{ "139873-21886260": { "datetime_modified":"20251008T085458", "datetime_start":"20251022T151000", "datetime_end":"20251022T161000", "has_end_time":1, "date_start":"2025-10-22", "date_end":"2025-10-22", "time_start":"15:10:00", "time_end":"16:10:00", "time_zone":"America\/Detroit", "event_title":"CANCELED: MIPSE Seminar | Building Bridges \u2013 U.S. Fusion Energy Sciences Vision, Strategy, and Roadmap", "occurrence_title":"", "combined_title":"CANCELED: MIPSE Seminar | Building Bridges \u2013 U.S. Fusion Energy Sciences Vision, Strategy, and Roadmap: Dr. Jean Paul Allain, U.S. Department of Energy Office of Science", "event_subtitle":"Dr. Jean Paul Allain, U.S. Department of Energy Office of Science", "event_type":"Lecture \/ Discussion", "event_type_id":"13", "description":"Abstract: \r\nThe U.S. Department of Energy\u2019s vision, strategy, and ongoing roadmap development effort toward the accelerated development of fusion energy will be discussed. The presentation will cover a range of topics, including the restructured Fusion Energy Sciences in the Office of Science (SC-FES) and its supporting programs, public-private partnerships and new programs bridging science to supporting a fusion power industry in the U.S., and international collaborations. Emphasis will be placed on outlining key challenges and gaps being defined in the Fusion Science & Technology Roadmap under development by SC-FES in areas of materials, internal components, and fusion nuclear sciences.\r\n\r\nAbout the Speaker: \r\nDr. Jean Paul Allain is the Associate Director of Science for Fusion Energy Sciences (FES) in the Department of Energy (DOE) Office of Science (SC). With an annual budget of approximately $800M, Dr. Allain leads the FES with multiple areas including enabling and foundational burning plasma science including advanced tokamaks, theoretical and simulations, and long-pulse fusion plasmas. In addition, FES supports research in fusion materials and nuclear science, discovery plasma science and plasma technology, high-energy density plasmas and inertial fusion energy. FES also supports the US participation in ITER and public-private partnerships. Prior to joining FES in July 2023, Dr. Allain was Professor and Head of the Department of Nuclear Engineering at Pennsylvania State University. He was associate head in the Department of Nuclear, Plasma, and Radiological Engineering at the University of Illinois Urbana-Champaign, and associate professor at Purdue University. Dr. Allain led the Radiation Surface Science and Engineering Laboratory (RSSEL) conducting research in plasma-material interactions and authored over 350 peer-reviewed and proceedings papers in experimental and computational modeling work in particle and plasma-surface interactions with high-temperature materials in nuclear fusion, plasma medicine and nanomaterials. Dr Allain was also Faculty Entrepreneurial Fellow at UIUC with over 10 patents in advanced materials, founder of Editekk Inc, Energy Driven Technologies LLC, and a Fulbright fellowship in tech innovation.\r\n\r\nThe seminar will be conducted in person, with livestream in Zoom. Check MIPSE website for details:\r\nhttps:\/\/mipse.umich.edu\/seminars_2526.php", "occurrence_notes":null, "guid":"139873-21886260@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/139873", "building_id":"1000448", "building_name":"Electrical Engineering and Computer Science Building", "campus_maps_id":"56", "room":"1003", "location_name":"Electrical Engineering and Computer Science Building", "has_livestream":0, "cost":"", "tags":["Talk","seminar","Plasma","Physics","In Person","Lecture","Michigan Engineering"], "website":"https:\/\/mipse.umich.edu\/seminars_2526.php", "sponsors":[ { "group_name":"Michigan Institute for Plasma Science and Engineering (MIPSE)", "group_id":"4073", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2025\/09\/event_139873_original-1.jpg", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2025\/09\/event_139873_original-1.jpg", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2025\/09\/event_139873_original-1.jpg", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2025\/09\/event_139873_original-1.jpg", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2025\/09\/event_139873_original-1.jpg", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2025\/09\/event_139873_original-1.jpg", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2025\/09\/event_139873_original-1.jpg", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2025\/09\/event_139873_original-1.jpg", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2025\/09\/event_139873_original-1.jpg", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2025\/09\/event_139873_original-1.jpg", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2025\/09\/event_139873_original-1.jpg", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2025\/09\/event_139873_original-1.jpg", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2025\/09\/event_139873_original-1.jpg", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2025\/09\/event_139873_original-1.jpg", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2025\/09\/event_139873_original-1.jpg", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2025\/09\/event_139873_original-1.jpg" }, "occurrence_count":1, "first_occurrence":21886260 } , "137214-21879974": { "datetime_modified":"20251007T225713", "datetime_start":"20251022T153000", "datetime_end":"20251022T170000", "has_end_time":1, "date_start":"2025-10-22", "date_end":"2025-10-22", "time_start":"15:30:00", "time_end":"17:00:00", "time_zone":"America\/Detroit", "event_title":"Algebraic Geometry Seminar: Anosov representations and Hodge theory", "occurrence_title":"", "combined_title":"Algebraic Geometry Seminar: Anosov representations and Hodge theory: Simion Filip (U. Chicago)", "event_subtitle":"Simion Filip (U. Chicago)", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Discrete subgroups of Lie groups are much studied and appear throughout mathematics. Anosov subgroups form a class which is intermediate between lattices in higher rank semisimple Lie groups and Fuchsian subgroups of SL(2,R) that uniformize Riemann surfaces. After providing the necessary background, I will explain how Anosov representations can arise as monodromies of families of algebraic manifolds and how this phenomenon is related to Hodge theory. I will then describe some uniformization results for \"non-classical\" variations of Hodge structure and explain some Torelli theorems for certain 1-dimensional families of Calabi-Yau manifolds.", "occurrence_notes":null, "guid":"137214-21879974@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/137214", "building_id":"1000166", "building_name":"East Hall", "campus_maps_id":"53", "room":"4096", "location_name":"East Hall", "has_livestream":0, "cost":"", "tags":["Mathematics"], "website":"", "sponsors":[ { "group_name":"Algebraic Geometry Seminar - Department of Mathematics", "group_id":"4880", "website":"" }, { "group_name":"Department of Mathematics", "group_id":"3791", "website":"" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21879974 } , "120629-21886650": { "datetime_modified":"20251001T100117", "datetime_start":"20251022T153000", "datetime_end":"20251022T161500", "has_end_time":1, "date_start":"2025-10-22", "date_end":"2025-10-22", "time_start":"15:30:00", "time_end":"16:15:00", "time_zone":"America\/Detroit", "event_title":"LSA Transfer Information Session", "occurrence_title":"", "combined_title":"LSA Transfer Information Session: For prospective transfer students who have not applied", "event_subtitle":"For prospective transfer students who have not applied", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Join the LSA Transfer Recruitment Team for our virtual sessions where we will discuss LSA requirements, transfer credit, pre-transfer academic advising, LSA opportunities and other transfer tidbits. \r\n\r\nRegistration is required. Register using link to the right.", "occurrence_notes":null, "guid":"120629-21886650@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/120629", "building_id":"null", "building_name":"Off Campus Location", "campus_maps_id":"1", "room":"", "location_name":"Virtual", "has_livestream":0, "cost":"", "tags":["Transfer Students"], "website":"https:\/\/app.acuityscheduling.com\/schedule.php?owner=20431355&appointmentType=33675577", "sponsors":[ { "group_name":"LSA Transfer Student Recruitment", "group_id":"4063", "website":"" }, { "group_name":"LSA Transfer Student Center", "group_id":"4442", "website":"" }, { "group_name":"LSA Student Recruitment", "group_id":"4928", "website":"https:\/\/lsa.umich.edu\/lsa\/faculty-staff\/undergraduate-education\/student-recruitment.html" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2024\/03\/event_120629_original-1.jpeg", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2024\/03\/event_120629_original-1.jpeg", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2024\/03\/event_120629_original-1.jpeg", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2024\/03\/event_120629_original-1.jpeg", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2024\/03\/event_120629_original-1.jpeg", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2024\/03\/event_120629_original-1.jpeg", