{ "135175-21876452": { "datetime_modified":"20250508T104759", "datetime_start":"20250512T100000", "datetime_end":"20250512T110000", "has_end_time":1, "date_start":"2025-05-12", "date_end":"2025-05-12", "time_start":"10:00:00", "time_end":"11:00:00", "time_zone":"America\/Detroit", "event_title":"Bioinformatics Town Hall at NCRC - Rescheduled", "occurrence_title":"", "combined_title":"Bioinformatics Town Hall at NCRC - Rescheduled", "event_subtitle":"", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"The event on Monday, May 12, will be rescheduled. You are invited to join us on Thursday, May 15, from 11:00 am - 12:00 pm, at the Taubman Health Sciences Library (THSL), Room 6000. Learn more and Register (https:\/\/medresearch.umich.edu\/events\/bioinformatics-town-hall-thsl\/2025-05-15). You are also invited to take a short survey (https:\/\/umich.qualtrics.com\/jfe\/form\/SV_5mYSQ3OszoHn2UC). \r\n---\r\nWe need your help with an important initiative in the Med School Office of Research and Biomedical Research Core Facilities (BRCF) to better align bioinformatics support with research needs.\r\n\r\nSince becoming a recharge facility in 2012, the BRCF Bioinformatics Core has seen major changes in the bioinformatics landscape. Platforms now offer bundled analysis support, and researchers use commercial or open-source systems (e.g., nf-Core\/Seqera, Epi2Me, Illumina Partek).\r\n\r\nOther informatics cores at U-M have also expanded, and labs are gaining computational skills. Despite this, bioinformatics still presents challenges and frustrations for many researchers. Changes at the NIH may also impact the availability of bioinformatics support.\r\n\r\nTo address these issues, we aim to engage the research community and ensure the BRCF Bioinformatics Core meets evolving needs. We are gathering feedback through focus groups, surveys, and town halls:\r\n\r\nJoin us for coffee, cookies, and an open discussion of bioinformatics needs. \r\n\r\nNCRC - Monday, May 12, 10:00 am - 11:00 am, Building 10, Rooms G063\/G064 --> This event will be rescheduled.\r\nMed Campus - Thursday, May 15, 11:00 am - 12:00 pm, Taubman Health Sciences Library (THSL), Room 6000\r\n\r\nRegister today! https:\/\/forms.gle\/Br2Zex7Uv7zT7UNg6\r\n\r\nCan't make the town halls? No problem! Consider filling out this short survey: michmed.org\/jVmMy", "occurrence_notes":null, "guid":"135175-21876452@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/135175", "building_id":"null", "building_name":"North Campus Research Complex Building 10", "campus_maps_id":"615", "room":"Rooms G063\/G064", "location_name":"North Campus Research Complex Building 10", "has_livestream":0, "cost":"", "tags":["Research Core","Research"], "website":"https:\/\/medresearch.umich.edu\/office-research\/about-office-research\/biomedical-research-core-facilities", "sponsors":[ { "group_name":"Biomedical Research Core Facilities", "group_id":"4565", "website":"http:\/\/brcf.medicine.umich.edu" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21876452 } , "135369-21876759": { "datetime_modified":"20250505T140109", "datetime_start":"20250512T110000", "datetime_end":"20250512T120000", "has_end_time":1, "date_start":"2025-05-12", "date_end":"2025-05-12", "time_start":"11:00:00", "time_end":"12:00:00", "time_zone":"America\/Detroit", "event_title":"Laura Reitz Dissertation Defense", "occurrence_title":"", "combined_title":"Laura Reitz Dissertation Defense: Genomic Insights into Cyanotoxins and Microbial Interaction in Cyanobacterial Harmful Algal Blooms", "event_subtitle":"Genomic Insights into Cyanotoxins and Microbial Interaction in Cyanobacterial Harmful Algal Blooms", "event_type":"Lecture \/ Discussion", "event_type_id":"13", "description":"Cyanobacterial harmful algal blooms (cHABs) are the proliferation of a diverse community of photosynthetic bacteria in marine and freshwater ecosystems. cHABs are globally distributed and pose risk to humans and wildlife health due to their ability to produce secondary metabolites that have toxic effects, known as cyanotoxins. Changes in the climate such as increased temperature and precipitation, which causes excess loading of nutrients such as nitrogen and phosphorus from runoff into waterways, promote proliferation of cHABs. Microcystis spp. are often the dominant genera in freshwater cHABs globally and produce the cyanotoxin microcystin, which has hepatotoxic effects. In the western basin of Lake Erie, annual cHABs dominated by Microcystis spp. have occurred May through September for over four decades, often yielding microcystin concentrations exceeding the World Health Organization and United States federal Environmental Protection Agency\u2019s drinking water guideline of 1-1.6\u00b5g\/L.