{ "138628-21883506": { "datetime_modified":"20251020T140116", "datetime_start":"20251120T133000", "datetime_end":"20251120T143000", "has_end_time":1, "date_start":"2025-11-20", "date_end":"2025-11-20", "time_start":"13:30:00", "time_end":"14:30:00", "time_zone":"America\/Detroit", "event_title":"ChE SEMINAR: Allie Obermeyer, Columbia University", "occurrence_title":"", "combined_title":"ChE SEMINAR: Allie Obermeyer, Columbia University: \"Metabolic activity to animate coacervate materials\"", "event_subtitle":"\"Metabolic activity to animate coacervate materials\"", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"A reception with light refreshments will be held in the B10 lobby before each seminar from 1-1:30 p.m.\r\n\r\nAllie Obermeyer is an Associate Professor of Chemical Engineering at Columbia University. The Obermeyer Group harnesses the biological and polymeric properties of proteins to create new materials. These studies blend approaches from chemical and synthetic biology, protein engineering, and polymer physics. Allie obtained her undergraduate degree in Chemistry from Rice University and performed undergraduate research in the laboratory of Seiichi P.T. Matsuda. She then joined the Department of Chemistry at UC Berkeley and earned a PhD degree under the guidance of Matthew Francis as a part of the Chemical Biology Graduate Program. She subsequently conducted postdoctoral training in the Chemical Engineering department at MIT as an Arnold Beckman postdoctoral fellow in the laboratory of Bradley Olsen. In 2017, she started her independent career at Columbia University. She has been the recipient of an NSF CAREER and NIH MIRA award as well as a Camille Dreyfus Teacher Scholar Award and a Teaching Award from the Columbia Engineering Alumni Association. \r\n\r\nProtein de-mixing is essential to the organization of cellular components. These phase separated membraneless organelles, termed biomolecular condensates, create distinct environments that are essential to cellular processes ranging from signaling to gene expression and stress response. Equilibrium theories reasonably describe the formation of and biomolecule partitioning in these biomolecular condensates, but cellular activities regularly create unstable nonequilibrium compositions. Here I share our efforts to understand how model biomolecular condensates respond when forced out of equilibrium. We create model condensates via the complex coacervation of an enzyme and a polyion. The phase behavior of the resulting liquid-like drops is coupled to their catalytic activity via the local pH. Reaction with chemical \u201cfuel\u201d lowers the pH, creating unstable nonequilibrium conditions, ultimately triggering the formation of internal vacuoles and size dependent droplet dissolution. These responses depend on the rate of reaction-induced pH changes relative to relaxation mechanisms inside the drops. Slow changes are controlled by equilibrium thermodynamics; faster pH changes couple to macromolecule transport on the drop scale. Finally, we demonstrate that these findings translate to more biologically relevant condensates.", "occurrence_notes":null, "guid":"138628-21883506@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/138628", "building_id":"null", "building_name":"North Campus Research Complex Building 10", "campus_maps_id":"615", "room":"Auditorium", "location_name":"North Campus Research Complex Building 10", "has_livestream":0, "cost":"", "tags":["Undergraduate","seminar","Graduate","Free","chemical engineering"], "website":"", "sponsors":[ { "group_name":"Chemical Engineering", "group_id":"3218", "website":"http:\/\/che.engin.umich.edu\/" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2025\/09\/event_138628_original-1.png", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2025\/09\/event_138628_original-1.png", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2025\/09\/event_138628_original-1.png", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2025\/09\/event_138628_original-1.png", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2025\/09\/event_138628_original-1.png", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2025\/09\/event_138628_original-1.png", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2025\/09\/event_138628_original-1.png", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2025\/09\/event_138628_original-1.png", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2025\/09\/event_138628_original-1.png", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2025\/09\/event_138628_original-1.png", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2025\/09\/event_138628_original-1.png", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2025\/09\/event_138628_original-1.png", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2025\/09\/event_138628_original-1.png", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2025\/09\/event_138628_original-1.png", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2025\/09\/event_138628_original-1.png", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2025\/09\/event_138628_original-1.png" }, "occurrence_count":1, "first_occurrence":21883506 } , "141298-21888551": { "datetime_modified":"20251029T152544", "datetime_start":"20251120T140000", "datetime_end":"20251120T150000", "has_end_time":1, "date_start":"2025-11-20", "date_end":"2025-11-20", "time_start":"14:00:00", "time_end":"15:00:00", "time_zone":"America\/Detroit", "event_title":"Webinar: Building a Collaborative Water Quality Monitoring Strategy for a Changing St. Louis River Estuary", "occurrence_title":"", "combined_title":"Webinar: Building a Collaborative Water Quality Monitoring Strategy for a Changing St. Louis River Estuary", "event_subtitle":"", "event_type":"Lecture \/ Discussion", "event_type_id":"13", "description":"The St. Louis River Estuary, located at the headwaters of Lake Superior, is nearing a major milestone: its anticipated delisting as a Great Lakes Area of Concern by 2030. Yet even as remediation and restoration successes are celebrated, new environmental stressors, particularly harmful algal blooms, raise concerns about the estuary\u2019s long-term water quality health. In response, a group of local, state, federal, and tribal partners who have long worked in and cared for the estuary began calling for a science-based monitoring strategy that could respond to emerging threats and support ongoing stewardship beyond delisting. This group of partners, who had long advocated for a coordinated monitoring effort, collaborated closely with the Lake Superior National Estuarine Research Reserve to launch this collaborative research project.\r\n\r\nTogether, they shaped a shared vision: a comprehensive program of observations, analyses, and public reporting that would protect remediation and restoration investments and inform future decision-making. The partners and project team developed a research approach that combined strong scientific design to build foundational understanding of phytoplankton dynamics with a focus on generating practical, actionable insights for a shared long term monitoring strategy. In this webinar, the project team will share more about predictors of cyanobacteria biovolume identified in the estuary and an actionable sampling approach they developed to improve bloom detection and efficient water quality monitoring into the future.", "occurrence_notes":null, "guid":"141298-21888551@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/141298", "building_id":"null", "building_name":"Off Campus Location", "campus_maps_id":"1", "room":"", "location_name":"Virtual", "has_livestream":1, "livestream_type":"other", "livetream_require_login":0, "livestream_id":"", "livestream_link":"", "cost":"", "tags":["Sustainability","Environment"], "website":"https:\/\/nerrssciencecollaborative.org\/event\/wqm-st-louis", "sponsors":[ { "group_name":"Graham Sustainability Institute", "group_id":"1807", "website":"http:\/\/graham.umich.edu" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", 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