{ "151229-21911127": { "datetime_modified":"20260909T131136", "datetime_start":"20260925T120000", "datetime_end":"20260925T130000", "has_end_time":1, "date_start":"2026-09-25", "date_end":"2026-09-25", "time_start":"12:00:00", "time_end":"13:00:00", "time_zone":"America\/Detroit", "event_title":"MCDB Seminar Series> Rewriting the rules of DNA synthesis: Reverse transcriptases in antiviral defense", "occurrence_title":"", "combined_title":"MCDB Seminar Series> Rewriting the rules of DNA synthesis: Reverse transcriptases in antiviral defense: Sam Sternberg, Columbia University", "event_subtitle":"Sam Sternberg, Columbia University", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"CRISPR\u2013Cas systems illustrate how noncoding RNAs (ncRNA) can program immune functions by targeting foreign DNA for degradation. Intriguingly, a widespread family of defense-associated reverse transcriptases (DRTs) instead leverages noncoding RNAs to direct programmable DNA synthesis during antiviral defense. Here we investigate the mechanism of immunity mediated by tripartite DRT10 systems, which rely on a membrane effector protein and RT-catalyzed generation of repetitive DNA. The RT associates with a structured ncRNA and uses a short template region to catalyze protein-primed, processive synthesis of tandem DNA repeats. Repeat addition proceeds through iterative cycles of template-directed extension and realignment encoded within the ncRNA. This mechanism closely parallels the repeat-addition strategy of telomerase, revealing an unexpected connection between antiviral RT systems in bacteria and conserved pathways of repetitive DNA synthesis in eukaryotes that maintain genome integrity.", "occurrence_notes":null, "guid":"151229-21911127@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/151229", "building_id":"1005169", "building_name":"Biological Sciences Building", "campus_maps_id":"631", "room":"1060", "location_name":"Biological Sciences Building", "has_livestream":0, "cost":"", "tags":["Biology","Bsbsigns"], "website":"https:\/\/lsa.umich.edu\/mcdb\/news-events\/seminar-series.html", "sponsors":[ { "group_name":"Department of Molecular, Cellular, and Developmental Biology", "group_id":"3755", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2026\/09\/event_151229_original-1.jpg", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_thumb\/media\/attachments\/2026\/09\/crop-event_151229_original-1.jpg", "event_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_large\/media\/attachments\/2026\/09\/crop-event_151229_original-1.jpg", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2026\/09\/crop-event_151229_original-1.jpg", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_large_lightbox\/media\/attachments\/2026\/09\/crop-event_151229_original-1.jpg", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb\/media\/attachments\/2026\/09\/crop-event_151229_original-1.jpg", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb_square\/media\/attachments\/2026\/09\/crop-event_151229_original-1.jpg", "group_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large\/media\/attachments\/2026\/09\/crop-event_151229_original-1.jpg", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large_lightbox\/media\/attachments\/2026\/09\/crop-event_151229_original-1.jpg", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_large_crop\/media\/attachments\/2026\/09\/crop-event_151229_original-1.jpg", "event_list":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_list\/media\/attachments\/2026\/09\/crop-event_151229_original-1.jpg", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2026\/09\/crop-event_151229_original-1.jpg", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2026\/09\/crop-event_151229_original-1.jpg", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_grid_2x\/media\/attachments\/2026\/09\/crop-event_151229_original-1.jpg", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_feature_large\/media\/attachments\/2026\/09\/crop-event_151229_original-1.jpg", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_feature_thumb\/media\/attachments\/2026\/09\/crop-event_151229_original-1.jpg" }, "occurrence_count":1, "first_occurrence":21911127 } , "150465-21909480": { "datetime_modified":"20260825T094950", "datetime_start":"20260925T120000", "datetime_end":"20260925T120000", "has_end_time":1, "date_start":"2026-09-25", "date_end":"2026-09-25", "time_start":"12:00:00", "time_end":"12:00:00", "time_zone":"America\/Detroit", "event_title":"Michigan in Washington Application Deadline-Winter 2027\/Early Admission Fall 2027", "occurrence_title":"", "combined_title":"Michigan in Washington Application Deadline-Winter 2027\/Early Admission Fall 2027", "event_subtitle":"", "event_type":"Careers \/ Jobs", "event_type_id":"2", "description":"Michigan in Washington (MIW) is a full-semester program in Washington, D.C., open to U-M students from all majors. Students complete a full-time internship during the day and take U-M courses in the evening. MIW provides support with the internship search, application materials, interviews, housing, and the transition to living and working in D.C.\nWinter 2027 applications are due September 25, but we will begin reviewing applications and interviewing qualified students as they are submitted. Admission decisions will also be made on a rolling basis, so we strongly encourage you to apply early rather than waiting until the deadline.\nPlease also keep in mind that our two required professional development sessions will be held on Saturday, October 3, and Saturday, October 31 and they are mandatory.", "occurrence_notes":null, "guid":"150465-21909480@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/150465", "building_id":"", "building_name":"", "campus_maps_id":"", "room":"", "location_name":null, "has_livestream":0, "cost":"", "tags":["Activism","AEM Featured","Applications","Business","Career","Community Service","Deadlines","Department Of Political Science","Diversity","first-generation","Free","Human Rights","Interdisciplinary","Internship","Law","Leadership","Majors","Multicultural","Networking","Political Science","Politics","Pre-Law","Professional Development","Prospective Undergraduate Students","Public Policy","Recruiting","Scholarship","Scholarships","Social Impact","Social Justice","Social Sciences","Study Abroad","Transfer Students","Undergraduate","Undergraduate Students"], "website":"https:\/\/www.instagram.com\/miwdcgoblue\/?hl=en#", "sponsors":[ { "group_name":"Michigan in Washington