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2024\/03\/event_120629_original-1.jpeg", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2024\/03\/event_120629_original-1.jpeg", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2024\/03\/event_120629_original-1.jpeg", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2024\/03\/event_120629_original-1.jpeg", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2024\/03\/event_120629_original-1.jpeg", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2024\/03\/event_120629_original-1.jpeg", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2024\/03\/event_120629_original-1.jpeg", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2024\/03\/event_120629_original-1.jpeg", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2024\/03\/event_120629_original-1.jpeg", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2024\/03\/event_120629_original-1.jpeg" }, "occurrence_count":4, "first_occurrence":21884102 } , "140824-21887692": { "datetime_modified":"20251106T123213", "datetime_start":"20251022T153000", "datetime_end":"20251022T163000", "has_end_time":1, "date_start":"2025-10-22", "date_end":"2025-10-22", "time_start":"15:30:00", "time_end":"16:30:00", "time_zone":"America\/Detroit", "event_title":"Pathways Into Teaching - The Marshall Teacher Residency", "occurrence_title":"", "combined_title":"Pathways Into Teaching - The Marshall Teacher Residency", "event_subtitle":"", "event_type":"Careers \/ Jobs", "event_type_id":"2", "description":"\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0Thinking About Teaching? Let\u2019s Talk Pathways with MarshallThis workshop will provide a comprehensive overview of the various pathways into the teaching profession, including\u00a0Master\u2019s programs,\u00a0Intern Programs, and\u00a0Teacher Residencies. Designed for individuals considering a career in education, the session will be facilitated by arepresentative from the Marshall Teacher Residency\u00a0. Learn more about us and gain valuable insight into the preparation options available and the steps needed to pursue a successful career in teaching.", "occurrence_notes":null, "guid":"140824-21887692@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/140824", "building_id":"", "building_name":"", "campus_maps_id":"", "room":"", "location_name":"", "has_livestream":0, "cost":"", "tags":[], "website":"", "sponsors":[ { "group_name":"University Career Center UCC", "group_id":"1140", "website":"http:\/\/careercenter.umich.edu" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21887692 } , "139119-21884929": { "datetime_modified":"20251106T123134", "datetime_start":"20251022T160000", "datetime_end":"20251022T164500", "has_end_time":1, "date_start":"2025-10-22", "date_end":"2025-10-22", "time_start":"16:00:00", "time_end":"16:45:00", "time_zone":"America\/Detroit", "event_title":"A Day in the Life of a Sales Intern to Full-Time Professional", "occurrence_title":"", "combined_title":"A Day in the Life of a Sales Intern to Full-Time Professional", "event_subtitle":"", "event_type":"Careers \/ Jobs", "event_type_id":"2", "description":"Join us for an exclusive session with former Gallagher interns sharing their secrets to a successful internship and insights on how they transitioned from an Intern to Full-time employee at Gallagher.\u00a0 Gainvaluable tips and insights to navigate challenges and seize opportunitiesin the sales world. Bring your questions and uncover your pathway to success with Gallagher!\u00a0", "occurrence_notes":null, "guid":"139119-21884929@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/139119", "building_id":"", "building_name":"", "campus_maps_id":"", "room":"", "location_name":"", "has_livestream":0, "cost":"", "tags":[], "website":"", "sponsors":[ { "group_name":"University Career Center UCC", "group_id":"1140", "website":"http:\/\/careercenter.umich.edu" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21884929 } , "140009-21886498": { "datetime_modified":"20251007T092937", "datetime_start":"20251022T160000", "datetime_end":"20251022T170000", "has_end_time":1, "date_start":"2025-10-22", "date_end":"2025-10-22", "time_start":"16:00:00", "time_end":"17:00:00", "time_zone":"America\/Detroit", "event_title":"CCMB\/DCMB Weekly Seminar Series featuring Hyunghoon Cho, PhD (Prof. at Yale School of Medicine)", "occurrence_title":"", "combined_title":"CCMB\/DCMB Weekly Seminar Series featuring Hyunghoon Cho, PhD (Prof. at Yale School of Medicine): \"Enabling Collaborative Genomic Studies with Privacy\u201d\"", "event_subtitle":"\"Enabling Collaborative Genomic Studies with Privacy\u201d\"", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"Abstract\r\n\r\nThe