{ "130748-21866759": { "datetime_modified":"20250110T130940", "datetime_start":"20250228T120000", "datetime_end":"20250228T160000", "has_end_time":1, "date_start":"2025-02-28", "date_end":"2025-02-28", "time_start":"12:00:00", "time_end":"16:00:00", "time_zone":"America\/Detroit", "event_title":"More than Gray: Reimagining Early America in Full Color", "occurrence_title":"", "combined_title":"More than Gray: Reimagining Early America in Full Color", "event_subtitle":"", "event_type":"Exhibition", "event_type_id":"7", "description":"The American past was lived in full color, but this vibrant history can be easily missed in surviving evidence. You can\u2019t deny that there\u2019s something about a black-and-white photograph that feels\u2026 stuffy. With portraits showing people with their shirts buttoned right to the neck and everything in shades of gray and brown, our imaginations can incline to thinking of the past as a bit staid, if not downright dull. But look a little closer, and you\u2019ll see signs that the fashion choices available to those who came before us were more colorful than you might first think. From the fabrics they wore, to the games they played, or the books they read, their world was alive with bright hues. This exhibit invites you to reimagine history with a fuller color palette and picture the vibrancy and joy that just might be hidden behind the unsmiling photographs.\r\n\r\nExhibition opening weekdays from 12-4.", "occurrence_notes":null, "guid":"130748-21866759@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/130748", "building_id":"1000159", "building_name":"William Clements Library", "campus_maps_id":"165", "room":"", "location_name":"William Clements Library", "has_livestream":0, "cost":"", "tags":["american history","history","Free","Exhibition","Exhibit","american culture","libraries","Library"], "website":"https:\/\/myumi.ch\/zXQ3w", "sponsors":[ { "group_name":"William L. 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Along the way, she encounters long-necked plesiosaurs, giant turtles, enormous fish, fierce sharks, and the most dangerous sea monster of all\u2013 the mosasaur.", "occurrence_notes":null, "guid":"121866-21866323@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/121866", "building_id":"1005169", "building_name":"Museum of Natural History", "campus_maps_id":"646", "room":"Planetarium & Dome Theater", "location_name":"Museum of Natural History", "has_livestream":0, "cost":"Tickets are $8 and are available in the museum store on the day of the show.", "tags":["Museum","natural history museum","museums"], "website":"", "sponsors":[ { "group_name":"Planetarium & Dome Theater at the Museum of Natural History", "group_id":"3825", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2024\/05\/event_121866_original-1.jpg", "styled_images":{ 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Here, we integrate solution NMR spectroscopy and chemical probing approaches to visualize a two-state conformational ensemble for the central stem-loop 3 (SL3) of 7SK RNA, a critical element for 7SK RNA function in transcription regulation. We find that the SL3 distal end undergoes slow exchange between two equally populated yet structurally distinct states in both isolated SL3 constructs and full-length 7SK RNA. We rationally designed constructs that lock SL3 into a single state and demonstrate that both NMR and chemical probing data fit to a linear combination of the two states. A survey of vertebrate 7SK RNA sequences shows exquisite sequence dependence on the two-state equilibrium. Moreover, we find that changing environmental variables such as temperature and ionic strength shifts the equilibrium between the two states. We determine thermodynamic parameters such as divalent cation binding affinities for individual states and find that the two states have strikingly different responses to addition of divalent cations. Together, these data indicate that the two states significantly differ in their structural and dynamic properties, which may impact SL3 function in transcription regulation. These results provide new insights into 7SK RNA structural dynamics and demonstrate the utility of integrating chemical probing with NMR spectroscopy to gain quantitative insights into RNA conformational ensembles.", "occurrence_notes":null, "guid":"125334-21854754@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/125334", "building_id":"1000158", "building_name":"Chemistry Dow Lab", "campus_maps_id":"34", "room":"1640", "location_name":"Chemistry Dow Lab", "has_livestream":0, "cost":"", "tags":["Biophysics"], "website":"", "sponsors":[ { "group_name":"LSA Biophysics", "group_id":"3767", "website":"" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21854754 } , "125537-21866407": { "datetime_modified":"20250207T161055", "datetime_start":"20250228T123000", "datetime_end":"20250228T130000", "has_end_time":1, "date_start":"2025-02-28", "date_end":"2025-02-28", "time_start":"12:30:00", "time_end":"13:00:00", "time_zone":"America\/Detroit", "event_title":"Coral Reef Tank Visit", "occurrence_title":"", "combined_title":"Coral Reef Tank Visit", "event_subtitle":"", "event_type":"Tours", "event_type_id":"25", "description":"Join Professor Jim Bardwell for a peek behind the scenes at his large coral reef tank featuring many species of coral, anemone, and fish. Explore reef ecology and, if you're lucky, get a glimpse of a reclusive octopus! 30 minutes, limit 12 people. This program takes place in the research area of the Biological Sciences Building and is recommended for ages 6 and up.\r\nSpace is available first come, first served. Sign up and meet at the Welcome desk.", "occurrence_notes":null, "guid":"125537-21866407@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/125537", "building_id":"1005169", "building_name":"Museum of Natural History", "campus_maps_id":"646", "room":"Welcome Desk", "location_name":"Museum of Natural History", "has_livestream":0, "cost":"", "tags":["natural history museum","Museum"], "website":"", "sponsors":[ { "group_name":"Museum of Natural History", "group_id":"3445", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2024\/09\/event_125537_original-1.jpeg", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2024\/09\/event_125537_original-1.jpeg", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2024\/09\/event_125537_original-1.jpeg", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2024\/09\/event_125537_original-1.jpeg", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2024\/09\/event_125537_original-1.jpeg", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2024\/09\/event_125537_original-1.jpeg", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2024\/09\/event_125537_original-1.jpeg", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2024\/09\/event_125537_original-1.jpeg", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2024\/09\/event_125537_original-1.jpeg", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2024\/09\/event_125537_original-1.jpeg", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2024\/09\/event_125537_original-1.jpeg", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2024\/09\/event_125537_original-1.jpeg", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2024\/09\/event_125537_original-1.jpeg", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2024\/09\/event_125537_original-1.jpeg", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2024\/09\/event_125537_original-1.jpeg", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2024\/09\/event_125537_original-1.jpeg" }, "occurrence_count":40, "first_occurrence":21855342 } }