Program", "group_id":"3627", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2026\/08\/event_150465_original-1.png", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_thumb\/media\/attachments\/2026\/08\/event_150465_original-1.png", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2026\/08\/event_150465_original-1.png", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2026\/08\/event_150465_original-1.png", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2026\/08\/event_150465_original-1.png", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb\/media\/attachments\/2026\/08\/event_150465_original-1.png", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb_square\/media\/attachments\/2026\/08\/event_150465_original-1.png", "group_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large\/media\/attachments\/2026\/08\/event_150465_original-1.png", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large_lightbox\/media\/attachments\/2026\/08\/event_150465_original-1.png", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_large_crop\/media\/attachments\/2026\/08\/event_150465_original-1.png", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2026\/08\/event_150465_original-1.png", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2026\/08\/event_150465_original-1.png", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2026\/08\/event_150465_original-1.png", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_grid_2x\/media\/attachments\/2026\/08\/event_150465_original-1.png", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_feature_large\/media\/attachments\/2026\/08\/event_150465_original-1.png", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2026\/08\/event_150465_original-1.png" }, "occurrence_count":1, "first_occurrence":21909480 } , "152619-21914187": { "datetime_modified":"20260922T091323", "datetime_start":"20260925T120000", "datetime_end":"20260925T140000", "has_end_time":1, "date_start":"2026-09-25", "date_end":"2026-09-25", "time_start":"12:00:00", "time_end":"14:00:00", "time_zone":"America\/Detroit", "event_title":"Mid-Autumn Moon Festival", "occurrence_title":"", "combined_title":"Mid-Autumn Moon Festival", "event_subtitle":"", "event_type":"Fair \/ Festival", "event_type_id":"10", "description":"Please join the Language Resource Center and the Asian Languages and Cultures, featuring our Chinese and Vietnamese language programs, to celebrate the Mid-Autumn Moon Festival! Come learn more about the celebration in both culture and enjoy food, games, crafts and more!", "occurrence_notes":"Main Center of the LRC", "guid":"152619-21914187@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/152619", "building_id":"1005177", "building_name":"North Quad", "campus_maps_id":"553", "room":"1500", "location_name":"North Quad", "has_livestream":0, "cost":"", "tags":["All Majors Welcome","Asia","Asian Languages And Cultures","center for southeast asian studies","Chinese","Chinese Studies","cultural","Culture","Festival","Food","Free","Games","In Person","Language","Language Resource Center","Languages","Multicultural","Southeast Asia","Southeast Asian Studies","Vietnam"], "website":"http:\/\/lsa.umich.edu\/lrc", "sponsors":[ { "group_name":"Language Resource Center", "group_id":"3209", "website":"http:\/\/lsa.umich.edu\/lrc" }, { "group_name":"Asian Languages and Cultures", "group_id":"3364", "website":"http:\/\/www.lsa.umich.edu\/asian" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2026\/09\/event_152619_original-1.png", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_thumb\/media\/attachments\/2026\/09\/event_152619_original-1.png", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2026\/09\/event_152619_original-1.png", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2026\/09\/event_152619_original-1.png", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2026\/09\/event_152619_original-1.png", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb\/media\/attachments\/2026\/09\/event_152619_original-1.png", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb_square\/media\/attachments\/2026\/09\/event_152619_original-1.png", "group_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large\/media\/attachments\/2026\/09\/event_152619_original-1.png", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large_lightbox\/media\/attachments\/2026\/09\/event_152619_original-1.png", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_large_crop\/media\/attachments\/2026\/09\/event_152619_original-1.png", "event_list":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_list\/media\/attachments\/2026\/09\/event_152619_original-1.png", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2026\/09\/event_152619_original-1.png", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2026\/09\/event_152619_original-1.png", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_grid_2x\/media\/attachments\/2026\/09\/event_152619_original-1.png", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_feature_large\/media\/attachments\/2026\/09\/event_152619_original-1.png", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2026\/09\/event_152619_original-1.png" }, "occurrence_count":1, "first_occurrence":21914187 } , "151986-21912544": { "datetime_modified":"20260910T200155", "datetime_start":"20260925T120000", "datetime_end":"20260925T130000", "has_end_time":1, "date_start":"2026-09-25", "date_end":"2026-09-25", "time_start":"12:00:00", "time_end":"13:00:00", "time_zone":"America\/Detroit", "event_title":"Museum Studies Program, Museums at Noon", "occurrence_title":"", "combined_title":"Museum Studies Program, Museums at Noon: Uncovering the Legacy of the Hominin Cast Collection at the Field Museum", "event_subtitle":"Uncovering the Legacy of the Hominin Cast Collection at the Field Museum", "event_type":"Presentation", "event_type_id":"16", "description":"Because fossils of our human ancestors (hominins) remain in their country of discovery, museum collections relating to human origins predominantly consist of casts. 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After completing this activity participants will be able to engage and pursue new experimental methods and arenas of investigation and incorporate knowledge into pathological diagnostic algorithms.", "occurrence_notes":null, "guid":"125220-21913958@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/125220", "building_id":"", "building_name":"", "campus_maps_id":"", "room":"", "location_name":"3699 Med Sci II (South Lecture Hall)", "has_livestream":0, "cost":"", "tags":["Sessions"], "website":"https:\/\/sessions.studentlife.umich.edu\/p\/track\/12247", "sponsors":[ { "group_name":"Sessions @ Michigan", "group_id":"4791", "website":"https:\/\/sessions.studentlife.umich.edu\/" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21913958 } }