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        "event_title":"60 Minutes Around the Globe",
        "occurrence_title":"60 Minutes Around the Globe: U.S. Territories",
        "combined_title":"60 Minutes Around the Globe: 60 Minutes Around the Globe: U.S. Territories",
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        "event_type_id":"21",
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        "location_name":"International House Ann Arbor (921 Church Street)",
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        "datetime_modified":"20261020T211151",
        "datetime_start":"20261113T150000",
        "datetime_end":"20261113T160000",
        "has_end_time":1,
        "date_start":"2026-11-13",
        "date_end":"2026-11-13",
        "time_start":"15:00:00",
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        "time_zone":"America\/Detroit",
        "event_title":"AIM Seminar: Geometry for Physics Simulation",
        "occurrence_title":"",
        "combined_title":"AIM Seminar: Geometry for Physics Simulation: Oliver Gross (Computer Science and Engineering, University of California San Diego)",
        "event_subtitle":"Oliver Gross (Computer Science and Engineering, University of California San Diego)",
        "event_type":"Lecture \/ Discussion",
        "event_type_id":"13",
        "description":"Abstract: Advances in simulation and scientific machine learning have made computation an engine of discovery. For increasingly complex physical systems, however, computational scale and model expressiveness alone may not suffice for faithful simulation, exploration, and inverse design. General-purpose representations often describe a space much larger than the set of physically admissible states. Computing in this larger space can require substantial effort to ensure that solutions respect the underlying geometry, topology, and conservation laws. A complementary path is to make this structure explicit. Through examples ranging from bending rods and slithering snakes to fluid flows and magnetic fields in plasmas, this talk shows how geometric insight can make difficult problems computationally tractable, how the resulting structure can be preserved and encoded in algorithms, and how the exchange among theory, discretization, and application yields new mathematics alongside more effective computational tools.\n\n\nContact: Ian Tobasco",
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                "guid":"148882-21905044@events.umich.edu",
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        "room":"1084",
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        "tags":["Mathematics","Applied Mathematics"],
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    {
        "datetime_modified":"20261002T094642",
        "datetime_start":"20261113T150000",
        "datetime_end":"20261113T170000",
        "has_end_time":1,
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        "date_end":"2026-11-13",
        "time_start":"15:00:00",
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        "time_zone":"America\/Detroit",
        "event_title":"Alan J. Hunt Memorial Lecture-U-M Biomedical Engineering",
        "occurrence_title":"",
        "combined_title":"Alan J. Hunt Memorial Lecture-U-M Biomedical Engineering: \"Physical principles of cardiac sarcomere organization in health and disease,\" featuring Alex Dunn, Ph.D.",
        "event_subtitle":"\"Physical principles of cardiac sarcomere organization in health and disease,\" featuring Alex Dunn, Ph.D.",
        "event_type":"Lecture \/ Discussion",
        "event_type_id":"13",
        "description":"2026 Alan J. Hunt Memorial Lecture\n\nPhysical principles of cardiac sarcomere organization in health and disease\n\nAbstract:\nThe remarkable capabilities of living tissues reflect the self-assembly of biological macromolecules into structures far larger and more complex than their individual components. The Dunn laboratory seeks to understand the physical principles that allow molecular interactions to produce organized, functional tissues. In this talk, I will focus on cardiomyocytes, whose contractile machinery provides a striking example of biological self-assembly. Using single-molecule force spectroscopy, we find that \u03b1-actinin-2, a core component of the sarcomeric Z-disc, binds actin in a strongly force- and direction-dependent manner. This behavior suggests a mechanism by which forces generated during contraction can help organize and stabilize sarcomeric architecture. In parallel, we are investigating how inherited cardiomyopathy mutations perturb sarcomere mechanics and organization. Genetically encoded force sensors reveal how disease-associated myosin mutations alter force propagation within sarcomeres, while cryo-electron tomography shows how these mutations disrupt sarcomere order at the molecular scale. These and other data suggest that alterations in sarcomeric organization may be intimately linked to the development of cardiomyopathy. Finally, I will describe emerging approaches for scaling single-molecule biophysics from measurements of individual interactions to systematic surveys of hundreds of molecular variants. These approaches open the door to studies of mechanobiology at scale and to the design and characterization of new molecular mechanosensors.