{ "108086-21818925": { "datetime_modified":"20240409T110807", "datetime_start":"20240422T160000", "datetime_end":"20240422T173000", "has_end_time":1, "date_start":"2024-04-22", "date_end":"2024-04-22", "time_start":"16:00:00", "time_end":"17:30:00", "time_zone":"America\/Detroit", "event_title":"Gomberg Lecture - \"Structural Biology of Bacterial Antiphage Defense\"", "occurrence_title":"", "combined_title":"Gomberg Lecture - \"Structural Biology of Bacterial Antiphage Defense\": Dinshaw Patel (Memorial Sloan Kettering Cancer Center)", "event_subtitle":"Dinshaw Patel (Memorial Sloan Kettering Cancer Center)", "event_type":"Lecture \/ Discussion", "event_type_id":"13", "description":"The lecture will begin by describing research on CRISPR systems containing single subunit Cas proteins and multi-subunit Cascade complexes with the emphasis on assembly, target recognition, cleavage autoimmunity and the impact of anti-CRIPR proteins in suppressing the CRISPR-Cas surveillance pathway. The lecture will next focus on multi-subunit type Ill CRISPR Csm complexes outlining mechanisms underlying target RNA binding and cleavage, as well as cyclic oligoadenylate (cOA) second messenger formation. Next, the lecture will address mechanistic insights into cOA-mediated activation of CARF\u00adeffector cassettes with the emphasis on effectors that are nucleases, transmembrane domains, deaminases and NADases, that trigger abortive infection. The lecture will end with a mechanistic description on some examples of recently identified bacterial systems involved in antiphage defense.", "occurrence_notes":null, "guid":"108086-21818925@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/108086", "building_id":"1000158", "building_name":"Chemistry Dow Lab", "campus_maps_id":"34", "room":"", "location_name":"Chemistry Dow Lab", "has_livestream":0, "cost":"", "tags":["Gomberg Lecture","Science","Chemistry"], "website":"https:\/\/www.mskcc.org\/research\/ski\/labs\/dinshaw-patel", "sponsors":[ { "group_name":"Department of Chemistry", "group_id":"3761", "website":"https:\/\/lsa.umich.edu\/chem" }, { "group_name":"Chemical Biology", "group_id":"4385", "website":"" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", 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given through the Elizalde-Winikates Family Fund in Economics and the Economics Strategic Fund.", "occurrence_notes":null, "guid":"117369-21839222@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/117369", "building_id":"1000154", "building_name":"Lorch Hall", "campus_maps_id":"88", "room":"201", "location_name":"Lorch Hall", "has_livestream":0, "cost":"", "tags":["seminar","Public Finance","Economics"], "website":"http:\/\/www.lsa.umich.edu\/econ", "sponsors":[ { "group_name":"Department of Economics", "group_id":"3302", "website":"http:\/\/www.lsa.umich.edu\/econ" }, { "group_name":"Public Finance", "group_id":"3553", "website":"" }, { "group_name":"Department of Economics Seminars", "group_id":"3566", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2024\/04\/event_117369_original-2.jpeg", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2024\/04\/event_117369_original-2.jpeg", 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Topics include the following:\r\n\r\n(1) A corpus study on the role of the sonority hierarchy in consonant cluster mispronunciations in English and Thai-speaking children;\r\n\r\n(2) A combined corpus \/ experimental study on the effects of screen time exposure in Mainstream American English (MAE) on African-American English (AAE)-speaking toddlers' phonology;\r\n\r\n(3) A longitudinal experimental study on vocabulary regression in school-age heritage speakers of Spanish attending English-language schools;\r\n\r\n(4) An experimental study on the extent to which bilinguals of morphophonologically similar (Spanish-Portuguese) and dissimilar (Spanish-German) languages depend on the lexical constraint of mutual exclusivity across the developmental trajectory;\r\n\r\n(5) A corpus study on the acquisition of grammatical gender among bilingual speakers of languages with differing gender systems (French, Russian);\r\n\r\n(6) An experimental study on the acquisition of syntactic and lexical reflexivity in bilingual (Spanish-English) and monolingual children.", "occurrence_notes":null, "guid":"121593-21846807@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/121593", "building_id":"1000154", "building_name":"Lorch Hall", "campus_maps_id":"88", "room":"471", "location_name":"Lorch Hall", "has_livestream":0, "cost":"", "tags":["Graduating Seniors"], "website":"", "sponsors":[ { "group_name":"Department of Linguistics", "group_id":"3480", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2024\/04\/event_121593_original-1.png", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2024\/04\/event_121593_original-1.png", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2024\/04\/event_121593_original-1.png", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2024\/04\/event_121593_original-1.png", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2024\/04\/event_121593_original-1.png", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2024\/04\/event_121593_original-1.png", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2024\/04\/event_121593_original-1.png", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2024\/04\/event_121593_original-1.png", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2024\/04\/event_121593_original-1.png", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2024\/04\/event_121593_original-1.png", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2024\/04\/event_121593_original-1.png", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2024\/04\/event_121593_original-1.png", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2024\/04\/event_121593_original-1.png", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2024\/04\/event_121593_original-1.png", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2024\/04\/event_121593_original-1.png", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2024\/04\/event_121593_original-1.png" }, "occurrence_count":1, "first_occurrence":21846807 } , "121656-21846875": { "datetime_modified":"20240421T144047", "datetime_start":"20240422T160000", "datetime_end":"20240422T170000", "has_end_time":1, "date_start":"2024-04-22", "date_end":"2024-04-22", "time_start":"16:00:00", "time_end":"17:00:00", "time_zone":"America\/Detroit", "event_title":"Polypositroids", "occurrence_title":"", "combined_title":"Polypositroids: