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    "153672-21916164":
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        "datetime_modified":"20261014T043502",
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        "has_end_time":1,
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        "event_title":"Biomedical Engineering (BME 500) Seminar Series",
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        "combined_title":"Biomedical Engineering (BME 500) Seminar Series: \"When Nanoparticles Talk to Proteins: Learning the Rules of Nanoscale Recognition,\" with Angela Violi, Ph.D.",
        "event_subtitle":"\"When Nanoparticles Talk to Proteins: Learning the Rules of Nanoscale Recognition,\" with Angela Violi, Ph.D.",
        "event_type":"Workshop \/ Seminar",
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        "description":"When Nanoparticles Talk to Proteins: Learning the Rules of Nanoscale Recognition\n\nAbstract:\nWhether a nanoparticle becomes a therapeutic, a diagnostic, or a toxin is decided at the moment it contacts a biomolecule. Our group has spent years developing molecular-scale descriptions of how nanoparticles form, what chemical identities they acquire, and how those identities govern their behavior in various environments.  Yet predicting where and how a given contact occurs remains slow and largely empirical: experiments are costly, atomistic simulations are computationally prohibitive, and existing computational models are built around protein-specific features that do not transfer to engineered nanomaterials.\n\nI will first show what this molecular-scale view makes possible by examining one system in detail. Bacterial biofilms resist both antibiotics and mechanical disruption, in part because their extracellular matrix is reinforced by amyloid fibers assembled from phenol-soluble modulin peptides. Combining simulation with experiment, we found that graphene quantum dots form supramolecular complexes with these peptides, docking near the peptide N-terminus, shifting the peptide's secondary structure away from the alpha-helix, and preventing fibrillation, thereby dispersing mature Staphylococcus aureus biofilms without killing the individual bacteria.\n\nIdentifying such interactions one simulation at a time, however, does not scale. I will then describe NeCLAS, a machine learning framework that predicts partner-specific nanoscale interactions across chemical domains. By combining a coarse-grained structural representation with features that encode the physicochemical neighborhood at multiple scales, NeCLAS predicts protein-nanoparticle contacts more accurately than existing methods, remains competitive with protein-specific models for protein-protein interactions, and extends to nanoparticle self-assembly. Together, these efforts point toward rational, predictive design of nanomaterials for biological targets, and our ongoing work pursues both directions: deeper mechanistic understanding of nanoparticle interactions with bacterial communities, and broader predictive models that make such interactions findable by design.\n    \nBio:\nAngela Violi is the Dennis Assanis Collegiate Professor and Arthur F. Thurnau Professor at the University of Michigan, where she serves as Associate Chair for Research in Mechanical Engineering. She holds appointments in Mechanical Engineering, Chemical Engineering, Electrical Engineering and Computer Science, Applied Physics, and the Biophysics Program. Her research sits at the intersection of nanoscience, molecular simulation, and biology, using computational methods (from quantum chemistry and molecular dynamics to machine learning) to understand how molecular-scale processes determine the formation, transformation, and function of nanomaterials, and what happens when those materials encounter living systems.\n\nVioli received her M.Sc. and Ph.D. in Chemical Engineering from the University of Naples \"Federico II\" in Italy. Before joining the University of Michigan faculty in 2006, she held research appointments at the University of Utah and at a Department of Energy ASCI center for science-based simulation of accidental fires and explosions. Her early work made foundational contributions to computational nanoscience, including multiscale models of carbonaceous nanoparticle inception and growth, as well as studies of the health effects of combustion-generated particles. In 2019, she led a U-M BlueSky Initiative that brought together engineering, medicine, microbiology, chemistry, and computational science to pursue nanoparticle design for health applications, the direction that anchors her current work.\n\nHer many honors include the U-M College of Engineering Research Excellence Award, selection as Michigan's nominee for the Michigan Distinguished Professor of the Year competition, the ASME George Westinghouse Silver Medal, the NSF CAREER Award, and election as a Fellow of the Combustion Institute.",
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        "tags":["Basic Science","Biointerfaces","Biology","biomedical","biomedical engineering","Bioninterfaces","Biosciences","Biotechnology","bme","engineer","engineering","Medicine","Michigan Engineering","Research","seminar"],
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        "datetime_modified":"20261007T170020",
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        "has_end_time":1,
        "date_start":"2026-10-22",
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        "time_start":"15:00:00",
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        "time_zone":"America\/Detroit",
        "event_title":"First Aid Kit Making Event",
        "occurrence_title":"",
        "combined_title":"First Aid Kit Making Event",
