, Peru. We will explore the worship of glaciers personified as megalithic stones believed to help flock fertility and protect herders and their animals.", "occurrence_notes":null, "guid":"132247-21870659@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/132247", "building_id":"1000221", "building_name":"School of Education", "campus_maps_id":"136", "room":"1322", "location_name":"School of Education", "has_livestream":0, "cost":"", "tags":["Anthropology","Archaeology"], "website":"", "sponsors":[ { "group_name":"Museum of Anthropological Archaeology", "group_id":"3760", "website":"" }, { "group_name":"Department of Anthropology", "group_id":"3469", "website":"https:\/\/lsa.umich.edu\/anthro" }, { "group_name":"Interdepartmental Program in Ancient Mediterranean Art and Archaeology", "group_id":"3719", "website":"" }, { "group_name":"Archaeology at Michigan", "group_id":"5160", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2025\/02\/event_132247_original-1.jpeg", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2025\/02\/event_132247_original-1.jpeg", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2025\/02\/event_132247_original-1.jpeg", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2025\/02\/event_132247_original-1.jpeg", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2025\/02\/event_132247_original-1.jpeg", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2025\/02\/event_132247_original-1.jpeg", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2025\/02\/event_132247_original-1.jpeg", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2025\/02\/event_132247_original-1.jpeg", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2025\/02\/event_132247_original-1.jpeg", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2025\/02\/event_132247_original-1.jpeg", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2025\/02\/event_132247_original-1.jpeg", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2025\/02\/event_132247_original-1.jpeg", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2025\/02\/event_132247_original-1.jpeg", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2025\/02\/event_132247_original-1.jpeg", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2025\/02\/event_132247_original-1.jpeg", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2025\/02\/event_132247_original-1.jpeg" }, "occurrence_count":1, "first_occurrence":21870659 } , "121866-21866320": { "datetime_modified":"20250806T162329", "datetime_start":"20250207T120000", "datetime_end":"20250207T123000", "has_end_time":1, "date_start":"2025-02-07", "date_end":"2025-02-07", "time_start":"12:00:00", "time_end":"12:30:00", "time_zone":"America\/Detroit", "event_title":"Sea Monsters", "occurrence_title":"", "combined_title":"Sea Monsters", "event_subtitle":"", "event_type":"Film Screening", "event_type_id":"11", "description":"The film follows a curious and adventurous Dolichorhynchops \u2013 familiarly known as a \u2018dolly\u2019 \u2013 as she travels through the most dangerous oceans in history. Along the way, she encounters long-necked plesiosaurs, giant turtles, enormous fish, fierce sharks, and the most dangerous sea monster of all\u2013 the mosasaur.", "occurrence_notes":null, "guid":"121866-21866320@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/121866", "building_id":"1005169", "building_name":"Museum of Natural History", "campus_maps_id":"646", "room":"Planetarium & Dome Theater", "location_name":"Museum of Natural History", "has_livestream":0, "cost":"Tickets are $8 and are available in the museum store on the day of the show.", "tags":["Museum","museums","natural history museum"], "website":"", "sponsors":[ { "group_name":"Planetarium & Dome Theater at the Museum of Natural History", "group_id":"3825", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2024\/05\/event_121866_original-1.jpg", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2024\/05\/event_121866_original-1.jpg", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2024\/05\/event_121866_original-1.jpg", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2024\/05\/event_121866_original-1.jpg", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2024\/05\/event_121866_original-1.jpg", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2024\/05\/event_121866_original-1.jpg", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2024\/05\/event_121866_original-1.jpg", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2024\/05\/event_121866_original-1.jpg", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2024\/05\/event_121866_original-1.jpg", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2024\/05\/event_121866_original-1.jpg", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2024\/05\/event_121866_original-1.jpg", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2024\/05\/event_121866_original-1.jpg", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2024\/05\/event_121866_original-1.jpg", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2024\/05\/event_121866_original-1.jpg", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2024\/05\/event_121866_original-1.jpg", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2024\/05\/event_121866_original-1.jpg" }, "occurrence_count":180, "first_occurrence":21847469 } , "131545-21868743": { "datetime_modified":"20250121T181724", "datetime_start":"20250207T120000", "datetime_end":"20250207T123000", "has_end_time":1, "date_start":"2025-02-07", "date_end":"2025-02-07", "time_start":"12:00:00", "time_end":"12:30:00", "time_zone":"America\/Detroit", "event_title":"Vinson Lam, carillon", "occurrence_title":"", "combined_title":"Vinson Lam, carillon", "event_subtitle":"", "event_type":"Performance", "event_type_id":"15", "description":"Vinson Lam performs on the Charles Baird Carillon, an instrument of 53 bronze bells located inside the Burton Memorial Tower. The largest bell, which strikes the hour, weighs 12 tons, while the smallest bell, 4\u00bd octaves above, weighs just 15 pounds.\n\nThirty-minute recitals are performed on the Charles Baird\u00a0Carillon\u00a0at noon every weekday that classes are in session, followed by visitor Q&A with the carillonist.\u00a0The bell chamber may be accessed via a combination of elevator and stairs. Take the elevator to the highest floor possible (floor 8), and then climb two flights of stairs (39 steps) to the bell chamber (floor 10). Hearing protection earmuffs are provided for visitors. Be prepared to walk on ice and snow in the bell chamber during winter.\u00a0Built in 1936, the Charles Baird\u00a0Carillon\u00a0is not ADA accessible. Visitors with mobility concerns are invited to\u00a0visit the Lurie\u00a0Carillon.", "occurrence_notes":null, "guid":"131545-21868743@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/131545", "building_id":"1000155", "building_name":"Burton Memorial Tower", "campus_maps_id":"25", "room":"", "location_name":"Burton Memorial Tower", "has_livestream":0, "cost":"Free - no tickets required", "tags":["Free","Music","Talk"], "website":"", "sponsors":[ { "group_name":"School of Music, Theatre & Dance (SMTD)", "group_id":"155", "website":"http:\/\/smtd.umich.edu\/events" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2025\/01\/event_131545_original-1.jpg", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2025\/01\/event_131545_original-1.jpg", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2025\/01\/event_131545_original-1.jpg", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2025\/01\/event_131545_original-1.jpg", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2025\/01\/event_131545_original-1.jpg", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2025\/01\/event_131545_original-1.jpg", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2025\/01\/event_131545_original-1.jpg", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2025\/01\/event_131545_original-1.jpg", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2025\/01\/event_131545_original-1.jpg", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2025\/01\/event_131545_original-1.jpg", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2025\/01\/event_131545_original-1.jpg", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2025\/01\/event_131545_original-1.jpg", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2025\/01\/event_131545_original-1.jpg", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2025\/01\/event_131545_original-1.jpg", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2025\/01\/event_131545_original-1.jpg", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2025\/01\/event_131545_original-1.jpg" }, "occurrence_count":1, "first_occurrence":21868743 } }