sensitive nature of genomic data poses significant challenges for data sharing and collaboration in biomedicine. Traditional safeguards, such as access control mechanisms, often lead to data fragmentation across silos, hindering large-scale analysis. In this talk, I will describe our recent work on secure federated (SF) algorithms, which leverage cryptography and distributed computing to enable collaborative genomic research without compromising privacy. I will showcase practical tools we have developed for key analysis tasks, including genome-wide association studies (Nature Genetics, 2025), principal component analysis (IEEE S&P, 2023), and the identification of genetic relatives (Genome Research, 2024). Finally, I will discuss our recent efforts to deploy these methods across the NIH All of Us and VA Million Veteran Program biobanks, as well as the broader opportunities that privacy-enhancing technologies offer for advancing biomedical data science\r\n\r\nShort Bio\r\n\r\nHyunghoon (Hoon) Cho received his Ph.D. in Electrical Engineering and Computer Science at MIT in 2019. Previously, he received his M.S. and B.S. with Honors in Computer Science from Stanford University. His research focuses on overcoming key computational challenges in analyzing massive and distributed biomedical data, creating modern tools from applied cryptography and machine learning. He is especially interested in solving problems in the areas of biomedical data privacy, single-cell genomics, and network biology. He is a recipient of the NIH Director's Early Independence Award.", "occurrence_notes":null, "guid":"140009-21886498@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/140009", "building_id":"1005047", "building_name":"Palmer Commons", "campus_maps_id":"188", "room":"Forum Hall", "location_name":"Palmer Commons", "has_livestream":0, "cost":"", "tags":["Biomedical Engineering","Bioinformatics","Basic Science","Artificial Intelligence"], "website":"https:\/\/medschool.umich.edu\/events\/ccmb-seminar-series\/ccmb-seminar-hyunghoon-cho-phd\/2025-10-22", "sponsors":[ { "group_name":"Department of Computational Medicine and Bioinformatics DCMB", "group_id":"5384", "website":"" }, { "group_name":"DCMB Seminar Series", "group_id":"3754", "website":"" } ], "image_url":"https:\/\/events.umich.edu\/media\/attachments\/2025\/09\/event_140009_original-1.jpg", "styled_images":{ "event_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_thumb\/media\/attachments\/2025\/09\/event_140009_original-1.jpg", "event_large":"https:\/\/events.umich.edu\/media\/cache\/event_large\/media\/attachments\/2025\/09\/event_140009_original-1.jpg", "event_large_2x":"https:\/\/events.umich.edu\/media\/cache\/event_large_2x\/media\/attachments\/2025\/09\/event_140009_original-1.jpg", "event_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/event_large_lightbox\/media\/attachments\/2025\/09\/event_140009_original-1.jpg", "group_thumb":"https:\/\/events.umich.edu\/media\/cache\/group_thumb\/media\/attachments\/2025\/09\/event_140009_original-1.jpg", "group_thumb_square":"https:\/\/events.umich.edu\/media\/cache\/group_thumb_square\/media\/attachments\/2025\/09\/event_140009_original-1.jpg", "group_large":"https:\/\/events.umich.edu\/media\/cache\/group_large\/media\/attachments\/2025\/09\/event_140009_original-1.jpg", "group_large_lightbox":"https:\/\/events.umich.edu\/media\/cache\/group_large_lightbox\/media\/attachments\/2025\/09\/event_140009_original-1.jpg", "event_large_crop":"https:\/\/events.umich.edu\/media\/cache\/event_large_crop\/media\/attachments\/2025\/09\/event_140009_original-1.jpg", "event_list":"https:\/\/events.umich.edu\/media\/cache\/event_list\/media\/attachments\/2025\/09\/event_140009_original-1.jpg", "event_list_2x":"https:\/\/events.umich.edu\/media\/cache\/event_list_2x\/media\/attachments\/2025\/09\/event_140009_original-1.jpg", "event_grid":"https:\/\/events.umich.edu\/media\/cache\/event_grid\/media\/attachments\/2025\/09\/event_140009_original-1.jpg", "event_grid_2x":"https:\/\/events.umich.edu\/media\/cache\/event_grid_2x\/media\/attachments\/2025\/09\/event_140009_original-1.jpg", "event_feature_large":"https:\/\/events.umich.edu\/media\/cache\/event_feature_large\/media\/attachments\/2025\/09\/event_140009_original-1.jpg", "event_feature_thumb":"https:\/\/events.umich.edu\/media\/cache\/event_feature_thumb\/media\/attachments\/2025\/09\/event_140009_original-1.jpg" }, "occurrence_count":1, "first_occurrence":21886498 } , "137757-21880684": { "datetime_modified":"20251015T124301", "datetime_start":"20251022T160000", "datetime_end":"20251022T180000", "has_end_time":1, "date_start":"2025-10-22", "date_end":"2025-10-22", "time_start":"16:00:00", "time_end":"18:00:00", "time_zone":"America\/Detroit", "event_title":"Exploring Well-Being in Graduate Education: A Rackham Symposium", "occurrence_title":"Poster Session Reception", "combined_title":"Exploring Well-Being in Graduate Education: A Rackham Symposium: Multiple conference events and sessions: Poster Session Reception", "event_subtitle":"Multiple conference events and sessions", "event_type":"Conference \/ Symposium", "event_type_id":"5", "description":"Join faculty, staff, and students for a transformative event dedicated to advancing mental health and well-being in graduate education. Together, we'll explore research, share strategies, and build supportive academic communities.", "occurrence_notes":null, "guid":"137757-21880684@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/137757", "building_id":"", "building_name":"", "campus_maps_id":"", "room":"", "location_name":"4th Floor Assembly Hall", "has_livestream":0, "cost":"", "tags":["Sessions","Rgs-events","Rgs Events"], "website":"https:\/\/sessions.studentlife.umich.edu\/p\/track\/14589", "sponsors":[ { "group_name":"Sessions @ Michigan", "group_id":"4791", "website":"https:\/\/sessions.studentlife.umich.edu\/" }, { "group_name":"Rackham Graduate School", "group_id":"1187", "website":"https:\/\/www.facebook.com\/umichgradschool" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":22, "first_occurrence":21880684 } , "138386-21882885": { "datetime_modified":"20251014T155632", "datetime_start":"20251022T160000", "datetime_end":"20251022T171500", "has_end_time":1, "date_start":"2025-10-22", "date_end":"2025-10-22", "time_start":"16:00:00", "time_end":"17:15:00", "time_zone":"America\/Detroit", "event_title":"Gomberg Lecture with Andy Borovik \"Biological C\u2013H Bond Cleavage\"", "occurrence_title":"", "combined_title":"Gomberg Lecture with Andy Borovik \"Biological C\u2013H Bond Cleavage\": Andy Borovik (UC Irvine)", "event_subtitle":"Andy Borovik (UC Irvine)", "event_type":"Workshop \/ Seminar", "event_type_id":"21", "description":"The oxidation of substrates via the cleavage of thermodynamically strong C\u2013H bonds is an essential part of mammalian metabolism. These reactions are predominantly carried out by enzymes that produce high valent metal\u2013oxido species, which are directly responsible for cleaving the C\u2013H bonds. While much is known about the identity of these transient intermediates, the mechanistic factors that enable metal\u2013oxido species to accomplish such difficult transformations are still incomplete. For synthetic metal\u2013oxido species, C\u2013H bond cleavage is often mechanistically described as synchronous proton coupled electron transfer (PCET). However, data have emerged that suggest the basicity of the M\u2013 oxido unit is the key determinant in achieving enzymatic function, thus requiring alternative mechanisms whereby proton transfer (PT) has a more dominate role than electron transfer (ET). This presentation will describe our research to gain mechanistic insights into how metal\u2013oxido complexes activate C\u2013H bonds. We have used a series of well-characterized Mn(III)\u2013 and M(IV)\u2013oxido complexes to show that PT has a dominate role in the activation processes. Our experimental findings led to a proposed PCET mechanism with asynchronous transition states that is dominated by PT. To support this premise, a new semi-empirical free energy analysis was developed that can predict the relative contributions of PT and ET for a given set of substrates. These findings underscore why the basicity of M\u2013oxido units needs to be considered in C\u2013H functionalization.", "occurrence_notes":null, "guid":"138386-21882885@events.umich.edu", "permalink":"http:\/\/events.umich.edu\/event\/138386", "building_id":"1000158", "building_name":"Chemistry Dow Lab", "campus_maps_id":"34", "room":"1640", "location_name":"Chemistry Dow Lab", "has_livestream":0, "cost":"", "tags":["Chemistry"], "website":"https:\/\/www.chem.uci.edu\/~aborovik\/Borovik_Homepage\/Andy_Borovik.html", "sponsors":[ { "group_name":"Department of Chemistry", "group_id":"3761", "website":"https:\/\/lsa.umich.edu\/chem" } ], "image_url":"", "styled_images":{ "event_thumb":"", "event_large":"", "event_large_2x":"", "event_large_lightbox":"", "group_thumb":"", "group_thumb_square":"", "group_large":"", "group_large_lightbox":"", "event_large_crop":"", "event_list":"", "event_list_2x":"", "event_grid":"", "event_grid_2x":"", "event_feature_large":"", "event_feature_thumb":"" }, "occurrence_count":1, "first_occurrence":21882885 } }