{ "154409-21917688": { "datetime_modified":"20261102T091118", "datetime_start":"20261109T150000", "datetime_end":"20261109T160000", "has_end_time":1, "date_start":"2026-11-09", "date_end":"2026-11-09", "time_start":"15:00:00", "time_end":"16:00:00", "time_zone":"America\/Detroit", "event_title":"HEP-Astro Seminar | The galaxy's history under our feet: paleo-detection of cosmic rays with PRimuS", "occurrence_title":"", "combined_title":"HEP-Astro Seminar | The galaxy's history under our feet: paleo-detection of cosmic rays with PRimuS: Claudio Galelli (INFN Milano)", "event_subtitle":"Claudio Galelli (INFN Milano)", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"The sources and history of cosmic rays are largely unknown because of the intrinsic deflection and delay imposed by cosmic magnetic fields. Minerals might offer a way to investigate this mystery from the rock record, as they preserve the damage tracks of the particles that crossed them over their geological history. This idea, known as paleo-detection, is mostly known for rare-event searches, such as WIMP recoils and neutrino interactions, where nanometre-scale tracks and the need for ultraclean minerals require a demanding readout. Cosmic rays are the opposite case: the signal is expected to be abundant, and the micron-to-tens-of-micron tracks can be revealed with simple etching and optical microscopy. \n\nI will present the simulation framework we built to predict the track-length spectrum for a given mineral and flux history. It combines MCEq and Geant4, follows the overburden history of the sample, and folds in detection efficiency and measurement effects. I will then show how these predictions are confronted with data in PRImuS, our experimental proof of concept: chemical etching of obsidian, argon-plasma etching of halite, automated optical microscopy, and OptimusPrimus, a deep-learning tool for track recognition. The pipeline is validated on obsidian, and its application to halite is the next step. I will conclude with the outlook toward the possible GALACTIC project, based on light-sheet microscopy.", "occurrence_notes":null, "guid":"154409-21917688@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/154409", "building_id":"1000167", "building_name":"West Hall", "campus_maps_id":"163", "room":"340", "location_name":"West Hall", "has_livestream":0, "cost":"", "tags":["Physics","Science"], "website":"", "sponsors":[ { "group_name":"HEP - Astro Seminars", "group_id":"3799", "website":"" }, { "group_name":"Department of Physics", "group_id":"1965", "website":"" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21917688 } , "154463-21917780": { "datetime_modified":"20261102T204011", "datetime_start":"20261109T150000", "datetime_end":"20261109T160000", "has_end_time":1, "date_start":"2026-11-09", "date_end":"2026-11-09", "time_start":"15:00:00", "time_end":"16:00:00", "time_zone":"America\/Detroit", "event_title":"Math Grad Show and Tell Seminar: The surprising asymptotics of bingo", "occurrence_title":"", "combined_title":"Math Grad Show and Tell Seminar: The surprising asymptotics of bingo: Surya Subbarao", "event_subtitle":"Surya Subbarao", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Inspired by Okta Verify Bingo in the graduate lounge, consider an N by N square of cells. Every second, a uniformly random cell is chosen (with replacement) and filled in. What is the expected amount of time until a bingo, i.e. a fully filled in row, column, or diagonal? How does this grow asymptotically as N increases? The answer involves some interesting mathematics and may surprise you.", "occurrence_notes":null, "guid":"154463-21917780@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/154463", "building_id":"1000166", "building_name":"East Hall", "campus_maps_id":"53", "room":"4088", "location_name":"East Hall", "has_livestream":0, "cost":"", "tags":["Mathematics"], "website":"https:\/\/public.websites.umich.edu\/~mmadrugo\/MGSTS\/", "sponsors":[ { "group_name":"Math Grad Show and Tell Seminar - Department of Mathematics", "group_id":"5515", "website":"" }, { "group_name":"Department of Mathematics", "group_id":"3791", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2026\/11\/event_154463_original-1.png", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2026\/11\/event_154463_original-1.png", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2026\/11\/event_154463_original-1.png", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2026\/11\/event_154463_original-1.png", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2026\/11\/event_154463_original-1.png", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2026\/11\/event_154463_original-1.png", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2026\/11\/event_154463_original-1.png", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2026\/11\/event_154463_original-1.png", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2026\/11\/event_154463_original-1.png", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2026\/11\/event_154463_original-1.png", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2026\/11\/event_154463_original-1.png", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2026\/11\/event_154463_original-1.png", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2026\/11\/event_154463_original-1.png", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2026\/11\/event_154463_original-1.png", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2026\/11\/event_154463_original-1.png", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2026\/11\/event_154463_original-1.png" }, "occurrence_count":1, "first_occurrence":21917780 } , "154033-21917057": { "datetime_modified":"20261023T103023", "datetime_start":"20261109T150000", "datetime_end":"20261109T160000", "has_end_time":1, "date_start":"2026-11-09", "date_end":"2026-11-09", "time_start":"15:00:00", "time_end":"16:00:00", "time_zone":"America\/Detroit", "event_title":"MCDB Seminar> How Dynein Teams Adapt to Load and Coordinate Their Motors", "occurrence_title":"", "combined_title":"MCDB Seminar> How Dynein Teams Adapt to Load and Coordinate Their Motors: Arne Gennerich, Professor Albert Einstein College of Medicine", "event_subtitle":"Arne Gennerich, Professor Albert Einstein College of Medicine", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Cytoplasmic dynein drives long-distance transport along microtubules, but how motor complexes adapt to mechanical loads and coordinate their activities remains poorly understood. I will present our discovery that the dynein\u2013dynactin\u2013BicD2 (DDB) complex dynamically recruits a third dynein under load through an auxiliary BicD2 adaptor that interacts with the dynein light intermediate chain (LIC), increasing force generation from 7 to 9 pN. I will also show how our investigation of the neurodevelopmental disease-associated DYNC1H1 mutation P3018S revealed that the trailing dynein determines the velocity of multi-dynein complexes, while the leading dynein stimulates the trailing motor through its LIC. Together, these findings uncover unexpected roles for LICs in load-dependent motor recruitment and inter-motor communication, establishing new principles of dynein force adaptation and coordination.\n\n\nThe Gennerich Lab investigates the molecular mechanisms by which biomolecular motors generate force and motion in eukaryotic cells. We focus on understanding how defects in these processes contribute to human disease. Our research combines single-molecule biophysics, molecular biology, and biochemistry to study the function and regulation of microtubule-based motors\u2014kinesins and cytoplasmic dynein\u2014as well as RNA polymerase II during transcription elongation through chromatin.\n\nUsing a multidisciplinary approach that includes high-resolution optical trapping, single-molecule fluorescence microscopy, and CRISPR-Cas9-based genetic tools, we dissect how these motor proteins convert chemical energy into mechanical work and how their activity is modulated in different cellular contexts. Our long-term goal is to uncover the design principles of biomolecular motors and to elucidate the molecular basis of diseases caused by impaired motor function.", "occurrence_notes":null, "guid":"154033-21917057@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/154033", "building_id":"1005169", "building_name":"Biological Sciences Building", "campus_maps_id":"631", "room":"1010", "location_name":"Biological Sciences Building", "has_livestream":0, "cost":"", "tags":["Biology","Bsbsigns"], "website":"https:\/\/lsa.umich.edu\/mcdb\/news-events\/all-events.html#q=&filter=&start=&end=10\/23\/2027&tags=", "sponsors":[ { "group_name":"Department of Molecular, Cellular, and Developmental Biology", "group_id":"3755", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2026\/10\/event_154033_original-1.jpg", "styled_images":{ 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It offers a simple roadmap for using AI audits to make product and policy changes that benefit companies and the public alike. The book aims to convince readers that AI systems should be subject to robust audits to protect all of us from the dangers of these systems. Readers will come away with an understanding of what an AI audit is, why AI audits are important, key components of an audit that follows best practices, how to interpret an audit, and the available choices to act on an audit\u2019s results.\n\nThe book is organized around canonical examples: from AI-powered drones mistakenly targeting civilians in conflict areas to false arrests triggered by facial recognition systems that misidentified people with dark skin tones to HR hiring software that prefers men. It explains these definitive cases of AI decision-making gone wrong and then highlights specific audits that have led to concrete changes in government policy and corporate practice.\n\nAbout the ESC:\nThe Center for Ethics, Society, and Computing (ESC \u2013 pronounced \u201cescape\u201d) is dedicated to intervening when digital media and computing technologies reproduce inequality, exclusion, corruption, deception, racism, or sexism. ESC is generously supported by the School of Information; the Center for Political Studies at the Institute for Social Research; and the Department of Communication & Media in the College of Literature, Science, and the Arts at the University of Michigan.", "occurrence_notes":null, "guid":"154564-21917935@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/154564", "building_id":"null", "building_name":"Off Campus Location", "campus_maps_id":"1", "room":"", "location_name":"Cahoots Event Space, 206 E. 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