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        "time_end":"17:15:00",
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        "event_title":"Mechanistic Insights into Metal-Protein Interactions: Implications for Neurodegenerative Disease Progression and Intervention",
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        "combined_title":"Mechanistic Insights into Metal-Protein Interactions: Implications for Neurodegenerative Disease Progression and Intervention: Katlyn Meier | University of Miami",
        "event_subtitle":"Katlyn Meier | University of Miami",
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        "description":"Elevated levels of protein expression and aberrant metal exposure have been reported in many neurodegenerative diseases, including Huntington\u2019s Disease (HD). While there is currently no cure for HD, metal chelation therapies have been shown to assuage disease symptoms including chorea. These observations underscore the critical need to understand how metal-protein interactions are involved in disease pathogenesis. Our objective in this work is to elucidate the role of copper (Cu) and other biorelevant metals in HD and, more specifically, their interactions with the huntingtin protein (htt). We aimed to characterize the Cu-htt interaction and speciation trends in our in vitro HD system, as well as the influence of disease-relevant Cu concentrations on protein oligomerization\/aggregation both in vitro and in vivo. We utilized multiple spectroscopic techniques (circular dichroism, electron paramagnetic resonance, UV-Vis absorption, dynamic light scattering, and mass spectrometry) that cover a broad range of energy scales, allowing us to characterize protein structure at the molecular, secondary structure, and quaternary structure levels. Additionally, site-directed mutagenesis of several putative metal binding residues was used to define the roles of specific amino acids in mediating oligomerization\/aggregation, metal binding, and redox chemistry. Taken together, our work has led to the first report of multiple copper binding sites in non-pathological htt and provides insight into one pathway for depletion of native htt pools that may contribute to HD.",
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        "tags":["Chemistry","Inorganic Chemistry"],
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        "time_zone":"America\/Detroit",
        "event_title":"Maize & Blue Cupboard Volunteering",
        "occurrence_title":"MBC Operating Hours",
        "combined_title":"Maize & Blue Cupboard Volunteering: Multiple conference events and sessions: MBC Operating Hours",
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        "event_type_id":"5",
        "description":"Come help us during normal operating hours; as well as, unload our weekly Food Gatherers deliveries and stock our shelves!\u00a0If you are outside the U-M community, please reach out to maize.blue.cupboard@umich.edu to sign up.",
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        "location_name":"Maize and Blue Cupboard inside Betsy Barbour",
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        "event_title":"Markley (2026-2027) (Housing)",
        "occurrence_title":"Donuts with DPSS",
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        "location_name":"Markley Concourse",
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        "event_title":"U-M Global StorySLAM!",
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        "description":"Join us for a special evening as members of the U-M community share personal stories of living, learning, and growing in new places\u2014whether that\u2019s studying abroad or navigating life as an international student in the U.S. Hear candid accounts of funny, moving, eye-opening, and transformative moments that shape our global journeys, both near and far. Celebrate cultural insights, new perspectives, and the power of storytelling with our international community.Light refreshments provided. All are welcome!\nThis event is organized by the Center for Global & Intercultural Study, Global Engagement \u2014 Office of the Provost, the International Institute, International Programs in Engineering, Ross Global Initiatives, and the International Center.",
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        "location_name":"North Quad, Space 2435",
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        "website":"https:\/\/sessions.studentlife.umich.edu\/p\/track\/17716",
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        "datetime_modified":"20261006T113424",
        "datetime_start":"20261020T180000",
        "datetime_end":"20261020T193000",
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        "time_start":"18:00:00",
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        "event_title":"UMS 101: All About the Piano",
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        "combined_title":"UMS 101: All About the Piano: with Dr. Kathryn Goodson and Robert Grijalva",
        "event_subtitle":"with Dr. Kathryn Goodson and Robert Grijalva",
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        "description":"Ever wondered what goes on inside a concert grand piano before a master pianist takes the stage? Or how a master tuner coaxes the perfect sound out of thousands of moving parts?\n\nJoin us for All About the Piano, a fun, casual, 90-minute workshop that takes you behind the scenes of one of the world\u2019s most versatile instruments. Whether you are a lifelong classical music fan or just curious about how it all works, this session will deepen your appreciation for your next UMS performance. This workshop will feature a professional piano tuner and a concert pianist as panelists. Together, they will guide us through:\n\nThe Mechanics\nHow a piano actually works from the inside out.\n\nThe Art of Tuning\nThe meticulous process of tuning and choosing the perfect instrument for a live performance.\n\nLive Demonstrations\nReal-time examples and participatory activities that bring the music and mechanics to life.\n\nCome with your curiosity and your questions \u2014 and leave with a whole new perspective on every note you hear!",
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        "location_name":"Northside Community Church (929 Barton Dr)",
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        "tags":["Michigan Arts Festival","Music","Piano","UMS"],
        "website":"https:\/\/ums.org\/performance\/ums-101-all-about-the-piano\/",
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