\n\nBio:\nAlex Dunn is a Professor in the Department of Chemical Engineering at Stanford University. His research focuses on understanding how living cells sense mechanical stimuli, with particular interests in stem cell biology and tissue engineering. Dr. Dunn worked as a postdoctoral scholar with James Spudich in the Department of Biochemistry at the Stanford University School of Medicine. He received his Ph.D. at the California Institute of Technology under the direction of Harry Gray, where his work focused on understanding the catalytic mechanism selective C-H bond oxidation by cytochrome P450 enzymes. His work has been recognized with numerous awards, including the Hertz Fellowship, the Burroughs Wellcome Career Award at the Scientific Interface, the NIH Director\u2019s New Innovator Award, and the HHMI Faculty Scholar Award.",
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                "guid":"153197-21915407@events.umich.edu",
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        "building_name":"Gerald Ford Library",
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        "room":"Auditorium",
        "location_name":"Gerald Ford Library",
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        "tags":["Basic Science","Biointerfaces","Biology","biomedical","biomedical engineering","Bioninterfaces","Biosciences","Biotechnology","bme","Discussion","engineer","engineering","In Person","Lecture","Medicine","Michigan Engineering","Research"],
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        "date_start":"2026-11-13",
        "date_end":"2026-11-13",
        "time_start":"15:00:00",
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        "time_zone":"America\/Detroit",
        "event_title":"Explore the MSI - Fall 2027 Admission Cycle",
        "occurrence_title":"Explore the MSI (November)",
        "combined_title":"Explore the MSI - Fall 2027 Admission Cycle: Explore the MSI (November)",
        "event_subtitle":"",
        "event_type":"Workshop \/ Seminar",
        "event_type_id":"21",
        "description":"Curious about the field of information and where a Master of Science in Information (MSI) degree can lead? This session offers a broad introduction to the University of Michigan School of Information and the MSI experience. We\u2019ll explore what an information degree is, who comes to UMSI, the program\u2019s structure and student experience, and the career pathways pursued by alumni. You\u2019ll also have an opportunity to ask questions and consider whether UMSI could be a place where your interests and goals can grow.Students who attend a live session will receive an application fee waiver following the presentation.\nThis session is designed as a general program overview rather than an application workshop. For in-depth guidance on the application process, prospective students are encouraged to attend an Apply to MSI session.All listed Explore the MSI sessions feature the same presentation and are offered at different times for your convenience, so you only need to attend one.",
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        "location_name":"Virtual",
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        "datetime_start":"20261113T150000",
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        "time_zone":"America\/Detroit",
        "event_title":"HET Seminar | Euclidean Wormholes and Axion Cosmology",
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        "combined_title":"HET Seminar | Euclidean Wormholes and Axion Cosmology: Gary Shiu (Wisconsin)",
        "event_subtitle":"Gary Shiu (Wisconsin)",
        "event_type":"Lecture \/ Discussion",
        "event_type_id":"13",
        "description":"Axions arise ubiquitously in theories of particle physics and quantum gravity and may play important roles in cosmology, from inflation and dark matter to dark energy. This raises a basic question: does quantum gravity constrain the allowed parameter space of axions, and can such constraints have observable consequences? I will discuss how Euclidean wormholes provide a surprising connection between these questions and quantum gravity. I will first review the axionic Weak Gravity Conjecture (aWGC), including the importance of its order-one coefficient for axion phenomenology, and then describe how Euclidean wormholes may give rise to this bound. I will discuss the perturbative stability of axion wormholes and their explicit realization in string theory, both in flat space and in AdS. Finally, I will present recent work showing that the aWGC can arise directly from the nonperturbative fragmentation of Euclidean wormholes into charged defects. Requiring such fragmentation to lower the Euclidean action fixes the action-to-charge bound and its order-one coefficient, and reveals a direct connection to the Imaginary Distance Bound. This suggests that quantum-gravitational constraints on axions can be understood as conditions on the non-perturbative stability of gravitational saddles, with implications for axion cosmology and the consistency of effective field theories.",
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        "tags":["Physics","High Energy Theory Seminar","Lecture","Science","Seminar","Talk"],
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