\r\n\r\nIn this dissertation, three studies used genomic analyses to identify specific cyanobacterial genotypes involved in cyanotoxin production and investigated how they interact with other microbes in cHABs, leveraging Lake Erie as a model system for similar blooms in other regions. In Chapter 2, single-copy core genes were identified as markers of Microcystis strain diversity and were found via comparative genomics to resolve Microcystis phylogenies better than previously identified marker genes. The markers identified were also found to be useful in inferring Microcystis gene content and phenotypes such as potential production of secondary metabolites such as cyanotoxins. Chapter 3 characterized and linked mcy genotypes with microcystin congeners via spatiotemporal profiling. Results show that the diversity of microcystin congener type is due to a combination of environmental and genetic diversity. Even with genetic diversity not being the sole driver of congener diversity, specific single nucleotide polymorphisms were identified to be associated with biochemically important domains within the mcy operon and to be strongly correlated to the increased abundance of specific congeners. Lastly, in chapter 4, the cyanobacterium Pseudanabaena, which is commonly associated with\r\nMicrocystis and inhabits the Microcystis phycosphere, was genetically and metabolomically characterized to provide insight potential interactions between these two organisms. Pseudanabaena was found to have the capability to produce many different compounds which could have mutualistic and potentially allelopathic effects on Microcystis and its associated microbiome. Together, these studies highlight the genetic variability in cyanobacteria and how it can be an indicator of production for specific natural compounds such as cyanotoxins, which could influence how the organism interacts with other community members and its impact on the environment. Additionally, it serves as a basis for future studies to elucidate mechanisms of genetic regulation of production of microcystins.", "occurrence_notes":null, "guid":"135369-21876759@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/135369", "building_id":"1000188", "building_name":"1100 North University Building", "campus_maps_id":"628", "room":"2540", "location_name":"1100 North University Building", "has_livestream":0, "cost":"", "tags":["Dissertation"], "website":"", "sponsors":[ { "group_name":"Earth and Environmental Sciences", "group_id":"3170", "website":"http:\/\/www.lsa.umich.edu\/earth" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2025\/05\/event_135369_original-1.png", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2025\/05\/event_135369_original-1.png", 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"event_type":"Presentation", "event_type_id":"16", "description":"Join Zaira Pagan Cajigas\u00a0for their PhD defense: https:\/\/ioe.engin.umich.edu\/people\/pagan-cajigas-zaira\/\r\n\r\nChair: Seth Guikema", "occurrence_notes":null, "guid":"135162-21876437@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/135162", "building_id":"1000429", "building_name":"Industrial and Operations Engineering Building", "campus_maps_id":"73", "room":"G690", "location_name":"Industrial and Operations Engineering Building", "has_livestream":1, "livestream_type":"zoom", "livetream_require_login":0, "livestream_id":"97960655778", "livestream_password":"Phd!", "livestream_link":"https:\/\/umich.zoom.us\/j\/97960655778", "cost":"", "tags":["Michigan Engineering","Ioephdstudents","Ioe Defenses","Industrial And Operations Engineering"], "website":"", "sponsors":[ { "group_name":"Industrial & Operations