{ "143191-21892406": { "datetime_modified":"20260105T124948", "datetime_start":"20260129T120000", "datetime_end":"20260129T130000", "has_end_time":1, "date_start":"2026-01-29", "date_end":"2026-01-29", "time_start":"12:00:00", "time_end":"13:00:00", "time_zone":"America\/Detroit", "event_title":"DCMB Tools and Technology Seminar by Haoran Li", "occurrence_title":"", "combined_title":"DCMB Tools and Technology Seminar by Haoran Li: \u201cImproving gene isoform quantification with miniQuant\u201d", "event_subtitle":"\u201cImproving gene isoform quantification with miniQuant\u201d", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Abstract\r\nRNA sequencing has been widely applied for gene isoform quantification, but limitations exist in quantifying isoforms of complex genes accurately, especially for short reads. Here we identify genes that are difficult to quantify accurately with short reads and illustrate the information benefit of using long reads to quantify these regions. We present miniQuant, which ranks genes with quantification errors caused by the ambiguity of read alignments and integrates the complementary strengths of long reads and short reads with optimal combination in a gene- and data-specific manner to achieve more accurate quantification. These results are supported by rigorous mathematical proofs, validated with a wide range of simulation data, experimental validations and more than 17,000 public datasets from GTEx, TCGA and ENCODE consortia. We demonstrate miniQuant can uncover isoform switches during the differentiation of human embryonic stem cells to pharyngeal endoderm and primordial germ cell-like cells.\r\n\r\nAbout the DCMB Tools & Technology Seminar Series\r\n\r\nThe DCMB Tools and Technology Seminar Series is held in Medical Science Building 1 (MS1), Room 4B700, each Thursday at 12pm EST. Each seminar highlights a computational tool, technology, or methodology that is under development or in current use and is of special interest to DCMB and University researchers. Presenters are U-M researchers and students.\r\n\r\nThese seminars are live-streamed and recorded and made available for future viewing via the DCMB YouTube Channel", "occurrence_notes":null, "guid":"143191-21892406@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/143191", "building_id":"1000190", "building_name":"Medical Science Unit I", "campus_maps_id":"104", "room":"Room 4B700", "location_name":"Medical Science Unit I", "has_livestream":0, "cost":"", "tags":["Life Science","Bioinformatics","Biology","Biosciences","Research","Basic Science"], "website":"https:\/\/medschool.umich.edu\/events\/tools-technology-seminar-series\/tools-and-technology-seminar-haoran-li\/2026-01-29", "sponsors":[ { "group_name":"Department of Computational Medicine and Bioinformatics DCMB", "group_id":"5384", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2026\/01\/event_143191_original-1.png", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2026\/01\/event_143191_original-1.png", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2026\/01\/event_143191_original-1.png", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2026\/01\/event_143191_original-1.png", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2026\/01\/event_143191_original-1.png", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2026\/01\/event_143191_original-1.png", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2026\/01\/event_143191_original-1.png", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2026\/01\/event_143191_original-1.png", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2026\/01\/event_143191_original-1.png", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2026\/01\/event_143191_original-1.png", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2026\/01\/event_143191_original-1.png", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2026\/01\/event_143191_original-1.png", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2026\/01\/event_143191_original-1.png", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2026\/01\/event_143191_original-1.png", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2026\/01\/event_143191_original-1.png", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2026\/01\/event_143191_original-1.png" }, "occurrence_count":1, "first_occurrence":21892406 } , "143999-21894405": { "datetime_modified":"20260224T101438", "datetime_start":"20260129T120000", "datetime_end":"20260129T160000", "has_end_time":1, "date_start":"2026-01-29", "date_end":"2026-01-29", "time_start":"12:00:00", "time_end":"16:00:00", "time_zone":"America\/Detroit", "event_title":"Revolutionary Paine: Andy Murphy Student-Curated Class Exhibit Common Sense", "occurrence_title":"", "combined_title":"Revolutionary Paine: Andy Murphy Student-Curated Class Exhibit Common Sense", "event_subtitle":"", "event_type":"Exhibition", "event_type_id":"7", "description":"Thomas Paine\u2019s \u201cCommon Sense\u201d was one of the most influential works of the American Revolution. The first edition was published on January 10, 1776, with an initial print run of just 1,000 copies; but within weeks demand soared. The students of Andy Murphy\u2019s POLISCI 495 course co-curated the exhibition \u201cRevolutionary Paine\u201d to document the whirlwind caused by its publication. On view at the Clements January 16-May 8, weekdays from 12-4 pm.", "occurrence_notes":null, "guid":"143999-21894405@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/143999", "building_id":"1000159", "building_name":"William Clements Library", "campus_maps_id":"165", "room":"Avenir Foundation Reading Room", "location_name":"William Clements Library", "has_livestream":0, "cost":"", "tags":["history","Americana","Exhibit","Exhibition"], "website":"https:\/\/clements.umich.edu\/exhibit\/revolutionary-paine\/", "sponsors":[ { "group_name":"William L. 