Mia Smith", "event_subtitle":"Mia Smith", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"To any matroid $M$, one can associate a matroid polytope $P_M$. It is well-known that these matroid polytopes arise from generalized permutohedra. In 2020, Lam and Postnikov observed that a matroid $M$ is a positroid iff the matroid polytope $P_M$ is an alcoved polytope. This motivated the definition of a polypositroid, a polytope which is both a generalized permutohedra and an alcoved polytope. In this talk, we'll define and explore polypositroids with an eye towards understanding the cone of polypositroids in relation to the cone of generalized permutohedra and the cone of alcoved polytopes.", "occurrence_notes":null, "guid":"121656-21846875@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/121656", "building_id":"1000166", "building_name":"East Hall", "campus_maps_id":"53", "room":"3866", "location_name":"East Hall", "has_livestream":0, "cost":"", "tags":["Graduate","Graduate Students","Mathematics"], "website":"", "sponsors":[ { "group_name":"Student Combinatorics Seminar - Department of Mathematics", "group_id":"4907", "website":"" }, { "group_name":"Department of Mathematics", "group_id":"3791", "website":"" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21846875 } , "120920-21845549": { "datetime_modified":"20240329T134536", "datetime_start":"20240422T160000", "datetime_end":"20240422T180000", "has_end_time":1, "date_start":"2024-04-22", "date_end":"2024-04-22", "time_start":"16:00:00", "time_end":"18:00:00", "time_zone":"America\/Detroit", "event_title":"Seed Library Kickoff", "occurrence_title":"", "combined_title":"Seed Library Kickoff", "event_subtitle":"", "event_type":"Other", "event_type_id":"22", "description":"Come celebrate the kickoff of our seed library on Earth Day! \r\n\r\nCreate cyanotype prints and artwork, make a seed dumpling, connect with student sustainability groups, and share seed stories in the Shapiro Gallery (Clark Commons, 3rd floor).\r\n\r\nCheck out free native Michigan plant and regionally-grown vegetable seed varieties from the Design-o-matic vending machine near the Design Lab (1st floor Shapiro Library). \r\n\r\nAs always, our events are open to the public.", "occurrence_notes":null, "guid":"120920-21845549@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/120920", "building_id":"1000227", "building_name":"Shapiro Library", "campus_maps_id":"139", "room":"Shapiro Gallery, 3rd Floor", "location_name":"Shapiro Library", "has_livestream":0, "cost":"", "tags":["Free","Library"], "website":"", "sponsors":[ { "group_name":"University Library", "group_id":"1186", "website":"https:\/\/www.facebook.com\/UMichLibrary\/" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2024\/03\/event_120920_original-1.png", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2024\/03\/event_120920_original-1.png", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2024\/03\/event_120920_original-1.png", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2024\/03\/event_120920_original-1.png", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2024\/03\/event_120920_original-1.png", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2024\/03\/event_120920_original-1.png", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2024\/03\/event_120920_original-1.png", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2024\/03\/event_120920_original-1.png", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2024\/03\/event_120920_original-1.png", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2024\/03\/event_120920_original-1.png", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2024\/03\/event_120920_original-1.png", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2024\/03\/event_120920_original-1.png", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2024\/03\/event_120920_original-1.png", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2024\/03\/event_120920_original-1.png", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2024\/03\/event_120920_original-1.png", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2024\/03\/event_120920_original-1.png" }, "occurrence_count":1, "first_occurrence":21845549 } , "112535-21829089": { "datetime_modified":"20240417T174854", "datetime_start":"20240422T161500", "datetime_end":"20240422T173000", "has_end_time":1, "date_start":"2024-04-22", "date_end":"2024-04-22", "time_start":"16:15:00", "time_end":"17:30:00", "time_zone":"America\/Detroit", "event_title":"GLNT: Vanishing of Selmer groups for Siegel modular forms", "occurrence_title":"", "combined_title":"GLNT: Vanishing of Selmer groups for Siegel modular forms: Samuel Mundy (Princeton)", "event_subtitle":"Samuel Mundy (Princeton)", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Let \u03c0 be a cuspidal automorphic representation of Sp_2n over Q which is holomorphic discrete series at infinity, and \u03c7 a Dirichlet character. Then one can attach to \u03c0 an orthogonal p-adic Galois representation \u03c1 of dimension 2n+1. Assume \u03c1 is irreducible, that \u03c0 is ordinary at p, and that p does not divide the conductor of \u03c7. I will describe work in progress which aims to prove that the Bloch--Kato Selmer group attached to the twist of \u03c1 by \u03c7 vanishes, under some mild ramification assumptions on \u03c0; this is what is predicted by the Bloch--Kato conjectures.\r\n\r\nThe proof uses \"ramified Eisenstein congruences\" by constructing p-adic families of Siegel cusp forms degenerating to Klingen Eisenstein series of nonclassical weight, and using these families to construct ramified Galois cohomology classes for the Tate dual of the twist of \u03c1 by \u03c7.", "occurrence_notes":null, "guid":"112535-21829089@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/112535", "building_id":"1000166", "building_name":"East Hall", "campus_maps_id":"53", "room":"3088", "location_name":"East Hall", "has_livestream":0, "cost":"", "tags":["Mathematics"], "website":"", "sponsors":[ { "group_name":"Group, Lie and Number Theory Seminar - Department of Mathematics", "group_id":"4892", "website":"" }, { "group_name":"Department of Mathematics", "group_id":"3791", "website":"" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21829089 } }