Engineering", "group_id":"3301", "website":"http:\/\/ioe.engin.umich.edu\/" } ], 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Clements Library is pleased to announce a forthcoming exhibition in recognition of the 250th Anniversary of the military hostilities that began the American Revolutionary War. The Battles of Lexington and Concord are firmly established in American memory as the culmination of a range of governmental, political, economic, and social tensions that amplified in the decade leading up to 1775. In this exhibit, visitors will have the opportunity to see original historical manuscript letters, documents, newspapers, and artwork that reveal aspects of the bloody work of Empire and individual alike in April 1775.\r\n\r\nAmong the items on display will be Commander in Chief of the British Army, General Thomas Gage's draft orders for the Concord Expedition, April 18, 1775; a bundle of letters collected by former Sons of Liberty supporter Dr. Benjamin Church, which he secretly turned over to British Army intelligence; letters by Silas Deane, John Hancock, and Rachel Revere; and much more.\r\n\r\nOpen weekdays from 12-4 pm.", "occurrence_notes":null, "guid":"134875-21875529@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/134875", "building_id":"1000159", "building_name":"William Clements Library", "campus_maps_id":"165", "room":"", "location_name":"William Clements Library", "has_livestream":0, "cost":"", "tags":["Ann Arbor","Library","libraries","history","Free","Exhibition","Exhibit","Americana","american history","american culture"], "website":"", "sponsors":[ { "group_name":"William L. 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Kahn, MD", "event_subtitle":"Barbara B. Kahn, MD", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Biology and Therapeutic Potential of a Class of Lipids with Anti-Diabetic and Anti-Inflammatory Effects\r\n\r\nBarbara B. Kahn, MD\r\nGeorge R. Minot Professor of Medicine\r\nHarvard Medical School\r\nVice-Chair for Research Strategy, Department of Medicine\r\nSenior Faculty and Former Chief,\r\nDivision of Endocrinology, Diabetes and Metabolism\r\nBeth Israel Deaconess Medical Center Institute Member\r\nBroad Institute of MIT and Harvard\r\n\r\nLunch served at 11:15 a.m. Please RSVP for lunch using the following link: https:\/\/umich.qualtrics.com\/jfe\/form\/SV_0AgMmLmOWHkuYlg", "occurrence_notes":null, "guid":"135149-21876425@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/135149", "building_id":"null", "building_name":"North Campus Research Complex Building 10", "campus_maps_id":"615", "room":"South Atrium", "location_name":"North Campus Research Complex Building 10", "has_livestream":0, "cost":"", "tags":["Basic Science","Virtual","Science","Research","Postdoctoral Research Fellows","North campus","In Person","Free","Food","Faculty","Biosciences"], "website":"", "sponsors":[ { "group_name":"Caswell Diabetes Institute", "group_id":"4748", "website":"" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21876425 } , "101962-21865210": { "datetime_modified":"20241217T091825", "datetime_start":"20250512T120000", "datetime_end":"20250512T125000", "has_end_time":1, "date_start":"2025-05-12", "date_end":"2025-05-12", "time_start":"12:00:00", "time_end":"12:50:00", "time_zone":"America\/Detroit", "event_title":"Take Command Of Your Dissertation With Microsoft Word", "occurrence_title":"", "combined_title":"Take Command Of Your Dissertation With Microsoft Word", "event_subtitle":"", "event_type":"Livestream \/ Virtual", "event_type_id":"24", "description":"You are an expert in your field, but you may not be an expert in Rackham\u2019s rules around properly formatting your dissertation or thesis. This 50-minute online workshop will save you hours of time in creating your dissertation \u2014 and in any other writing you do with Microsoft Word.\r\n\r\nIn this online workshop, the experts from the University Library will introduce you to lesser-known features of Microsoft Word that can help you ensure consistent formatting through the document, as well as manage margin size, insert captions, and create an automatic Table of Contents, List of Figures, or a List of Tables. 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