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A century later, it was an abandoned building with an uncertain future. From cornerstone to keystone, from the first director to the people who saved it from destruction, explore the life of a historic observatory 170 years in the making.\n\n\"Watcher of the Sky\" is being developed by student docents at the Detroit Observatory. Presented by the Judy and Stanley Frankel Detroit Observatory, part of the Bentley Historical Library.\n\n\"Watcher of the Sky\" is now on display at the Detroit Observatory (1398 Ann Street, Ann Arbor, 48109). View the exhibit during the Observatory's open hours:\nThursdays 12-5 pm\nFridays 12-11 pm\nSelected Saturdays 12-5 pm", "occurrence_notes":null, "guid":"138950-21884300@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/138950", "building_id":"1000198", "building_name":"Detroit Observatory", "campus_maps_id":"189", "room":"", "location_name":"Detroit Observatory", "has_livestream":0, "cost":"", "tags":["astronomy","university of michigan history","university history","U-m History","museums","Astronomers","bentley historical library","bentley library","Education","educational","Exhibition","free","history","Museum","Science"], "website":"https:\/\/detroitobservatory.umich.edu\/exhibit\/watcher-of-the-sky-making-and-remaking-the-detroit-observatory\/", "sponsors":[ { "group_name":"Judy and Stanley Frankel Detroit Observatory", "group_id":"5385", "website":"https:\/\/detroitobservatory.umich.edu\/" }, { "group_name":"Bentley Historical Library", "group_id":"2901", "website":"http:\/\/bentley.umich.edu" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2025\/09\/event_138950_original-1.jpg", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2025\/09\/event_138950_original-1.jpg", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2025\/09\/event_138950_original-1.jpg", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2025\/09\/event_138950_original-1.jpg", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2025\/09\/event_138950_original-1.jpg", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2025\/09\/event_138950_original-1.jpg", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2025\/09\/event_138950_original-1.jpg", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2025\/09\/event_138950_original-1.jpg", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2025\/09\/event_138950_original-1.jpg", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2025\/09\/event_138950_original-1.jpg", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2025\/09\/event_138950_original-1.jpg", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2025\/09\/event_138950_original-1.jpg", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2025\/09\/event_138950_original-1.jpg", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2025\/09\/event_138950_original-1.jpg", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2025\/09\/event_138950_original-1.jpg", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2025\/09\/event_138950_original-1.jpg" }, "occurrence_count":96, "first_occurrence":21884281 } , "143726-21893716": { "datetime_modified":"20260112T181655", "datetime_start":"20260129T121500", "datetime_end":"20260129T124500", "has_end_time":1, "date_start":"2026-01-29", "date_end":"2026-01-29", "time_start":"12:15:00", "time_end":"12:45:00", "time_zone":"America\/Detroit", "event_title":"Division Street Pipes", "occurrence_title":"", "combined_title":"Division Street Pipes", "event_subtitle":"", "event_type":"Performance", "event_type_id":"15", "description":"Join us for a 30-minute organ recital by Takeshi Nagayasu and Alex Sheng, secondary students of Caroline Robinson.\n\nDivision Street Pipes concerts features talented students and faculty of the U-M Organ Department on Thursdays at 12:15pm on the Richards-Fowkes organ at St. Andrew's Episcopal Church. These 30-minute performances are free and open to the public, and audience members are invited to enjoy their lunch while listening. \n\nThe series is co-sponsored by the University of Michigan Organ Department and St. Andrew\u2019s Episcopal Church in an effort to bring organ music to local audiences while connecting U-M organ students with the wider community. Concerts offer attendees the opportunity to hear the versatility of the pipe organ beyond a worship setting. The Winter 2026 concert series begins on January 15 and it will continue weekly through April 16 (with the exception of April 2).", "occurrence_notes":null, "guid":"143726-21893716@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/143726", "building_id":"null", "building_name":"Off Campus Location", "campus_maps_id":"1", "room":"", "location_name":"St. Andrew\u2019s Episcopal Church, 306 N. 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Examples range from theories of quantum gravity such as string theory, over cosmological theories such as inflation, to BSM theories such as low energy supersymmetry. In some cases, high hopes of discovery were not fulfilled or announcements of discovery turned out ill-founded. One response to this series of disappointments, both in physics and the philosophy of physics, has been an endorsement of scientific agnosticism. In experimental physics, this position amounts to emphasizing experimental strategies that are as little theory driven as possible. In theoretical physics, it amounts to avoiding any open declaration of trust in their theory by those working on theories that have not found conclusive empirical testing. In the philosophy of science, it amounts to focusing on reasons for a theory\u2019s pursuit-worthiness rather than arguments for its viability.\n\nIn this talk, I aim to show that the described tendency is based on a misreading of the recent history of physics, is conceptually unsatisfactory, and may, in the long run, carry serious risks for fundamental physics. 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