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However, how lipid metabolism regulates lysosomal homeostasis remains poorly understood.\n\nHere, we performed a genome-wide CRISPR screen in Mucolipidosis V (LYSET-deficient) cells and identified ether lipid synthesis as a key regulator of lysosomal homeostasis. Genetic or pharmacological inhibition of ether lipid synthesis reduced lysosome accumulation and partially restored lysosomal degradative capacity. Mechanistically, ether lipid reduction partially restored the maturation of a subset of lysosomal hydrolases and enhanced lysosomal exocytosis, thereby promoting lysosomal substrate clearance. These findings uncover a previously unrecognized mechanism by which lipid metabolism regulates lysosomal homeostasis and suggest new therapeutic opportunities for lysosomal storage disorders.", "occurrence_notes":null, "guid":"150858-21910314@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/150858", "building_id":"1005169", "building_name":"Biological Sciences Building", "campus_maps_id":"631", "room":"1010", "location_name":"Biological Sciences Building", "has_livestream":0, "cost":"", "tags":["Graduate Students","Dissertation Defense","Dissertation","Bsbsigns","Biology"], "website":"https:\/\/lsa.umich.edu\/mcdb\/news-events.html", "sponsors":[ { "group_name":"Department of Molecular, Cellular, and Developmental Biology", "group_id":"3755", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2026\/08\/event_150858_original-1.jpg", "styled_images":{ 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This year we celebrate the 250th anniversary of the signing of the Declaration of Independence.\n\nItems on display are from the Joseph A. 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Doors open at 9:30am.\n\nPreregistration is encouraged.", "occurrence_notes":null, "guid":"148922-21905217@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/148922", "building_id":"null", "building_name":"Off Campus Location", "campus_maps_id":"1", "room":"Atrium and Towsley Auditorium", "location_name":"Washtenaw Community College Morris Lawrence Building", "has_livestream":0, "cost":"", "tags":["Geriatrics","aging","Astronomy","Brunch","Culture","Volunteer","Social","Retirement","Reception","Lifelong Learning","Interdisciplinary","In Person","Free"], "website":"https:\/\/mmcommunityprograms.med.umich.edu\/umich\/course\/course.aspx?catId=73", "sponsors":[ { "group_name":"Osher Lifelong Learning Institute at the University of Michigan (OLLI)", "group_id":"4951", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2026\/06\/event_148922_original-1.jpg", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2026\/06\/event_148922_original-1.jpg", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2026\/06\/event_148922_original-1.jpg", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2026\/06\/event_148922_original-1.jpg", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2026\/06\/event_148922_original-1.jpg", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2026\/06\/event_148922_original-1.jpg", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2026\/06\/event_148922_original-1.jpg", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2026\/06\/event_148922_original-1.jpg", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2026\/06\/event_148922_original-1.jpg", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2026\/06\/event_148922_original-1.jpg", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2026\/06\/event_148922_original-1.jpg", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2026\/06\/event_148922_original-1.jpg", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2026\/06\/event_148922_original-1.jpg", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2026\/06\/event_148922_original-1.jpg", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2026\/06\/event_148922_original-1.jpg", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2026\/06\/event_148922_original-1.jpg" }, "occurrence_count":1, "first_occurrence":21905217 } , "149864-21907279": { "datetime_modified":"20260811T153533", "datetime_start":"20260902T100000", "datetime_end":"20260902T100000", "has_end_time":1, "date_start":"2026-09-02", "date_end":"2026-09-02", "time_start":"10:00:00", "time_end":"10:00:00", "time_zone":"America\/Detroit", "event_title":"Goosechase: Welcome to Michigan", "occurrence_title":"", "combined_title":"Goosechase: Welcome to Michigan", "event_subtitle":"", "event_type":"Recreational \/ Games", "event_type_id":"18", "description":"Flock In! 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Click this link here to join, https:\/\/join.goosechase.com\/53332432-9fc7-4ccd-9a36-d16c7b7502c9\n\nCCI Goosechase Page: https:\/\/campusinvolvement.umich.edu\/article\/goosechase-welcome-michigan", "occurrence_notes":null, "guid":"149864-21907279@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/149864", "building_id":"null", "building_name":"Off Campus Location", "campus_maps_id":"1", "room":"", "location_name":"Goosechase App: Download in the App Store & follow the instructions on CCI's website to join!", "has_livestream":0, "cost":"", "tags":["Anchor2026","Cci","Welcome2026"], "website":"https:\/\/join.goosechase.com\/53332432-9fc7-4ccd-9a36-d16c7b7502c9", "sponsors":[ { "group_name":"Center for Campus Involvement CCI", "group_id":"1023", "website":"http:\/\/campusinvolvement.umich.edu" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2026\/08\/event_149864_original-2.png", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_thumb\/media\/attachments\/2026\/08\/event_149864_original-2.png", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2026\/08\/event_149864_original-2.png", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_large_2x\/media\/attachments\/2026\/08\/event_149864_original-2.png", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2026\/08\/event_149864_original-2.png", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb\/media\/attachments\/2026\/08\/event_149864_original-2.png", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_thumb_square\/media\/attachments\/2026\/08\/event_149864_original-2.png", "group_large":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large\/media\/attachments\/2026\/08\/event_149864_original-2.png", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/resolve\/group_large_lightbox\/media\/attachments\/2026\/08\/event_149864_original-2.png", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_large_crop\/media\/attachments\/2026\/08\/event_149864_original-2.png", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2026\/08\/event_149864_original-2.png", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2026\/08\/event_149864_original-2.png", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2026\/08\/event_149864_original-2.png", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/resolve\/event_grid_2x\/media\/attachments\/2026\/08\/event_149864_original-2.png", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2026\/08\/event_149864_original-2.png", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2026\/08\/event_149864_original-2.png" }, "occurrence_count":22, "first_occurrence":21907270 } }