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        "description":"Stop by Room 1174 of the LSA Building anytime between 3-7pm on Thursday, 10\/22 to customize your own first aid kit! All materials (first aid pouches, bandages, antiseptic wipes, scissors, thermometers and much more) are provided and FREE. No sign-up required, tell your friends, and come grab what you need for your basic first aid kit! This event is organized by the LSA Student Government Health Subcommittee in collaboration with the UofM Red Cross Club.",
        "occurrence_notes":"In the LSA SG Office!",
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        "has_end_time":1,
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        "date_end":"2026-10-22",
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        "time_zone":"America\/Detroit",
        "event_title":"Georgetown Law School Webinar for UM Students only",
        "occurrence_title":"",
        "combined_title":"Georgetown Law School Webinar for UM Students only: Georgetown Law Admissions Team",
        "event_subtitle":"Georgetown Law Admissions Team",
        "event_type":"Presentation",
        "event_type_id":"16",
        "description":"Georgetown Law, located in the heart of where the law is made, offers an unparalleled education in which theory and practice uniquely intersect.  We invite you to learn more about Georgetown Law and the admissions process, and meet a member of the Admissions team, during a virtual information session.\n\nThis session is exclusively for University of Michigan Students. \n\nRegister to receive the Zoom link: https:\/\/georgetown.zoom.us\/meeting\/register\/DHCNAlbwTxGgvK1rPpZcRQ#\/registration",
        "occurrence_notes":"Register for the Zoom link",
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        "tags":["Law","Law School","Law School Application Preparation","Lsa","Lsa Newnan Academic Advising Center","Pre Law","Pre-Law","Pre-professional"],
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        "event_title":"Grants office hours: Get support applying for one of SSC's Sustainability Grants!",
        "occurrence_title":"",
        "combined_title":"Grants office hours: Get support applying for one of SSC's Sustainability Grants!",
        "event_subtitle":"",
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        "description":"Drop in to our weekly open office hours to learn and get support applying to our Planet Blue Student Innovation Fund (PBSIF) or Social and Environmental Sustainability Grant (SES).",
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        "tags":["Environment","Social Impact","Student Org","Sustainability"],
        "website":"https:\/\/planetblue.umich.edu\/campus\/get-involved\/for-students\/ssc\/grants\/",
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        "datetime_modified":"20260910T134907",
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        "event_title":"Hopwood Tea",
        "occurrence_title":"",
        "combined_title":"Hopwood Tea",
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        "tags":["Ann Arbor","Books","Creative Writing","English Language And Literature","Food","Free","Graduate Students","Hopwood Program","Literary Arts","Literature","The Helen Zell Writers' Program","Undergraduate Students","Well-being","Writing"],
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        "event_title":"IES Energy Seminar Series - Nuclear Energy\u2019s Next Act: Innovation, Federal Support and the Role of Modeling and Simulation",
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        "combined_title":"IES Energy Seminar Series - Nuclear Energy\u2019s Next Act: Innovation, Federal Support and the Role of Modeling and Simulation: Emily Shemon, Argonne National Laboratory",
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        "description":"Abstract:\nThe U.S. nuclear industry is entering a new chapter, driven by rising energy demand, renewed public interest, and unprecedented federal support. This talk will explore the forces behind today\u2019s nuclear momentum, including efforts to deploy advanced reactors, strengthen domestic nuclear capabilities, and sustain the performance of the existing reactor fleet. It will also highlight the growing role of modeling and simulation in this evolving landscape. As innovative reactor concepts move from idea to deployment, predictive tools are increasingly essential for understanding system behavior, guiding design and licensing, and evaluating technologies for which experimental data remain limited. Together, public investment, industry innovation, and advanced computational tools are helping shape nuclear energy\u2019s next act.\n\nBiography:\nDr. Emily Shemon is a nuclear engineer at the Department of Energy\u2019s Argonne National Laboratory. She serves on the extended leadership team of the DOE\u2019s Nuclear Energy Advanced Modeling and Simulation (NEAMS) Program where she manages development, validation, and deployment of multiphysics tools for nuclear reactor analysis. She currently leads technical teams that develop high fidelity meshing software as well as fast reactor technology modeling capabilities. She co-leads the National Reactor Innovation Center\u2019s Virtual Test Bed efforts, which supports industry adoption of advanced modeling and simulation through the open sharing of models. Dr. Shemon also has a background in high-performance computing and is on staff at Argonne\u2019s Leadership Computing Facility. She is a graduate of the University of Michigan\u2019s Department of Nuclear Engineering & Radiological Sciences where she received a Ph.D. in 2011.\n\n\nFor the most up to date information on the location, please check the related link the week of this event",
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